期刊
INTERNATIONAL MATERIALS REVIEWS
卷 67, 期 4, 页码 347-384出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09506608.2021.1946236
关键词
Electrospinning; 3D printing; extrusion printing; biofabrication; bioprinting; periodontal regeneration; craniomaxillofacial regeneration; bone regeneration; additive manufacturing
资金
- National Institutes of Health (NIH)
- National Institute of Dental and Craniofacial Research [K08DE023552, R01DE026578]
- Osteology Foundation
- Osteo Science Foundation US
- International Association for Dental Research
- American Academy of Implant Dentistry Foundation
- European Union [874827]
- Netherlands Organization for Scientific Research [024.003.013]
This paper provides a detailed analysis of scaffold strategies for craniomaxillofacial bone and periodontal regeneration, focusing on the latest 3D printing technologies. The future direction discussed includes the utilization of complementary biomaterials and fabrication technologies for effective translation of personalized and functional scaffolds into clinical applications.
From a materials perspective, the pillars for the development of clinically translatable scaffold-based strategies for craniomaxillofacial (CMF) bone and periodontal regeneration have included electrospinning and 3D printing (biofabrication) technologies. Here, we offer a detailed analysis of the latest innovations in 3D (bio)printing strategies for CMF bone and periodontal regeneration and provide future directions envisioning the development of advanced 3D architectures for successful clinical translation. First, the principles of electrospinning applied to the generation of biodegradable scaffolds are discussed. Next, we present on extrusion-based 3D printing technologies with a focus on creating scaffolds with improved regenerative capacity. In addition, we offer a critical appraisal on 3D (bio)printing and multitechnology convergence to enable the reconstruction of CMF bones and periodontal tissues. As a future outlook, we highlight future directions associated with the utilisation of complementary biomaterials and (bio)fabrication technologies for effective translation of personalised and functional scaffolds into the clinics.
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