Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation

LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival

(2021) Yu Geon Lee et al.   Oncogenesis

Mitochondria-Associated Proteostasis

(2020) Linhao Ruan et al.   Annual Review of Biophysics

Mitochondrial Lon protease - depleted HeLa cells exhibit proteome modifications related to protein quality control, stress response and energy metabolism

(2020) Marie-Paule Hamon et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Mitochondrial Lon Protease: Novel Functions off the Beaten Track?

(2020) Wolfgang Voos et al.   Biomolecules

Global Proteome of LonP1+/− Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

(2019) Jana Key et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analysis of heat-induced protein aggregation in human mitochondria

(2018) Anne Wilkening et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

(2018) Olga Zurita Rendón et al.   MOLECULAR AND CELLULAR BIOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria Dysfunction and Neurodegenerative Disorders: Cause or Consequence

(2017) Vanessa A. Morais et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Mitochondrial Protein Quality Control in Oxidative Stress-induced Neurodegenerative Diseases

(2016) Giovanna Cenini et al.   Current Alzheimer Research

Protein quality control at the mitochondrion

(2016) W. Voos et al.   Essays in Biochemistry

TIM29 is a subunit of the human carrier translocase required for protein transport

(2016) Sylvie Callegari et al.   FEBS LETTERS

Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders

(2016) Daniela A. Bota et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fast and Accurate Protein False Discovery Rates on Large-Scale Proteomics Data Sets with Percolator 3.0

(2016) Matthew The et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease

(2016) Shiri Levy et al.   NUCLEIC ACIDS RESEARCH

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

(2016) Yilin Kang et al.   eLife

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

(2015) Iliana A. Chatzispyrou et al.   CANCER RESEARCH

Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells

(2014) Lara Gibellini et al.   FASEB JOURNAL

Effects of Lon protease down-regulation on the mitochondrial function and proteome

(2014) Marie-Paule Hamon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutations inCOA6cause CytochromecOxidase Deficiency and Neonatal Hypertrophic Cardiomyopathy

(2014) Fabian Baertling et al.   HUMAN MUTATION

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity

(2014) Pedro M. Quirós et al.   Cell Reports

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Chaperone–protease networks in mitochondrial protein homeostasis

(2012) Wolfgang Voos   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome

(2012) Nika Erjavec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode

(2012) Dorothea Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

(2012) Bin Lu et al.   MOLECULAR CELL

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Multitasking in the mitochondrion by the ATP-dependent Lon protease

(2011) Sundararajan Venkatesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impairment of Lon-Induced Protection Against the Accumulation of Oxidized Proteins in Senescent Wi-38 Fibroblasts

(2011) J. K. Ngo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease

(2011) Tom Bender et al.   MOLECULAR BIOLOGY OF THE CELL

Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber

(2010) Sun-Shin Cha et al.   EMBO JOURNAL

Role of mitochondria in aging and age-related disease

(2010) Heinz D. Osiewacz   EXPERIMENTAL GERONTOLOGY

Identification of Novel Oxidized Protein Substrates and Physiological Partners of the Mitochondrial ATP-dependent Lon-like Protease Pim1

(2010) Aurélien Bayot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM)

(2010) Y. Matsushima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of protein quality control in mitochondrial protein homeostasis under oxidative stress

(2010) Tom Bender et al.   PROTEOMICS

Mitochondrial Lon protease is a human stress protein

(2009) Jenny K. Ngo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases

(2009) Wolfgang Voos   RESEARCH IN MICROBIOLOGY

Non-parametric estimation of posterior error probabilities associated with peptides identified by tandem mass spectrometry

(2008) L. Kall et al.   BIOINFORMATICS

Mitochondrial protein quality control: Implications in ageing

(2008) Bertrand Friguet et al.   Biotechnology Journal