期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/jbm.a.37284
关键词
antibacterial effect; layered double hydroxides; osteogenesis; titanium
资金
- National Natural Science Foundation of China [81802133, 82002278]
- Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0084]
By preparing LDH films containing Ga and Sr ions on titanium substrates, this study showed enhanced osteogenic cell differentiation and inhibition of bacterial activity. LDH250 demonstrated strong antibacterial properties, inducing an alkaline microenvironment and improving the bone integrative capacity of titanium implants.
Bacterial infection and poor osteogenic capacity can result in the loosing or failure of titanium (Ti)-based implants in the clinic. Therefore, it is urgent to design an effective approach to enhance the osteogenic property and restrict bacterial activity. In this study, a layered double hydroxide (LDH) composed of Ga and Sr ions on Ti substrates by a hydrothermal method, then calcined in 250 degrees C and denoted as LDH250. The scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were confirmed that the LDH films were successfully formed on the Ti substrates. Importantly, the obtained LDH films can induce an alkaline microenvironment around the Ti surface and regulate the behaviors of osteogenic cells and bacteria. In vitro cellular experiments, the LDH250 can enhance the differentiation of both MC3T3-E1 cells and osteoblasts, stimulate alkaline phosphatase activity (ALP), collagen secretion, and mineralization levels. Meanwhile, antimicrobial assay against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) demonstrated that the LDH250 samples had strong antibacterial abilities, which attributed to the release profile of Ga3+ could act as a Trojan horse to destroy the bacterial iron metabolism, inducing of local alkaline environment, and producing reactive oxygen species. Hence, this study provides an effective method for reducing antibacterial infection and enhancing the bone integrative capacity of Ti-based implants for orthopedic applications.
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