Article
Multidisciplinary Sciences
Helen E. Parker, Sanghamitra Sengupta, Achar Harish, Ruben R. G. Soares, Haakan N. Joensson, Walter Margulis, Aman Russom, Fredrik Laurell
Summary: Microfluidics, specifically droplet microfluidics, is a rapidly developing field that offers independent manipulation and high-throughput analysis of droplets. In this study, we propose an optofluidic Lab-in-a-Fiber scheme using a periscope fiber for stable and compact alignment. We integrate droplet microfluidics with laser-induced fluorescence detection, demonstrating the generation of monodisperse droplets and achieving a limit of detection of fluorescein. Furthermore, we show the device's capability in detecting reverse-transcription loop-mediated isothermal amplification (RT-LAMP) products for COVID-19 diagnostics, highlighting its potential as a point-of-care droplet digital RT-LAMP platform.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Deraldo de Carvalho Jacobina de Andrade, Bahareh Nojabaei
Summary: Molecular dynamics simulation was used to study the phase behavior and composition distribution of an ethane/heptane binary mixture in oil-wet graphite nanopores with pore size distribution. The results showed that nanopore confinement affects phase equilibrium of multicomponent hydrocarbon mixtures, with stronger effects observed in smaller pores. Adsorption dominated in smaller pores, leading to different compositions of hydrocarbon mixtures depending on pore size.
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Article
Chemistry, Analytical
Canan Ozyurt, Inci Uludag, Bahar Ince, Mustafa Kemal Sezginturk
Summary: Lab-on-a-chip (LOC) or micro total analysis system is a microfluidic technology that integrates and automates analytical laboratory procedures into a single instrument or chip. This article reviews the recent developments in the application of LOC biosensors for cancer detection. Microfluidics has revolutionized healthcare diagnosis by enabling the reconstruction of functional organ units on chips and studying human diseases like cancer. In the past five years, LOCs have been widely used in various biomedical applications such as bioassays, cell analysis, drug discovery, and personalized medicine. This review provides an overview of microfluidic-based cancer research, including its pros, cons, and future prospects.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Fang Wang, Jiaomeng Zhu, Xuejia Hu, Longfei Chen, Yunfeng Zuo, Yi Yang, Fenghua Jiang, Chengjun Sun, Weihong Zhao, Xiaotian Han
Summary: A portable device utilizing innovative three-dimensional double microstructured assisted reactors was developed for rapid nitrate determination. The device showed fast detection speed, low reagent consumption, good reproducibility, and low toxic reagent consumption, indicating a wide range of applications in water quality monitoring.
Article
Engineering, Chemical
Zhaojie Song, Yilei Song, Jia Guo, Dong Feng, Jiangbo Dong
Summary: The study investigated the effects of capillarity and adsorption on phase behavior and transport of shale fluids in the Bakken shale oil reservoir. An improved phase equilibrium model incorporating adsorption effects was developed and used to analyze black-oil properties and well performance under different pressure and confinement conditions. The results showed that adsorption had a more significant impact on the fluid properties and production performance under high-pressure conditions, while capillary pressure played a more significant role under low-pressure conditions.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Biophysics
Donato Calabria, Ilaria Trozzi, Elisa Lazzarini, Andrea Pace, Martina Zangheri, Lorenzo Iannascoli, Nithin Maipan Davis, Sagar Sarvad Gosikere Matadha, Thiago Baratto De Albuquerque, Simone Pirrotta, Marta Del Bianco, Gabriele Impresario, Liyana Popova, Nicola Lovecchio, Giampiero de Cesare, Domenico Caputo, John Brucato, Augusto Nascetti, Massimo Guardigli, Mara Mirasoli
Summary: Space exploration is entering a new era with planned missions to the Moon and Mars, making the development and validation of new technologies crucial. Biosensors and lab-on-chip devices can play a key role in analyzing biological samples, monitoring environmental safety, and searching for signs of life in extra-terrestrial environments. Small satellites like CubeSats are being utilized as cost-effective platforms for technology validation. A fully autonomous lab-on-chip platform has been developed for performing bioassays in space, simplifying device design and protocols and enhancing stability of reagents.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Mahesh P. Bhat, Mahaveer Kurkuri, Dusan Losic, Madhuprasad Kigga, Tariq Altalhi
Summary: A PDMS microfluidic channel integrated with a UV-vis fibre-optic spectrometer and a new colorimetric probe was developed for sensitive and real-time quantitative measurements of fluoride ions (F). The device features an 'S' shaped microchannel acting as a microreactor to enhance the reaction between the colorimetric probe and F ions. This optofluidic device demonstrates high sensitivity and selectivity for F ions, outperforming conventional methods in detecting real samples.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Joydip Sengupta, Chaudhery Mustansar Hussain
Summary: Analytical lab-on-chip devices are widely used in various fields, with graphene being an important component. To achieve sustainability, environmental compatibility needs to be considered. This paper reviews prospective pathways for the feasible fabrication of environmentally friendly graphene-based lab-on-chip devices.
Article
Engineering, Multidisciplinary
Tong Hou, Hui Chang, Haoliang Jiang, Pengcheng Wang, Na Li, Yongxin Song, Dongqing Li
Summary: The smartphone integrated microfluidic lab-on-chip device enables real-time detection, counting, and sizing of living algae in ship's ballast water, achieving high accuracy and convenience in operation.
Article
Energy & Fuels
Xiangji Dou, Yisong Zhang, Jing Guo, Kun Qian
Summary: The confinement effect of nanopores significantly influences the fluid-phase behavior of shale oil reservoirs. Understanding the phase change characteristics of fluids in nanopores is crucial for designing development plans, production systems, and enhanced oil recovery (EOR) methods for shale oil reservoirs. Molecular dynamics simulation was used to analyze the phase behavior of single-component and hydrocarbon-CO2 mixture systems in organic nanopores. The results revealed that the confinement effect on the phase change pressure of single-component systems varied depending on the electron cloud distribution. The confinement effect became stronger as the carbon chain length of hydrocarbons increased. Furthermore, the confinement effect shrank the P-T phase envelope, making CO2 more miscible with shale oil in nanopores and reducing the adsorption of hydrocarbons on organic pore walls.
JOURNAL OF PETROLEUM EXPLORATION AND PRODUCTION TECHNOLOGY
(2023)
Article
Environmental Sciences
Natalia Bourguignon, Mauricio Alessandrello, Ross Booth, Constanza Belen Lobo, Maria Silvina Juarez Tomas, Luis Cumbal, Maximiliano Perez, Shekhar Bhansali, Marcela Ferrero, Betiana Lerner
Summary: This study used a microfluidic platform to explore the development, properties, and applications of biofilms in fluid flow, aiming to screen for biofilms capable of degrading PAHs. Computational fluid dynamics was used to optimize and evaluate the flow condition in microchannels, and the efficiency of PAHs removal was determined through HPLC analysis.
Article
Chemistry, Applied
Nafiseh Bagheri, Haider A. J. Al Lawati, Javad Hassanzadeh
Summary: A microfluidic device was developed for simultaneous analysis of total flavonoids and total phenolic acids, utilizing magnetic ZIF-4 for separation and sensitive detection. The method showed high accuracy and recovery rates, proving successful in analyzing tea and honey samples.
Article
Biochemical Research Methods
Noah Goshi, Gregory Girardi, Felipe da Costa Souza, Alexander Gardner, Pamela J. Lein, Erkin Seker
Summary: The study investigates the impact of microchannel geometry and cell seeding density on the performance of compartmentalized microfluidic neural cell culture platforms. It concludes that microchannel height is the primary determinant of device performance, while other parameters offer additional flexibility for customization. This research provides design rules for engineering microfluidic neural culture platforms and demonstrates their utility in long-term studies.
Article
Chemistry, Physical
Arabinda Bera, Kurt Binder, Sergei A. Egorov, Subir K. Das
Summary: Based on molecular dynamics simulations, this study examines the structure and dynamics of mixtures of active colloids and passive polymers confined in a repulsive boundary spherical container. By introducing velocity-aligning activity to the colloids, the shape of the polymer-rich domain transitions to an ellipsoid, while the colloid-rich domain develops a macroscopic angular momentum around the long axis. The orientation of this axis evolves through diffusion in the steady state, with the magnitude depending weakly on the activity strength.
Article
Energy & Fuels
Navin Kumar, Ryan Von Ness, Reynaldo Chavez, Debjyoti Banerjee, Arun Muley, Michael Stoia
Summary: Salt hydrates as phase change materials have high potential in thermal energy storage, but their practical feasibility is limited due to low power rating and long-term stability issues.
JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME
(2021)
Article
Energy & Fuels
Binjian Ma, Donghyun Shin, Debjyoti Banerjee
Summary: The study examined the feasibility of using molten salt nanofluids as TES medium based on their thermophysical properties, corrosion behavior, and economic value. The one-step synthesis protocol for nanofluids involving generation of nanoparticles in-situ from cheap additives was found to be a viable and cost-effective approach in industrial applications for enhancing energy storage capacity and power rating while extending equipment lifespan.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Energy & Fuels
Aditya Chuttar, Ashok Thyagarajan, Debjyoti Banerjee
Summary: Phase change materials (PCMs) have gained attention for thermal energy storage (TES) due to their high storage density. Inorganic PCMs have a high latent heat value but face reliability issues. Cold Finger Technique (CFT) can enhance reliability by leaving a small fraction of PCM in solid phase. Machine learning (ML) techniques, specifically artificial neural networks (ANN), are used to improve the efficacy of CFT. This study demonstrates that ANN can predict the time required to achieve a chosen melt fraction of PCM.
JOURNAL OF ENERGY RESOURCES TECHNOLOGY-TRANSACTIONS OF THE ASME
(2022)
Article
Computer Science, Information Systems
Aditya Chuttar, Debjyoti Banerjee
Summary: This study investigates the real-time prediction of melt-fraction in thermal energy storage platforms using artificial neural networks. Training the ANN model with two different approaches can improve the efficiency and reliability of heat transfer systems.
Article
Thermodynamics
G. Ren, A. Chuttar, D. Banerjee
Summary: Thermal Energy Storage (TES) platforms use phase change materials (PCMs) to absorb and release thermal energy, addressing the imbalance between energy consumption and supply. Inorganic PCMs offer higher latent heat values but suffer from reliability issues due to the need for higher supercooling. The Cold Finger Technique (CFT) helps mitigate these issues at the cost of storage capacity. This study leverages machine learning techniques to predict the time required to reach a desired melt-fraction using temperature transients from PCM melting experiments.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Chemistry, Multidisciplinary
Qi Yang, Ran Bi, Debjyoti Banerjee, Hadi Nasrabadi
Summary: The characterization of fluid phase transitions in nanoscale pores is important for various applications and poses challenges due to the dominance of fluid-surface interactions at this scale. Limited experimental observations have been made due to difficulties in performing experiments at the nanoscale. In this study, for the first time, the vapor-liquid phase transitions of n-butane in a 2 nm slit pore were directly observed and visualized using lab-on-a-chip technology. The experiments measured the deviation of the phase transition pressure compared to the unconfined or bulk value, and revealed significant differences between the liquid-vapor and vapor-liquid phase transition pressures.
Article
Computer Science, Artificial Intelligence
Muhammed A. Hassan, Mohamed Abubakr Hassan, Debjyoti Banerjee, Hussien Hegab
Summary: This study proposes and implements a method for predicting and optimizing the thermal conductivity and dynamic viscosity of hybrid nanofluids (HNFs). By using LSSVR models and multi-objective genetic optimization of thermal properties, excellent predictive results are achieved.
APPLIED SOFT COMPUTING
(2022)
Article
Thermodynamics
Vish Prasad, Karan Kakroo, Debjyoti Banerjee
Summary: The study reveals that the anomalous behavior of supercritical fluid extends to subcritical liquid state and shows that argon can be used as an alternative supercritical fluid for thermal transport with lower pressure and temperature requirements, as well as nonreactive and noncorrosive properties. The research also indicates that there is a significant enhancement in heat transfer at high-supercritical pressures, especially at lower temperatures.
HEAT TRANSFER RESEARCH
(2022)
Proceedings Paper
Engineering, Multidisciplinary
Alaba Bamido, Debjyoti Banerjee
Summary: The study aimed to develop a microfluidic system for precise water delivery to individual plants in the field, using thermally-actuated microvalves designed and tested. Two types of actuation, air and Phase Change Material (PCM), were utilized, with PCM design showing lower energy consumption but higher manufacturing costs, and air actuation design showing higher energy consumption but faster operation speeds.
PROCEEDINGS OF ASME 2021 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2021), VOL 3
(2021)
Proceedings Paper
Engineering, Multidisciplinary
Lamees El Nihum, Nandan Shettigar, Debjyoti Banerjee, Robert Krencik
Summary: This review focuses on advances in three-dimensional organoids, with a particular emphasis on the engineering of microfluidic device platforms for investigating neuro-organoids. The paper also assesses current limitations in microfluidic design to realize the full potential of brain-on-a-chip devices.
PROCEEDINGS OF ASME 2021 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2021), VOL 3
(2021)
Proceedings Paper
Engineering, Multidisciplinary
Nandan Shettigar, Lamees El Nihum, Ashok Thyagarajan, Debjyoti Banerjee, Robert Krencik
Summary: The study utilized soft lithography techniques to fabricate a microfluidic chip serving as a brain-on-a-chip model, where neural organoids were introduced and subjected to various stimuli to observe their electrical responses.
PROCEEDINGS OF ASME 2021 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2021), VOL 3
(2021)
Proceedings Paper
Engineering, Multidisciplinary
Ashok Thyagarajan, Debjyoti Banerjee, Vijay Dhir
Summary: This study evaluated a novel apparatus capable of dynamic flash evaporation and phase separation using centrifugal flow to form a stable air core. The experimental data obtained can be used as a preliminary indicator for separation efficiency in water remediation applications involving the production of potable water from saline water.
PROCEEDINGS OF ASME 2021 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2021), VOL 3
(2021)
Proceedings Paper
Engineering, Multidisciplinary
Lamees El Nihum, Ponraj Chinnadurai, C. Huie Lin, Debjyoti Banerjee
Summary: The focus of this study is on the importance of using advanced imaging technology and computational simulations in evaluating hemodynamic changes in patients with congenital heart disease (CHD). Co-validation of experimental (4D MRI) and simulation (CFD) models is crucial for accurately depicting flow dynamics in human vasculature and improving tools and methodologies used in cardiovascular hemodynamics analysis.
PROCEEDINGS OF ASME 2021 FLUIDS ENGINEERING DIVISION SUMMER MEETING (FEDSM2021), VOL 1
(2021)
Proceedings Paper
Thermodynamics
Alaba Bamido, Nandan Shettigar, Ashok Thyagrajan, Debjyoti Banerjee
Summary: This study investigated the temperature-dependent mechanical properties of PDMS in thermomechanical applications through experimental and numerical simulations, filling a gap in the current literature.
PROCEEDINGS OF THE TWENTIETH INTERSOCIETY CONFERENCE ON THERMAL AND THERMOMECHANICAL PHENOMENA IN ELECTRONIC SYSTEMS (ITHERM 2021)
(2021)
Proceedings Paper
Thermodynamics
Aditya Chuttar, Nandan Shettigar, Ashok Thyagrajan, Debjyoti Banerjee
Summary: The study investigates the use of Artificial Intelligence (AI), particularly Deep Learning, to predict the time remaining to reach a target melt fraction at any instant during the melting cycle. By correlating the PCM melt fraction and temperature transients at multiple locations within the TES platform using an Artificial Neural Network (ANN), the goal of this research is to develop prediction tools that can make real-time predictions based on instantaneous values of temperature during operation.
PROCEEDINGS OF THE TWENTIETH INTERSOCIETY CONFERENCE ON THERMAL AND THERMOMECHANICAL PHENOMENA IN ELECTRONIC SYSTEMS (ITHERM 2021)
(2021)
Article
Thermodynamics
Haolei Yang, Xiaoqiang Bian, Lianguo Wang
Summary: A new association model, CPA-MHV1, combining the SRK equation of state with the CPA equation based on Michelsen's improved Huron-Vidal mixing rule, is developed. The model is used to investigate the vapor-liquid equilibrium of binary mixtures involving CH4, CO2, and H2O, as well as ternary mixtures containing NaCl. The results show that considering the solvation between CO2 and H2O yields the best performance, while CH4 with a pseudo-association scheme has the highest comprehensive prediction performance.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Vikas K. Sinha, Atanu K. Metya, Chandan K. Das
Summary: In this study, the solid-liquid coexistence curve for water was developed using coarse-grained mW and machine-learned ML-BOP water models. The ML-BOP model exhibited lower densities, a broader density-temperature hysteresis loop, and higher free energy compared to the mW model. The pressure dependence fusion curve for both models aligned with previous literature. This analysis demonstrates that the free energy method accurately captures the solid-liquid transformation and the thermodynamic melting point of water.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Curtis Hays Whitson
Summary: This article tells the story of an extraordinary individual who made numerous and valued contributions, portrayed through a few images and short stories.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Joe Hajjar, Sabine Enders
Summary: A generalized theoretical framework is introduced for multicomponent reactive nonuniform systems, combining the modified and generalized Cahn-Hilliard equation with a chemical kinetics model. The framework allows for the modelling and investigation of the combined reaction and diffusion in reactive liquid-liquid systems. It is found that for reacting mixtures with much smaller reaction rates than diffusion rates, the mixture will remain in phase equilibrium upon reaction and the interfacial chemical reaction will not affect the overall system dynamics, which are only influenced by the kinetics of the bulk phases.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Keycianne da Cruz Silva, Leticia Daniela de Souza, Vinicius Azevedo Gomes, Leandro Rodrigues de Lemos
Summary: Phase diagrams of four aqueous two-phase systems were determined experimentally, and conclusions were drawn regarding the effect of temperature on system enthalpy change and the influence of macromolecules on phase separation.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Yuanqing Wu, Shuyu Sun
Summary: The sparse-grid guided PINN training method improves the accuracy of the PINN surrogate model by rearranging collocation points and reduces the training time complexity. Experimental results demonstrate its clear advantages in terms of convergence, stability, and accuracy.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Peter Englezos
Summary: This article discusses the research progress and challenges in the field of canonical clathrate or gas hydrate phase equilibria, as well as the application of computational methods and models. It also explores the potential of machine learning techniques in hydrate and thermodynamic calculations.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Ying-Chieh Hung, Shao-Wei Su, Jia-Wei Yan, Gui-Bing Hong
Summary: In this study, VLE data for five binary systems were measured and successfully correlated using models. The predictive models were used to predict the binary VLE phase diagram and explain the mechanism of separation efficiency. The strength of electrostatic interactions and temperature-dependent separation behavior were determined through the analysis of molecular surface charge distribution.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Matevz Turk, Tomaz Urbic
Summary: By molecular dynamics and Monte Carlo simulations, this study determined the regions and hierarchy of anomalies in a purely repulsive core-softened system. It was found that in two dimensional systems, a size of 100 particles is sufficient for obtaining accurate details.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Adnan Jaradat, Rakan Al-Salman, Abdalla Obeidat
Summary: The vapor-liquid equilibrium of six primary alcohols were studied using molecular dynamics simulations and compared with experimental results. The study found that neglecting the Lennard-Jones interaction significantly reduced the critical temperature values and determining the critical temperature using surface tension gave more accurate results. The TraPPE-UA potential field showed good accuracy in predicting the critical temperature.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Michele Valsecchi, Amparo Galindo, George Jackson
Summary: The thermodynamic properties of aqueous mixtures of polyethylene glycol (PEG) are described using the SAFT-gamma Mie group-contribution equation of state. The model successfully predicts the miscibility gaps in a temperature range and shows good agreement with experimental results.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Roman Tomaschitz
Summary: Analytic closed-form expressions for the liquid and vapor saturation densities defining the coexistence curve are obtained. The coexistence curves of nitrogen, ethene, and sulfur hexafluoride are derived using high-precision data, and the critical power-law scaling of the order parameter and coexistence-curve diameter is examined. The Log-Log slopes of various quantities are used to determine the ideal power-law scaling regime and illustrate the slope evolution in the subcritical regime.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Nivaar Brijmohan, Kuveneshan Moodley, Caleb Narasigadu
Summary: An artificial neural network-based QSPR model was developed to estimate binary interaction parameters for the temperature-dependant form of the NRTL model. This model serves as a supplement to overcome limitations of group contribution methods in solvent screening and has been proven to be effective in improving the robustness of the screening process.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Marco Campestrini, Paolo Stringari, Salem Hoceini
Summary: In this paper, the solubility of benzene in different phases of methane was predicted using the GERG-2008 equation of state and the Gibbs free energy equation. The obtained results were in good agreement with experimental data and emphasized the significance of accurately representing the density of the fluid phase for predicting the solubility of solids in fluids.
FLUID PHASE EQUILIBRIA
(2024)
Article
Thermodynamics
Nefeli Novak, Georgios M. Kontogeorgis, Marcelo Castier, Ioannis G. Economou
Summary: This paper discusses theoretical considerations on electrolyte thermodynamic models for single and mixed solvent solutions. The authors find that there is no consensus among researchers on many fundamental issues in this field. They point out the need to convert electrolyte terms to the framework of the physical model and emphasize the importance of the Born term for liquid-liquid equilibrium calculations.
FLUID PHASE EQUILIBRIA
(2024)
