Review
Chemistry, Analytical
Ruiyuan Pan, Guoliang Li, Shucheng Liu, Xianlong Zhang, Jianghua Liu, Zhuoqun Su, Yongning Wu
Summary: Food safety issues are a serious threat to human health, and appropriate detection technologies can effectively ensure food safety. Immunoassay serves as a good platform for food contaminants detection, and nanomaterials as novel labels show great potential in enhancing detection sensitivity and stability.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Qingqing Li, Hongqi Huo, Ying Wu, Lanlan Chen, Lichao Su, Xuan Zhang, Jibin Song, Huanghao Yang
Summary: Surface-enhanced Raman scattering (SERS) is a feasible and ultra-sensitive method for biomedical imaging and disease diagnosis. The recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed, including various SERS substrates and their successful utilization in in vivo imaging, as well as the role of highly sensitive SERS biosensors in disease detection and prevention. Additionally, the review highlights the use of SERS in the identification and resection of microtumors, as well as its potential as a diagnostic and therapeutic platform.
Article
Chemistry, Analytical
Di Liu, Huimin Gao, Wenji Jiang, Su Yan, Hao Liu, Junjie Chen, Sisi Wen, Wei Zhang, Xu Wang, Bing Zhao, Wei Song
Summary: In this study, three-dimensional Ag aerogel-supported Hg single-atom catalysts were used as an efficient SERS substrate for monitoring enhanced oxidase-like reactions. The effect of Hg2+ concentrations on the SERS properties of 3D Hg/Ag aerogel networks was investigated, and an optimized addition of Hg2+ resulted in specific enhancement. The formation of Ag-supported Hg SACs was confirmed using HAADF-STEM imaging and XPS measurement, and the oxidase-like catalytic mechanism of Hg/Ag SACs was revealed using DFT. This research provides a mild synthetic strategy for fabricating Ag aerogel-supported Hg single atoms with promising prospects in various catalytic fields.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Zi-Chun Chia, Li-Xing Yang, Ting-Yu Cheng, Ya-Jyun Chen, Horng-Long Cheng, Fei-Ting Hsu, Ying-Jan Wang, Yu-Ying Chen, Tzu-Chi Huang, Yi-Syun Fang, Chih-Chia Huang
Summary: The study designed and synthesized polyaniline-containing galactosylated gold nanoparticles, which produced electromagnetic enhancement in surface-enhanced Raman scattering and could detect low concentrations of bacteria. In addition, high accumulation of the nanoparticles promoted the immune response of tumor-associated macrophages.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Zhenbiao Wang, Wei Chen, Xueying Liu, Shaowei Lin, Baichang Deng, Jiaqing Shen, Fajun Li, Jinfeng Zhu
Summary: The roughness of gold nanohole metasurfaces greatly affects the plasmonic sensing of tumor markers; high-roughness metasurfaces show higher surface sensitivity to multilayer polyelectrolyte molecules; high-roughness metasurfaces also demonstrate higher immunoassay sensitivity to multiple lung cancer biomarkers.
Review
Chemistry, Multidisciplinary
Mohamed A. Ettabib, Almudena Marti, Zhen Liu, Bethany M. Bowden, Michalis N. Zervas, Philip N. Bartlett, James S. Wilkinson
Summary: Waveguide enhanced Raman spectroscopy (WERS) utilizes high-index contrast dielectric waveguides to generate a strong evanescent field for direct identification of biochemical species. Advancements in technology have made portable and high sensitivity WERS Raman systems a realistic possibility.
Article
Chemistry, Multidisciplinary
Kosti Tapio, Amr Mostafa, Yuya Kanehira, Antonio Suma, Anushree Dutta, Ilko Bald
Summary: DNA origami technology enables precise assembly of chemical entities at the nanoscale, creating sophisticated functional materials. By assembling Au or Ag nanoparticle dimers, a versatile DNA origami nanofork antenna (DONA) has been developed, achieving signal enhancements in surface-enhanced Raman scattering (SERS) up to 10(11). Using the DNA origami structure, single-molecule SERS measurements of three dyes, cytochrome c, and horseradish peroxidase proteins have been successfully demonstrated.
Article
Chemistry, Analytical
Wen Sheng-Ping, Zhu Jun-Jie
Summary: SERS technique, as a significant spectral analysis tool, demonstrates distinctive attributes like in situ nondestructive nature, finger recognition and single-molecule level detection, showing great potential in fields such as food safety, environmental monitoring, and biological analysis. This review focuses on the current progress of SERS-based biosensing and bioimaging, discussing possible development tendencies and prospects of SERS in bioanalysis in the future.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Jiang Wang, Hua Xu, Li Luo, Nannan Li, Chunxia Qiao, Jianfeng Wu, Lei Guo, Jianwei Xie
Summary: This study presents a reliable sandwich immunoassay based on surface-enhanced Raman scattering for the detection and differentiation of active ricin protein. The method has the potential to be applied in the timely response of ricin-related risk assessment in terrorist events and human intoxication.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Food Science & Technology
Jinrui Shan, Longhua Shi, Yuechun Li, Xuechi Yin, Shaochi Wang, Sijie Liu, Jing Sun, Daohong Zhang, Yanwei Ji, Jianlong Wang
Summary: SERS-based immunoassay is a powerful analytical method for monitoring harmful substances in food, offering new hope for food safety regulation. This article provides a comprehensive overview of the development trends, enhancement mechanisms, and classification of SERS-based immunoassays. Different types of SERS immune sensing strategies and their advantages are discussed, along with representative applications for food hazard detection.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Younju Joung, Kihyun Kim, Seungwoo Lee, Byung-Seon Chun, Sangyeop Lee, Joonki Hwang, Suji Choi, Taejoon Kang, Mi-Kyung Lee, Lingxin Chen, Jaebum Choo
Summary: This study developed a portable surface-enhanced Raman scattering (SERS)-LFA reader based on localized surface plasmon effects to improve the detection sensitivity of commercial LFA strips. Testing 54 clinical samples, the SERS-LFA reader demonstrated a significantly reduced false-negative rate compared to commercial LFA strips.
Review
Chemistry, Analytical
Vahid Eskandari, Saeideh Mehmandoust, Zahra Farahani, Negin Poorbeik Mohammad, Amin Hadi
Summary: The special features of liposome-based drug delivery systems have proven useful in overcoming biological and pharmacodynamic challenges. Liposomes, especially those used for targeted drug delivery to pathological tissues, are considered the simplest mimic of biological cells in medicine, attracting the attention of many researchers. Surface-enhanced Raman scattering (SERS) offers nondestructive analysis and high detection sensitivity, making it ideal for single molecular detection. This study reviews recent literature on SERS-based biosensors for enhancing diagnostic and therapeutic platforms, drug delivery systems, and pharmaceutical applications, aiming to aid researchers in making more advanced and successful systems in this sensitive and important field.
VIBRATIONAL SPECTROSCOPY
(2023)
Review
Agriculture, Multidisciplinary
Yaozhong Hu, Yi Wang, Jing Lin, Sihao Wu, Serge Muyldermans, Shuo Wang
Summary: The unique characteristics of camelid heavy-chain only antibodies (HCAb) derived nanobodies (Nbs) have led to their widespread application in various fields. However, their application in food allergen inspection and immunotherapy has been lacking. Nbs possess strong properties and a simple selecting strategy, making them advantageous for immunoassays and as blocking antibodies. The development of specific Nbs against food allergens shows their potential in food allergen surveillance and immunotherapy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jiuxing Li, Yingfu Li
Summary: Pd-Ir nanocubes, with high peroxidase-like activity and a uniform cubic structure enclosed by (100) facets, are a promising nanomaterial for bioanalysis. A novel method has been developed to synthesize Pd-Ir nanocubes with atomic Ir shell thickness in an aqueous solution at room temperature. These nanocubes have demonstrated potential applications in immunoassays and aptamer-based biosensors, thanks to their excellent peroxidase activity and fluorescence quenching ability. This work represents a significant advancement in the practical use of Pd-Ir nanocubes for bioanalysis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hui He, Lingli Zhou, Zhanchen Guo, Pengfei Li, Song Gao, Zhen Liu
Summary: A novel dual biomimetic recognition-driven plasmonic nanogap-enhanced Raman scattering strategy was reported for ultrasensitive protein fingerprinting and quantitation. By trapping target proteins into plasmonic nanogaps, ultra-high Raman signal amplification was achieved, along with a ratiometric assay for robust quantitation.
Article
Food Science & Technology
Yuanli Zhao, Zhenbao Zhu, Jianghua Liu, Jichao Liu, Guoliang Li
Summary: The study successfully extracted and detected PAEs in edible vegetable oils using magnetic covalent organic framework nanospheres, showing high sensitivity, good linearity, and satisfactory recovery rates. After optimizing parameters, the method demonstrated excellent extraction efficiency under optimal conditions.
FOOD ANALYTICAL METHODS
(2021)
Review
Agriculture, Multidisciplinary
Zhuoqun Su, Tong Li, Di Wu, Yongning Wu, Guoliang Li
Summary: Rapid and sensitive detection technologies for food contaminants are crucial for ensuring food safety. Traditional methods often struggle with accuracy, sensitivity, and specificity issues due to the complexity of food samples and trace amount distributions. Over the past decades, single-molecule detection (SMD) has emerged as a promising approach to achieve rapid and ultrasensitive measurements with minimal sample consumption, particularly in the field of food contaminants detection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shasha Chen, Na Hu, Honglun Wang, Yongning Wu, Guoliang Li
Summary: Pn3G5G, derived from LRF, exhibited strong antioxidant capacity and protective effects on CML-treated cells. In aging mice, Pn3G5G improved cognitive impairment, neuroinflammation, and neuronal apoptosis. These findings suggest the potential development of Pn3G5G as a healthcare product or potent dietary supplement with antioxidant and neuroprotective effects.
Article
Chemistry, Analytical
Yan Yang, Zhuoqun Su, Di Wu, Jianghua Liu, Xianlong Zhang, Yongning Wu, Guoliang Li
Summary: In this study, a polystyrene-mediated surface-enhanced Raman scattering aptasensor was developed for the ultrasensitive and simultaneous detection of multiple mycotoxins in food samples. The proposed strategy showed reliability and high sensitivity, with a limit of detection as low as 0.159 fg L-1, 2.015 fg L-1, and 1.561 fg L-1 for ZEN, OTA, and AFB1, respectively. This research not only introduces a novel concept for designing Raman tags but also expands the application of SERS for the detection of trace targets.
ANALYTICA CHIMICA ACTA
(2022)
Article
Agriculture, Multidisciplinary
Qianyu Li, Jianghua Liu, Luyao Zhang, Yiheng Shi, Guoliang Li
Summary: This study proposes a SIL method based on CuAAC click-reaction for quantitative analysis of synthetic steroid hormones in complex food samples by HPLC-MS/MS. The method effectively eliminates matrix effects and improves ionization efficiency and sensitivity by labeling steroid hormones in the samples. It demonstrates unique advantages for trace analysis of steroid hormones in foodstuffs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Ruiyuan Pan, Jianghua Liu, Panxue Wang, Di Wu, Jian Chen, Yongning Wu, Guoliang Li
Summary: This study proposes an ultrasensitive surface-enhanced Raman scattering (SERS) biosensor driven by CRISPR/Cas12a for on-site nucleic acid detection. The biosensor achieves precise target DNA recognition and signal amplification through specific base pairing and efficient trans-cleavage capability of CRISPR/Cas12a. The strategy exhibits an ultralow detection limit and is successfully applied to milk authenticity detection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Xianlong Zhang, Lihua Fan, Zhuoqun Su, Qinfeng Xu, Lingyi Xi, Lin Li, Yongning Wu, Guoliang Li
Summary: In this study, a sensitive fluorescent clickase-linked immunosorbent assay (FCLISA) platform was established for detection of food allergenic protein using an artificial clickase-catalyzed bio-conjugation strategy. The FCLISA showed high sensitivity and accuracy, with a potential application in food safety assay.
Article
Agriculture, Multidisciplinary
Jiahui Chen, Jianghua Liu, Di Wu, Ruiyuan Pan, Jian Chen, Yongning Wu, Mingquan Huang, Guoliang Li
Summary: In this study, a precisely regulated DNA-templated silver nanocluster (DNA-AgNC) sensor based on CRISPR/Cas12a was designed for sensitive detection of meat adulteration. The strategy achieved a satisfactory linear range and a low limit of detection, providing an accurate and efficient method for monitoring meat authenticity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Physical
Xianlong Zhang, Yiheng Shi, Guang Chen, Di Wu, Yongning Wu, Guoliang Li
Summary: Rapid, sensitive, and accurate detection of pathogens is crucial for preventing infectious diseases and improving healthcare systems. Inspired by the CRISPR/Cas system, new biosensors have been developed and applied in the detection of infectious viruses and pathogenic bacteria.
Review
Agriculture, Multidisciplinary
Jian Chen, Yuxi Guo, Xianlong Zhang, Jianghua Liu, Pin Gong, Zhuoqun Su, Lihua Fan, Guoliang Li
Summary: Nanoparticles have small size, high surface activity, and antibacterial and antioxidant properties, making them widely used in the food industry. However, their migration from the environment to food increases the exposure risk to humans. Carbon-based NPs, nanoselenium NPs, and rare earth oxide NPs are three emerging NPs that are commonly used in the food industry. The potential risk mechanisms and absorption pathways of NPs into the human body are discussed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Food Science & Technology
Xianlong Zhang, Yan Yang, Juanjuan Cao, Zihe Qi, Guoliang Li
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has been a global threat due to its high transmissibility. While person-to-person transmission is the main route, there are concerns about transmission through contaminated cold-chain food and packaging.
Article
Chemistry, Analytical
Panxue Wang, Xiang Li, Yan Sun, Li Wang, Ying Xu, Guoliang Li
Summary: The combination of Surface Enhanced Raman Spectroscopy (SERS) and Dispersive Liquid-Liquid Microextraction (DLLME) led to the development of a rapid and reliable method for the detection of organophosphorus pesticides (OPPs) in liquid samples. The method showed good sensitivity and stability for the detection and quantification of OPPs.
ANALYTICAL METHODS
(2022)
Article
Biochemistry & Molecular Biology
Yueqiu Liu, Wen Zheng, Lu Zhang, Liqiang Hu, Xin Liu, Jingqiu Cheng, Guoliang Li, Meng Gong
Summary: This study investigated the hypoglycemic and metabolic effects of Ficus racemosa fruit in diabetic mice and explored its potential mechanisms using a metabolomics approach. The results showed that Ficus racemosa fruit could lower blood glucose levels and improve tissue lesions, primarily by altering amino acid, organic acid, and nucleotide metabolism.
