Article
Chemistry, Physical
Mirella Ramirez, Louis Vaught, Chiu Law, Jacob L. Meyer, Rani Elhajjar
Summary: Dielectric elastomers (DE) are novel composite architectures capable of large actuation strains. DE fibers, particularly attractive for their use in artificial muscle architectures, are being explored in various applications such as tissue engineering, filtration, drug delivery, catalysis, protective textiles, and sensors. Various methods, including electrospinning, are being investigated to manufacture micro or nanoscale DE fibers.
Article
Materials Science, Multidisciplinary
Yuxin Li, Dianyu Wang, Eryun Yan, Jianwei Gao, Yan Wang, Shaobin Li, Yuwei Wang, Liquan Fan, Shengnan Chen, Deqing Zhang
Summary: Xylan/PCL core-shell nanofibers were successfully prepared using coaxial electrospinning, and they exhibited good degradation performance under acidic or neutral conditions. These nanofibers can act as drug carriers and showed excellent bactericidal activity.
Article
Chemistry, Physical
Marta Lech, Joanna Mastalska-Poplawska, Jadwiga Laska
Summary: This paper described the detailed studies of fabricating electrospun fibers of polyurethane/polylactide mixtures, with a focus on the influence of different solvents and diluents on the rheological parameters and electrospinning process. It was found that solutions with higher polyurethane content became less viscous with the addition of acetone or DCM, while solutions with more polylactide showed different viscosity changes. The optimized electrospinning process resulted in fibers with diameters ranging from 250 nm to 1 µm, with thinner and more aligned fibers produced when more DCM was present in the mixture.
Article
Polymer Science
Aref Fakhrali, Mina Nasari, Nazanin Poursharifi, Dariush Semnani, Hossein Salehi, Mohammad Ghane, Sajjad Mohammadi
Summary: Research on tissue engineering, particularly heart tissue engineering, is rapidly expanding. Investigated the properties of PCL/PGS and PCL/PGS/graphene nanofibrous scaffolds, finding that blending PGS with PCL enhances elongation and decreases elastic modulus. The addition of PGS reduces hydrophobicity of PCL nanofibers, and graphene balances hydrophilicity. Degradation rate of nanofibers increases in the presence of PGS.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Suruchi Poddar, Piyush Sunil Agarwal, Ajay Kumar Sahi, Neelima Varshney, Kiran Yellappa Vajanthri, Sanjeev Kumar Mahto
Summary: The study successfully blended psyllium husk powder/gelatin with polyvinyl alcohol to create an electrospinnable solution for nanofiber fabrication. The psyllium-based nanofibers showed promising potential for wound healing and other biomedical applications based on various evaluations of properties and biological compatibility.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Fatemeh Dehghan, Adeleh Gholipour-Kanani, Mehdi Kamali Dolatabadi, Seyed Hajir Bahrami
Summary: In this study, nanofibrous webs loaded with different amounts of aloe vera extract were fabricated using electrospinning technique. The PCL-PEG-aloe vera nanofibers with a 1:1:1 mass ratio exhibited a bead-less bimodal morphology consisting of nano-scale and micro-scale fibers, and showed higher mechanical strength and cell compatibility compared to unloaded nanofibers. The nanofibrous scaffolds incorporated with aloe vera extract also exhibited excellent ability for bone repair, as confirmed by the higher amount of calcium deposition.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Kerim Emre Oksuz, Nese Kurt Ozkaya, Zeynep Deniz Sahin Inan, Ali Ozer
Summary: A novel wound dressing material was developed by embedding natural spider silk in Poly(vinyl alcohol)/Sodium alginate, which was found to accelerate wound healing, improve collagen formation rate, and reduce inflammatory cell amount based on in-vivo and in-vitro experiments. This suggests that the developed PVA/NaAlg/SS nanofiber mats might be a promising bioactive wound dressing for clinical applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Composites
Runlian Zhong, Zhennan Luan, Siwei Yan, Quande Cui, Fuhao Zhu, Qianqian Qi, Qingguo Wang
Summary: This article prepared advanced biodegradable thermoplastic elastomer (BTPE)/reduced graphene oxide (rGO) nanocomposites using aliphatic diols, aliphatic dibasic acids, and graphene oxide (GO) as raw materials. The rGO is well dispersed in the BTPE matrix through its predispersion in aliphatic diols before the polycondensation of the polyester prepolymers. The addition of GO greatly enhances the tensile strength, elongation at break, biodegradability, and electrical conductivity of the BTPE/rGO nanocomposites.
POLYMER COMPOSITES
(2023)
Article
Engineering, Chemical
Pratikshkumar R. Patel, Komal Pandey, Naresh Killi, Rathna Venkata Naga Gundloori
Summary: A hybrid system of PLA and PCL, incorporating EA, was designed to improve cell interactions. The addition of EA increased the swelling rate of NM and decreased contact angle. Moreover, EA enhanced the inhibition of bacterial growth by NM.
POLYMER ENGINEERING AND SCIENCE
(2021)
Article
Polymer Science
Aleksandra Bandzerewicz, Kamil Wierzchowski, Jolanta Mierzejewska, Piotr Denis, Tomasz Golofit, Patrycja Szymczyk-Ziolkowska, Maciej Pilarek, Agnieszka Gadomska-Gajadhur
Summary: This study focuses on a less studied polyester, poly(1,3-propanediol citrate), and its porous and non-porous materials properties, including mechanical, thermal, and surface properties, morphology, and degradation. The main focus is on assessing the biocompatibility and antimicrobial properties of the materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Materials Science, Composites
Mallampati Somaiah Chowdary, Gujjala Raghavendra, M. S. R. Niranjan Kumar, Shakuntala Ojha, Manne Anupama Ammulu, P. Phani Prasanthi
Summary: Hybrid composites with Kevlar/K, Sisal/S, and Polyester reinforcement, enhanced with varying percentages of Nano clay, demonstrated excellent mechanical properties and erosion wear resistance, particularly suitable for engineering materials in the aviation and automobile industry.
POLYMER COMPOSITES
(2022)
Article
Engineering, Chemical
Pamela M. Johnson, Justin M. Lehtinen, Jennifer L. Robinson
Summary: Emulsion electrospinning was used to develop porous scaffolds for controlled drug delivery in tissue engineering, with the study showing the significant impact of drug interactions with emulsion chemistry on drug loading efficiency and release rates. The results highlighted the need to independently control intermolecular interactions and drug phase solubility in designing fibers for tunable drug delivery systems.
Article
Polymer Science
Sawan Shetty, Selvakumar Murugesan, Sahar Salehi, Alexandra Pellert, Melanie Scheibel, Thomas Scheibel, Srinivasan Anandhan
Summary: In this study, biocompatible ultrafine fibers based on talc nanosheets (TNS)/PVDF composites were fabricated, showing robust electromechanical responses. Piezoresponse force microscopy (PFM) was used to analyze ferroelectric and piezoelectric coefficients. The 0.5 wt% TNS dispersed ultrafine fibers exhibited well-defined ferroelectric characteristics with an enhanced piezoelectric coefficient (d(33)) of approximately 43.3 pm/V. The piezoelectric coefficients strongly depended on the morphology and electroactive phase fraction of the composite ultrafine fiber. In vitro cytotoxicity tests showed that the TNS/PVDF composite ultrafine fibers had no cytotoxic response and promoted cell viability. These TNS/PVDF piezoelectric ultrafine fibers are thus suitable for bioelectronics applications, especially as flexible wearable electronic devices and sensors.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Xuefei Shao, Junnan He, Xuemei Zhao, Yubin Zheng, Nan Zheng
Summary: Cationic polyesters are widely used as efficient gene delivery carriers due to their ability to bind genes based on the electrostatic effect. Functionalized polyesters with DPA-Zn have been successfully prepared, showing the ability to bind genes into nanocomplexes around 200 nm in size.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Composites
Sreenivas Huligere Thimmaiah, Krishnamurthy Narayanappa, Yashas Thyavihalli Girijappa, Arpitha Gulihonenahali Rajakumara, Mohit Hemath, Senthil Muthu Kumar Thiagamani, Akarsh Verma
Summary: This research aims to study the hybridization of fiber-reinforced composites using kenaf fabric and kevlar fabric as reinforcement. Through testing and a prediction model, the tribological behavior and wear rate of the composites, as well as the wear principle of the structure under different conditions, can be understood.
POLYMER COMPOSITES
(2023)
Article
Polymer Science
Shiva Irani, Sajjad Tavakkoli, Mohamad Pezeshki-Modaress, Elham Taghavifar, Marjan Mohammadali, Hamed Daemi
Summary: This study successfully achieved chondrogenic differentiation of human bone marrow mesenchymal stem cells using PVA/ALG-S nanofibrous mats as support. Alginate sulfate played a crucial role in cell differentiation and exhibited good cytocompatibility.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hengameh Bakhtiar, Sarah Rajabi, Mohammad Pezeshki-Modaress, Mohammad Reza Ellini, Mahsa Panahinia, Solmaz Alijani, Amir Mazidi, Amir Kamali, Amir Azarpazhooh, Anil Kishen
Summary: The study aimed to characterize the effects of various decellularization protocols on bovine dental pulp ECM. Results showed successful decellularization in all groups, with protocol P7 (12E-0S-1T) demonstrating the highest retention of glycosaminoglycan and minimal DNA content. Overall, the tested treatments hold potential for producing xenogeneic dental pulp ECM scaffolds, with P7 being a promising option due to its minimal structural damage and acceptable host immune response.
JOURNAL OF ENDODONTICS
(2021)
Article
Biochemistry & Molecular Biology
Sarah Karimi, Zohreh Bagher, Najmeh Najmoddin, Sara Simorgh, Mohamad Pezeshki-Modaress
Summary: The study developed alginate hydrogels incorporating magnetic short nanofibers for encapsulation of OE-MSCs, which showed improved cell viability and enhanced proliferation rate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Hadi Salehi, Hooman Golbaten-Mofrad, Seyed Hassan Jafari, Vahabodin Goodarzi, Maliheh Entezari, Mehrdad Hashemi, Soheila Zamanlui
Summary: Bacterial cellulose aerogel was successfully used as a matrix for embedding nanomaterials and polymers to form conductive composite materials. The inclusion of nano-clay and polyaniline in the aerogel led to a significant improvement in electrical conductivity and thermal stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Maryam Khajavi, Abdolmajid Hajimoradloo, Mojgan Zandi, Mohamad Pezeshki-Modaress, Shahin Bonakdar, Abbas Zamani
Summary: The study successfully engineered a cartilage-like scaffold using ECM from sturgeon fish cartilage to stimulate cartilaginous matrix synthesis in human adipose stem cells. The porous scaffold derived from fish cartilage ECM showed excellent potential for cartilage tissue engineering, supporting cell adhesion, proliferation, and chondrogenic differentiation. The scaffold was demonstrated to facilitate the synthesis of specific cartilage proteins, such as collagen type II and aggrecan, making it a promising option for tissue regeneration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Mahdi Eskandarian Boroujeni, Leila Simani, Hans A. R. Bluyssen, Hamid Reza Samadikhah, Soheila Zamanlui Benisi, Sanaz Hassani, Nader Akbari Dilmaghani, Mobina Fathi, Kimia Vakili, Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Meysam Hassani Moghaddam, Mohammad-Amin Abdollahifar, Abbas Aliaghaei
Summary: The study revealed inflammatory and immune responses in the post-mortem cerebral cortex of severe COVID-19 patients, with oxidative stress potentially leading to neuronal cell death.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maryam Abdollahi Asl, Saeed Karbasi, Saeed Beigi-Boroujeni, Soheila Zamanlui Benisi, Mahdi Saeed
Summary: Efficient design for bone tissue engineering involves selecting biomimetic materials and scalable fabrication technologies. In this study, PHB and starch were used to create novel scaffolds with improved tensile strength and biocompatibility. The addition of starch enhanced scaffold performance and promoted cell proliferation and activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Biomaterials
Masumeh Staji, Negar Sadeghzadeh, Soheila Zamanlui, Mojgan Azarani, Ali Golchin, Masoud Soleimani, Abdolreza Ardeshirylajimi, Arash Khojasteh, Simzar Hosseinzadeh
Summary: This study investigated the synergistic effect of an electrospun scaffold made of polyurethane, gelatin, and human amniotic polymers in the co-culture of mesenchymal stem cells and human keratinocytes. The results showed that this scaffold promoted cell proliferation and epithelial differentiation, and had a significant influence in mice experiments.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Polymer Science
Behnam Davoodi, Vahabodin Goodarzi, Hadi Hosseini, Mahtab Tirgar, Shahrokh Shojaei, Azadeh Asefnejad, Ardeshir Saeidi, Fatemeh Oroojalian, Soheila Zamanlui
Summary: The application of green-approach synthesized biopolymers in tissue engineering fields has gained significant attention due to their biocompatibility and biodegradability. This research focuses on the development of a new substrate with similar morphological structures to natural extracellular matrices. The innovative tubular bionanocomposite blends based on PGS and PCL, containing nanoclay or GO, show ordered porous texture and exfoliated morphology. The inclusion of GO improves storage modulus and increases Tg value, while maintaining good biocompatibility and potential application in the biomedical area.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Polymer Science
Saba Seyfikar, Masoomeh Asgharnejad-laskoukalayeh, Seyed Hassan Jafari, Vahabodin Goodarzi, Mohammad Hadi Salehi, Soheila Zamanlui
Summary: A three-dimensional porous structure of poly(glycerol sebacate urethane) (PGSU) containing nanoclay and polyacrylic acid (PAAc) was successfully synthesized in this study. The particulate leaching technique using spun sugar as a porogen was employed for fabricating the porous structure. The viscoelastic behavior, hydrophilicity, and biocompatibility of the scaffolds were evaluated, indicating improved properties by incorporating nanoclay and PAAc. The feasibility of PGSU-based scaffolds for tissue engineering was confirmed through in vitro biocompatibility testing and significant cell adhesion in plasma-treated PGSU/PAAC/nanoclay.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Fatemeh Maghfoori, Najmeh Najmoddin, Mohamad Pezeshki-Modaress
Summary: This study developed PCL nanofiber scaffolds by in-situ synthesis of well-distributed ZnO nanorods decorated on clay platelets. Increasing the content of ZnO nanorods significantly improved the mechanical properties of the scaffold, and the well-covered ZnO nanorods enhanced its antibacterial performance. This engineered nanocomposite shows great potential for biomedical applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Amirhesam Arabsorkhi-Mishabi, Mojgan Zandi, Fahimeh Askari, Mohamad Pezeshki-Modaress
Summary: Different polycaprolactone (PCL) soft blocks were incorporated into poly(glycerol sebacate) (PGS) structure to prepare a series of PGS-based elastomers with varied chemical compositions and mechanical properties. The PGS and PGS-co-PCL elastomers were prepared through thermal curing without any catalysts. The synthesized PGS-co-PCL elastomers exhibited tunable mechanical properties in the range of soft tissues and showed promising potential in biomedical applications and soft tissue engineering.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Khadijeh Baaji, Mohamad Pezeshki-Modaress, Sarah Rajabi
Summary: In this study, a bioactive scaffold was prepared from natural polymeric hydrogel extracted from bovine aorta using the freeze-drying method, with advantages of appropriate structure, well-defined architecture, and interconnected pores for vascular tissue engineering. Various analyses were conducted on the prepared biological scaffolds, revealing a porosity of over 90% and better survival, proliferation, and migration of HUVECs with 4% aorta-ECM compared to 2% and 3%.
PROGRESS IN BIOMATERIALS
(2022)