Review
Biochemistry & Molecular Biology
Simeon C. Daeschler, Konstantin Feinberg, Leila Harhaus, Ulrich Kneser, Tessa Gordon, Gregory H. Borschel, Aleksey Zaitsev
Summary: Peripheral nerve injuries have significant impacts on individuals and society, resulting in functional impairments, lengthy rehabilitation, and socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug with neuroregenerative properties, shows promise in accelerating nerve fiber regeneration. This review explores the therapeutic potential of tacrolimus through investigating its mechanisms of action and discussing practical barriers for clinical translation, providing insights into its translational perspectives as an adjunct therapy for nerve regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pao-Jen Kuo, Cheng-Shyuan Rau, Shao-Chun Wu, Chia-Wei Lin, Lien-Hung Huang, Tsu-Hsiang Lu, Yi-Chan Wu, Chia-Jung Wu, Chia-Wen Tsai, Ching-Hua Hsieh
Summary: Following nerve injuries, macrophages induce autophagy and affect inflammatory responses. The combination of FK506 and ADSCs has positive effects on nerve regeneration and protection. Locally applied ADSC-F-exo can reduce macrophage autophagy levels after nerve injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Xiangyu Zeng, Wei Bian, Ziwen Liu, Jianming Li, Shuai Ren, Jian Zhang, Haoran Zhang, Bu Tegeleqi, Guanyi He, Mingyan Guan, Zewei Gao, Chi Huang, Jianyu Liu
Summary: This study demonstrated that muscle-derived stem cell (MDSC) exosomes with overexpressed miR-214 can promote the proliferation and migration of Schwann cells (SCs), increase the expression of neurotrophic factors, and positively affect the recovery of nerve structure and function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Sara Saffari, Tiam M. Saffari, Katelyn Chan, Gregory H. Borschel, Alexander Y. Shin
Summary: The study investigated the combined effect of mesenchymal stem cells (MSC) and local delivery of tacrolimus (FK506) on nerve regeneration in nerve autografts and decellularized allografts. Results showed that either MSC or FK506 treatment alone improved neurite outgrowth, and their combination further enhanced neurite extension in both types of grafts.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Cell Biology
Bruno Henrique de Melo Lima, Andre Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues De Oliveira
Summary: The expression of MHC-I and other related molecules following peripheral nerve injury is associated with the recovery of neurons, glial cells, sensorimotor function, gait, and nociceptive threshold in mice. Different strains of mice exhibit varying recovery capacities.
Article
Environmental Sciences
Bin Bin Wang, Chao Guo, Sheng Qiao Sun, Xing Nan Zhang, Zhen Li, Wei Jie Li, De Zhi Li, Michael Schumacher, Song Liu
Summary: This study compared the effect of different peripheral nerve injury models on nerve regeneration through animal experiments. It was found that the regeneration speed was faster in the crush injury model, while it was slower in the transection injury model. This provides some reference for the selection of clinical research models.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2023)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Imran, Ghulam Hussain, Arruje Hameed, Iqra Iftikhar, Muhammad Ibrahim, Rahat Asghar, Izzat Nisar, Tahir Farooq, Tanzila Khalid, Kanwal Rehman, Mohammed A. Assiri
Summary: This study screened the functional metabolites of Moringa oleifera and found that they play an important role in accelerated functional recovery after peripheral nerve injury. The extracts from Moringa showed potential in promoting the recovery of sensory and motor functions, as well as controlling oxidative stress and facilitating nerve regeneration. This study highlights the significance of Moringa as a sustainable source of nutritive metabolites and a valuable target for drug development.
Article
Biochemistry & Molecular Biology
Svetlana Demyanenko, Maria A. Pitinova, Yulia N. Kalyuzhnaya, Andrey M. Khaitin, Svetlana A. Batalshchikova, Natalya M. Dobaeva, Yulia A. Shevtsova, Kirill Goryunov, Egor Y. Plotnikov, Svetlana G. Pashkevich, Gennady T. Sukhikh, Denis N. Silachev
Summary: Peripheral nerve injury is a significant medical problem without effective treatment currently. However, the use of multipotent mesenchymal cells (MSCs)-derived extracellular vesicles (EVs) shows promise in promoting the regeneration of peripheral nerves after injury. In a rat model of sciatic nerve injury, the application of MSCs-EVs gel significantly reduced muscle atrophy and improved functional recovery. The results suggest that this therapeutic approach may be efficient for the treatment of acute peripheral nervous system injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan Motiwala, Shihong Shi, D. Kacy Cullen, Anh D. Le
Summary: This study generated gingiva-derived mesenchymal stem cell (GMSC)-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model. The results showed that the Schwann-like cells converted from GMSCs were able to promote functional recovery and axonal regeneration of injured sciatic nerves.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Neurosciences
Xiangyun Yao, Zhiwen Yan, Xiaojing Li, Yanhao Li, Yuanming Ouyang, Cunyi Fan
Summary: Peripheral nerve injuries are common traumatic injuries worldwide, and the use of FK506-stimulated ADSCs has shown potential in promoting nerve regeneration, offering hope for the treatment of severe PNIs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Luana Gabriel de Souza, Ketlyn Germann Hendler, Alexandre Marcio Marcolino, Heloyse Uliam Kuriki, Ramon Bauer Cardoso, Marisa de Cassia Registro Fonseca, Rafael Inacio Barbosa
Summary: The study showed that PBM alone was more effective compared to Simvastatin alone or the combination of PBM and Simvastatin for sciatic nerve injury in mice.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Orthopedics
Chen Yu, Xiaoxu Wang, Jian Qin
Summary: Necrostatin-1 (Nec-1) can reduce peripheral nerve lesions and protect Schwann cells and axons by inhibiting necroptosis. It also reduces inflammation and oxidative stress by inhibiting RIP1.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Allison Podsednik, Raysa Cabrejo, Joseph Rosen
Summary: Currently, there are various surgical techniques for peripheral nerve repair, with a novel addition of fat grafting to the repair site. However, there is no clear evidence on the improved outcomes of this procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Evan B. Marsh, Lauren Schellhardt, Daniel A. A. Hunter, Susan E. E. Mackinnon, Alison K. K. Snyder-Warwick, Matthew D. D. Wood
Summary: The dual administration of FK506 and E-stim does not have significant additive effects on regeneration and recovery compared to either therapy alone. The combination of FK506 and E-stim appears to combine the relative strengths of each therapeutic.
Article
Anesthesiology
En -Bo Wu, Shi-Cong Huang, Hung- Lu, Amina M. Illias, Pei-Ming Wang, Chia-Jung Huang, Tsung-Hsiao Shih, Jo-Chi Chin, Shao-Chun Wu
Summary: This study investigated the influence of different neuromuscular blocking agents and reversal agents on the early removal of chest tube drainage after video-assisted thoracoscopic surgery. It found that the use of rocuronium and sugammadex was associated with a shorter duration of chest tube drainage, a lower likelihood of delayed removal of the chest tube, and a reduced incidence of postoperative atelectasis and consolidation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Clinical Neurology
En -Bo Wu, Chia-Chi Hsiao, Kuo-Chuan Hung, Chao-Ting Hung, Chih-Chun Chen, Shao-Chun Wu, Jo -Chi Chin, I-Wen Chen, Sheng-Dean Luo
Summary: This retrospective observational study evaluated the intraoperative advantages and analgesic effects of pre-operative ultrasound-guided interscalene nerve block (UISB) during shoulder arthroscopy. The results showed that preoperative UISB effectively reduced the consumption of opioids and volatile gases during surgery and had satisfactory postoperative pain scores.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Respiratory System
Min-Hsiang Chuang, I-Wen Chen, Jen-Yin Chen, Fu-Chi Kang, Chun-Ning Ho, Shao-Chun Wu, Ming Yew, Kuo-Mao Lan, Kuo-Chuan Hung
Summary: This article analyzed five studies and found that moderate-to-high dose gefapixant can effectively reduce the frequency of chronic cough, but also increase the risk of adverse events. Further research is needed to investigate the feasibility of moderate-dose gefapixant in clinical practice.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Health Care Sciences & Services
Shih-Kai Liu, Shao-Chun Wu, Shao-Chi Hung, Kuen-Bao Chen, Amina M. M. Illias, Yung-Fong Tsai
Summary: The programmed intermittent epidural bolus (PIEB) setting in conjunction with a patient-controlled epidural analgesia (PCEA) setting can improve the quality of labor analgesia, reduce the number of medical staff, and increase patient satisfaction.
Article
Otorhinolaryngology
Wei-Chih Chen, Ching-Nung Wu, Yu-Ming Wang, Tai-Jan Chiu, Shao-Chun Wu, Yao-Hsu Yang, Sheng-Dean Luo
Summary: The objective of this retrospective cohort study was to investigate the clinical benefit of routine esophageal screening in newly diagnosed HNSCC patients. The study found that esophageal screening can detect esophageal tumors at an early stage and improve overall survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Multidisciplinary Sciences
Chen-Hung Chou, Chia-Ling Tsai, Kai-Lieh Lin, Shao-Chun Wu, Min-Hsien Chiang, Hui-Wen Huang, Kuo-Chuan Hung
Summary: This retrospective study aimed to develop a new formula for selecting the appropriate size and determining the depth of a cuffed nasotracheal intubation (NTI) for pediatric dental surgery patients. The study compared clinical data with age-based formulas to evaluate correlation. The results showed that the actual tube size was smaller and the depth was greater than the age-based formulas, and predictors for size and depth were determined using linear regression analysis.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Kuo-Chuan Hung, Jen-Yin Chen, Shao-Chun Wu, Po-Yu Huang, Jheng-Yan Wu, Ting-Hui Liu, Chien-Cheng Liu, I-Wen Chen, Cheuk-Kwan Sun
Summary: This study conducted a meta-analysis to compare the efficacy and safety of Ciprofol and propofol in clinical practice. The results showed that Ciprofol and propofol had similar efficacy for sedation and anesthetic induction, but Ciprofol had lower risks of hypotension and pain on injection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Chih-Hung Cha, Wei-Chih Chen, Yu-Ming Wang, Shao-Chun Wu, Tai-Jan Chiu, Ching-Nung Wu, Yinshen Wee, Ching-Shuen Wang, Yao-Hsu Yang, Sheng-Dean Luo
Summary: By analyzing the microbiological findings of patients with fungal and non-fungal rhinosinusitis, this study found a higher detection rate of Pseudomonas aeruginosa in the fungal group and a lower proportion of patients requiring revision surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
En-Bo Wu, Yan-Yi Li, Kuo-Chuan Hung, Amina M. Illias, Yung-Fong Tsai, Ya-Ling Yang, Jo-Chi Chin, Shao-Chun Wu
Summary: In this retrospective study, the use of rocuronium and sugammadex combination in open spine surgery did not reduce the length of hospital stay, but it was associated with a decreased incidence of postoperative chest radiographic abnormalities.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Pao-Jen Kuo, Cheng-Shyuan Rau, Ching-Hua Tsai, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh
Summary: The EZ-ALBI score can predict mortality risk in adult trauma patients in the ICU. This study found that the EZ-ALBI scores were higher in deceased patients compared to survivors. Multivariate logistic analysis revealed that the EZ-ALBI score is an independent risk factor for mortality. Patients with scores >= -26.5 had a 2.1-fold higher adjusted mortality rate compared to those with scores < -26.5.
Article
Medicine, General & Internal
Cheng-Shyuan Rau, Spencer Chia-Hao Kuo, Ching-Hua Tsai, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh
Summary: This study found a significant association between stress-induced hyperglycemia (SIH) and increased counts of monocytes, neutrophils, and lymphocytes in trauma patients. No such association was observed in patients with normal blood glucose levels or diabetic hyperglycemia.
Article
Biochemistry & Molecular Biology
Lien-Hung Huang, Cheng-Shyuan Rau, Yueh-Wei Liu, Hui-Ping Lin, Yi-Chan Wu, Chia-Wen Tsai, Peng-Chen Chien, Chia-Jung Wu, Chun-Ying Huang, Ting-Min Hsieh, Ching-Hua Hsieh
Summary: This study identified alterations in protein levels within circulating exosomes in patients with hepatocellular carcinoma (HCC). Increased levels of von Willebrand factor and proteasome subunit beta type-2, as well as decreased levels of cathelicidin antimicrobial peptide, were observed. The study also provided evidence that cathelicidin antimicrobial peptide may act as a tumor suppressor in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Wei-Ti Su, Cheng-Shyuan Rau, Sheng-En Chou, Ching-Hua Tsai, Hang-Tsung Liu, Shiun-Yuan Hsu, Ching-Hua Hsieh
Summary: The De Ritis ratio and its association with mortality outcomes in adult thoracoabdominal trauma patients were examined in this retrospective study. The study found that an increased De Ritis ratio was mainly due to elevated AST levels. In addition, a De Ritis ratio > 1.64 was identified as a useful biomarker for identifying patients at a higher risk of mortality.
Article
Health Care Sciences & Services
Cheng-Shyuan Rau, Shao-Chun Wu, Ching-Hua Tsai, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh
Summary: There were no significant differences in the subtypes of white blood cells and immune-inflammatory status indicators between deceased and surviving patients with polytrauma. However, a significantly higher lymphocyte count may be associated with a worse mortality.
Article
Surgery
Johnson Chia-Shen Yang, Shao-Chun Wu, Yu-Ming Wang, Sheng-Dean Luo, Spencer Chia-Hao Kuo, Peng-Chen Chien, Pei-Yu Tsai, Ching-Hua Hsieh, Wei-Che Lin
Summary: This study found significant reductions in muscle edema and limb/subfascial volumes in the affected limb after lymphaticovenous anastomosis (LVA). Significant alleviation of muscle edema was also evident in the contralateral limbs, despite no statistically significant difference in limb and subfascial volumes.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
