Article
Cell Biology
Camilla Paoletti, Elena Marcello, Maria Luna Melis, Carla Divieto, Daria Nurzynska, Valeria Chiono
Summary: The direct reprogramming of adult human cardiac fibroblasts into induced cardiomyocytes using a combination of microRNAs has been achieved. This study demonstrates that the use of a cardiac-like extracellular matrix and specific culture conditions can significantly improve the efficiency of direct reprogramming.
Article
Multidisciplinary Sciences
Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H. Gunaratne, Na Li, Robert J. Schwartz, Bradley K. McConnell
Summary: This study presents an effective protocol for directly reprogramming human cardiomyocytes into cardiac Purkinje-like cells using small molecules. The generated cells exhibit genetic and functional similarities to native cardiac Purkinje cells, showing expression of key cardiac Purkinje genes and increased velocity of electrical signal conduction. This research has significant implications for the development of optimized cell therapies for heart regeneration.
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Materials Science, Multidisciplinary
Dawei Dong, Minghua Zhang, Yafei Xiao, Zhaojie Yang, Ke Wang, Minmin Fan
Summary: In this study, QBPEI@N-GQDs were introduced into the QPSU polymer matrix to prepare QQ-n-N-GQDs composite AEMs. The composite membranes showed improved performance due to the formation of a hydrophilic/hydrophobic microphase separation structure, resulting in higher water uptake, swelling ratio, ionic conductivity, and maximum power density of single fuel cell.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Amit Ahlawat, Pawan S. Rana, Pratima R. Solanki
Summary: This study reported the photocatalytic degradation of RhB using microwave synthesized carbon quantum dots, confirming its ability to efficiently degrade RhB under UV light irradiation.
Article
Nanoscience & Nanotechnology
Junyeop Kim, Yujung Chang, Yerim Hwang, Sumin Kim, Yu-Kyoung Oh, Jongpil Kim
Summary: In this study, graphene nanosheets were found to efficiently mediate direct reprogramming into induced cardiomyocytes in vivo, providing a significant role in cardiac repair.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Camilla Paoletti, Valeria Chiono
Summary: Ischemic heart disease is a major cause of mortality worldwide, and current pharmacological approaches have not yet achieved cardiac regeneration. Direct reprogramming of fibroblasts into induced cardiomyocytes and the use of microRNAs for transfection show promising potential for myocardial regeneration. Further advancements in nanocarrier technology and 3D culture microenvironments are enhancing the efficiency of this approach for future clinical translation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Analytical
Ana Patricia Reyes-Cruzaley, Adrian Ochoa-Teran, Antonio Tirado-Guizar, Rosa Maria Felix-Navarro, Gabriel Alonso-Nunez, Georgina Pina-Luis
Summary: In this work, Cu and Ag nanoclusters capped with PEI were prepared by chemical reduction, showing excellent water dispersibility, stability, and a wide pH response range. PEI-AgNCs exhibited better reversibility and sensitivity, making them suitable for pH visual detection and potential cellular imaging applications.
ANALYTICAL METHODS
(2021)
Article
Multidisciplinary Sciences
Shingo Narita, Kazumasa Unno, Katsuhiro Kato, Yusuke Okuno, Yoshitaka Sato, Yusuke Tsumura, Yusuke Fujikawa, Yuuki Shimizu, Ryo Hayashida, Kazuhisa Kondo, Rei Shibata, Toyoaki Murohara
Summary: This study demonstrated the successful direct reprogramming of adult ADRCs into cardiomyocytes, and showed the therapeutic potential of these reprogrammed cells in treating acute myocardial infarction.
Article
Chemistry, Physical
Yuan Li, Zhuanzhuan Shi, Chunmei Zhang, Xiaoshuai Wu, Liang Liu, Chunxian Guo, Chang Ming Li
Summary: A novel sensor was successfully developed for sensitive, rapid, and convenient detection of Cu2+, with wide detection range, low detection limit, fast response time, and simple operation, ranking among the top in Cu2+ sensors. The sensor showed a synergistic effect of BP and PEI, and was applied in real water samples for Cu2+ detection, demonstrating its feasibility in water environment control.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Shuo Wu, Xunxun Deng, Shiyu Zang, Xiaobo Liu, Yingyan Ma
Summary: Dopamine and PEI copolymerized nanodots with fluorescence emission and quenching properties were synthesized. The fluorescence and quenching properties of the nanodots can be controlled by adjusting the ratio of dopamine and PEI. These nanodots showed strong green fluorescence emission and high quenching efficiency, making them suitable for miRNA analysis. With their high quenching efficiency, stable fluorescence emission, easily assembled interface, and uniform morphology, these nanodots have great potential as a universal nanoplatform for ratiometric fluorescence nanoprobes.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jiahao Huang, Chen Dong, Jiahui Xu, Jun Xuan, Qin Cheng, Hong Bi
Summary: N,Cl-CDs carbon dots have the potential to be used in plant lighting due to their blue-white emission, and their blue and red emission ranges meet the optimal requirement of plant lighting without the need for other luminescent materials.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Anumol Mathew, Arun Varghese, K. R. Sunaja Devi, Dephan Pinheiro
Summary: Carbon dots have gained significant attention in the biomedical realm due to their exceptional characteristics. The introduction of heteroatoms via doping further enhances their unique attributes. Researchers have developed various techniques for doping carbon dots with metallic and non-metallic elements. This review compiles the methodologies and elements employed in recent times and discusses the biomedical applications of doped carbon dots.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Jojibabu Panta, Andrew N. Rider, John Wang, Richard Yang, Narelle Brack, Y. X. Zhang
Summary: Incorporating branched polyethyleneimine dendrimer (PEI) functionalized carbon nanotubes (CNTs) and a phase-separated triblock copolymer significantly enhanced the lap shear strength of epoxy-based adhesive. The level of PEI grafting was controlled by adjusting the CNT to PEI dispersion ratio and led to grafting percentages ranging from 5% to 51%. The highest grafting ratios improved the dispersion of CNTs, but heterogeneous curing reactions and localised stress concentrations caused a reduction in lap shear strength.
APPLIED SURFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Huanhuan Wang, Rumeng Qu, Qi Chen, Ting Zhang, Xiaoyu Chen, Baoyan Wu, Tongsheng Chen
Summary: In this study, a new nanodrug platform was developed to enhance the efficacy of photodynamic therapy (PDT) by combining polyethyleneimine (PEI) cytotoxicity and oxygen self-supply. By releasing PEI in the acidic tumor microenvironment, tumor cell uptake was facilitated and cytotoxicity increased. Moreover, the conversion of hydrogen peroxide into oxygen by Prussian blue (PB) nanozymes relieved tumor hypoxia and strengthened PDT. The new platform showed promising therapeutic efficacy in breast cancer cells and tumor-bearing mice.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)