期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms22158106
关键词
zinc oxide; quantum dot; polyvinylpyrrolidone; photodynamic therapy; photosensitizers; reactive oxygen species; nanoparticle; SW480 cancer cell
资金
- National Key Research and Development Project [2016YFA0602701]
- National Key Scientific Instrument and Equipment Development Project [42027804]
The study shows the potential applications of zinc oxide quantum dots in photodynamic therapy, demonstrating their good photoluminescent properties and significant inhibitory effects on SW480 tumor cells.
Despite the numerous available treatments for cancer, many patients succumb to side effects and reoccurrence. Zinc oxide (ZnO) quantum dots (QDs) are inexpensive inorganic nanomaterials with potential applications in photodynamic therapy. To verify the photoluminescence of ZnO QDs and determine their inhibitory effect on tumors, we synthesized and characterized ZnO QDs modified with polyvinylpyrrolidone. The photoluminescent properties and reactive oxygen species levels of these ZnO/PVP QDs were also measured. Finally, in vitro and in vivo experiments were performed to test their photodynamic therapeutic effects in SW480 cancer cells and female nude mice. Our results indicate that the ZnO QDs had good photoluminescence and exerted an obvious inhibitory effect on SW480 tumor cells. These findings illustrate the potential applications of ZnO QDs in the fields of photoluminescence and photodynamic therapy.
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