Article
Chemistry, Analytical
Ian Oesterle, Dominik Braun, Annette Rompel, Benedikt Warth
Summary: Establishing a targeted LC-MS/MS method for human biomonitoring of polyphenols allows for accurate quantification of various polyphenol classes and high-throughput sample processing in large-scale population studies. The method demonstrates high extraction efficiency and low detection limits across multiple sample types. In a validation and proof-of-principle study, the method successfully detected and studied the concentration changes of multiple polyphenols in urine after ingestion of a high polyphenol smoothie.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Katarina Rihackova, Ales Pindur, Klara Komprdova, Nina Palesova, Jiri Kohoutek, Petr Senk, Jana Navratilova, Lenka Andryskova, Ludmila Sebejova, Richard Hulek, Mazen Ismael, Pavel Cupr
Summary: The CELSPAC-FIREexpo biomonitoring study investigates the long-term effects of chemical exposure on firefighters' wellness and fitness. The study found that firefighters had significantly higher PFAS levels compared to the control group, and these levels were associated with their length of firefighting career, age, blood donation, and population size.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Tiina Santonen., Petra Apel., Paula. Alvito, Elena. Anastasi, Helle Raun Andersen, Anna-Maria Andersson, Lenka Andryskova, Jean-Philippe Antignacj, Brice Appenzeller, Fabio Barbone, Zohar Barnett-Itzhaki, Robert Barouki, Tamar Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Canas-Portilla, Adrian Covaci, Zsofia Csako, Elly Den Hond, Darina Dvorakova, Lucia Fabelova, Tony Fletcherx, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Goen, Thorhallur Halldorsson, Line S. Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Natasa Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klanova, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuki, Matthieu Meslin, Hans Molar, Parisa Montazeri, Aline Murawski, Sonia Namorado, Lars Niemann, Stefanie Nabler, Baltazar Nunes, Kristin Olafsdottir, Lubica Palkovicova Murinova, Nafsika Papaioannou, Susana Pedraza-Diaz, Pavel Pileri, Veronika Plichta, Michael Poteser, Nicole Probst-Hensch, Loic Rambaud, Elke Rauscher-Gabernig, Katarina Rausova, Sylvie Remy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rather, Denis Sarigiannis, Maria J. Silva, Zdenka Slejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamas Szigeti, Jose V. Tarazona, Cathrine Thomsen, Ziga Tkalec, Hanna Tolonen, Tomas Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wasowicz, Till Weber, Sona Wimmerova, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonari, Holger Koch, Marike Kolossa-Gehring, Marta Esteban Lopez, Argelia Castano, Lorraine Stewartx, Ovnair Sepaix, Greet Schoeters
Summary: As part of the European Human Biomonitoring Initiative, a human biomonitoring survey was conducted in 23 countries to produce comparable data for the EU. The survey utilized existing HBM capacity in Europe and aligned national or regional studies under the HBM4EU program. The survey included over 10,000 participants from different age groups and measured various biomarkers to assess exposure levels to different chemicals. The data obtained can be used as a reference for global comparison, evaluate the effectiveness of the European Commission's chemical strategy, and guide policy-making.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Lei Fu, Shaofang Song, Xinni Luo, Yangxu Luo, Chongshan Guo, Yufei Liu, Xiaoyan Luo, Lixi Zeng, Lei Tan
Summary: This study investigated the relationship between dietary exposure and human internal exposure to phthalates. The results showed that dietary intake was the predominant exposure route for phthalates, and children exhibited the highest concentration of phthalate metabolites (mPAEs). Using Monte Carlo simulation to estimate phthalate exposure's health risk, it was found that a significant portion of the volunteers had hazard quotient (HQ) levels higher than 1.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Ana Maria Tavares, Susana Viegas, Henriqueta Louro, Thomas Goeen, Tiina Santonen, Mirjam Luijten, Andreas Kortenkamp, Maria Joao Silva
Summary: This study conducted a mixture risk assessment (MRA) based on human biomonitoring (HBM) data in Europe to evaluate the co-exposure of hexavalent chromium, nickel, and polycyclic aromatic hydrocarbons. The results indicate that there is concern regarding the occupational health risk of co-exposure to these substances, particularly in welding activities and waste incineration settings. It highlights the importance of considering exposure to the mixture rather than the individual components to manage workplace risk and protect workers' health.
Article
Environmental Sciences
Eva Ougier, Florence Zeman, Jean-Philippe Antignac, Christophe Rousselle, Rosa Lange, Marike Kolossa-Gehring, Petra Apel
Summary: The European Human Biomonitoring Initiative (HBM4EU) establishes human biomonitoring guidance values (HBM-GVs) for substances such as BPA, using total BPA in urine as the primary exposure biomarker for BPA. Different HBM-GV(GenPop) values were developed for adults and children based on toxicological data, aiming to reflect a steady-state exposure to the temporary Tolerable Daily Intake (t-TDI) set by the European Food Safety Authority (EFSA).
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Philipp Zimmermann, Domenica Hahn, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Thorhallur I. Halldorsson, Asa Eiriksdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goeen, Stefanie Nuebler, Moritz Schaefer, Karin Haji Abbas Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: Acrylamide, a potential carcinogen, has been found in common dietary products and tobacco smoke. The European Commission has taken measures to reduce its content in food. The HBM4EU project shows an overall increase in acrylamide exposure between 2001 and 2017, but a decline in exposure values after 2018. Regional differences do not affect the overall time trend of exposure.
Article
Public, Environmental & Occupational Health
Dorothy Ubong, Lorraine Stewart, Ovnair Sepai, Lisbeth E. Knudsen, Tamar Berman, Hans Reynders, Karen Van Campenhout, Andromachi Katsonouri, An Van Nieuwenhuyse, Anna Maria Ingelido, Argelia Castano, Susana Pedraza-Diaz, Asa Valgerour Eiriksdottir, Cathrine Thomsenj, Christina Hartmann, Dragan Gjorgjev, Elena De Felip, Hanna Tolonen, Tiina Santonen, Jana Klanova, Karin Norstrom, Lijana Kononenko, Maria Joao Silva, Maria Uhl, Marike Kolossa-Gehring, Petra Apels, Merli Joemaa, Michal Jajcaj, Milada Estokova, Mirjam Luijten, Erik Lebret, Natalie von Goetz, Natasa Janev Holcer, Nicole Probst-Hensch, Rita Cavaleiro, Robert Barouki, Elena Tarroja, Rosita Marija Balciene, Loreta Strumylaite, Siiri Latvala, Sonia Namorado, Tamas Szigeti, Thorhallur Ingi Halldorsson, Kristin Olafsdottir, Wojciech Wasowicz
Summary: Most countries recognize the importance of assessing and quantifying internal exposure to chemicals in various aspects of daily life. Human biomonitoring is a valuable tool to measure such exposures and effects, and its results can contribute to improving public health and informing evidence-based policies. The HBM4EU project aims to harmonize procedures and advance research on the health impacts of environmental chemical exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Max Scherer, Wolf Petreanu, Till Weber, Gerhard Scherer, Nikola Pluym, Marike Kolossa-Gehring
Summary: The fragrance chemical 2-(4-tert-butylbenzyl)propionaldehyde is commonly used in cosmetic products. A new LC-MS/MS method was developed to analyze four lysmeral metabolites in urine samples collected between 2000 and 2018, revealing a significant decline in exposure to lysmeral. Efforts to reduce exposure are still needed, as adverse effects cannot be excluded despite the decreasing trend observed in the data.
Article
Engineering, Environmental
Barbara Kasprzyk-Hordern, Frederic Been, Lubertus Bijlsma, Werner Brack, Sara Castiglioni, Adrian Covaci, Bice S. Martincigh, Jochen F. Mueller, Alexander L. N. van Nuijs, Temilola Oluseyi, Kevin V. Thomas
Summary: Water-based environmental monitoring (WBE) has become a useful tool for SARS-CoV-2 surveillance and has been applied to assess illicit drug consumption in communities. It is important to expand its use to evaluate community exposure to chemical stressors. The goal of WBE is to measure exposure, identify exposure-outcome associations, and implement interventions for exposure prevention and public health promotion. To fully utilize WBE, further action is needed, such as integrating WBE with human biomonitoring initiatives, conducting global WBE monitoring campaigns, combining WBE with One Health actions, and advancing analytical tools and methodologies.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Environmental Sciences
Mostafa Hadei, Abbas Shahsavani, Philip K. Hopke, Simin Naseri, Ahmadreza Yazdanbakhsh, Mohsen Sadani, Alireza Mesdaghinia, Maryam Yarahmadi, Masoumeh Rahmatinia, Sevda Fallah, Bahaaran Emam, Majid Kermani, Nemat Jaafarzadeh, Mohammadreza Alipour, Vajihe Hassanzadeh, Shahriyar Bazzazpour, Seyed Saeed Hashemi Nazari
Summary: This study systematically reviewed biomonitoring studies on carcinogen environmental pollutants in Iran, finding high concentrations of cadmium and arsenic in breast milk. The results highlighted the need for comprehensive action plans to reduce population exposure to these environmental contaminants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Matthieu Meslin, Claire Beausoleil, Florence Anna Zeman, Jean-Philippe Antignac, Marike Kolossa-Gehring, Christophe Rousselle, Petra Apel
Summary: This paper presents the derivation of Human Biomonitoring Guidance Values (HBM-GVs) for bisphenol S (BPS) for the general population and workers within the European Joint Programme HBM4EU. The study illustrates the usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) and highlights the difference in risk assessments between the two bisphenols. Results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.
Review
Engineering, Environmental
Xin Wang, Qingqing Zhu, Chunyang Liao, Guibin Jiang
Summary: Organophosphate flame retardants (OPFRs), especially organophosphate esters (OPEs), have raised concerns on environmental and health risks. Biomonitoring research provides precise information on human exposure, while knowledge on biotransformation and metabolism of OPEs is crucial for understanding internal exposure. Further developments in methodologies for urine sampling and estimation on internal exposure to OPEs are needed.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Public, Environmental & Occupational Health
Rosa Lange, Petra Apel, Christophe Rousselle, Sandrine Charles, Fatoumata Sissoko, Marike Kolossa-Gehring, Eva Ougier
Summary: The widespread internal exposure of the European population to plasticizers has sparked the urgent need for toxicological interpretation. The European Human Biomonitoring Initiative (HBM4EU) has significantly contributed to understanding actual exposure levels and their impact on health. Human biomonitoring guidance values (HBM-GVs) have been derived for various phthalates and a non-phthalate substitute, aiding in health risk assessment.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Nikola Pluym, Therese Burkhardt, Nadine Roegner, Gerhard Scherer, Till Weber, Max Scherer, Marike Kolossa-Gehring
Summary: Human biomonitoring (HBM) of the banned feed additive ethoxyquin (EQ) using a newly established method revealed a ubiquitous exposure of the non-occupationally exposed population. A decline in exposure was observed after the EU wide ban of EQ as a feed additive, with the majority of the population having a low level of exposure below the derived no-effect level (DNEL). However, the presence of the carcinogen p-phenetidine in EQ poses a potential risk for higher burden in a small fraction of the population, indicating the need for further investigation and targeted campaigns.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Domenica Hahn, Nina Vogel, Christian Hoera, Alexander Kaempfe, Maria Schmied-Tobies, Thomas Goeen, Annette Greiner, Annette Aigner, Marike Kolossa-Gehring
Summary: This study investigated the association between dietary factors and blood lead levels in children and adolescents in Germany. The results showed that lead intake through tap water was the predominant exposure pathway, and meat, fruit, and fruit juice consumption were also associated with blood lead levels.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Anna-Maria Andersson, Brice M. R. Appenzeller, Fabio Barbone, Argelia Castano, Dries Coertjens, Elly Den Hond, Vazha Dzhedzheia, Ivan ErZen, Marta Esteban Lopez, Lucia Fabelova, Clemence Fillol, Carmen Franken, Hanne Frederiksen, Catherine Gabriel, Line Smastuen Haug, Milena Horvat, Thorhallur Ingi Halldorsson, Beata Janasik, NataSa Janev Holcer, Reka Kakucs, Spyros Karakitsios, Andromachi Katsonouri, Jana Klanova, Tina Kold-Jensen, Marike Kolossa-Gehring, Corina Konstantinou, Jani Koponen, Sanna Lignell, Anna Karin Lindroos, Konstantinos C. Makris, Darja Mazej, Bert Morrens, Lubica PalkoviCova Murinova, Sonia Namorado, Susana Pedraza-Diaz, Jasmin Peisker, Nicole Probst-Hensch, Loic Rambaud, Valentina Rosolen, Enrico Rucic, Maria Ruether, Dimosthenis Sarigiannis, Janja Snoj Tratnik, Arnout Standaert, Lorraine Stewart, Tamas Szigeti, Cathrine Thomsen, Hanna Tolonen, Asa Eiriksdottir, An Van Nieuwenhuyse, Veerle J. Verheyen, Jelle Vlaanderen, Nina Vogel, Wojciech Wasowicz, Till Weber, Jan-Paul Zock, Ovnair Sepai, Greet Schoeters
Summary: This study describes the organization of the first HBM4EU-aligned studies in Europe, aiming to monitor the internal exposure of European citizens to environmental chemicals by collecting comparable human biomonitoring data.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Aline Murawski, Phillipp Schmidt, Maria Ruther, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Edda Dufthaksdottir, Kristin Olafsdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goen, Stefanie Nuebler, Moritz Schaefer, Karin H. A. Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: This report summarizes the results of the HBM4EU project and associated studies regarding acrylamide exposure levels. The findings show an increasing trend in acrylamide exposure in children, while the trend is less significant in adults and smokers. The average acrylamide exposure still exceeds suggested benchmark levels, raising specific concerns for children. Further research is needed to confirm the declining trend observed in recent years.
Article
Environmental Sciences
Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Philipp Zimmermann, Domenica Hahn, Marike Kolossa-Gehring, Sonia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Thorhallur I. Halldorsson, Asa Eiriksdottir, Line Smastuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loic Rambaud, Margaux Riou, Thomas Goeen, Stefanie Nuebler, Moritz Schaefer, Karin Haji Abbas Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer
Summary: Acrylamide, a potential carcinogen, has been found in common dietary products and tobacco smoke. The European Commission has taken measures to reduce its content in food. The HBM4EU project shows an overall increase in acrylamide exposure between 2001 and 2017, but a decline in exposure values after 2018. Regional differences do not affect the overall time trend of exposure.
Article
Environmental Sciences
Domenica Hahn, Maria Schmied-Tobies, Enrico Rucic, Nikola Pluym, Max Scherer, Malgorzata Debiak, Aline Murawski, Marike Kolossa-Gehring
Summary: Passive smoking is a significant cause of health problems, especially for children, and it is still a relevant issue in Germany. The study found that 42% of children and adolescents lived with at least one smoker in the household. The most significant predictor of passive smoke exposure was smoking at home, but parental smoking and passive smoking among friends and relatives also had an impact.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shoji F. Nakayama, Annie St-Amand, Tyler Pollock, Petra Apel, Yu Ait Bamai, Dana Boyd Barr, Jos Bessems, Antonia M. Calafat, Argelia Castano, Adrian Covaci, Radu Corneliu Duca, Sarah Faure, Karen S. Galea, Sean Hays, Nancy B. Hopf, Yuki Ito, Maryam Zare Jeddi, Marike Kolossa-Gehring, Eva Kumar, Judy S. LaKind, Marta Esteban Lopez, Henriqueta Louro, Kristin Macey, Konstantinos C. Makris, Lisa Melnyk, Aline Murawski, Josh Naiman, Julianne Nassif, Nolwenn Noisel, Devika Poddalgoda, Lesliam Quiros-Alcala, Ata Rafiee, Loic Rambaud, Maria Joao Silva, Jun Ueyama, Marc-Andre Verner, Maisarah Nasution Waras, Kate Werry
Summary: Human biomonitoring (HBM) data can be used to compare population exposures, but finding the relevant health-based biomonitoring guidance values can be time-consuming. To address this issue, an online repository called the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard has been created. This database provides a centralized location for researchers and decision makers to access and interpret HBM data.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Eva Govarts, Liese Gilles, Laura Rodriguez Martin, Tiina Santonen., Petra Apel., Paula. Alvito, Elena. Anastasi, Helle Raun Andersen, Anna-Maria Andersson, Lenka Andryskova, Jean-Philippe Antignacj, Brice Appenzeller, Fabio Barbone, Zohar Barnett-Itzhaki, Robert Barouki, Tamar Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Canas-Portilla, Adrian Covaci, Zsofia Csako, Elly Den Hond, Darina Dvorakova, Lucia Fabelova, Tony Fletcherx, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Goen, Thorhallur Halldorsson, Line S. Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Natasa Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klanova, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuki, Matthieu Meslin, Hans Molar, Parisa Montazeri, Aline Murawski, Sonia Namorado, Lars Niemann, Stefanie Nabler, Baltazar Nunes, Kristin Olafsdottir, Lubica Palkovicova Murinova, Nafsika Papaioannou, Susana Pedraza-Diaz, Pavel Pileri, Veronika Plichta, Michael Poteser, Nicole Probst-Hensch, Loic Rambaud, Elke Rauscher-Gabernig, Katarina Rausova, Sylvie Remy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rather, Denis Sarigiannis, Maria J. Silva, Zdenka Slejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamas Szigeti, Jose V. Tarazona, Cathrine Thomsen, Ziga Tkalec, Hanna Tolonen, Tomas Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wasowicz, Till Weber, Sona Wimmerova, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonari, Holger Koch, Marike Kolossa-Gehring, Marta Esteban Lopez, Argelia Castano, Lorraine Stewartx, Ovnair Sepaix, Greet Schoeters
Summary: As part of the European Human Biomonitoring Initiative, a human biomonitoring survey was conducted in 23 countries to produce comparable data for the EU. The survey utilized existing HBM capacity in Europe and aligned national or regional studies under the HBM4EU program. The survey included over 10,000 participants from different age groups and measured various biomarkers to assess exposure levels to different chemicals. The data obtained can be used as a reference for global comparison, evaluate the effectiveness of the European Commission's chemical strategy, and guide policy-making.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nina Vogel, Phillipp Schmidt, Rosa Lange, Antje Gerofke, Amrit K. Sakhi, Line S. Haug, Tina Kold Jensen, Hanne Frederiksen, Tamas Szigeti, Zsofia Csako, Lubica Palkovicova Murinova, Miroslava Sidlovska, Beata Janasik, Wojciech Wasowicz, Janja Snoj Tratnik, Darja Mazej, Catherine Gabriel, Spyros Karakitsios, Fabio Barbonem, Valentina Rosolen, Loic Rambaud, Margaux Riou, Aline Murawski, Daan Leseman, Gudrun Koppen, Adrian Covaci, Sanna Lignell, Anna Karin Lindroos, Martin Zvonar, Lenka Andryskova, Lucia Fabelova, Denisa Richterova, Milena Horvatj, Tina Kosjekj, Denis Sarigiannis, Marios Maroulis, Susana Pedraza-Diaz, Ana Canas, Veerle J. Verheyen, Michiel Bastiaensen, Liese Gilles, Greet Schoeters, Marta Esteban-Lopez, Argelia Castano, Eva Govarts, Holger M. Kochx, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers for PVC and are associated with adverse effects on the reproductive system. The HBM4EU Aligned Studies have investigated the exposure to ten phthalates and the substitute chemical DINCH in European children and adolescents. The study provides detailed data on exposure levels and differences across European regions, as well as comparisons to biomonitoring guidance values.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nina Vogel, Hanne Frederiksen, Rosa Lange, Niels Jorgensen, Holger M. Koch, Till Weber, Anna-Maria Andersson, Marike Kolossa-Gehring
Summary: It has been observed over the past 25 years that exposure to certain phthalates can have negative effects on human health, such as disrupting the endocrine system. As a result, the EU implemented regulations which led to a decrease in production of restricted phthalates and an increase in the production of substitutes. A recent study examined the impact of these regulations on exposure patterns in two European populations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Engineering, Environmental
Muhammad Usman, Jochen Kuckelkorn, Alexander Kaempfe, Christian Zwiener, Thomas A. Wintgens, Volker Linnemann
Summary: The study developed a semi-automated workflow that combined data from target and non-target screening, toxicities, and calculated and measured risks to assess the overall potential chemical risk of therapeutic pools. It also demonstrated the use of complementary analytical techniques for better identification of novel disinfection by-products (DBPs) in future studies.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Laura Rodriguez Martin, Ilse Ottenbros, Nina Vogel, Marike Kolossa-Gehring, Phillipp Schmidt, Katarina Rihackova, Miguel Julia Molina, Elena Varea-Jimenez, Eva Govarts, Susana Pedraza-Diaz, Erik Lebret, Jelle Vlaanderen, Mirjam Luijten
Summary: Human health risk assessment of chemical mixtures is complex due to the almost infinite number of possible combinations of chemicals. Human biomonitoring approaches, such as network analysis, can provide valuable information on real-life exposure patterns. Applying network analysis to HBM datasets from different countries showed the existence of densely correlated groups of biomarkers, which is relevant for regulatory risk assessment and mixture exposure experiment design.
Article
Environmental Sciences
Miranda M. Loh, Phillipp Schmidt, Yvette Christopher de Vries, Nina Vogel, Marike Kolossa-Gehring, Jelle Vlaanderen, Erik Lebret, Mirjam Luijten
Summary: In the past, chemical mixture risk assessment has focused on external exposures. This study demonstrates the use of human biomonitoring data to assess the internal concentration of chemicals and their potential health risks. It identifies correlated biomarkers and uses a biomonitoring hazard index to evaluate the health concerns of chemical co-occurrence patterns. The importance rating for this study is 8 out of 10.
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Engineering, Environmental
Cynthia Kalweit, Sabrina Berger, Alexander Kaempfe, Thomas Rapp
Summary: This study evaluates the formation and stability of the water contaminant [1] in migration waters of PE-X pipes. It was found that [1] reaches equilibrium with [2] under acidic conditions and completely transforms into [2] under alkaline conditions. Comparative analysis using GC-MS and HPLC-MS/MS methods shows consistent results for the concentrations of [1] and [2].
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)