Article
Food Science & Technology
Hang Chen, Xueqin Shi, Lanyan Cen, Lin Zhang, Yifeng Dai, Shuyi Qiu, Xiangyong Zeng, Chaoyang Wei
Summary: In this study, different fermentations were conducted on Dendrobium officinale polysaccharides, and it was found that yeast fermentation could effectively reduce the molecular weight and improve the antioxidant activity of the polysaccharides, indicating a potential way to enhance their antioxidant activity. Additionally, four homogeneous polysaccharides with different compositions and molecular weights were obtained. These findings are significant for further research on Dendrobium officinale polysaccharides.
Review
Nutrition & Dietetics
Yuan He, Lin Li, Hao Chang, Bin Cai, Huajun Gao, Guoyu Chen, Wen Hou, Zubaydan Jappar, Yizhe Yan
Summary: Dendrobium officinale is a traditional medicinal and food homologous plant that possesses polysaccharides with various biological activities, including antioxidant, hepatoprotective, immunomodulatory, gastrointestinal protection, hypoglycemic, and anti-tumor activities.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Huan Gong, Xiaona Gan, Yingzhe Li, Jie Chen, Yongbin Xu, Songshan Shi, Tingzhao Li, Bo Li, Huijun Wang, Shunchun Wang
Summary: Polygonatum sibiricum and Polygonatum odoratum have gained attention for their nutritional and health benefits and have been included in China's Medicinal Food Directory. Polysaccharides are considered the main functional component, with various biological and health-promoting properties such as immunomodulatory, anti-inflammatory, cardiovascular protective, neuroprotective, antitumor, antidiabetic, antiosteoporosis, and hepatoprotective properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chunfei Zhong, Wenni Tian, Hongzhu Chen, Yunyun Yang, Yanan Xu, Yanlan Chen, Pei Chen, Siyang Zhu, Pan Li, Bing Du
Summary: Two polysaccharides, DLP-1 and DLP-2, extracted from Dendrobium officinale leaves showed different compositions and structures, both exhibiting remarkable immunoregulatory bioactivities.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Chuanbo Sun, Nuo Zhang, Guangpei Xu, Ping Jiang, Shiping Huang, Qun Zhao, Yanfei He
Summary: This study demonstrates that Dendrobium officinale polysaccharides (DOP) have antitumor and immunomodulatory activities, inhibiting tumor growth through multiple pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Food Science & Technology
Jiamei Zheng, Mingyue Shang, Guona Dai, Jingjing Dong, Yaping Wang, Baozhong Duan
Summary: Momordica charantia L. is a plant with high pharmaceutical and nutritional values. Its polysaccharides have attracted attention for their various bioactivities, but their development is hindered by the lack of understanding of their structure-activity relationship, modification, applications, and safety.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Xiaoyu Xu, Cheng Zhang, Ning Wang, Yu Xu, Guoyi Tang, Lin Xu, Yibin Feng
Summary: Dendrobium officinale, a functional food and medicinal herb with a long history of use, contains abundant bioactive compounds that exhibit various biological properties and health benefits. This review summarizes the phytochemical studies, bioactivities, and safety of Dendrobium officinale, and discusses its potential for drug and functional food development as well as clinical applications.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Agriculture, Multidisciplinary
Xilai Wang, Xin Zhou, Kai Wang, Xianying Cao
Summary: The polysaccharide extracted from the fermentation broth of Dendrobium officinale demonstrated strong antioxidant properties and protective effects against cytotoxicity induced by lipopolysaccharide. Additionally, it showed inhibitory effects on cytokines production.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Ming Cai, Hua Zhu, Lei Xu, Jian Wang, Jing Xu, Zhenhao Li, Kai Yang, Jianyong Wu, Peilong Sun
Summary: This study aimed to investigate the antifatigue and prebiotic effects of three ethanol precipitated polysaccharides from Dendrobium officinale (EPDO-40, EPDO-60, and EPDO-80) and their relationships to the structure properties. EPDOs with antifatigue activity were screened through forced swimming test, and various indicators including blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), and gut microflora were examined. The purified EPDO-60, with a molecular weight of 277.3 kDa and a backbone consisting of 4-Manp and 4-Glcp, exhibited the best antifatigue activity by significantly prolonging forced swimming time, reducing BLA and BUN levels, and increasing SOD. Treatment with EPDO-60 also led to an increase in the proportion of Bacteroidetes and Firmicutes and the abundance of Lactobacillus and Bifidobacterium in gut microflora. Therefore, EPDO-60 could influence the community structure of gut microflora, promoting the balance of oxidation and antioxidation, and accelerating fatigue metabolism in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Jiale Wang, Guona Dai, Mingyue Shang, Yaping Wang, Conglong Xia, Baozhong Duan, Li Xu
Summary: Pueraria lobata polysaccharides (PLPs) are the main bioactive components of P. lobata, exhibiting various activities such as antidiabetic, antioxidant, and immunological activities. However, the chemical structure and mechanism of PLPs are still unclear and require further study. This review provides an overview of the recent progress in isolation, identification, pharmacological properties, and possible therapeutic mechanisms of PLPs, aiming to update the understanding of these valuable natural polysaccharides. Additionally, the structure-activity relationships, application status, and toxic effects of PLPs are discussed to enhance the comprehension of PLPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Zemei Zhu, Tingting Liang, Guona Dai, Jiamei Zheng, Jingjing Dong, Conglong Xia, Baozhong Duan
Summary: Bletilla striata is a well-known medicinal plant with high pharmaceutical and ornamental values. Its polysaccharide, the most important bioactive ingredient, has various health benefits. Recently, B. striata polysaccharides (BSPs) have attracted attention for their remarkable therapeutic effects, but there is still limited knowledge regarding their SARs, safety concerns, and applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Zhengxin Shan, Yue Wang, Ziyi Jin, Jie Liu, Nifei Wang, Xiaoyu Guo, Steve W. Cui, Qingbin Guo
Summary: Dendrobium officinale polysaccharide (DOP) was treated with ultrasound and alkaline methods to obtain DOPs with different molecular weights (Mw) and degrees of acetylation (DA). In a mouse study, the DOPs obtained through ultrasonic degradation and deacetylation modification showed differential effects on restoring organ indexes, improving immune response, enhancing cytokine release, and modulating gut microbiota structure. The immune activity recovery was highest for UDOP-2, followed by DADOP-1, DOP, UDOP-1, and DADOP-2. The results suggest that short-time ultrasonication can enhance immune activity, and polysaccharide fractions with lower Mw and similar acetyl group content have stronger immune activity.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Yongshuai Jing, Jinying Hu, Yameng Zhang, Junxiang Sun, Jinyun Guo, Yuguang Zheng, Danshen Zhang, Lanfang Wu
Summary: The polysaccharide DOP from Dendrobium officinale shows antioxidant and chelating properties, significantly improving alcoholic gastric mucosa and liver injury.
NATURAL PRODUCT RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xiaoyang Zhang, Yanfeng Yan, Yunxia Lv, Xin Li, Leiyao Chen, Zihui Huang, Junbo Zhou, Yong Wang, Xiaoming Wang, Xu Wang, Hongwei Gu
Summary: Urinary tract infections (UTI) caused by uropathogenic Escherichia coli (UPEC) can be attenuated by Dendrobium officinale polysaccharides (DOPs), which possess anti-inflammatory properties and inhibit the activation of NLRP3 pathway and ROS signal. DOPs effectively mitigate UPEC-induced pyroptosis in macrophage cells by reducing cell damage and pro-inflammatory cytokine secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Fangyi Pei, Xinbo Cao, Xuemeng Wang, Yanxin Ren, Jingping Ge
Summary: This study explores the effects of probiotic fermentation on the structure and properties of blue honeysuckle polysaccharides. Fermentation was found to decrease the molecular weight and increase the galactonic acid content of the polysaccharides, leading to changes in their surface morphology. Additionally, fermented polysaccharides exhibited stronger antioxidant, hypoglycemic, and hypolipidemic activities compared to unfermented polysaccharides. However, fermentation also resulted in a decrease in the thermal stability of the polysaccharides. Network analysis further revealed that the uronic acid content was positively correlated with reducing power, while the molecular weight was negatively correlated.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Meteorology & Atmospheric Sciences
Jianguo Wu
Summary: This study used fuzzy set-based classification, Monte Carlo scheme, and climate shift data to determine the risk of reduction in distributional ranges of alpine graminoid species. The results showed that the main factor leading to range shifts was changes in the temperature index. Adaptation measures are needed to cope with future climatic conditions.
THEORETICAL AND APPLIED CLIMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yue Shen, Sheng-Di Wu, Yao Chen, Xin-Yue Li, Qin Zhu, Kiyoko Nakayama, Wan-Qin Zhang, Cheng-Zhao Weng, Jun Zhang, Hai-Kun Wang, Jian Wu, Wei Jiang
Summary: This study aimed to characterize the gut microbiota in patients with chronic hepatitis B virus infection-associated liver diseases (HBV-CLD) and evaluate their effects on peripheral immunity. The results revealed that disease progression and antiviral treatment were the two main factors contributing to the shift in microbiome and metabolome composition in HBV-CLD patients.
Article
Engineering, Electrical & Electronic
Guolin Yang, Xingliang Jiang, Jianlin Hu, Xiaodong Ren, Tao Li, Jianguo Wu, Zhijin Zhang, Qin Hu, Hualong Zheng
Summary: This study investigates the effects of particle concentration, particle size, and particle dielectric constant on the DC breakdown characteristics of unclean air gap. It is found that the presence of solid particles increases the breakdown voltage of the gap, with the increase being related to the particle concentration, size, and dielectric constant. Additionally, the presence of particles enhances both the ionization process and particle adsorption, leading to an increase in the gap breakdown voltage.
Article
Environmental Sciences
Yan Ding, Dongqi Wang, Guanghui Zhao, Shu Chen, Taihu Sun, Hechen Sun, Chenyang Wu, Yizhe Li, Zhongjie Yu, Yu Li, Zhenlou Chen
Summary: Plant litter input is a crucial factor in the turnover of soil/sediment organic carbon (SOC). This study investigated the effects of leaf litter and stem litter input on SOC dynamics using the 13C isotope technique. It was found that both leaf and stem litter input facilitated SOC accumulation, with leaf litter having a higher contribution. However, leaf litter input also promoted SOC mineralization more than stem litter input. Overall, litter input led to a net increase in SOC accumulation but accelerated the loss of native SOC.
ENVIRONMENTAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yu Song, Jiayi Wei, Rong Li, Ruifeng Fu, Pei Han, Heming Wang, Guangcong Zhang, Shuyu Li, Sinuo Chen, Zhiyong Liu, Yicheng Zhao, Changfeng Zhu, Jimin Zhu, Shuncai Zhang, Hao Pei, Jiefei Cheng, Jian Wu, Ling Dong, Guangqi Song, Xizhong Shen, Qunyan Yao
Summary: TrkB is decreased in liver fibrosis and its overexpression can inhibit the activation of TGF-beta/SMAD signaling and alleviate hepatic fibrosis, making it a potential therapeutic target.
Article
Computer Science, Artificial Intelligence
Chi Zhang, Jian Cui, Jianguo Wu, Xi Zhang
Summary: A steel plate surface defect detection method is proposed in this study, utilizing contextual information and attention mechanism, as well as a multi-layer feature extraction method and fusion framework based on low-level statistical textures. Through pixel-level spatial and correlation relationship identification, characteristics of low-level defects are extracted. A novel quantization technique is developed to effectively incorporate statistical texture in Convolutional Neural Networks (CNN). The empirical results demonstrate the feasibility of the proposed approach in practical steel plate testing and ablation experiments show that it enhances surface defect detection for steel plates.
JOURNAL OF INTELLIGENT MANUFACTURING
(2023)
Article
Thermodynamics
Alejandro Gallegos, Jianzhong Wu
Summary: The study aims to develop a predictive model for describing the electrostatic behavior of amino acids in aqueous solutions. A three-bead coarse-grained model is proposed, and a thermodynamic model accounting for nonideality effects is developed to capture how the interaction varies with solution conditions.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Article
Engineering, Civil
Guanghui Zhao, Dongqi Wang, Taihu Sun, Yan Ding, Shu Chen, Yizhe Li, Hechen Sun, Chenyang Wu, Zhongjie Yu, Zhenlou Chen
Summary: Urban rivers are significant hotspots for greenhouse gas (GHG) emissions. This study investigated the impact of different rainfall events on GHG emissions from Suzhou Creek in Shanghai. It was found that typhoon events significantly increased GHG emissions, with factors such as rainfall dilution, pump station drainage, sediment disturbance, and high gas transfer coefficient playing important roles. The study highlights the importance of understanding the dynamic response of urban river GHG emissions to rainfall and typhoons.
JOURNAL OF HYDROLOGY
(2023)
Article
Chemistry, Physical
Debadutta Prusty, Alejandro Gallegos, Jianzhong Wu
Summary: The interfacial behavior of associating species is crucial for both fundamental physics and industrial applications. This study investigates the adsorption behavior of a mixture of nanoparticles and polymer chains, representing asphaltene and resin molecules, onto an attractive surface. The results provide insights into the effects of various characteristics of these molecules on the adsorption amount and reveal the interplay between different driving forces.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Coatings & Films
Yinchun Fang, Jianguo Wu, Shuo Chang, Lingshuang Wu
Summary: This study used bio-based phytic acid (PA) and gelatine (G) to improve the flame retardancy and anti-dripping properties of polyethylene terephthalate (PET) fabric. The coated PET fabric showed a limiting oxygen index (LOI) value greater than 29.5% and no dripping phenomenon, indicating significant improvement in flame retardancy and anti-dripping properties. The PA/G coating altered the decomposition stability and degradation process of PET fabric, promoting the formation of a stable char. The coating formed an intumescent flame retardant (IFR) system on PET fabric, functioning through the IFR mechanism.
SURFACE ENGINEERING
(2023)
Article
Virology
Weijie Chen, Yukun Li, Xiuling Yu, Zhenwei Wang, Wenbiao Wang, Menglan Rao, Yongkui Li, Zhen Luo, Qiwei Zhang, Jinbiao Liu, Jianguo Wu
Summary: In this study, it was found that Zika virus infection upregulated 7-dehydrocholesterol reductase (DHCR7) expression, which in turn facilitated viral infection. The nonstructural protein NS4B of Zika virus interacted with DHCR7 to induce its expression, thereby inhibiting the immune response and facilitating viral evasion. This study expands our understanding of the mechanisms by which viral nonstructural proteins antagonize innate immunity during viral infection via cholesterol metabolic enzymes and intermediates.
Article
Automation & Control Systems
Zhiyong Hu, Chao Wang, Jianguo Wu, Dongping Du
Summary: The development of sensor technologies has allowed the acquisition of high dimensional sensing data, which has led to the development of multi-output modeling techniques for decision making. However, missing values in the data often result in information loss and affect the modeling performance. This study proposes a new multi-output modeling method based on GPLVM to exploit useful information in the data and improve modeling accuracy. The method demonstrates superior performance in both simulation and case studies, making it a powerful tool for process automation.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Medicine, Research & Experimental
Yuan Zhou, Li Zhang, Yue Ma, Li Xie, Yong-Yu Yang, Cheng Jin, Hui Chen, Ying Zhou, Guang-Qi Song, Jia Ding, Jian Wu
Summary: This study found that senescent hepatic stellate cells (HSCs) play a crucial role in the development of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Senescent HSCs secrete proteins that activate morphogenic hedgehog or oncogenic Wnt signaling pathways, promoting the malignant transformation of steatotic or dysplastic hepatocytes.
Article
Mathematics, Applied
Marco Tosato, Xue Zhang, Jianhong Wu
Summary: We investigate the behavior of solutions to a scalar Delay Differential Equation (DDE) with periodic switching between two constant values. This equation naturally arises in structured vector populations involved in the spread of various vector-borne diseases in a periodically changing environment. We examine the influence of two different time lags and the switching time on the existence and patterns of periodic solutions, with a specific focus on multi-cycles within the prime period.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
