Article
Oncology
Thomas B. Brunner, Dominik Bettinger, Michael Schultheiss, Lars Maruschke, Lukas Sturm, Nico Bartl, Ivana Koundurdjieva, Simon Kirste, Hannes P. Neeff, Christian Goetz, Nils Henrik Nicolay, Gabriele Ihorst, Fabian Bamberg, Robert Thimme, Anca-Ligia Grosu, Eleni Gkika
Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pablo Munoz-Schuffenegger, Aisling Barry, Eshetu G. Atenafu, John Kim, James Brierley, Jolie Ringash, Anthony Brade, Robert Dinniwell, Rebecca K. S. Wong, Charles Cho, Tae Kyoung Kim, Gonzalo Sapisochin, Laura A. Dawson
Summary: This study investigated the long-term outcomes of patients with HCC and MVI treated with SBRT, showing promising results in terms of local control and overall survival. Patients who received sorafenib treatment after SBRT had longer survival, but some patients experienced adverse events like gastrointestinal bleeding.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Allison Kwong, Bilal Hameed, Shareef Syed, Ryan Ho, Hossein Mard, Sahar Arshad, Isaac Ho, Tashfeen Suleman, Francis Yao, Neil Mehta
Summary: A prediction model for waitlist dropout among liver transplant candidates with HCC was developed using 5 variables, achieving a concordance statistic of 0.74. This model can effectively prioritize patients with HCC and their need for transplant.
Article
Oncology
Marie Cantaloube, Florence Castan, Morgane Creoff, Jessica Prunaretty, Karl Bordeau, Morgan Michalet, Eric Assenat, Boris Guiu, Georges-Philippe Pageaux, Marc Ychou, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: The study demonstrates that stereotactic body radiation therapy (SBRT) using volumetric modulated arc therapy (VMAT) and real-time adaptive tumor gating for hepatocellular carcinoma (HCC) is effective with optimal local control and low toxicity, especially in patients not eligible for other local therapies. Additionally, the diameter of lesions and the volume of PTV were found to be associated with disease-free survival and overall survival in HCC patients receiving SBRT with VMAT.
Article
Oncology
Karl Bordeau, Morgan Michalet, Valerie Dorion, Aicha Keskes, Simon Valdenaire, Pierre Debuire, Marie Cantaloube, Morgane Cabaille, Roxana Draghici, Marc Ychou, Eric Assenat, Marta Jarlier, Sophie Gourgou, Boris Guiu, Jose Ursic-Bedoya, Norbert Ailleres, Pascal Fenoglietto, David Azria, Olivier Riou
Summary: Magnetic Resonance guided Radiotherapy (MRgRT) for primary liver tumors is safe and achieves excellent local control without severe adverse events. This study observed no significant acute or late toxicities related to radiotherapy, and high overall survival and local control rates. Further research is ongoing in these areas.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Oncology
Canyu Liu, Qiong Yi, Xuerong Zhou, Xu Han, Rui Jiang
Summary: This retrospective clinical study examined the efficacy and safety of stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) and liver metastasis tumors. The study found that SBRT was an effective and safe treatment option for liver cancer patients, with minimal side effects.
Article
Oncology
Nalee Kim, Jason Chia-Hsien Cheng, Nitin Ohri, Wen-Yen Huang, Tomoki Kimura, Zhao Chong Zeng, Victor Ho Fun Lee, Chul Seung Kay, Jinsil Seong
Summary: This study identified a positive association between HCV infection and LC after SBRT for HCC, along with the favorable impact of small tumor size and high BED on LC. TCP models indicated a 10-20% absolute increase in predicted LC across the range of SBRT doses and tumor sizes.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Oncology
Changchen Jiang, Shenghua Jing, Han Zhou, Aomei Li, Xiangnan Qiu, Xixu Zhu, Zetian Shen
Summary: The combination of TACE and CyberKnife SBRT demonstrated optimal efficacy and tolerable toxicity in treating BCLC stage B HCC. Results indicated high rates of local control and survival among patients in the study.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sumin Lee, Jinhong Jung, Jin-Hong Park, So Yeon Kim, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Hee Hyun Park, Jong Hoon Kim, Sang Min Yoon
Summary: This study evaluated the clinical outcomes of patients with single viable hepatocellular carcinoma (HCC) who received stereotactic body radiation therapy (SBRT) after incomplete transarterial chemoembolization (TACE). The results showed that SBRT could be considered a feasible salvage treatment option for HCC, with high rates of local control and overall survival.
Article
Gastroenterology & Hepatology
Tomoki Kimura, Atsuya Takeda, Naoko Sanuki, Keisuke Ariyoshi, Takuhiro Yamaguchi, Toshiyuki Imagumbai, Norio Katoh, Takahisa Eriguchi, Yohei Oku, Shuichi Ozawa, Yuichiro Tsurugai, Masaki Kokubo, Shinichi Shimizu, Satoshi Ishikura
Summary: The study demonstrated low incidence of SBRT-related toxicities. Local control and overall survival after SBRT were comparable for previously untreated solitary HCC patients unfit for resection or radiofrequency ablation. Although a definitive conclusion cannot be drawn from this study, the promising results suggest that SBRT may be an alternative option in the management of early HCC.
HEPATOLOGY RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yuri Jeong, Kyung Jin Lee, So Jung Lee, Yong Moon Shin, Min-Ju Kim, Young-Suk Lim, Han Chu Lee, Jinhong Jung, Jin-hong Park, Jong Hoon Kim, So Yeon Kim, Sang Min Yoon
Summary: This study compared the clinical outcomes of radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma patients, finding comparable results in terms of local control rates, overall survival rates, and intrahepatic recurrence-free survival rates. SBRT appears to be a viable alternative method for small hepatocellular carcinomas that are not suitable for RFA due to tumor location.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo
Summary: This study compared the waitlist and post-transplant outcomes of liver transplantation alone (LTA) and simultaneous liver kidney (SLK) listings. It found that SLK patients had lower mortality on the waitlist and higher survival rates after transplantation. Therefore, the kidney function of patients should be taken into consideration when choosing the transplantation method.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Shirley Lewis, Laura Dawson, Aisling Barry, Teodor Stanescu, Issa Mohamad, Ali Hosni
Summary: This review discusses the treatment modalities for hepatocellular carcinoma, including liver transplant, surgery, chemotherapy, and radiation therapy. The role of stereotactic body radiation therapy (SBRT) in the treatment of hepatocellular carcinoma has been refined and adopted in recent years, but there is currently a lack of high-quality level I evidence supporting its use.
Article
Medicine, General & Internal
Ren Ji, Kelvin K. Ng, Wenqi Chen, Weihong Yang, Hongtao Zhu, Tan-To Cheung, Chi-Leung Chiang, Tiffany C. L. Wong, Feng-Ming Kong, G. Wu, Chung-Mau Lo
Summary: This study compared the clinical outcomes of SBRT and RFA for patients with unresectable HCC. The results showed that there was no significant difference in the short-term and long-term clinical outcomes between SBRT and RFA, including the complete remission rate and local tumor control rate. Both treatments had a low incidence of complications. Therefore, SBRT can be considered as an alternative to RFA for the treatment of unresectable HCC.
Review
Medicine, Research & Experimental
Michael King Yung Chung, Lanqi Gong, Dora Lai-Wan Kwong, Victor Ho-Fun Lee, Ann Wing-Mui Lee, Xin-Yuan Guan, Ngar-Woon Kam, Wei Dai
Summary: Most mature B cells can be classified into four subtypes based on surface markers IgD and CD27. DN B cells, although present in small numbers, are crucial in various diseases, playing different roles depending on the disease. Further understanding of the mechanisms underlying DN B cell involvement in these diseases is essential for therapeutic strategies.
EMBO MOLECULAR MEDICINE
(2023)
Article
Clinical Neurology
Julia Chan, Danielle Wing Lam Ng, Qiuyan Liao, Richard Fielding, Inda Soong, Karen Kar Loen Chan, Conrad Lee, Alice Wan Ying Ng, Wing Kin Sze, Wing Lok Chan, Victor Ho Fun Lee, Wendy Wing Tak Lam
Summary: The study aims to examine the trajectories of sleep disturbance in cancer survivors during the first 2 years post-treatment and to investigate whether psychological, cognitive, and physical factors differentiate these trajectories. The findings showed that one in three cancer survivors experienced persistent high sleep disturbance, with higher rates of intrusive thoughts and cancer-related hyperarousal compared to stable good sleepers. Higher depression scores also predicted membership in the persistent high sleep disturbance group.
Article
Oncology
Lok-Man Ho, Sai-Kit Lam, Jiang Zhang, Chi-Leung Chiang, Albert Chi-Yan Chan, Jing Cai
Summary: This study investigates the association between pre-treatment multi-phasic MR-based radiomics and treatment response to a novel therapeutic regimen for unresectable HCC. The study identifies specific radiomic features that are associated with treatment response and demonstrates the potential for pre-treatment identification of responsive HCC patients. The findings highlight the importance of personalized oncology for HCC management.
Article
Oncology
Jina Kim, Jason Chia-Hsien Cheng, Taek-Keun Nam, Jin Hee Kim, Byoung Kuk Jang, Wen-Yen Huang, Hiroshi Aikata, Myungsoo Kim, Jung Hyun Kwon, Jinbo Yue, Victor Ho Fun Lee, Zhaochong Zeng, Jinsil Seong
Summary: This study compared the efficacy of liver-directed combined radiotherapy (LD combined RT) with sorafenib in hepatocellular carcinoma patients presenting portal vein tumor thrombosis. The LD combined RT group showed significantly improved overall survival and a higher conversion rate to curative surgery. Despite the multimodality of the treatment, LD combined RT had comparable toxicity rates to sorafenib.
Review
Gastroenterology & Hepatology
Tan-To Cheung, Simon Chun-Ho Yu, Stephen L. Chan, Ronnie T. P. Poon, Philip Kwok, Ann-Shing Lee, Anna Tai, Derek Tam, Chin-Cheung Cheung, Tak-Wing Lai, Nam-Hung Chia, Ada Law, Tracy Shum, Yim-Kwan Lam, Vince Lau, Victor Lee, Charing Chong, Chung-Ngai Tang, Thomas Yau
Summary: This article summarizes the expertise and latest evidence-based recommendations on the treatment of hepatocellular carcinoma (HCC) by Hong Kong clinicians.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Letter
Gastroenterology & Hepatology
Sebastian Staubli, Alexander Steen Grover, Benedict R. H. Turner, Dimitri A. Raptis, Michael Spiro, Marina Berenguer, Pascale Tinguely, LDL Tregistry Org Collaborative
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Aya El Helali, Tai-Chung Lam, Elaine Yee-Ling Ko, David J. H. Shih, Chun Kau Chan, Charlene H. L. Wong, Jason W. H. Wong, Lydia W. T. Cheung, Johnny K. S. Lau, Anthony P. Y. Liu, Ann S. Y. Chan, Herbert H. Loong, Stephen Tak Sum Lam, Godfrey Chi-Fung Chan, Victor H. F. Lee, Kwok Keung Yuen, Wai-Tong Ng, Anne W. M. Lee, Edmond S. K. Ma
Summary: This study investigated the feasibility of the HKU-HKSH Multi-disciplinary Molecular Tumour Board (MTB) in determining genome-guided therapy for treatment-refractory solid cancers in Hong Kong. The results showed that MTB-guided treatment positively impacted patients' overall survival, illustrating the applicability of next-generation sequencing comprehensive gene profiling (CGP) in real-world clinical practice.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Gastroenterology & Hepatology
Lung-Yi Mak, Albert C. Y. Chan, Tiffany C. L. Wong, Wing-Chiu Dai, Wong-Hoi She, Ka-Wing Ma, Sui-Ling Sin, Ka-Wan Chu, Wai-Kay Seto, Man-Fung Yuen, Chung-Mau Lo, James Fung
Summary: This study aimed to determine the prevalence of de novo steatosis and MAFLD in liver transplant patients. The results showed that post-transplant de novo graft steatosis is common in Chinese patients, with the majority classified as MAFLD. The development of graft steatosis was not associated with an increase in graft fibrosis but was associated with worse metabolic control and graft dysfunction.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Kevin Tak-Pan Ng, Jiang Liu, Oscar Wai-Ho Yeung, Li Pang, Hoi Chung Shiu, Hui Liu, Xin Xiang Yang, Albert Chi-Yan Chan, Tiffany Cho-Lam Wong, Chung Mau Lo, Kwan Man
Summary: This study found that post-transplant cytokines CCL11, IFN alpha 2, and IL17A are significant predictors of tumor recurrence and survival after liver transplantation for hepatocellular carcinoma. A prediction model including these cytokines, the UCSF criteria, and pre-transplant AFP accurately predicted post-transplant tumor recurrence and guided refinements in surveillance and therapeutic strategies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Infectious Diseases
Victor Ho-Fun Lee, Sik-Kwan Chan, Yiu-Ho Tam, Tin-Ching Chau, Jasper Fuk Woo Chan, Sum-Yin Chan, Chun-Yat Ip, Horace Cheuk-Wai Choi, Sherry Chor-Yi Ng, Kwok Keung Yuen
Summary: This study aimed to identify the predictors of delayed viral clearance in cancer patients with asymptomatic COVID-19 when the SARS-CoV-2 Omicron variants prevailed in Hong Kong. Multiple predictors were evaluated using machine learning algorithms, and it was found that age >65 years, male sex, high Charlson comorbidity index, lung cancer, immune checkpoint inhibitor, and receipt of one or no dose of COVID-19 vaccine were significant predictors. These findings contribute to targeted interventions for patients with delayed viral clearance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Zofia Piotrowska, Daniel Shao-Weng Tan, Egbert F. Smit, Alexander I. Spira, Ross A. Soo, Danny Nguyen, Victor Ho-Fun Lee, James Chih-Hsin Yang, Vamsidhar Velcheti, John M. Wrangle, Mark A. Socinski, Marianna Koczywas, John E. Janik, Jeffrey Jones, Helena Alexandra Yu
Summary: This study demonstrates that Zipalertinib has encouraging antitumor activity in heavily pretreated patients with EGFR ex20ins-mutant NSCLC, with an acceptable safety profile and low frequency of high-grade diarrhea and rash.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Charles Shing Kam, Daniel Wai-Hung Ho, Vanessa Sheung-In Ming, Lu Tian, Karen Man-Fong Sze, Vanilla Xin Zhang, Yu-Man Tsui, Abdullah Husain, Joyce Man-Fong Lee, Carmen Chak-Lui Wong, Albert Chi-Yan Chan, Tan-To Cheung, Lo-Kong Chan, Irene Oi-Lin Ng
Summary: The up-regulation of PFKFB4 expression is associated with more aggressive tumor behavior in hepatocellular carcinoma (HCC) and plays a critical role in HCC development, with therapeutic implications.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Victor Chun -Lam Wong, Ming-In Wong, Victor Ho-Fun Lee, Kwan Man, Kevin Tak-Pan Ng, Tan To Cheung
Summary: This study aimed to develop liquid biopsy assays for early HCC diagnosis and prognosis. A panel of 23 microRNAs (HCCseek-23 panel) was consolidated based on their reported functions in HCC development. Serum samples were collected from 103 early-stage HCC patients before and after hepatectomy. Quantitative PCR and machine learning random forest models were applied to develop diagnostic and prognostic models.
Article
Surgery
Yan Luk, Wong Hoi She, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan, Tan To Cheung, Chung Mau Lo
Summary: This study compared the survival outcomes of patients with resection of non-colorectal liver metastases (NCLM) versus colorectal liver metastases (CLM) and identified prognostic factors for resection of NCLM. The results showed that surgical resection of NCLM had comparable survival outcomes with CLM, and the indication of liver resection could be expanded to NCLM with appropriate patient selection.
LANGENBECKS ARCHIVES OF SURGERY
(2023)