Xinyang Tablet inhibits MLK3-mediated pyroptosis to attenuate inflammation and cardiac dysfunction in pressure overload

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

(2020) Anita A. Pinar et al.   PHARMACOLOGY & THERAPEUTICS

Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice

(2020) Xueling Li et al.   CARDIOVASCULAR DRUGS AND THERAPY

Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy

(2020) Zongna Ren et al.   CIRCULATION

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats

(2020) Xiaoping Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammasomes and Proteostasis Novel Molecular Mechanisms Associated With Atrial Fibrillation

(2020) Na Li et al.   CIRCULATION RESEARCH

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

(2020) Junyan Wang et al.   Cell Death & Disease

Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction

(2020) Max J. M. Silvis et al.   Journal of Cardiovascular Translational Research

Traditional Chinese medicine in cardiovascular drug discovery

(2020) Elaine Lai-Han Leung et al.   PHARMACOLOGICAL RESEARCH

Efficacy and safety of high-dose Xueshuantong injection (lyophilised) in reducing the incidence of major adverse cardiovascular events in patients with unstable angina: a protocol of a randomised, parallel-arm, controlled, double-blind and multicentre clinical trial based on dual antiplatelet therapy

(2020) Wenjie Long et al.   BMJ Open

Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages

(2019) Priyanka Saminathan et al.   Journal of Neuroimmune Pharmacology

Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF

(2019) Michael R. Zile et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy

(2019) Sumit Kar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High-throughput screening identifies mixed lineage kinase 3 as a key host regulatory factor in Zika virus infection

(2019) Hua Xu et al.   JOURNAL OF VIROLOGY

Characteristics, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: The China PEACE Retrospective Heart Failure Study

(2019) Yuan Yu et al.   Journal of the American Heart Association

New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity

(2019) Aaron J. Rhee et al.   Annual Review of Physiology

Multimodality Imaging of Inflammation and Ventricular Remodeling in Pressure Overload Heart Failure

(2019) Aylina Glasenapp et al.   JOURNAL OF NUCLEAR MEDICINE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery

(2018) Nikolaos A. Afratis et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation

(2018) Chunxia Yao et al.   CIRCULATION

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

(2018) Wenbin Gao et al.   Frontiers in Physiology

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload

(2018) Timothy D. Calamaras et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult

(2017) Han Xiao et al.   EUROPEAN HEART JOURNAL

The role of chemokines in hypertension and consequent target organ damage

(2017) Nathan P. Rudemiller et al.   PHARMACOLOGICAL RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Chronic Heart Failure and Inflammation

(2016) Sarah A. Dick et al.   CIRCULATION RESEARCH

Protective role of downregulated MLK3 in myocardial adaptation to chronic hypoxia

(2016) Siyi He et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model

(2014) Kun Hyoe Rhoo et al.   PLoS One

Fibrosis and heart failure

(2012) Ana Maria Segura et al.   HEART FAILURE REVIEWS

Novel biomarkers in chronic heart failure

(2012) Tariq Ahmad et al.   Nature Reviews Cardiology

Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease

(2011) Yue Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In search of new therapeutic targets and strategies for heart failure: recent advances in basic science

(2011) Ajay M Shah et al.   LANCET

Cardiac mast cells: the centrepiece in adverse myocardial remodelling

(2010) S. P. Levick et al.   CARDIOVASCULAR RESEARCH