Review
Immunology
Chunping Liu, Huiqi Chen, Yanjiao Liu, Haiding Huang, Wanling Yu, Tingting Du, Xinyao Long, Xinming Chen, Zhijun Chen, Sien Guo, Jinxin Li, Zebo Jiang, Lei Wang, Chuanjian Lu
Summary: Psoriasis is a persistent inflammatory disease with a genetic predisposition, and it is often associated with the involvement of multiple organs. Atherosclerosis is a common complication in severe psoriasis patients. The specific pathogenesis of psoriasis is still unclear, but it is believed to be a polygenic genetic disease influenced by factors such as heredity and environment. Immune-mediated inflammatory pathways are involved in the proliferation of keratinocytes and the release of inflammatory factors. Psoriasis and atherosclerosis are closely related, and systemic inflammation may be a common feature of both conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Madison C. B. Paton, Megan Finch-Edmondson, Russell C. Dale, Michael C. Fahey, Claudia A. Nold-Petry, Marcel F. Nold, Alexandra R. Griffin, Iona Novak
Summary: Research has shown that inflammation plays a role in brain injury and the development of cerebral palsy (CP). It is believed that inflammation may persist as a comorbidity in CP, contributing to ongoing functional impairments. Studies have found significant differences in inflammatory markers between CP patients and controls, particularly cytokines such as tumor necrosis factor, Interleukin (IL)-6, and IL-10. These differences in inflammation may also vary among different subgroups of CP. Further research is needed to fully understand the complexity of inflammation and its long-term effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Sanggeeta Surandran, Saad Ahmed, Tom Walton, Elena Nikiphorou, Mrinalini Dey
Summary: Early identification and management of multimorbidity in patients with rheumatic and musculoskeletal diseases (RMDs) is critical for disease outcome and treatment response.
Review
Immunology
Homa Seyedmirzaei, Nima Rezaei
Summary: Psoriasis is a chronic immune-mediated disease affecting 125 million people globally, with non-cutaneous manifestations such as joint symptoms and other immune-mediated diseases. Imbalanced cytokines can lead to abnormal keratinocytes, neovascularization, and inflammation in psoriasis patients, highlighting the importance of understanding cytokine roles for treatment. Cytokines may also serve as severity markers for monitoring psoriasis patients.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey, Susanne Russ, Felix Schulze, Liza Mccann, Susanne Abraham, Christian M. Hedrich
Summary: This study investigated disease-associated DNA methylation patterns in CD4(+) T-cells from psoriasis and psoriatic arthritis (PsA) patients. The DNA methylation profiles in CD4(+) T-cells can distinguish between skin psoriasis and PsA, and may be used to quantify disease activity and guide individualized treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Toshihiro Kishikawa, Noriko Arase, Shigeyoshi Tsuji, Yuichi Maeda, Takuro Nii, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Kotaro Ogawa, Shiro Ohshima, Hidenori Inohara, Atsushi Kumanogoh, Manabu Fujimoto, Yukinori Okada
Summary: This study conducted metabolome analysis to identify metabolite biomarkers of psoriasis and its subtypes PsA and PsC, revealing significant changes in specific metabolites and differences between PsA and PsC, contributing to the understanding of psoriasis pathophysiology.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Rheumatology
Liliana F. Mellor, Nuria Gago-Lopez, Latifa Bakiri, Felix N. Schmidt, Bjorn Busse, Simon Rauber, Maria Jimenez, Diego Megias, Sergio Oterino-Soto, Ricardo Sanchez-Prieto, Sergei Grivennikov, Xinzhu Pu, Julia Oxford, Andreas Ramming, Georg Schett, Erwin F. Wagner
Summary: Keratinocyte-derived S100A9 plays a regulatory role in psoriatic skin and joint disease. In addition, S100A9 and CP have the potential to serve as biomarkers for identifying Ps patients at risk of developing PsA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Yixin Zheng, Jianan Zhao, Yu Shan, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation in synovial tissues. Granzymes (Gzms) are serine proteases that enter target cells to induce programmed cell death. Increased levels of Gzms have been found in RA patients and they may contribute to inflammation by degrading extracellular matrix and promoting cytokine release. Although their exact role is yet to be fully understood, Gzms have the potential to be used as biomarkers for RA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Lili Borbala Flink, Ameneh Ghaffarinia, Benjamin Tamas Papp, Akos Varga, Andras Istvan Vigh, Daniel Laszlo Vidacs, Robert Kui, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Renata Bozo
Summary: Psoriatic skin shows abnormal wound healing-like characteristics, even in non-lesional skin. Elevated levels of fibroblast-derived dermal periostin were observed in psoriatic patients, especially in those receiving systemic treatment. Basal keratinocytes in psoriatic skin exhibited significant periostin positivity, both in non-lesional, lesional, and previously-lesional areas. This abnormal wound healing-like phenotype with overexpression of periostin in psoriatic skin suggests a potential compensatory mechanism initiated by basal membrane injury, which can persist in healed skin.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Bai Ruiyang, Adriana Panayi, Wu Ruifang, Zhang Peng, Fu Siqi
Summary: Psoriasis is an immune-mediated skin disease associated with multiple metabolic comorbidities. Recent research has highlighted the central role of adiponectin in psoriasis and its comorbidities.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Immunology
Theo Wirth, Nathalie Balandraud, Laurent Boyer, Pierre Lafforgue, Thao Pham
Summary: PsA diagnosis and treatment is often delayed, resulting in joint damage and disability. Research has identified potential biomarkers to improve PsA diagnosis and prognosis, but further studies are needed to evaluate their performance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Dermatology
D. M. W. Balak, L. M. Perez-Chada, L. N. Guo, C. Mita, A. W. Armstrong, S. J. Bell, G. C. Gondo, W. Liao, J. F. Merola
Summary: This systematic literature review identified various definitions of psoriasis remission and cure. Most definitions used Psoriasis Area and Severity Index (PASI) endpoints and descriptive endpoints related to 'skin clearance'. Few definitions specified time-frame, on/off treatment, or other psoriasis-related disease domains. While there is no cure, some studies used similar endpoints to define psoriasis cure. These findings will contribute to the development of consensus-based definitions for psoriasis remission.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Freddy Lattekivi, Irina Guljavina, Getnet Midekessa, Janeli Viil, Paul R. Heath, Rikke Baek, Malene Moller Jorgensen, Aneta Andronowska, Kulli Kingo, Alireza Fazeli
Summary: Psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) are inflammatory diseases with unresolved pathophysiological aspects. In this study, the miRNA contents and surface proteome of blood serum extracellular vesicles (EVs) were compared between PsV and PsA patients and healthy controls. It was found that there were differentially enriched EV-bound miRNAs in both PsV and PsA groups, suggesting that EVs may play a role in the pathophysiological processes of PsV and PsA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Kristina Callis Duffin, Luis Daniel Mazzuoccolo, Maria Julia Cura, Maria Esposito, Anthony P. Fernandez, Paolo Gisondi, Alessandro Giunta, Tom Hillary, Stefano Piaserico, James A. Solomon, Joseph F. Merola
Summary: This study aimed to summarize and evaluate the current evidence on the efficacy of therapies for cutaneous psoriasis in patients with psoriatic arthritis. The findings suggest that several pharmacologic therapeutic classes have high-quality evidence demonstrating efficacy for cutaneous psoriasis in the psoriatic arthritis population.
JOURNAL OF RHEUMATOLOGY
(2023)
