期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/ijms22136851
关键词
age-related macular degeneration; complement cascade; clinical trial; therapeutics
资金
- Basic Science Research Program through the National Research Foundation (NRF) of Korea - Ministry of Education, Science, and Technology [2017R1A2B2005309, 2019R1G1A1100084]
- National Research Foundation of Korea [2019R1G1A1100084, 2017R1A2B2005309] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Age-related macular degeneration (AMD) is a complex disease characterized by neovascularization or geographic atrophy. The complement system plays a crucial role in AMD and has become a therapeutic target. Further research is needed to fully understand the mechanism of complement disease propagation in AMD.
Age-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type). The complement system is an intrinsic component of innate immunity. There has been growing evidence that the complement system plays an integral role in maintaining immune surveillance and homeostasis in AMD. Based on the association between the genotypes of complement variants and AMD occurrence and the presence of complement in drusen from AMD patients, the complement system has become a therapeutic target for AMD. However, the mechanism of complement disease propagation in AMD has not been fully understood. This concise review focuses on an overall understanding of the role of the complement system in AMD and its ongoing clinical trials. It provides further insights into a strategy for the treatment of AMD targeting the complement system.
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