期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 606, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120921
关键词
Progesterone; Ocular insert; Oxidative stress; Retinitis pigmentosa; Ex vivo diffusion studies; Trans-corneal and trans-scleral drug delivery; HET-CAM assay
资金
- University CEU Cardenal Herrera, (Valencia, Spain)
- Ayudas a la formacion de Jovenes Investigadores CEU-SANTANDER 20/21
Progesterone delivers neuroprotection in degenerative diseases related to oxidative stress, and ocular inserts containing PG were developed for potential treatment of various eye diseases. The inserts showed controlled diffusion of progesterone with higher accumulation in scleras than in corneas, demonstrating potential efficacy in ocular drug delivery.
Progesterone (PG) affords neuroprotection in degenerative diseases associated to oxidative stress, such as cataracts, age-related macular degeneration, glaucoma, diabetic retinopathy and retinitis pigmentosa. The aim of this project was to develop ocular inserts for delivery of PG to the eye. Different inserts with PG in its composition were formulated and the insert with the best characteristics (59% polyvinyl alcohol, 39% polyvinylpyrrolidone K30 and 2% propylene glycol) was selected for ex vivo studies. Physical characteristics and drug release patterns of the insert were analysed. In vitro diffusion studies revealed a controlled diffusion of progesterone. Ex vivo experiments demonstrated similar trans-corneal and trans-scleral PG diffusion (corneal apparent permeability coefficient 6.46 +/- 0.38 x 10(-7) cm/s and scleral apparent permeability coefficient 5.87 +/- 1.18 x 10(- 7) cm/s; mean +/- SD; n = 5). However, the amount of PG accumulated in scleras was statistically higher than in corneas (30.07 +/- 9.09 mu g/cm(2) and 15.56 +/- 4.36 mu g/cm(2) respectively). The PG-loaded inserts (55.6 mu g/cm(2)) were thin, translucent, showed no irritancy (HET-CAM test) and were elastic and robust, all suitable properties for its potential use in the treatment of several ocular diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据