Article
Biochemistry & Molecular Biology
Wojciech Krzeptowski, Patryk Chudy, Grzegorz Sokolowski, Monika Zukowska, Anna Kusienicka, Agnieszka Seretny, Agata Kalita, Alicja Czmoczek, Jakub Gubala, Sonia Baran, Damian Kloska, Mateusz Jez, Jacek Stepniewski, Krzysztof Szade, Agata Szade, Anna Grochot-Przeczek, Alicja Jozkowicz, Witold N. Nowak
Summary: G-quadruplexes are nucleic acid structures stabilized by heme, influencing DNA replication and gene transcription. The accumulation of G-quadruplexes is affected by heme oxygenase-1 expression in a cell-type-specific manner. Cellular co-localization of G-quadruplexes with helicases and HMOX1 can be detected using the proximity ligation assay, providing insights into potential roles of HMOX1 in G4 modifications.
Article
Chemistry, Multidisciplinary
Jessica A. Gable, Sarvind Tripathi, Thomas L. Poulos
Summary: A characteristic feature of cytochromes P450 is the generation of an intense absorption band at 450 nm when the ferrous heme iron forms a complex with carbon monoxide. The P450-to-P420 change is primarily due to an opening and disordering of the substrate binding pocket, rather than ligand displacement or swapping.
Article
Chemistry, Multidisciplinary
Qiuhua Liu, Junhao Gao, Yusheng Zhang, Xin Liu, Xi Zhang, Qin Lin, Wennan Zeng, Zaichun Zhou
Summary: In this study, a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of trans- precursor of porphyrinogen. Its single-crystal structure revealed the unique features of creating two secondary coordination sphere (SCS) bulks, maintaining a unique dome deformation, and making atomic out-of-plane deviation. This metallic complex integrates at least three key features, making it an ideal heme analog.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Organic
Alyssa F. J. van den Boom, Han Zuilhof
Summary: In this study, we successfully synthesized a wide range of sulfonamides at room temperature using 4-nitrophenyl benzylsulfonate as a starting material. We achieved yields and reaction times that were comparable to or better than previous reports, demonstrating the viability of sulfur-phenolate exchange as an alternative synthesis method.
Review
Plant Sciences
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Summary: Although the use of molecular hydrogen (H-2) for enhanced plant growth and postharvest storage of crops has not been widely accepted in the UK, evidence shows that it can alleviate plant stress and slow crop senescence. The effects of H-2 treatment appear to be mediated by the alteration of plant cell antioxidant capacity, with potential benefits in agriculture if the costs are justified. Hydrogen-rich water (HRW) is considered safe and relatively easy to use, suggesting that it could potentially be widely adopted in the UK and help reduce food waste in the future.
Article
Microbiology
Amber L. Grunow, Susan C. Carroll, Alicia N. Kreiman, Molly C. Sutherland
Summary: Heme trafficking is a fundamental biological process, and studying it has been challenging due to its tight regulation, cytotoxicity, and transient nature. The bacterial cytochrome c biogenesis pathways, especially System I, provide a model for understanding heme trafficking mechanisms. A detailed analysis of the WWD domain in CcmF reveals its interaction with heme and its role in attaching heme to apocytochrome c. This analysis also uncovers common mechanisms of heme interaction in different heme trafficking pathways.
Article
Chemistry, Multidisciplinary
Kaja Schubert, Meiyuan Guo, Kaan Atak, Simon Doerner, Christine Buelow, Bernd von Issendorff, Stephan Klumpp, J. Tobias Lau, Piter S. Miedema, Thomas Schlathoelter, Simone Techert, Martin Timm, Xin Wang, Vicente Zamudio-Bayer, Lucas Schwob, Sadia Bari
Summary: The study examined the electronic structure and deexcitation pathways of isolated cobalt protoporphyrin ions using near-edge X-ray absorption mass spectrometry and quantum-mechanical calculations. Results revealed that under resonant excitation, cobalt protoporphyrins form various charged fragments through competitive excitations to different molecular orbitals.
Article
Mechanics
Yuanqing Wu, Shuyu Sun
Summary: Pressure-temperature (PT) flash calculations are a performance bottleneck of compositional-flow simulations. The computing burden of PT flash calculations is shifted from the online stage to the offline stage with the sparse grid surrogate, achieving great acceleration. Physics-informed neural networks remove the computing burden of PT flash calculations in the offline stage by not carrying out the heavy-burden routines. Numerical experiments validate the correctness and applicability of this approach. To the best of our knowledge, this is the first work to remove the performance bottleneck of PT flash calculations during both the online and offline stages of compositional-flow simulations.
Article
Environmental Sciences
Zhiwei Zhu, Yuncheng Cao, Zihan Zheng, Nengyou Wu, Duofu Chen
Summary: This study applied the van der Waals-Platteeuw model to investigate the formation of CH4-H-2 hydrates in marine serpentinization environments, taking into account the effects of salinity. The model accurately predicted the three-phase equilibrium temperature and pressure for CH4-H-2 hydrates in pure water and provided theoretical insights for gas hydrate research in areas with marine serpentinization.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Chemistry, Inorganic & Nuclear
Luiz Gonzaga de Franca Lopes, Florencio S. Gouveia Junior, Alda Karine Medeiros Holanda, Idalina Maria Moreira de Carvalho, Elisane Longhinotti, Tercio F. Paulo, Dieric S. Abreu, Paul Bernhardt, Marie-Alda Gilles-Gonzalez, Izaura Cirino Nogueira Diogenes, Eduardo Henrique Silva Sousa
Summary: This article discusses the roles of diatomic molecules O-2, NO, and CO in biology, as well as the sensing proteins developed by nature to perceive and respond to changes in their levels. It focuses on heme-based proteins and their advanced structural and electronic adjustments for sensing, along with their possible role in redox sensing. Finally, the potential therapeutic interventions on these gas sensors and the design of small diatomic molecules for medical treatments are highlighted.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Amanda L. Steber, Wenqin Li, Brooks H. Pate, Alberto Lesarri, Cristobal Perez
Summary: We observed the sevoflurane trimer, a heavy molecular aggregate, through experimental and computational methods, and found that it adopts a new binding configuration predominantly formed by 17 CH center dot center dot center dot F hydrogen bonds resembling a nanomicellar arrangement.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Engineering, Chemical
Farnaz Esmaeili Rad, Javad Abbasian, Hamid Arastoopour
Summary: This study investigated the regeneration procedure of CO2laden amine-based solid sorbents in the regenerator fluidized bed. The simulation results showed that the carbonated solid sorbents could be regenerated up to 73% in this system. The effect of different regenerator configurations on the carbon dioxide concentration in the exiting gas flow was also studied, with the results showing that extending the fluidized bed height and providing heat through heating coils could significantly increase the carbon dioxide concentration.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Review
Microbiology
Aileen Krueger, Marc Keppel, Vikas Sharma, Julia Frunzke
Summary: Heme is a versatile molecule that is essential for cellular life, but elevated levels are toxic. The evolution of diverse heme sensor systems has helped regulate heme homeostasis. These systems have various functions, including controlling heme detoxification and uptake, and integrating heme and iron homeostasis. Understanding heme-regulated processes is important for cellular physiology and the development of antibacterial drugs and metabolic engineering strategies.
FEMS MICROBIOLOGY REVIEWS
(2022)
Article
Engineering, Environmental
Lin Qiao, Lirong Gao, Yang Liu, Di Huang, Da Li, Minghui Zheng
Summary: This study developed a new method to identify pollutants in the air that may have severe impacts on human health. By analyzing the compounds in the gas-phase and size-fractionated particle phases, previously overlooked pollutants were identified, showing discrepancies between their environmental fate and predicted health risks. The results suggest that these pollutants may pose more severe adverse effects on human health than conventionally monitored pollutants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Srinivas Doddipatla, Galiya R. Galimova, Hongji Wei, Aaron M. Thomas, Chao He, Zhenghai Yang, Alexander N. Morozov, Christopher N. Shingledecker, Alexander M. Mebel, Ralf I. Kaiser
Summary: This study reveals a new mechanism for the formation of aromatic molecules with five-membered rings such as indene, shedding light on the low-temperature chemistry of carbon in interstellar and combustion systems. The incorporation of a five-membered ring through the MACA mechanism may eventually lead to the formation of three-dimensional PAHs and fullerenes, offering a new concept for carbon chemistry in our galaxy.