SARS-CoV-2 S glycoprotein binding to multiple host receptors enables cell entry and infection

Can SARS-CoV-2 Virus Use Multiple Receptors to Enter Host Cells?

(2021) Laura Kate Gadanec et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

(2021) Najmeh Bozorgmehr et al.   mBio

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

(2021) Michel Thépaut et al.   PLoS Pathogens

Glycans in Virus-Host Interactions: A Structural Perspective

(2021) Nathaniel L. Miller et al.   Frontiers in Molecular Biosciences

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

(2020) Daniel Wrapp et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs

(2020) Abhigyan Choudhury et al.   JOURNAL OF MEDICAL VIROLOGY

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

(2020) Alexander V. Sorokin et al.   FASEB JOURNAL

Does SARS-CoV-2 Bind to Human ACE2 Stronger Than SARS-CoV?

(2020) Hoang Linh Nguyen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics

(2020) Eskild Petersen et al.   LANCET INFECTIOUS DISEASES

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

A potential role for Galectin-3 inhibitors in the treatment of COVID-19

(2020) John L. Caniglia et al.   PeerJ

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

(2020) Andreia Palmeira et al.   Pharmaceuticals

Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins

(2020) Maria Pia Lenza et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

(2020) Joana Damas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

The Sialoside-Binding Pocket of SARS-CoV-2 Spike Glycoprotein Structurally Resembles MERS-CoV

(2020) Mayanka Awasthi et al.   Viruses-Basel

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV

(2020) Mihkel Örd et al.   Scientific Reports

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

(2020) Lorenzo Casalino et al.   ACS Central Science

Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019

(2020) Anne-Sophie Bedin et al.   JOURNAL OF INFECTIOUS DISEASES

A Potential Role of Interleukin 10 in COVID-19 Pathogenesis

(2020) Ligong Lu et al.   TRENDS IN IMMUNOLOGY

N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

(2019) Xiuping Huang et al.   Nature Communications

The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size

(2018) Katharina Fuchs et al.   EMBO REPORTS

C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis

(2018) Zaopeng Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

(2016) Lise Roth et al.   Science Signaling

The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein

(2016) Dianyuan Zhao et al.   PLoS Pathogens

Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

(2016) Lise Roth et al.   Science Signaling

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

(2015) Laura K. Pritchard et al.   Nature Communications

Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response

(2015) J. van Tongeren et al.   Clinical and Translational Allergy

TLR Expression on Neutrophils at the Pulmonary Site of Infection: TLR1/TLR2-Mediated Up-Regulation of TLR5 Expression in Cystic Fibrosis Lung Disease

(2014) B. Koller et al.   JOURNAL OF IMMUNOLOGY

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion

(2013) Sandra J. van Vliet et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

(2013) Christine M Freeman et al.   RESPIRATORY RESEARCH

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system

(2012) Charlotte H. Maden et al.   DEVELOPMENTAL BIOLOGY

Isolated Toll-like Receptor Transmembrane Domains Are Capable of Oligomerization

(2012) James I. Godfroy et al.   PLoS One

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

Interactions between TLR2, TLR4, and mannose receptors with gp43 fromParacoccidioides brasiliensisinduce cytokine production by human monocytes

(2011) Erika Nakaira-Takahagi et al.   MEDICAL MYCOLOGY

Innate Immune Responses to Bacterial Ligands in the Peripheral Human Lung – Role of Alveolar Epithelial TLR Expression and Signalling

(2011) Andrew J. Thorley et al.   PLoS One

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

Macrophage Receptors for Influenza A Virus: Role of the Macrophage Galactose-Type Lectin and Mannose Receptor in Viral Entry

(2010) J. P. Upham et al.   JOURNAL OF VIROLOGY

Dual Specificity of Langerin to Sulfated and Mannosylated Glycans via a Single C-type Carbohydrate Recognition Domain

(2009) Hiroaki Tateno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells

(2008) Eveline C van Asbeck et al.   BMC MICROBIOLOGY

The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1

(2008) Ángeles Domínguez-Soto et al.   HEPATOLOGY

Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

(2008) Elizabeth A. Misch et al.   PLoS Neglected Tropical Diseases

Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission

(2007) Lot de Witte et al.   TRENDS IN MOLECULAR MEDICINE