Challenges and opportunities for in vivo PROTAC delivery

Pharmacokinetics and Drug–Drug Interactions of Long-Acting Intramuscular Cabotegravir and Rilpivirine

(2021) Daryl Hodge et al.   CLINICAL PHARMACOKINETICS

Prediction of Chameleonic Efficiency

(2021) Laurent David et al.   ChemMedChem

Optimization of a Series of RIPK2 PROTACs

(2021) Afjal H. Miah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs

(2021) Giuseppe Ermondi et al.   ACS Medicinal Chemistry Letters

Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC resistant to Second-Line Antiandrogen Therapy

(2020) Geun Taek Lee et al.   MOLECULAR CANCER THERAPEUTICS

Solution Conformations Shed Light on PROTAC Cell Permeability

(2020) Yoseph Atilaw et al.   ACS Medicinal Chemistry Letters

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

(2020) Guoshun Luo et al.   Acta Pharmaceutica Sinica B

Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs

(2016) Adrian Whitty et al.   DRUG DISCOVERY TODAY