Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7

Whole genome sequencing unveils genetic heterogeneity in optic nerve hypoplasia

(2020) Sara Dahl et al.   PLoS One

Co-occurrence of mutations in KIF7 and KIAA0556 in Joubert syndrome with ocular coloboma, pituitary malformation and growth hormone deficiency: a case report and literature review

(2020) Marcello Niceta et al.   BMC Pediatrics

These motors were made for walking

(2020) Byron Hunter et al.   PROTEIN SCIENCE

Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity

(2020) Laure Asselin et al.   Nature Communications

Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing

(2020) Shuzhang Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human papillomavirus 16 ( HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7

(2020) Yue Hu et al.   Thoracic Cancer

Mutations in KIF7 Implicated in Idiopathic Scoliosis in Humans and Axial Curvatures in Zebrafish

(2020) Elizabeth A. Terhune et al.   HUMAN MUTATION

Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7

(2019) Shuo Jiang et al.   DEVELOPMENTAL CELL

PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport

(2019) Nida Siddiqui et al.   Nature Communications

Olfactory bulb and olfactory tract abnormalities in acrocallosal syndrome and Greig cephalopolysyndactyly syndrome

(2019) Subramanian Subramanian et al.   PEDIATRIC RADIOLOGY

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

(2019) Kyoko Chiba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles

(2018) Sudhir Kumar Singh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling

(2018) Reza Asadollahi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

(2018) Michael T. Kelliher et al.   JOURNAL OF CELL BIOLOGY

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7

(2018) Yang Yue et al.   JOURNAL OF CELL BIOLOGY

Cilium structure, assembly, and disassembly regulated by the cytoskeleton

(2018) Mary Mirvis et al.   BIOCHEMICAL JOURNAL

Kinesin-5 Regulation and Function in Mitosis

(2018) Barbara J. Mann et al.   TRENDS IN CELL BIOLOGY

Parts list for a microtubule depolymerising kinesin

(2018) Claire T. Friel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Altered GLI3 and FGF8 signaling underlies Acrocallosal syndrome phenotypes in Kif7 depleted mice

(2018) Audrey Putoux et al.   HUMAN MOLECULAR GENETICS

Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition

(2018) Jinqi Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition

(2017) Kai Yau Wong et al.   Oncotarget

The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus

(2017) Ching-In Lau et al.   Oncotarget

Kinesin-4 KIF21B is a potent microtubule pausing factor

(2017) Wilhelmina E van Riel et al.   eLife

Refining the phenotypical and mutational spectrum of Taybi-Linder syndrome

(2016) A. Putoux et al.   CLINICAL GENETICS

Cilium assembly and disassembly

(2016) Irma Sánchez et al.   NATURE CELL BIOLOGY

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

(2016) Amy E. Ghiretti et al.   NEURON

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations

(2016) Sarah Bianchi et al.   Scientific Reports

Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses

(2016) Shinsuke Niwa et al.   Cell Reports

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

(2016) Uchenna Emechebe et al.   eLife

NovelKIF7missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome

(2015) Sanjin Tunovic et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A novel KIF7 mutation in two affected siblings with acrocallosal syndrome

(2015) Kadri Karaer et al.   CLINICAL DYSMORPHOLOGY

Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity

(2015) R Bachmann-Gagescu et al.   JOURNAL OF MEDICAL GENETICS

Characterizing KIF16B in Neurons Reveals a Novel Intramolecular "Stalk Inhibition" Mechanism That Regulates Its Capacity to Potentiate the Selective Somatodendritic Localization of Early Endosomes

(2015) A. Farkhondeh et al.   JOURNAL OF NEUROSCIENCE

Microtubule-associated proteins control the kinetics of microtubule nucleation

(2015) Michal Wieczorek et al.   NATURE CELL BIOLOGY

Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module

(2015) Johanna Roostalu et al.   NATURE CELL BIOLOGY

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms

(2015) Garry L. Coles et al.   PLoS Genetics

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling

(2014) Long Cheng et al.   NEURON

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

(2014) Y. C. Liu et al.   Science Signaling

The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline

(2013) L. S. Williams et al.   DEVELOPMENT

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor

(2013) Babet van der Vaart et al.   DEVELOPMENTAL CELL

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

(2013) Ashish Kumar Maurya et al.   PLoS Genetics

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis

(2012) Z. J. Li et al.   DEVELOPMENT

Acrocallosal syndrome: Identification of a novel KIF7 mutation and evidence for oligogenic inheritance

(2012) Diana M. Walsh et al.   European Journal of Medical Genetics

NovelKIF7mutations extend the phenotypic spectrum of acrocallosal syndrome

(2012) Audrey Putoux et al.   JOURNAL OF MEDICAL GENETICS

A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance

(2012) Bassam R Ali et al.   Orphanet Journal of Rare Diseases

The CC1-FHA Tandem as a Central Hub for Controlling the Dimerization and Activation of Kinesin-3 KIF1A

(2012) Lin Huo et al.   STRUCTURE

Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming

(2011) P. Moua et al.   DEVELOPMENT

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

(2011) Claudia Dafinger et al.   JOURNAL OF CLINICAL INVESTIGATION

KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

(2011) Audrey Putoux et al.   NATURE GENETICS

T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension

(2011) P. Di Tommaso et al.   NUCLEIC ACIDS RESEARCH

The Translocation Selectivity of the Kinesins that Mediate Neuronal Organelle Transport

(2011) Chun-fang Huang et al.   TRAFFIC

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms

(2010) Jennetta W. Hammond et al.   JOURNAL OF CELL BIOLOGY

Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner

(2010) M. Brunnbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

(2009) Christopher W. Wilson et al.   NATURE

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition

(2009) Jennetta W Hammond et al.   PLOS BIOLOGY