Article
Immunology
Jin-Seok Byun, Ho Yeop Lee, Jingwen Tian, Ji Sun Moon, Jaejin Choi, Sang-Hee Lee, Yong-Gun Kim, Hyon-Seung Yi
Summary: Periodontitis is caused by an imbalance of the local immune microenvironment due to oral microbial dysbiosis, which is exacerbated by insulin resistance and obesity. Increased levels of exosomal miR-25-3p in the saliva of obese patients with type 2 diabetes are found to be associated with periodontitis. The study also reveals that CD69 mRNA is a target of miR-25-3p and regulates the activation of gamma delta T cells and inflammatory response. Inhibition of miR-25-3p prevents local inflammation and reduces ligature-induced periodontal bone loss in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jie Lei, Peng Chen, Feng Zhang, Na Zhang, Jianfei Zhu, Xiaoping Wang, Tao Jiang
Summary: Research suggests that exosomal miR-501-3p derived from M2 macrophages promotes the progression of lung cancer (LC) by downregulating WDR82. This study provides important insights into the molecular mechanisms underlying the development of LC.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Fawad Ur Rehman, Yang Liu, Qingshan Yang, Haoying Yang, Runhan Liu, Dongya Zhang, Pir Muhammad, Yanjie Liu, Sumaira Hanif, Muhammad Ismail, Meng Zheng, Bingyang Shi
Summary: This study explores the use of exosomes secreted by allogeneic bone marrow mesenchymal stem cells as a nanocarrier for glioblastoma therapy. With the decoration of a specific peptide, the nanocarrier exhibits enhanced targeting ability for TMZ resistant GBM. Additionally, the system can deliver targeted siRNA to restore drug sensitivity and achieve treatment of drug-resistant GBM.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Deheng Li, Liangdong Li, Xin Chen, Wentao Yang, Yiqun Cao
Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Juan Cao, Uet Yu, Li Li, Xiuli Yuan, Senmin Chen, Huanli Xu, Meng Yi, Sixi Liu
Summary: This study investigated the potential role and molecular mechanisms of circKL in kidney cancer development. The results suggested that circKL suppressed the growth and metastasis of kidney cancer by sponging miR-182-5p and upregulating FBXW7 expression. This finding may provide a new targeted strategy for the treatment of kidney cancer.
Article
Virology
Mingwei Li, Yang Wu, Jianfei Chen, Hongyan Shi, Zhaoyanag Ji, Xin Zhang, Da Shi, Jianbo Liu, Jin Tian, Xiaobo Wang, Zhaorong Shi, Hongling Zhang, Hao Zhang, Longjun Guo, Li Feng
Summary: This study reveals that PEDV infection can bypass the host innate immune response by targeting and degrading FBXW7 protein, thereby impairing the host's ability to fight back against the virus.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Shouming Cao, Haiying Wu, Yan Niu, Lu Wang, Fengjun Wang
Summary: This study found that serum exosome-derived miRNAs have the potential to predict the early effectiveness of SLIT in AR patients. Among them, has-miR-24-3p and has-miR-128-3p showed decreased expression in the effective group, while has-miR-206 showed increased expression, indicating potential as biomarkers for predicting the early efficacy of SLIT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xiao Liu, Qingdong Guo, Guangxun Gao, Zhengcong Cao, Zhihao Guan, Bo Jia, Weizhong Wang, Kuo Zhang, Wangqian Zhang, Shuning Wang, Weina Li, Qiang Hao, Yingqi Zhang, Meng Li, Wei Zhang, Jintao Gu
Summary: In this study, it was found that exosomal circCABIN1 secreted from TMZ-resistant cells could disseminate TMZ resistance to recipient cells. CircCABIN1 showed high expression in GBM tissues and glioma stem cells, and played a crucial role in initiating acquired resistance and maintaining self-renewal of glioma stem cells. Mechanistically, circCABIN1 regulated OLFML3 expression by sponging miR-637, leading to the activation of the ErbB signaling pathway and stemness reprogramming associated with TMZ resistance. Targeting circCABIN1 and OLFML3 with engineered exosomes significantly improved the antitumor activity of TMZ in GBM xenografts in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Oncology
Yufan Wu, Taihe Fan, Yubin Zhao, Rongkuan Hu, Dongdong Yan, Ding Sun, Ling Gaol, Lei Qin, Xiaofeng Xue
Summary: The downregulation of hsa_circ_0001306 in HCC promotes tumor cell proliferation and invasion, and plays an important role through the miR-527/FBXW7 axis.
Article
Multidisciplinary Sciences
Simone Agostini, Elisabetta Bolognesi, Roberta Mancuso, Ivana Marventano, Lorenzo Agostino Citterio, Franca Rosa Guerini, Mario Clerici
Summary: The concentration of specific miRNAs (miR-27b-3p, miR-181a-5p, and miR-23a-3p) was found to be associated with a SNAP-25 polymorphism. In vitro experiments confirmed that miR-181a-5p and miR-23a-3p regulate SNAP-25 gene and protein expression, while miR-27b-3p does not. These findings suggest the potential use of miR-181a-5p and miR-23a-3p as biomarkers or therapeutic targets for diseases involving altered SNAP-25 expression.
Article
Cell & Tissue Engineering
Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang, Dianquan Zhang
Summary: The study investigated the potential of MSC-derived exosomes containing miR-542-3p in preventing ischemia-induced inflammatory response in glial cells by targeting TLR4. The results showed a decrease in miR-542-3p and an increase in TLR4 in MCAO mice, and overexpression of miR-542-3p alleviated cell apoptosis and inflammation induced by OGD. The delivery of exosome-miR-21-3p from MSCs also showed potential in relieving cerebral injury and inflammation caused by MCAO or OGD.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Xiangyun Zhu, Dechen Liu, Guoqing Li, Mengmeng Zhi, Ji Sun, Liang Qi, Jingbo Li, Stephen J. Pandol, Ling Li
Summary: This study reveals the impact of exosomal miRNA secreted by activated pancreatic stellate cells (PSCs) on beta-cell function. Specifically, the miR-140-3p and miR-143-3p in these exosomes induce cell death in beta-cells by targeting the B-cell lymphoma 2 gene. The findings highlight the communication mode between PSCs and beta-cells through exosomal miRNA transfer and offer potential therapeutic strategies.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jianglong Xu, Jia Song, Menglin Xiao, Changsheng Wang, Qisong Zhang, Xiaoye Yuan, Shaohui Tian
Summary: This study revealed the mechanism of TMZ resistance in GBM and identified the miR-128-3p/RUNX1 axis as a novel target. RUNX1 was found to be upregulated in GBM, while miR-128-3p overexpression restored sensitivity to TMZ in cells. Targeting the miR-128-3p/RUNX1 axis may provide a potential strategy to overcome TMZ resistance in GBM.
Article
Cell & Tissue Engineering
Guping Mao, Yiyang Xu, Dianbo Long, Hong Sun, Hongyi Li, Ruobin Xin, Ziji Zhang, Zhiwen Li, Zhi Yang, Yan Kang
Summary: This study identified a significant role for exosomal circRNA_0001236 in chondrogenic differentiation, promoting cartilage-specific gene and protein expression through the miR-3677-3p/Sox9 axis. Overexpression of exosomal circRNA_0001236 may alleviate cartilage degradation, suppress OA progression, and enhance cartilage repair, suggesting a potentially effective therapeutic strategy for treating OA.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Summary: The study suggests that microRNA-34a can effectively reduce the activation status of glioblastoma cells and enhance survival rates against multiple glioblastoma cell types. Combination therapy of temozolomide with microRNA-34a loaded nanocells targeted to epidermal growth factor receptor (EGFR) significantly enhances sensitivity of glioblastoma cells to treatment.
MOLECULAR MEDICINE
(2021)