Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems

Growth‐differentiation‐factor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function

(2021) Ulrika Andersson‐Hall et al.   CLINICAL ENDOCRINOLOGY

Practice patterns for prevention of chemotherapy‐induced nausea and vomiting and antiemetic guideline adherence based on real‐world prescribing data

(2021) Matti Aapro et al.   ONCOLOGIST

Central and peripheral emetic loci contribute to vomiting evoked by the Akt inhibitor MK-2206 in the least shrew model of emesis

(2021) Weixia Zhong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GDF15 Induces Anorexia through Nausea and Emesis

(2020) Tito Borner et al.   Cell Metabolism

Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting

(2020) Tong J. Gan et al.   ANESTHESIA AND ANALGESIA

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

(2020) Isabelle Ziffert et al.   Cell Communication and Signaling

COVID‐19: focus on the lungs but do not forget the gastrointestinal tract

(2020) Wiktor Smyk et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Effects of sacral nerve electrical stimulation on 5‑HT and 5‑HT3AR/5‑HT4R levels in the colon and sacral cord of acute spinal cord injury rat models

(2020) Yi Zhu et al.   Molecular Medicine Reports

Antiemetic Prophylaxis and Anesthetic Approaches to Reduce Postoperative Nausea and Vomiting in Bariatric Surgery Patients: a Systematic Review

(2020) Zaina Naeem et al.   OBESITY SURGERY

Chemotherapy-induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin-induced neurotoxicity

(2020) Kinga Sałat   Pharmacological Reports

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge

(2020) Tao Zuo et al.   GASTROENTEROLOGY

Potential neuroinvasive pathways of SARS‐CoV‐2: Deciphering the spectrum of neurological deficit seen in coronavirus disease‐2019 (COVID‐19)

(2020) Abdul Mannan Baig et al.   JOURNAL OF MEDICAL VIROLOGY

Emerging Novel Coronavirus is a Global Threat: Insight in the Biology of COVID-19 and its Hijacking Process of Hosts’ Cell

(2020) Debmalya Roy et al.   CURRENT PHARMACEUTICAL DESIGN

COVID‐19, nausea, and vomiting

(2020) Paul L R Andrews et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Preventive effects of naldemedine, peripherally acting μ-opioid receptor antagonist, on morphine-induced nausea and vomiting in ferrets

(2020) Toshiyuki Kanemasa et al.   LIFE SCIENCES

Neurobiology of coronaviruses: Potential relevance for COVID-19

(2020) Mauro Cataldi et al.   NEUROBIOLOGY OF DISEASE

GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

(2020) Danna M. Breen et al.   Cell Metabolism

Platinum-Based Drugs Cause Mitochondrial Dysfunction in Cultured Dorsal Root Ganglion Neurons

(2020) Markus Leo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome

(2020) Sonia Villapol   Translational Research

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway

(2020) Laurent L’homme et al.   Nutrients

The neural basis of motion sickness

(2019) Bernard Cohen et al.   JOURNAL OF NEUROPHYSIOLOGY

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality

(2019) Marlena Fejzo et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

Involvement of leukotriene pathway in the development of sevoflurane-induced pica in rats

(2019) Kouichi Yamamoto et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses

(2019) Ilyas Sahin et al.   CANCER BIOLOGY & THERAPY

Evolution of antiemetic studies for radiation-induced nausea and vomiting within an outpatient palliative radiotherapy clinic

(2019) Erin McKenzie et al.   SUPPORTIVE CARE IN CANCER

Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset

(2019) Hisaya K. Ono et al.   PLoS Pathogens

Cannabinoid hyperemesis syndrome

(2019) Tiffany N. Smith et al.   JAAPA-Journal of the American Academy of Physician Assistants

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders

(2019) Airi Jo-Watanabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isoflurane induces c-Fos expression in the area postrema of the rat

(2019) Tetsutaro Hase et al.   Journal of Anesthesia

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

(2019) Alexandra L. Chang-Graham et al.   Scientific Reports

Ultra-low doses of the transient receptor potential vanilloid 1 agonist, resiniferatoxin, prevents vomiting evoked by diverse emetogens in the least shrew (Cryptotis parva)

(2019) Nissar A. Darmani et al.   BEHAVIOURAL PHARMACOLOGY

Revisiting the physiology of nausea and vomiting—challenging the paradigm

(2019) Rita J. Wickham   SUPPORTIVE CARE IN CANCER

Nausea and vomiting of pregnancy and hyperemesis gravidarum

(2019) Marlena S. Fejzo et al.   Nature Reviews Disease Primers

Management of toxicity to isoform α-specific PI3K inhibitors

(2019) S E Nunnery et al.   ANNALS OF ONCOLOGY

Vestibular neurons with direct projections to the solitary nucleus in the rat

(2019) Amelia H. Gagliuso et al.   JOURNAL OF NEUROPHYSIOLOGY

Ameliorative Effect of Hesperidin Against Motion Sickness by Modulating Histamine and Histamine H1 Receptor Expression

(2019) Uma Maheswari Deshetty et al.   NEUROCHEMICAL RESEARCH

Δ9-THC and related cannabinoids suppress substance P- induced neurokinin NK1-receptor-mediated vomiting via activation of cannabinoid CB1 receptor

(2019) Nissar A. Darmani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway

(2019) Marie Helene Schernthaner-Reiter et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)

(2019) W. Zhong et al.   NEUROCHEMISTRY INTERNATIONAL

Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication

(2019) Dongcheng Bai et al.   VIROLOGY

Randomised clinical trial: faecal microbiota transplantation by colonoscopy plus vancomycin for the treatment of severe refractory Clostridium difficile infection-single versus multiple infusions

(2018) G. Ianiro et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Antiobesity and emetic effects of a short-length peptide YY analog and its PEGylated and alkylated derivatives

(2018) Ayumu Niida et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

(2018) A. Prasanth Saraswati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intracellular emetic signaling evoked by the L-type Ca 2+ channel agonist FPL64176 in the least shrew ( Cryptotis parva )

(2018) Weixia Zhong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reduction of Motion Sickness Through Targeting HistamineN-Methyltransferase in the Dorsal Vagal Complex of the Brain

(2018) Miao-Miao Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine

(2018) Yusuke Obara et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Peptide YY (3–36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons

(2018) Michelle Flores Domingues et al.   NEUROPEPTIDES

Lifetime of muscarinic receptor–G-protein complexes determines coupling efficiency and G-protein subtype selectivity

(2018) Olga S. Ilyaskina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection

(2018) Kwonil Jung et al.   RESEARCH IN VETERINARY SCIENCE

Impact of radiation-induced nausea and vomiting on quality of life

(2018) Caitlin Yee et al.   SUPPORTIVE CARE IN CANCER

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

(2018) Marlena S. Fejzo et al.   Nature Communications

The gut-brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

(2018) Nathalie Weltens et al.   Annals of the New York Academy of Sciences

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum

(2018) Marlena Fejzo et al.   GEBURTSHILFE UND FRAUENHEILKUNDE

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

(2018) Constanza Alcaino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting TRPV1 to relieve motion sickness symptoms in mice by electroacupuncture and gene deletion

(2018) Chanya Inprasit et al.   Scientific Reports

Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NK1R) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva)

(2018) W. Zhong et al.   NEUROCHEMISTRY INTERNATIONAL

Evolving role of neurokinin 1-receptor antagonists for chemotherapy-induced nausea and vomiting

(2018) Rudolph M. Navari et al.   OncoTargets and Therapy

First Insights Into Within Host Translocation of the Bacillus cereus Toxin Cereulide Using a Porcine Model

(2018) Tobias Bauer et al.   Frontiers in Microbiology

Natural and synthetic bioactive inhibitors of glycogen synthase kinase

(2017) Imran Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of prostanoid EP 3/1 receptors in mechanisms of emesis and defaecation in ferrets

(2017) Kelvin K.W. Kan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis

(2017) Juan J. Moreno   EUROPEAN JOURNAL OF PHARMACOLOGY

The anti-asthmatic drug pranlukast suppresses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva)

(2017) Nissar A. Darmani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neurons

(2017) Markus Leo et al.   EXPERIMENTAL NEUROLOGY

The emetic activity of staphylococcal enterotoxins, SEK, SEL, SEM, SEN and SEO in a small emetic animal model, the house musk shrew

(2017) Hisaya K. Ono et al.   MICROBIOLOGY AND IMMUNOLOGY

Cisplatin alters the function and expression of N-type voltage-gated calcium channels in the absence of morphological damage of sensory neurons

(2017) Markus Leo et al.   Molecular Pain

Heterogeneity of enterochromaffin cells within the gastrointestinal tract

(2017) S. Diwakarla et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Pharmacologic Treatment of Cannabinoid Hyperemesis Syndrome: A Systematic Review

(2017) John R. Richards et al.   PHARMACOTHERAPY

Ondansetron treatment reduces rotavirus symptoms—A randomized double-blinded placebo-controlled trial

(2017) Marie Hagbom et al.   PLoS One

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

(2017) Longlong Tu et al.   Frontiers in Physiology

Erratum to: Synthetic and natural antioxidants attenuate cisplatin-induced vomiting

(2017) Javaid Alam et al.   BMC Pharmacology & Toxicology

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Oxytocin, social factors, and the expression of conditioned disgust (anticipatory nausea) in male rats

(2016) Nathalie P. Boulet et al.   BEHAVIOURAL PHARMACOLOGY

Antiemetics: American Society of Clinical Oncology Focused Guideline Update

(2016) Paul J. Hesketh et al.   JOURNAL OF CLINICAL ONCOLOGY

Effects of Oxaliplatin Treatment on the Enteric Glial Cells and Neurons in the Mouse Ileum

(2016) Ainsley M. Robinson et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Thapsigargin-induced activation of Ca2+-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew

(2016) Weixia Zhong et al.   NEUROPHARMACOLOGY

G protein-coupled receptor kinases as regulators of dopamine receptor functions

(2016) Eugenia V. Gurevich et al.   PHARMACOLOGICAL RESEARCH

Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin)

(2016) Wenda Wu et al.   TOXICOLOGICAL SCIENCES

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

(2016) Jieqi Ke et al.   TUMOR BIOLOGY

Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting

(2016) Erin M. Rock et al.   Frontiers in Pharmacology

Cannabinoid hyperemesis syndrome: Marijuana is both antiemetic and proemetic

(2015) M. L. ROY et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Ondansetron rapidly dissolving film for the prophylactic treatment of radiation-induced nausea and vomiting—a pilot study

(2015) E. Wong et al.   Current Oncology

L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva)

(2015) Tarun E. Hutchinson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation

(2015) Nissar A. Darmani et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nausea: Current knowledge of mechanisms, measurement and clinical impact

(2015) Hannah Kenward et al.   VETERINARY JOURNAL

Prostanoids in allergy

(2015) Tetsuya Honda et al.   ALLERGOLOGY INTERNATIONAL

Nausea and vomiting induced by gastrointestinal radiation therapy

(2015) Kristopher Dennis et al.   Current Opinion in Supportive and Palliative Care

Pathophysiological Consequences of Calcium-Conducting Viroporins

(2015) Joseph M. Hyser et al.   Annual Review of Virology

A diversity of SERCA Ca2+pump inhibitors

(2015) Francesco Michelangeli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fos and pERK immunoreactivity in spinal cord slices: Comparative analysis of in vitro models for testing putative antinociceptive molecules

(2014) Francesco Ferrini et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Involvement of substance P in the development of cisplatin-induced acute and delayed pica in rats

(2014) Kouichi Yamamoto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aprepitant and granisetron for the prophylaxis of radiotherapy-induced nausea and vomiting after moderately emetogenic radiotherapy for bone metastases: a prospective pilot study

(2014) K. Dennis et al.   Current Oncology

The Medical Implications of Gastrointestinal Vagal Afferent Pathways in Nausea and Vomiting

(2014) Charles Horn   CURRENT PHARMACEUTICAL DESIGN

Antibiotics and the gut microbiota

(2014) Sheetal R. Modi et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors

(2014) Pavel Michal et al.   NEUROCHEMICAL RESEARCH

Serotonin 5-HT3 Receptor-Mediated Vomiting Occurs via the Activation of Ca2+/CaMKII-Dependent ERK1/2 Signaling in the Least Shrew (Cryptotis parva)

(2014) Weixia Zhong et al.   PLoS One

Radiation induced nausea and vomiting

(2013) Petra Feyer et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cyclophosphamide causes activation of protein kinase A (PKA) in the brainstem of vomiting least shrews (Cryptotis parva)

(2013) Tursun Alkam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva)

(2013) Nissar A. Darmani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system

(2013) Keith A. Sharkey et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Additive antiemetic efficacy of low-doses of the cannabinoid CB1/2 receptor agonist Δ9-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva)

(2013) Nissar A. Darmani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders

(2013) Mohammad Bashashati et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Conditioned flavor avoidance and conditioned gaping: Rat models of conditioned nausea

(2013) Linda A. Parker   EUROPEAN JOURNAL OF PHARMACOLOGY

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

(2013) Charles C. Horn et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Looking beyond 5-HT3 receptors: A review of the wider role of serotonin in the pharmacology of nausea and vomiting

(2013) Kevin D. Johnston et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Opioid induced nausea and vomiting

(2013) Howard S. Smith et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting

(2013) Chin-Chen Chu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of vagal neurocircuits in the regulation of nausea and vomiting

(2013) Tanja Babic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms of staphylococcal enterotoxin-induced emesis

(2013) Dong-Liang Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Olanzapine for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting

(2013) Rudolph M. Navari   EUROPEAN JOURNAL OF PHARMACOLOGY

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

Neuronal Mechanisms and the Treatment of Motion Sickness

(2013) F. Schmäl   PHARMACOLOGY

Why Can’t Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study

(2013) Charles C. Horn et al.   PLoS One

Tachykinin (NK1, NK2 and NK3) receptor, transient receptor potential vanilloid 1 (TRPV1) and early transcription factor, cFOS, mRNA expression in rat tissues following systemic capsaicin treatment

(2013) Dale A. Kunde et al.   REGULATORY PEPTIDES

Peptide YY3–36 and 5-Hydroxytryptamine Mediate Emesis Induction by Trichothecene Deoxynivalenol (Vomitoxin)

(2013) Wenda Wu et al.   TOXICOLOGICAL SCIENCES

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Effects of oxaliplatin on mouse myenteric neurons and colonic motility

(2013) Linah Wafai et al.   Frontiers in Neuroscience

Evidence-based analysis of risk factors for postoperative nausea and vomiting †

(2012) C.C. Apfel et al.   BRITISH JOURNAL OF ANAESTHESIA

The Brain Circuitry Underlying the Temporal Evolution of Nausea in Humans

(2012) V. Napadow et al.   CEREBRAL CORTEX

Cisplatin causes over-expression of tachykinin NK1 receptors and increases ERK1/2- and PKA‐ phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem

(2012) Nissar A. Darmani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting

(2012) Joseph V. Pergolizzi et al.   JOURNAL OF CLINICAL ANESTHESIA

Tumor Necrosis Factor Activation of Vagal Afferent Terminal Calcium Is Blocked by Cannabinoids

(2012) R. C. Rogers et al.   JOURNAL OF NEUROSCIENCE

Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: Evidence for the mechanisms of action

(2012) L. Mazzardo-Martins et al.   NEUROSCIENCE

Inhibition of endoplasmic reticulum Ca2+ ATPase in preBötzinger complex of neonatal rat does not affect respiratory rhythm generation

(2012) L. Beltran-Parrazal et al.   NEUROSCIENCE

Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target

(2012) Marion Bonnet et al.   Toxins

Role of Trpc channels, Stim1 and Orai1 in PGF2α-induced calcium signaling in NRK fibroblasts

(2011) W.H.M. Almirza et al.   CELL CALCIUM

Pyeongwee-San extract (KMP6): a new anti-allergic effect

(2011) Na-Ra Han et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Enteric neuropathy evoked by repeated cisplatin in the rat

(2011) G. Vera et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Structural and functional differences between L-type calcium channels: crucial issues for future selective targeting

(2011) Annalisa Zuccotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Rotavirus Stimulates Release of Serotonin (5-HT) from Human Enterochromaffin Cells and Activates Brain Structures Involved in Nausea and Vomiting

(2011) Marie Hagbom et al.   PLoS Pathogens

PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers

(2010) M. José Rodríguez-Lagunas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of SERCA pumps induces desynchronized RyR activation in overloaded internal Ca2+ stores in smooth muscle cells

(2010) Norma Leticia Gómez-Viquez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

Bacterial Toxins and the Nervous System: Neurotoxins and Multipotential Toxins Interacting with Neuronal Cells

(2010) Michel R. Popoff et al.   Toxins

The potential for μ-opioid receptor agonists to be anti-emetic in humans: a review of clinical data

(2009) KEVIN D. JOHNSTON   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Ablation of least shrew central neurokinin NK₁ receptors reduces GR73632-induced vomiting.

(2009) Andrew P. Ray et al.   BEHAVIORAL NEUROSCIENCE

Evidence for a Re-Evaluation of the Neurochemical and Anatomical Bases of Chemotherapy-Induced Vomiting

(2009) Nissar A. Darmani et al.   CHEMICAL REVIEWS

Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva)

(2009) Seetha Chebolu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modulation of neuropeptide Y receptors for the treatment of obesity

(2009) Nagaaki Sato et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

L-type Ca2+ channels in mast cells: Activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels

(2009) Tetsuro Yoshimaru et al.   MOLECULAR IMMUNOLOGY

Cav1.2 L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption

(2009) Yoshihiro Suzuki et al.   MOLECULAR IMMUNOLOGY

L-type Ca2+ channels: A new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells

(2009) Yoshihiro Suzuki et al.   MOLECULAR IMMUNOLOGY

Nausea and Vomiting Side Effects with Opioid Analgesics during Treatment of Chronic Pain: Mechanisms, Implications, and Management Options

(2009) Frank Porreca et al.   PAIN MEDICINE

Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva)

(2009) Andrew P. Ray et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

(2009) James R. Shoblock et al.   PSYCHOPHARMACOLOGY

Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness

(2008) Go Sato et al.   ACTA OTO-LARYNGOLOGICA

Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists

(2008) Nissar A. Darmani et al.   BRAIN RESEARCH

A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: Evidence from the least shrew

(2008) Nissar A. Darmani et al.   BRAIN RESEARCH

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

Histamine-induced Ca2+entry in human astrocytoma U373 MG cells: Evidence for involvement of store-operated channels

(2008) Margarita Barajas et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanism of the prostanoid TP receptor agonist U46619 for inducing emesis in the ferret

(2008) Kelvin K. W. Kan et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The antiemetic interaction of Δ9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew

(2008) Yaozhi Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuropeptide Y Y2 receptor in health and disease

(2007) S L Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

IP3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis

(2007) F Splettstoesser et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histamine and its receptors

(2006) Mike E Parsons et al.   BRITISH JOURNAL OF PHARMACOLOGY