Article
Biochemical Research Methods
Bingjie Wang, Richard Brown, Jay Chhablani, Shaohua Pi
Summary: In this study, an algorithm was developed to register OCT scans of patients with CSCR without the need for prior layer segmentation, and to calculate three-dimensional structural change maps. This tool can aid in monitoring disease progression and treatment efficacy.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Susana Penas, Teresa Araujo, Ana Maria Mendonca, Simao Faria, Jorge Silva, Aurelio Campilho, Maria Lurdes Martins, Vania Sousa, Amandio Rocha-Sousa, Angela Carneiro, Fernando Falcao-Reis
Summary: This study investigates the retinal and choroidal vascular reactivity to carbogen in patients with central serous chorioretinopathy (CSC). The results suggest that the vascular reactivity in the choroidal vessels of CSC patients is significantly higher compared to controls.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Zhengwei Zhang, Xiaona Bao, Zhifeng Wu, Jie Zhang
Summary: Half-dose or reduced-fluence photodynamic therapy (PDT) with verteporfin is recognized as an effective treatment for chronic central serous chorioretinopathy (CSC). However, a case was reported where choroidal neovascularization (CNV) developed only 3 weeks after such treatment, which had not been reported before. The patient was successfully treated with intravitreal injections of aflibercept after developing CNV.
Article
Multidisciplinary Sciences
Te-An Wang, Wei-Chun Chan, Shawn H. Tsai, Lee-Jen Chen
Summary: This study investigated the association between chronic central serous chorioretinopathy (CSC) and subsequent development of polypoidal choroidal vasculopathy (PCV). It found that pachyvessel characteristics in chronic CSC are associated with the development of PCV.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Medicine, General & Internal
Yoo-Ri Chung, Su Jeong Lee, Ji Hun Song
Summary: We evaluated the effect of intravitreal bevacizumab injection on chronic central serous chorioretinopathy and found that it significantly improved visual acuity and central retinal thickness. Early changes in choroidal thickness were associated with the therapeutic response.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Ophthalmology
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Pasquale Viggiano, Rossella D'Aloisio, Chiara De Nicola, Gennaro Falconio, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigated the changes in choroidal vascularity index (CVI) after oral eplerenone treatment in patients with chronic central serous chorioretinopathy (cCSC). The results showed that CVI decreased during follow-up in both eyes with subretinal fluid (SRF) and fellow eyes, indicating the effectiveness of mineral corticoid receptor antagonists in restoring choroidal morphology.
Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qiaozhu Zeng, Yuou Yao, Shu Tu, Mingwei Zhao
Summary: This study aimed to compare choroid blood flow and choroid thickness in eyes with central serous chorioretinopathy (CSC), fellow eyes, and healthy eyes using ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA). Results showed that CSC eyes had greater density of large-vessel choroidal layer, choroidal thickness, and volume compared to normal eyes. Compared to control eyes, CSC patients exhibited higher choriocapillaris density in certain subfields. This study may provide further evidence for the role of vortex vein congestion in the pathogenesis of CSC. UWF SS-OCTA can effectively evaluate choroidal abnormalities in CSC eyes, even at the periphery.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Summary: This study investigated differences in choroidal biomarkers between avascular (aFIPED) and vascularized (vFIPED) flat irregular pigment epithelial detachments in eyes with chronic CSC. The results showed that vFIPED patients had lower SFCT and higher CVI compared to aFIPED patients. Measurement of CVI along with SFCT may help differentiate aFIPED from vFIPED in CSC patients.
Article
Multidisciplinary Sciences
Seigo Yoneyama, Ayumi Fukui, Yoichi Sakurada, Nobuhiro Terao, Taiyo Shijo, Natsuki Kusada, Atsushi Sugiyama, Mio Matsubara, Yoshiko Fukuda, Wataru Kikushima, Ravi Parikh, Fumihiko Mabuchi, Chie Sotozono, Kenji Kashiwagi
Summary: This study investigated the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC), finding significant age differences, subfoveal choroidal thickness variations, and central retinal thickness disparities, as well as differences in the frequency of a descending tract between genders.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Malgorzata Latalska, Joanna Bartosinska, Slawomir Dresler, Mario Damiano Toro, Dorota Krasowska, Robert Rejdak
Summary: This study aimed to evaluate the results of nailfold videocapillaroscopies (NVCs) among patients with central serous chorioretinopathy (CSC) and their correlation with the choroid and retinal parameters. The results showed abnormal NVC patterns and dilated capillaries in CSC patients, and observed some microcirculation abnormalities among different types of CSC patients. These findings suggest that NVC examination may be helpful in assessing the prognosis of CSC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Woo Hyuk Lee, Bum Jun Kim, Yong Seop Han
Summary: This study presents a case of bilateral spontaneous large RPE tears in a patient with acute CSC without bullous RD, leading to decreased visual acuity. The findings suggest that large PED and old age may play a role in the development of RPE tears in CSC patients, emphasizing the importance of careful treatment consideration in such cases.
Article
Ophthalmology
Mitsuko Nakai, Hisashi Iwami, Hisashi Fukuyama, Fumi Gomi
Summary: The study showed that changes in the visualization of MAs associated with Mac Tel type 1 after direct photocoagulation can be monitored using OCTA. Eyes in which MAs disappeared after treatment could recover from cystoid macular edema, with a significant decrease in CRT.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Fumi Nishiguchi, Hiroto Ishikawa, Junichi Amaki, Yuki Komuku, Akiko Kimura, Fumi Gomi
Summary: The study demonstrated that cataract surgery significantly improved vision in Japanese patients with nAMD, especially in terms of distance vision. Patients were satisfied with the cataract surgery, but the surgery did not affect the AMD status.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Hisashi Fukuyama, Yuki Komuku, Fumi Gomi
Summary: This retrospective study analyzed data from 21 eyes of 17 patients and found that cystoid retinal changes in eyes with central serous chorioretinopathy (CSC) are associated with patchy retinal pigment epithelial atrophy and peripapillary atrophy. After treatment, most patients showed resolution of subretinal fluid and cystoid retinal changes.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Masahiko Sugimoto, Kohei Sampa, Hideyuki Tsukitome, Kumiko Kato, Hisashi Matsubara, Shin Asami, Kaori Sekimoto, Shigehiko Kitano, Shigeo Yoshida, Yoshihiro Takamura, Takao Hirano, Toshinori Murata, Miho Shimizu, Takamasa Kinoshita, Sentaro Kusuhara, Osamu Sawada, Masahito Ohji, Rina Yoshikawa, Kazuhiro Kimura, Hiroto Ishikawa, Fumi Gomi, Hiroto Terasaki, Mineo Kondo, Tomoaki Ikeda
Summary: The aim of this study was to determine the prevalence and progression of diabetic retinopathy (DR) in patients with hyperglycemic disorders during pregnancy (HDPs) in Japan. The study found that the prevalence of DR in patients with pre-existing diabetes was lower than previously reported, highlighting the need for more attention to be given to this patient population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Masashi Takata, Hiroto Ishikawa, Tomohiro Ikeda, Fumi Gomi
Summary: This study compared the surgical outcomes of conventional trabeculotomy (CT) and gonioscopy-assisted transluminal trabeculotomy (GATT) with and without simultaneous phacoemulsification. The results showed that GATT with phacoemulsification had a higher surgical success rate and a greater intraocular pressure (IOP)-lowering effect compared to CT with phacoemulsification. Factors associated with higher surgical success included combined phacoemulsification procedure and GATT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Xiaoyin Zhou, Yuki Komuku, Takashi Araki, Hiroto Terasaki, Akiko Miki, Soichiro Kuwayama, Tomo Nishi, Takamasa Kinoshita, Fumi Gomi
Summary: The study aims to identify the risk factors and characteristics of central serous chorioretinopathy (CSC) with subsequent macular neovascularisation (MNV) detected on optical coherence tomography angiography (OCTA). The results indicate that older age, chronic CSC, foveal leakage points, and recurrent fluid within the first year are risk factors for MNV. eyes with CSC complicated with MNV are characterized by poor visual acuity and low complete fluid resolution rates.
BMJ OPEN OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Kenji Yamashiro, Yasuo Yanagi, Hideki Koizumi, Hidetaka Matsumoto, Chui Ming Gemmy Cheung, Fumi Gomi, Tomohiro Iida, Akitaka Tsujikawa
Summary: Previous studies have shown inconsistent classification and understanding of pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). This study summarizes previous research and proposes a refined conceptual framework for future studies on PNV, PCV, and neovascular age-related macular degeneration (nAMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Takaaki Sugisawa, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, Takayuki Kanda, Masaru Takeuchi, Akiko Miki, Sentaro Kusuhara, Tetsuo Ueda, Nahoko Ogata, Masahiko Sugimoto, Mineo Kondo, Shigeo Yoshida, Tadahiko Ogata, Kazuhiro Kimura, Yoshinori Mitamura, Tatsuya Jujo, Hitoshi Takagi, Hiroto Terasaki, Taiji Sakamoto, Yuki Komuku, Fumi Gomi
Summary: This retrospective observational study investigated potential predictive factors for visual prognosis in Japanese patients with endogenous endophthalmitis. The study found that pressure injuries, severe clinical symptoms, pathogen identification, and poor baseline visual acuity were risk factors for visual impairment at 12 weeks after treatment initiation. Staphylococcus aureus and fungus were associated with a better visual impairment outcome.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Takeshi Kimura, Takashi Araki, Tsutomu Yasukawa, Aki Kato, Soichiro Kuwayama, Takamasa Kinoshita, Fumiki Okamoto, Tomoya Murakami, Yoshinori Mitamura, Taiji Sakamoto, Hiroto Terasaki, Sentaro Kusuhara, Akiko Miki, Yoshihiro Takamura, Mineo Kondo, Hisashi Matsubara, Tetsuo Ueda, Hiroki Tsujinaka, Fumi Gomi
Summary: This study evaluated the clinical characteristics, treatment trends, and visual prognosis of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (nAMD) and retinal arterial macroaneurysm (RAM). The findings showed that SMH caused by different underlying diseases had different characteristics and treatment strategies. The final best-corrected visual acuity (BCVA) significantly improved in the polypoidal choroidal vasculopathy (PCV) and RAM groups, with PCV group having better final BCVA than the other groups. The BCVA improvement in the RAM group was significantly greater than that in the nAMD and PCV groups. Younger age, better baseline BCVA, RAM subtype, and absence of nAMD were significantly associated with better final BCVA.
Article
Multidisciplinary Sciences
Tomo Nishi, Tetsuo Ueda, Yuutaro Mizusawa, Kayo Shinomiya, Yoshinori Mitamura, Naoki Kimura, Fumi Gomi, Akiko Miki, Makoto Nakamura, Takamasa Kinoshita, Shumpei Obata, Masahito Ohji, Takuya Tsuji, Shigeo Yoshida, Nahoko Ogata
Summary: Laser therapy is effective in treating retinopathy of prematurity (ROP). This study compared the foveal morphology in ROP eyes with full-term children. The results showed that laser-treated ROP eyes had thicker foveal thickness and abnormal retinal morphology compared to regressed ROP eyes and controls. Better visual acuity was associated with deeper foveal depression and later gestational age.
SCIENTIFIC REPORTS
(2022)
Letter
Ophthalmology
Ayame Imai, Hisashi Fukuyama, Fumi Gomi
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Oncology
Xiaoyin Zhou, Hiroto Ishikawa, Fumi Gomi
Summary: Choroidal melanoma complicated with a macular hole and vitreous hemorrhage is extremely rare. This case report presents the first case in Japan and reviews relevant literature. Macular edema may be the primary cause of macular hole formation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Kelvin Y. C. Teo, Satoko Fujimoto, Srinivas R. Sadda, Gregg Kokame, Fumi Gomi, Judy E. Kim, Mark F. S. Cheng, Giulia Corradetti, Anyarak Amornpetchsathaporn, Methaphon Chainakul, Won Ki Lee, Timothy Y. Y. Lai, Paisan Ruamviboonsuk, Chui Ming Gemmy Cheung
Summary: This study aimed to characterize geographic atrophy (GA) and evaluate differences between Asians and non-Asians. The results showed differences in GA lesion phenotype, associated features, and growth rate between Asians and non-Asian subjects.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Xiaoyin Zhou, Hisashi Fukuyama, Yoichi Okita, Hiroyuki Kanda, Yuki Yamamoto, Takashi Araki, Fumi Gomi
Summary: This study assessed the autonomic nervous system in patients with central serous chorioretinopathy (CSC) by measuring pupillary responses and heart rate variability (HRV). The results indicated parasympathetic inhibition and sympathetic activation in CSC patients, as well as larger pupil dilation during mental tasks, which could be a potential marker of psychophysiological stress.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)