Article
Chemistry, Medicinal
E. H. T. Thulshan Jayathilaka, Dinusha C. Rajapaksha, Chamilani Nikapitiya, Joeun Lee, Mahanama De Zoysa, Ilson Whang
Summary: Octoprohibitin, a synthetic antimicrobial peptide derived from the prohibitin-2 gene of Octopus minor, showed significant activity against multidrug resistant Acinetobacter baumannii, inhibiting both bacterial growth and biofilm formation.
Review
Medicine, General & Internal
Guido Granata, Fabrizio Taglietti, Francesco Schiavone, Nicola Petrosillo
Summary: This study assessed the efficacy and safety of a novel antibiotic, durlobactam, in the treatment of multidrug-resistant A. baumannii infections. Sixteen studies met the inclusion criteria, and it was found that durlobactam is effective when used in combination with sulbactam against A. baumannii. Further clinical trials are needed to confirm the potential of this combination therapy for treating infections caused by multidrug-resistant A. baumannii.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Susan Ibrahim, Nadal Al-Saryi, Israa M. S. Al-Kadmy, Sarah Naji Aziz
Summary: Acinetobacter baumannii has become a major concern in the scientific community due to its extensive antimicrobial resistance. The acquisition of mobile genetic elements has led to the prevalence of multidrug-resistant strains, including carbapenem-resistant A. baumannii (CR-Ab), which is a worldwide problem. Plasmid-mediated resistance has caused outbreaks of extensively drug-resistant A. baumannii (XDR-Ab), highlighting the importance of proper monitoring, prevention, and treatment to control infections.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Chemistry, Medicinal
Deepa Dehari, Aiswarya Chaudhuri, Dulla Naveen Kumar, Rohit Patil, Mayank Gangwar, Sonam Rastogi, Dinesh Kumar, Gopal Nath, Ashish Kumar Agrawal
Summary: In this study, Acinetobacter baumannii (A. baumannii)-specific bacteriophages (BPAB & phi;1) were isolated and loaded into chitosan microparticles dispersed in a gel, showing therapeutic efficacy against MDR A. baumannii clinical strains. The isolated BPAB & phi;1 belonged to the Corticoviridae family with a burst size of 102.12 ± 2.65 PFUs per infected host cell. The developed formulation exhibited excellent antibiofilm eradication potential in vitro and effective wound healing after topical application.
Article
Immunology
Michael J. McConnell, Antonio J. Martin-Galiano
Summary: This study utilized proteomic and computational data to identify a larger number of potentially immunogenic proteins in the Acinetobacter baumannii panproteome. The study found that certain antigens showed potential cross-reactivity with human proteins and were associated with different infection types. The integration of multi-omic data and knowledge of drug-resistant bacteria can aid in the development of effective multi-antigen vaccines against challenging infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Jia-Ling Yang, Chia-Jui Yang, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study evaluated the susceptibility of carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains to minocycline, and found a significant correlation between tetB carriage and minocycline susceptibility in CRAB.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Han Wu, Hongtong Chen, Jungan Zhang, Xinxin Hu, Chunyang Xie, Weiting Cao, Ziqi Zhao, Zengshuo Xiao, Yixin Ren, Luyao Dong, Peiyi Sun, Xuefu You, Xinyi Yang, Wei Hong, Hao Wang
Summary: This study found that 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline (PQZ) compounds exhibited strong antibacterial activities against A. baumannii, especially multidrug-resistant strains. These compounds showed better antibacterial effects compared to traditional antibiotics, and their combination with inhibitors reduced the required dosage and prevented resistance. These findings suggest that PQZ compounds could be a promising scaffold for the development of folate-metabolism inhibitors against multidrug-resistant A. baumannii.
Article
Immunology
Xiaobo Li, Yanqing Song, Lina Wang, Guangbo Kang, Ping Wang, Huabing Yin, He Huang
Summary: Berberine hydrochloride (BBH) can enhance the susceptibility of multidrug-resistant Acinetobacter baumannii to antibiotics, even reversing their resistance, making it a potential promising therapeutic adjuvant against MDR strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Flora Cruz-Lopez, Adrian Martinez-Melendez, Licet Villarreal-Trevino, Rayo Morfin-Otero, Hector Maldonado-Garza, Elvira Garza-Gonzalez
Summary: This review examines the contamination of CRAB on corporal surfaces of patients and healthcare workers, as well as environmental sites in healthcare-related settings. It summarizes the published data on potential reservoirs, contamination frequency, resistance mechanisms, and measures for eliminating CRAB from hospital surfaces.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Infectious Diseases
Neetu Gupta, Kalpana Angadi, Savita Jadhav
Summary: This review aims to understand the mechanisms of carbapenem resistance, categorize and discuss carbapenemases encoding genes and various mobile genetic elements, as well as the prevalence of carbapenemase genes in recent years in A. baumannii from various geographical regions.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Harald Seifert, Carina Mueller, Danuta Stefanik, Paul G. G. Higgins, Esther Wohlfarth, Michael Kresken
Summary: Cefiderocol has potent activity against multi-drug-resistant Gram-negative pathogens, including carbapenem-resistant Acinetobacter baumannii. However, some carbapenem-resistant Acinetobacter baumannii isolates have elevated minimum inhibitory concentrations, especially those carrying metallo-β-lactamase.
Review
Microbiology
Sunil Kumar, Razique Anwer, Arezki Azzi
Summary: Acinetobacter baumannii is a deadly opportunist pathogen in hospital-acquired infections, with limited treatment options due to the emergence of multidrug-resistant strains. Understanding the virulence factors of A. baumannii is crucial for overcoming this threat.
Article
Infectious Diseases
Sirijan Santajit, Phuangthip Bhoopong, Thida Kong-Ngoen, Witawat Tunyong, Dararat Horpet, Wanfudhla Paehoh-ele, Tasneem Zahedeng, Pornpan Pumirat, Nitat Sookrung, Woranich Hinthong, Nitaya Indrawattana
Summary: This study characterized the genetic traits of biofilm-forming carbapenem-resistant A. baumannii clinical isolates in a tertiary care hospital. The prevalence of biofilm-producing A. baumannii isolates was determined and their association with biofilm-related and antibiotic resistance-associated genotypes was investigated. The predominance of biofilm-producing CRAB isolates identified in this study is concerning, and understanding the risk factors could help control the selection and spread of A. baumannii in hospitals, thereby improving patient care quality.
Article
Biology
Tatjana Kirtikliene, Aiste Mierauskaite, Ilona Razmiene, Nomeda Kuisiene
Summary: The study analyzed multidrug-resistant Acinetobacter spp. isolates from human bloodstream infections in 14 healthcare institutions in Lithuania during 2014, 2016, and 2018. The results indicated potential relatedness of different Acinetobacter spp. isolates and circulation of resistance genes or profiles in different years of the study.
Article
Microbiology
Mohammad Al-Tamimi, Hadeel Albalawi, Mohamd Alkhawaldeh, Abdullah Alazzam, Hassan Ramadan, Majd Altalalwah, Ahmad Alma'aitah, Dua'a Al Balawi, Sharif Shalabi, Jumana Abu-Raideh, Ashraf Khasawneh, Farah Alhaj, Kamal Hijawi
Summary: This study is the first large-scale, multicenter, and prolonged research on Acinetobacter baumannii infections in Jordan, providing insights into the epidemiology and molecular characteristics of MDR-A. baumannii in the country. Attention to high-risk patients and early identification are crucial. Colistin and tigecycline are the most effective antimicrobials.
Article
Clinical Neurology
Rodolfo Furlan Damiano, Deusdedit Brandao Neto, Joao Vitor Ribeiro Oliveira, Jonatas Magalhaes Santos, Julia Vallin Rodrigues Alves, Bruno F. Guedes, Ricardo Nitrini, Adriana Ladeira de Araujo, Melaine Oliveira, Andre R. Brunoni, Richard Louis Voegels, Ricardo Ferreira Bento, Geraldo Busatto, Euripedes Constantino Miguel, Orestes V. Forlenza, Fabio de Rezende Pinna
Summary: Preliminary methodologically limited studies suggest an association between chemosensory impairments and neuropsychiatric symptoms in post-COVID-19 patients. This study aims to evaluate the relationship between chemosensory dysfunction and neuropsychiatric impairments in a well-characterized sample of post-COVID-19 patients. The findings indicate a positive association between chemosensory abnormalities and cognitive dysfunction in these patients.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Andres Mello Lopez, Igor Carmo Borges, Alessandra Luna-Muschi, Carlos Henrique Mesquita Peres, Paolo Gripp Carreno, Arthur Magalhaes de Oliveira, Humberto Bertola Siqueira de Almeida, Vivian Helena de Castro Marques, Felipe Corchs, Anna Sara Levin, Silvia Figueiredo Costa, Ana Marli Christovam Sartori
Summary: A survey of healthcare workers in Sao Paulo, Brazil found that younger age, previous COVID-19 infection, and burnout symptoms were associated with reduced adherence to protective measures following vaccination.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ana Paula M. Porto, Igor C. Borges, Lewis Buss, Anna Machado, Bil R. Bassetti, Brunno Cocentino, Camila S. Bicalho, Claudia Carrilho, Cristhieni Rodrigues, Eudes A. S. Neto, Evelyne S. Girao, Filipe Piastrelli, Giovanna Sapienza, Glaucia Varkulja, Karin Kolbe, Luciana Passos, Patricia Esteves, Pollyana Gitirana, Regia D. F. Feijo, Rosane L. Coutinho, Thais Guimaraes, Tiago L. L. Ferraz, Anna S. Levin, Silvia F. Costa
Summary: There was an increase in CLABSI incidence in Brazilian ICUs during the first months of the COVID-19 pandemic. Additionally, there was an increase in the proportion of CLABSI caused by E. faecalis and Candida spp during this period.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Adriana Coracini Tonacio, Ana Paula Marchi, Maria Luiza Bazzo, Gabriela Takeshigue Lemos, Jose Victor Bortolotto Bampi, Evelyn Patricia Sanchez Espinoza, Edson Luiz Tarsia Duarte, Roberta Cristina Ruedas Martins, Ana Paula Ramalho da Costa-Lourenco, Vitor Falcao de Oliveira, Marina Farrel Cortes, Sania Alves dos Santos, Lauro Vieira Perdigao Neto, Raquel Regina Bonelli, Maria Rita Elmore, Flavia Rossi, Gwenda Hughes, Silvia Figueiredo Costa
Summary: This study presents a rare case of gonococcal arthritis in a patient with Systemic Lupus Erythematosus (SLE). Whole genome sequencing (WGS) and molecular analysis were performed on the etiologic agent, which was found to be resistant to ciprofloxacin and tetracycline. The isolate had genetic features related to beta-lactam, tetracycline, and quinolone resistance, and 71 virulence genes were identified.
MICROBES AND INFECTION
(2023)
Review
Dermatology
Vitor Falcao de Oliveira, Marcello Mihailenko Chaves Magri, Anna S. Levin, Guilherme Diogo Silva
Summary: Neuroparacoccidioidomycosis (NPCM) is a neurological manifestation of paracoccidioidomycosis (PCM), and advanced neuroimaging techniques have played an important role in its diagnosis. Recent studies have demonstrated that MRI can show characteristic imaging findings, which can help differentiate it from other causes of brain lesions.
Article
Cardiac & Cardiovascular Systems
Ariana E. Fernandes, Paula W. L. Rosa, Maria E. Melo, Roberta C. R. Martins, Fernanda G. O. Santin, Aline M. S. H. Moura, Graziele S. M. A. Coelho, Ester C. Sabino, Cintia Cercato, Marcio C. Mancini
Summary: This study aimed to assess the associations between ultra-processed food (UPF) consumption and gut microbiota as well as obesity-related biometric measurements in women. The findings revealed that high UPF consumption was associated with increased risk of obesity and chronic changes in gut microbiota. The results also indicated a positive correlation between UPF consumption and leptin resistance. Furthermore, both UPF and unprocessed or minimally processed food (G1) consumption may have an impact on the composition of the gut microbiota.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Infectious Diseases
Ana Paula Marchi, Marina Farrel Cortes, Saidy Vasconez Noguera, Flavia Rossi, Anna Sara Levin, Silvia Figueiredo Costa, Lauro Vieira Perdigao Neto
Summary: The aim of this study was to evaluate the susceptibility of 32 gram-negative and 6 gram-positive isolates to chlorhexidine gluconate (CHG) in both planktonic cells and biofilm. The study found that gram-negative isolates had higher minimal concentrations than gram-positive isolates, and bacteria in biofilms were more tolerant than planktonic ones. There was no statistically significant correlation between minimal bactericidal concentration or minimal biofilm elimination concentration and biofilm formation. The occurrence of the Eagle effect was observed in 60.5% of the isolates, resulting in minimal concentration of CHG as high as 16,384 mu g/mL. Attention should be given to this phenomenon to avoid false susceptibility results.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Immunology
Lauro Vieira Perdigao Neto, Anna Silva Machado, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Florencia Comello, Ana Paula Matos Porto, Daila Sousa Lima, Thais Sabato Romano di Gioia, Victor Augusto Camarinha Castro Lima, Luis Arthur Brasil Gadelha Farias, Mariana Rolim Fernandes Macedo, Saidy Liceth Vasconez Noguera, Sandra Nascimento dos Anjos, Chayenne Mika Matsumoto Pinto Tonheiro, Brunno Cesar Batista Cocentino, Silvia Figueiredo Costa, Maura Salaroli de Oliveira
Summary: Effective therapies for MDR microorganisms, especially Gram-negative bacteria, are becoming rare. Solid-organ transplant recipients are at high risk of MDR Gram-negative bacilli infection. We describe a successful case of complicated urinary tract infection in a kidney transplant patient caused by XDR K. pneumoniae treated with a combination of chloramphenicol and ertapenem, which could be an alternative for MDR and/or XDR pathogens in renal transplant patients.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Infectious Diseases
Bruno Azevedo Randi, Eder Gatti Fernandes, Hermes Ryoiti Higashino, Marta Heloisa Lopes, Vanderson Geraldo Rocha, Silvia Figueiredo Costa, Ana Marli Christovam Sartori
Summary: A retrospective study in Sao Paulo, Brazil, investigated the timing of measles, mumps, and rubella (MMR) vaccination after hematopoietic stem cell transplant (HSCT). The study found that 75.6% of HSCT recipients received the MMR vaccine before 23 months post-transplantation, and no side effects were reported. The study supports the safety of MMR vaccination between 12 and 23 months after HSCT.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
Article
Infectious Diseases
Luis Arthur Brasil Gadelha Farias, Natalia Nogueira Firmino, Marcos Maciel Sousa, Mateus Lavor Lira, Leonardo Nogueira Meireles, Angela Maria Veras Stolp, Kelma Maria Maia, Silvia Figueiredo Costa, Lauro Vieira Perdigao Neto
Summary: Streptococcus constellatus, a gram-positive coccus member of the Streptococcus anginosus group, can be found in the oral flora and commonly cause abscesses in the gastrointestinal tract, lungs, and heart. While Streptococcus species other than S. pneumoniae are rare causes of brain abscesses, this case report highlights a severe case of extra and intracranial abscesses caused by S. constellatus in an immunocompetent host.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2023)
Article
Nursing
Caroline Lopes Ciofi-Silva, Luciana Cordeiro, Naila Albertina Oliveira, Giulia Marcelino Mainardi, Anna Sara Levin, Rodrigo Maximiano Antunes de Almeida, Juliana Falasco-Fantinatti, Maria Clara Padoveze
Summary: This study aims to adapt, validate, and assess the reliability of the National Aeronautics and Space Administration - Task Load Index instrument translated into Brazilian Portuguese. Through five steps, including translation, synthesis, back-translation, assessment by an expert committee, and pre-test, the final Portuguese version was found to have reliability and content validity evidence.
REVISTA BRASILEIRA DE ENFERMAGEM
(2023)
