期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms22126544
关键词
epigenetics; autophagy; atherosclerosis; cardiovascular diseases
资金
- Canadian Institutes of Health Research [153216]
- Heart and Stroke Foundation of Canada, Canada
Autophagy plays a crucial role in cardiovascular diseases, with complex regulation involving epigenetic pathways. Understanding these pathways not only enhances the comprehension of CVDs, but may also offer new therapeutic targets and biomarkers for CVDs.
Cardiovascular diseases (CVDs) are the number one cause of debilitation and mortality worldwide, with a need for cost-effective therapeutics. Autophagy is a highly conserved catabolic recycling pathway triggered by various intra- or extracellular stimuli to play an essential role in development and pathologies, including CVDs. Accordingly, there is great interest in identifying mechanisms that govern autophagic regulation. Autophagic regulation is very complex and multifactorial that includes epigenetic pathways, such as histone modifications to regulate autophagy-related gene expression, decapping-associated mRNA degradation, microRNAs, and long non-coding RNAs; pathways are also known to play roles in CVDs. Molecular understanding of epigenetic-based pathways involved in autophagy and CVDs not only will enhance the understanding of CVDs, but may also provide novel therapeutic targets and biomarkers for CVDs.
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