Review
Immunology
Sergey Ponomarev, Sergey Kalinin, Anastasiya Sadova, Marina Rykova, Kseniya Orlova, Brian Crucian
Summary: The exploration of outer space is crucial for national development and human civilization, but it can have negative effects on the immune system. Ground-based experiments are used to study the impact of confinement on immunity and develop strategies to counteract stress factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Yannick Simoni, Nicolas Chapuis
Summary: Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases with a high prevalence in elderly patients, and a tendency to progress to acute myeloid leukemia. Immune dysregulations play a critical role in the pathogenesis of MDS, and monitoring the immune system can help in precise diagnosis and identifying patients who may benefit from immunotherapy.
Review
Immunology
Yang Du, Zhiqiang Hu, Yien Luo, Helen Y. Wang, Xiao Yu, Rong-Fu Wang
Summary: The DNA-sensing receptor cGAS and its downstream signaling adaptor STING play crucial roles in immune defense against infectious pathogens, and the interplay between the cGAS-STING pathway and pathogens provides insight into the development of pharmacological approaches for treating infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Behazine Combadiere, Lucille Adam, Noelline Guillou, Paul Quentric, Pierre Rosenbaum, Karim Dorgham, Olivia Bonduelle, Christophe Parizot, Delphine Sauce, Julien Mayaux, Charles-Edouard Luyt, Alexandre Boissonnas, Zahir Amoura, Valerie Pourcher, Makoto Miyara, Guy Gorochov, Amelie Guihot, Christophe Combadiere
Summary: Neutrophil subsets in COVID-19 patients have prognostic value in predicting disease severity and thrombosis complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong, Chao Yang
Summary: This article provides an up-to-date overview of the strategies and applications of nanocarrier-assisted innate immune modulation for the management of infections and their associated complications. It discusses the importance of innate immunity in defending against pathogens and the role of immunomodulators in treating infectious diseases. The use of nanocarriers as a promising tool to overcome challenges in immunomodulator therapy is also explored.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Immunology
Osamu Kanauchi, Zhao Xuan Low, Kenta Jounai, Ryohei Tsuji, Sazaly Abubakar
Summary: This comprehensive review examines the medical impact of probiotics on infectious diseases, particularly focusing on the periods before, during, and after the COVID-19 pandemic. It finds that certain probiotic strains have shown clinical effectiveness in treating gastrointestinal diseases, the common cold, and flu. However, the direct effectiveness of probiotics in treating or preventing COVID-19 is still uncertain. As we enter the post-COVID-19 era, the relationship between COVID-19 and the innate immune system is gradually being understood, offering potential for developing novel vaccines and treatments. Further research is needed to explore the interaction between probiotics and the immune system and their role in immunoregulatory therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Guoxing Tang, Min Huang, Ying Luo, Wei Liu, Qun Lin, Liyan Mao, Shiji Wu, Zhigang Xiong, Hongyan Hou, Ziyong Sun, Feng Wang
Summary: This study reveals that COVID-19 deceased patients exhibit immune dysregulation, including increased neutrophils and IL-6, sustained low levels of CD8(+) T cells, NK cells, and dendritic cells. Among the immunological parameters, M-MDSCs show the best performance in predicting COVID-19 mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yongyi Feng, Chunliu Huang, Yingzhao Wang, Jun Chen
Summary: This review provides an overview of the research history, functional mechanisms, and therapeutic implications of targeting SIRPa in immuno-oncology.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Agazhe Aemro, Belayneh Shetie Workneh, Enyew Getaneh Mekonen, Mulugeta Wassie, Basazinew Chekol
Summary: The study assessed the prevalence of anaemia at the time of ART initiation among HIV-infected adults at Debre Markos Hospital. Factors associated with anaemia included gender, education level, baseline CD4+ T cell count, BMI, and baseline functional status. Developing targeted preventive strategies for anaemia is crucial based on these findings.
Review
Immunology
Rachael Y. M. Ryan, Jamie Seymour, Alex Loukas, J. Alejandro Lopez, Maria P. Ikonomopoulou, John J. Miles
Summary: This review explores the impact of venom on the human body, the effects of venom on the immune system, and venom-induced immunopathology. It examines in detail the immune pathology caused by venom, including allergies and systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
John C. Marshall, Aleksandra Leligdowicz
Summary: Infection leads to sepsis, and the development of clinical disease is triggered by the innate immune response of the host. However, the advancement of understanding in this biological response has not been matched by successful treatment development. The COVID-19 pandemic has brought about changes in this aspect, showing potential therapeutic approaches and the possibility of evaluating them. This article reviews the history of mediator-targeted therapy for sepsis and discusses the conceptual, biological, technological, and organizational challenges that need to be addressed to develop effective treatments for a leading cause of global morbidity and mortality.
Article
Obstetrics & Gynecology
R. Orefice
Summary: The human immune system consists of two defense components: innate and humoral immunity, which cooperate to protect the body from foreign organisms. Defects or malfunctions in these systems can lead to various illnesses. During pregnancy, there are immune shifts to promote maternal-fetal tolerance, indicating that the immune system is modulated rather than suppressed.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Review
Multidisciplinary Sciences
Jean-Laurent Casanova, Laurent Abel
Summary: Disease and inflammation are rare outcomes of viral infection in humans, often due to a failure in cell-intrinsic and leukocytic immunity to viruses. Inflammation indicates the efforts of newly recruited and activated leukocytes to resolve infection. Genetic studies can help clarify the underlying causes of inflammation and disease in viral infections.
Review
Oncology
Yu-Kuan Huang, Rita A. Busuttil, Alex Boussioutas
Summary: This review summarizes recent studies on the roles of innate immune cells in tumor invasion and metastasis, highlighting their interactions with tumor cells and the microenvironment, which contribute to cancer progression.
Article
Immunology
John E. E. Dobbs, Sarah R. R. Tritsch, Liliana Encinales, Andres Cadena, Karol Suchowiecki, Gary Simon, Christopher Mores, Silvana Insignares, Vierys Patricia Villamil Orozco, Mirna Ospino, Lil Avendano Echavez, Carlos Andres Herrera Gomez, Yerlenis Galvis Crespo, Richard Amdur, Alberto David Cabana Jimenez, Carlos Alberto Perez Hernandez, Jennifer Carolina Martinez Zapata, Alfonso Sucerquia Hernandez, Paula Bruges Silvera, Wendy Rosales, Evelyn Mendoza, Estefanie Osorio-Llanes, Jairo Castellar, Dennys Jimenez, Dan M. M. Cooper, Gary S. S. Firestein, Karen Martins, Aileen Y. Y. Chang
Summary: This study examined the regulatory T-cell immune response related to exercise-associated chikungunya arthritis flare (EACAF). The findings suggest that relative decreases in GARP expression may indicate a decreased level of immune suppression. Treg populations in patients with CHIKV arthritis may contribute to arthritis flares during exercise, though current research is conflicting.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeremie Rosain, Anna-Lena Neehus, Jeremy Manry, Rui Yang, Jeremie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Ozden Turel, Mathieu Bourgey, Masato Ogishi, Jean-Marc Doisne, Helena M. Izquierdo, Takayoshi Shirasaki, Tom Le Voyer, Antoine Guerin, Paul Bastard, Marcela Moncada-Velez, Ji Eun Han, Taushif Khan, Franck Rapaport, Seon-Hui Hong, Andrew Cheung, Kathrin Haake, Barbara C. Mindt, Laura Perez, Quentin Philippot, Danyel Lee, Peng Zhang, Darawan Rinchai, Fatima Al Ali, Manar Mahmoud Ahmad Ata, Mahbuba Rahman, Jessica N. Peel, Soren Heissel, Henrik Molina, Yasemin Kendir-Demirkol, Rasheed Bailey, Shuxiang Zhao, Jonathan Bohlen, Mathieu Mancini, Yoann Seeleuthner, Marie Roelens, Lazaro Lorenzo, Camille Soudee, Maria Elvira Josefina Paz, Maria Laura Gonzalez, Mohamed Jeljeli, Jean Soulier, Serge Romana, Anne-Sophie L'Honneur, Marie Materna, Ruben Martinez-Barricarte, Mathieu Pochon, Carmen Oleaga-Quintas, Alexandre Michev, Melanie Migaud, Romain Levy, Marie-Alexandra Alyanakian, Flore Rozenberg, Carys A. Croft, Guillaume Vogt, Jean-Francois Emile, Laurent Kremer, Cindy S. Ma, Jorg H. Fritz, Stanley M. Lemon, Andras N. Spaan, Nicolas Manel, Laurent Abel, Margaret R. MacDonald, Stephanie Boisson-Dupuis, Nico Marr, Stuart G. Tangye, James P. Di Santo, Qian Zhang, Shen-Ying Zhang, Charles M. Rice, Vivien Beziat, Nico Lachmann, David Langlais, Jean-Laurent Casanova, Philippe Gros, Jacinta Bustamante
Summary: Inborn errors of IFN-g-dependent macrophagic immunity cause mycobacterial diseases, while inborn errors of IFN-a/b-dependent intrinsic immunity lead to viral diseases. Children with complete IRF1 deficiency have early-onset, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. Their IFN-a/b-dependent antiviral immunity is largely normal, but their IFN-g-dependent macrophagic immunity is impaired.
Article
Medicine, General & Internal
Fabrice Cognasse, Hind Hamzeh-Cognasse, Mickael Rosa, Delphine Corseaux, Brigitte Bonneaudeau, Chloe Pierre, Julie Huet, Charles Antoine Arthaud, Marie Ange Eyraud, Amelie Prier, Anne Claire Duchez, Theo Ebermeyer, Marco Heestermans, Estelle Audoux-Caire, Quentin Philippot, Tom Le Voyer, Olivier Hequet, Anne-Marie Fillet, Patricia Chavarin, Dominique Legrand, Pascale Richard, France Pirenne, Pierre Gallian, Jean Laurent Casanova, Sophie Susen, Pascal Morel, Karine Lacombe, Paul Bastard, Pierre Tiberghien
Summary: COVID-19 convalescent plasma (CCP) contains neutralising antibodies that may be useful as passive immunotherapy. CCP showed increased levels of IL-6 and TNF-alpha and lower levels of IL-10 compared to control plasma. Auto-Antibodies against type I IFNs in CCP were not associated with reported adverse events. Further studies are needed to define the clinical relevance of these findings.
Article
Immunology
Ana Garcia-Garcia, Rebeca Perez de Diego, Carlos Flores, Darawan Rinchai, Jordi Sole-Violan, Angela Deya-Martinez, Blanca Garcia-Solis, Jose M. Lorenzo-Salazar, Elisa Hernandez-Brito, Anna-Lisa Lanz, Leen Moens, Giorgia Bucciol, Mohamed Almuqamam, Joseph Domachowske, Elena Colino, Juan Luis Santos-Perez, Francisco Marco, Claudio Pignata, Aziz Bousfiha, Stuart Turvey, Stefanie Bauer, Filomeen Haerynck, Javier Gonzalo Ocejo-Vinyals, Francisco Lendinez, Seraina Prader, Nora Naumann-Bartsch, Jana Pachlopnik Schmid, Catherine Biggs, Kyla Hildebrand, Alexandra Dreesman, Miguel Angel Cardenes, Fatima Ailal, Ibtihal Benhsaien, Giuliana Giardino, Agueda Molina-Fuentes, Claudia Fortuny, Swetha Madhavarapu, Daniel Conway, Carolina Prando, Laire Schidlowski, Maria Teresa Martinez de Saavedra Alvarez, Rafael Alfaro, Felipe Rodriguez de Castro, Isabelle Meyts, Fabian Hauck, Anne Puel, Paul Bastard, Bertrand Boisson, Emmanuelle Jouanguy, Laurent Abel, Aurelie Cobat, Qian Zhang, Jean-Laurent Casanova, Laia Alsina, Carlos Rodriguez-Gallego
Summary: X-linked recessive deficiency of TLR7 impairs SARS-CoV-2 recognition and type I IFN production, resulting in hypoxemic COVID-19 pneumonia. 22 unvaccinated patients with autosomal recessive MyD88 or IRAK-4 deficiency were infected with SARS-CoV-2, with a high risk of severe pneumonia. Impaired TLR7-dependent type I IFN production contributes to their susceptibility to SARS-CoV-2.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Kunihiko Moriya, Tomohiro Nakano, Yoshitaka Honda, Miyuki Tsumura, Masato Ogishi, Motoshi Sonoda, Masahiko Nishitani-Isa, Takashi Uchida, Mohamed Hbibi, Yoko Mizoguchi, Masataka Ishimura, Kazushi Izawa, Takaki Asano, Fumihiko Kakuta, Daiki Abukawa, Darawan Rinchai, Peng Zhang, Naotomo Kambe, Aziz Bousfiha, Takahiro Yasumi, Bertrand Boisson, Anne Puel, Jean-Laurent Casanova, Ryuta Nishikomori, Shouichi Ohga, Satoshi Okada, Yoji Sasahara, Shigeo Kure
Summary: This study reports six patients from five families with RELA mutations, leading to autoinflammatory and autoimmune manifestations. The mutations result in loss of function of RelA protein, leading to excessive IFN expression and autoimmune response. The DN RELA mutations are identified as a novel cause of chronic mucocutaneous ulcerations with autoinflammatory and autoimmune manifestations.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Martti Vanker, Karita Sarekannu, Arnaud Fekkar, Sofie Eg Jorgensen, Liis Haljasmagi, Anne Kallaste, Kalle Kisand, Margus Lember, Part Peterson, Madhvi Menon, Tracy Hussell, Sean Knight, James Moore-Stanley, Paul Bastard, Shen-Ying Zhang, Trine Mogensen, Quentin Philippot, Qian Zhang, Anne Puel, Jean-Laurent Casanova, Kai Kisand
Summary: Autoantibodies neutralizing type I interferons are present in 15% of critical COVID-19 cases, while the impact of autoimmunity toward type III interferons remains unexplored. In a study of COVID-19 patients and SARS-CoV-2naive individuals, it was found that autoantibodies targeting interferon-alpha were more common and associated with older age, while autoreactivity to interferon-gamma did not correlate with severe disease in COVID-19 patients.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2023)
Review
Medicine, General & Internal
Qiang Pan-Hammarstrom, Jean-Laurent Casanova
Summary: There is increasing evidence that severe disease in children infected with common viruses can result from inborn errors of immunity. Infection with SARS-CoV-2 can lead to acute hypoxemic COVID-19 pneumonia in children with inborn errors of type I interferon immunity, while children with inborn errors disrupting specific molecular bridges can manifest various forms of severe EBV disease. These experiments reveal the redundancy of different arms of immunity in host defense against these viruses.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Louise Malle, Roosheel S. Patel, Marta Martin-Fernandez, O'Jay Stewart, Quentin Philippot, Sofija Buta, Ashley Richardson, Vanessa Barcessat, Justin Taft, Paul Bastard, Julie Samuels, Clotilde Mircher, Anne-Sophie Rebillat, Louise Maillebouis, Marie Vilaire-Meunier, Kevin Tuballes, Brad R. Rosenberg, Rebecca Trachtman, Jean-Laurent Casanova, Luigi D. Notarangelo, Sacha Gnjatic, Douglas Bush, Dusan Bogunovic
Summary: Individuals with Down's syndrome (DS) exhibit multiple impairments such as cardiac, neurocognitive, and growth issues. They are also prone to severe infections and autoimmune disorders. This study reveals an autoimmune-prone state in DS characterized by persistent elevation of cytokines, chronic activation of CD4 T cells, and ongoing B cell activation. Furthermore, auto-antibodies targeting various organs and systems were detected in DS individuals' plasma, suggesting a breach in immune tolerance.
Review
Virology
Eugenia Quiros-Roldan, Alessandra Sottini, Simona Giulia Signorini, Federico Serana, Giorgio Tiecco, Luisa Imberti
Summary: Anti-cytokine autoantibodies, especially anti-type I interferons, are increasingly being found in immunodeficient, autoimmune, and immune-dysregulated conditions. These antibodies may lead to a predisposition to infections in otherwise healthy individuals. They have been implicated in the pathogenesis of COVID-19 and found mainly in critically ill patients, but have also been detected in patients with infections unrelated to COVID-19. This review provides an overview of these autoantibodies, their clinical associations, and their potential role as either beneficial or harmful agents, as well as their possible association with gender and immunosenescence.
Article
Biology
Lucia Liotti, Luca Pecoraro, Carla Mastrorilli, Riccardo Castagnoli, Francesca Saretta, Francesca Mori, Stefania Arasi, Simona Barni, Mattia Giovannini, Lucia Caminiti, Michele Miraglia Del Giudice, Elio Novembre
Summary: Angioedema (AE) is a vascular reaction that affects subcutaneous and submucosal tissues and is often accompanied by wheals. AE without wheals (AEwW) is rare, and distinguishing between mast cell-mediated and bradykinin-mediated or leukotriene-mediated AE is crucial for accurate diagnosis and treatment. AEwW can be hereditary or acquired, and different clinical features and responses to antihistamines can help determine the cause.
Review
Medicine, General & Internal
Ivan Taietti, Martina Votto, Maria De Filippo, Matteo Naso, Lorenza Montagna, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Riccardo Castagnoli
Summary: Selective Immunoglobulin M deficiency (SIgMD) has been recently classified as an inborn error of immunity (IEI) by the International Union of Immunological Societies Expert Committee. Limited understanding and unclear pathogenesis make it difficult to diagnose and manage SIgMD, especially in pediatric cases. Further research is needed to define the disease trajectory and better understand the molecular mechanisms in order to improve clinical management.
Review
Biology
Simona Barni, Francesca Mori, Mattia Giovannini, Lucia Liotti, Carla Mastrorilli, Luca Pecoraro, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Mariannita Gelsomino, Angela Klain, Michele Miraglia del Giudice, Elio Novembre
Summary: Allergic proctocolitis is a common non-IgE-mediated food allergy in children, characterized by bright red blood in stool. It is mostly caused by cow's milk proteins, but other food allergens can also be potential triggers. Treatment involves elimination diet and the prognosis is usually good, with most children tolerating the trigger food by one year of age.
Review
Medicine, Research & Experimental
Jean-Laurent Casanova, Mark S. Anderson
Summary: Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying severe viral illnesses. In 2006, autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)-driven T cell tolerance were discovered, but not initially linked to any viral disease. These two lines of clinical investigation converged in 2020, revealing that deficiencies of type I IFN immunity accounted for a significant percentage of critical COVID-19 cases in unvaccinated individuals.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Giorgia Bucciol, Leen Moens, Masato Ogishi, Darawan Rinchai, Daniela Matuozzo, Mana Momenilandi, Nacim Kerrouche, Catherine M. Cale, Elsa R. Treffeisen, Mohammad Al Salamah, Bandar K. Al-Saud, Alain Lachaux, Remi Duclaux-Loras, Marie Meignien, Aziz Bousfiha, Ibtihal Benhsaien, Anna Shcherbina, Anna Roppelt, C. O. V. I. D. Human Genetic Effort COVID Human Genetic Effort, Florian Gothe, Nadhira Houhou-Fidouh, Scott J. Hackett, Lisa M. Bartnikas, Michelle C. Maciag, Mohammed F. Alosaimi, Janet Chou, Reem W. Mohammed, Bishara J. Freij, Emmanuelle Jouanguy, Shen-Ping Zhang, Stephanie Boisson-Dupuis, Vivien Beziat, Qian Zhang, Christopher J. A. Duncan, Sophie Hambleton, Jean-Laurent Casanova, Isabelle Meyts
Summary: This study reports 23 patients with loss-of-function variants of STAT2, which may be associated with unresolved viral infection after viral infection or vaccination. Lack of STAT2CD8+ memory T cells may contribute to inflammation. Some patients died from viral infection or heart failure, indicating that complete STAT2 deficiency underlies severe viral diseases and significantly impacts survival.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Letter
Respiratory System
Quentin Philippot, Paul Bastard, Anne Puel, Jean-Laurent Casanova, Aurelie Cobat, Cedric Laouenan, Coralie Tardivon, Bruno Crestani, Raphael Borie
Summary: SARS-CoV2 infection has a poor prognosis in patients with idiopathic pulmonary fibrosis (IPF) who have autoantibodies neutralizing type I interferons (IFNs). A study screened the plasma of 247 IPF patients and found that only 3 of them had these autoantibodies. Among these patients, the one with documented SARS-CoV-2 infection had life-threatening COVID-19 pneumonia. However, the study did not find a significant association between these autoantibodies neutralizing type I IFNs and IPF.
RESPIRATORY RESEARCH
(2023)
Article
Immunology
Quentin Philippot, Masato Ogishi, Jonathan Bohlen, Julia Puchan, Andres Augusto Arias, Tina Nguyen, Marta Martin-Fernandez, Clement Conil, Darawan Rinchai, Mana Momenilandi, Seyed Alireza Mandaviani, Mohammad Keramatipour, Jeremie Rosain, Rui Yang, Taushif Khan, Anna-Lena Neehus, Marie Materna, Ji Eun Han, Jessica Peel, Federico Mele, Marc Weisshaar, Sandra Jovic, Paul Bastard, Romain Levy, Tom Le Voyer, Peng Zhang, Majistor Raj Luxman Maglorius Renkilaraj, Carlos A. Arango-Franco, Simon Pelham, Yoann Seeleuthner, Mathieu Pochon, Manar Mahmoud Ahmad Ata, Fatima Al Ali, Melanie Migaud, Camille Soudee, Tatiana Kochetkov, Anne Molitor, Raphael Carapito, Seiamak Bahram, Bertrand Boisson, Claire Fieschi, Davood Mansouri, Nico Marr, Satoshi Okada, Mohammad Shahrooei, Nima Parvaneh, Zahra Chavoshzadeh, Aurelie Cobat, Dusan Bogunovic, Laurent Abel, Stuart G. Tangye, Cindy S. Ma, Vivien Beziat, Federica Sallusto, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Anne Puel
Summary: Patients with IL-23R deficiency may suffer from Mendelian susceptibility to mycobacterial disease and chronic mucocutaneous candidiasis. IL-23 is essential for the production of IL-17A in MATT cells and for the production of IFN-y in both V62+ y6 T cells and MATT cells.
SCIENCE IMMUNOLOGY
(2023)