期刊
FITOTERAPIA
卷 113, 期 -, 页码 151-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2016.07.012
关键词
Callicarpa kwangtungensis; Abietane diterpenoids; NO inhibitory effects; Diterpenoids; TDDFT ECD calculations
资金
- National Natural Science Foundation of China [21372125, 81102331]
- Natural Science Foundation of Tianjin, China [16JCYBJC27700]
- State Key Laboratory of Medicinal Chemical Biology [201602007]
A phytochemical investigation of the leaves of Callicarpa kwangtungensis led to the isolation of three new diterpenoids (1-3), callipenes A-C, and eleven known analogues (4-14). Their structures were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compounds 1 and 2 are rare abietane diterpenoids possessing a peroxide bridge. All of the isolates were found to inhibit LPS-induced NO production in BV-2 cells. (C) 2016 Published by Elsevier B.V.
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