Article
Endocrinology & Metabolism
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Walter Paulus, Juergen Brockmoeller
Summary: This study found that caffeine consumption, time of day, and cortisol concentrations can affect the excitability and plasticity of the motor cortex. Moderate caffeine intake alters cortical excitability but does not affect plasticity aftereffects.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Marco Antonio Cavalcanti Garcia, Jordania Lindolfo-Almas, Renan Hiroshi Matsuda, Vitoria Labiapari Pinto, Anaelli Aparecida Nogueira-Campos, Victor Hugo Souza
Summary: This study aimed to evaluate the effect of three different sEMG electrode montages on the MEP amplitude. The results showed that different electrode montages can provide contrasting MEP amplitudes, highlighting the need for standard recommendations on electrode placement for MEP recordings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Clinical Neurology
Sangtae Ahn, Flavio Frohlich
Summary: This study provides causal evidence that the early TEP components reflect cortical reactivity to TMS, with the earliest component localized to the left M1, the following components mainly localized to the primary somatosensory cortex, and the later components largely localized to the auditory cortex. Transcranial direct current stimulation selectively modulated cortical and corticospinal excitability by modulating the pre-stimulus mu-rhythm oscillatory power.
Article
Neurosciences
S. N. Makarov, W. A. Wartman, G. M. Noetscher, K. Fujimoto, T. Zaidi, E. H. Burnham, M. Daneshzand, A. Nummenmaa
Summary: The optimized TMS inverse problem solutions improve the focality of the electric field induced by TMS and reduce the size of the field hot spot near the target. Additionally, uncertainties in coil position/orientation, conductivity, and head segmentation accuracy affect the performance of TMS-IP.
Review
Cell Biology
M. Garcia-Pallero, Diana Cardona, Lola Rueda-Ruzafa, Miguel Rodriguez-Arrastia, Pablo Roman
Summary: Phantom limb pain is a difficult-to-treat chronic pain syndrome. Neurostimulation treatment shows potential as an effective option, although more research evidence is needed. Repetitive transcranial magnetic stimulation and transcranial direct current stimulation have been found to be effective in reducing pain perception and relieving anxiety and depression symptoms in phantom limb pain patients.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Danny Adrian Spampinato, Jaime Ibanez, Lorenzo Rocchi, John Rothwell
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used to study the human brain. One outcome measure of TMS is the motor-evoked potential (MEP), which estimates changes in corticospinal excitability. This article summarizes the neural pathways and circuits contributing to MEP generation, discusses factors to consider when interpreting MEP amplitude in motor processing and neurological conditions, and explores how emerging technologies can enhance understanding of neural substrates influencing MEPs.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Neurosciences
Michal Demjan, Laura Saisanen, Jusa Reijonen, Saara Rissanen, Sara Maattaa, Petro Julkunen
Summary: Transcranial magnetic stimulation (TMS) can be used to induce motor evoked potentials (MEPs). This study aimed to characterize the individual near-threshold recruitment of MEPs and determine the proper suprathreshold stimulation intensity (SI). The study found that individual near-threshold characteristics significantly influenced MEP production at suprathreshold SIs and emphasized the importance of selecting the appropriate SI for TMS applications.
Article
Neurosciences
Janine Kesselheim, Mitsuaki Takemi, Lasse Christiansen, Anke Ninija Karabanov, Hartwig Roman Siebner
Summary: This study investigated whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. The results showed that multipulse TMSHAND at individual peak latency and trough latency facilitated MEP amplitudes and reduced resting motor threshold (RMT). This facilitation may be related to I-wave periodicity and slower-conducting indirect pyramidal tract projections, respectively.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Emmanuelle Wilhelm, Caroline Quoilin, Gerard Derosiere, Susana Paco, Anne Jeanjean, Julie Duque
Summary: In Parkinson's disease, the lack of preparatory suppression in the primary motor cortex is associated with motor slowness and is related to disease duration and motor impairment. This finding suggests a potential marker for assessing motor preparation and impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Ole Numssen, Anna-Leah Zier, Axel Thielscher, Gesa Hartwigsen, Thomas R. Knosche, Konstantin Weise
Summary: Transcranial magnetic stimulation (TMS) is a useful tool for studying causal structure-function relationships in the human brain, but the complex distribution of induced electric fields makes it challenging to precisely identify the stimulated neuronal populations. This study proposes a method to rapidly and feasibly localize cortical regions at the individual subject level by combining experimental data and numerically modeled fields. By establishing a functional link between the induced electric field and the modulated effect, the research demonstrates a fundamental step towards fully exploiting the potential of TMS for practical and clinical applications.
Article
Clinical Neurology
Mohd Faizal Mohd Zulkifly, Ornela Merkohitaj, Juergen Brockmoeller, Walter Paulus
Summary: The study investigated the impact of caffeine on brain plasticity and found that it increased motor cortex excitability in caffeine-naive subjects, enhanced PAS 25 effects, and affected alertness and motor evoked potentials under light deprivation. Time of day had no effect on tACS-induced plasticity in caffeine consumers.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Dusan Hirjak, Zhong-Lin Tan, Georg Northoff
Summary: This study compared the therapeutic efficacy of rTMS at the left motor cortex (lMC) and left dorsolateral prefrontal cortex (lDLPFC) in MDD patients. The results showed no significant difference in treatment outcomes and tolerability between the two groups. The findings suggest that lMC can be a potential and easily accessible rTMS target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neurosciences
Zsolt Turi, Nicholas Hananeia, Sina Shirinpour, Alexander Opitz, Peter Jedlicka, Andreas Vlachos
Summary: This study explored the effects of TMS in different cortical regions using multi-scale computational modeling and highlighted the limitations of conventional intensity selection methods. Personalized stimulation intensity selection could standardize the effects of TMS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Fiorenzo Moscatelli, Antonietta Messina, Anna Valenzano, Vincenzo Monda, Monica Salerno, Francesco Sessa, Ester La Torre, Domenico Tafuri, Alessia Scarinci, Michela Perrella, Gabriella Marsala, Marcellino Monda, Giuseppe Cibelli, Chiara Porro, Giovanni Messina
Summary: Transcranial magnetic stimulation, introduced in 1985, has provided important innovations in the study of cortical excitability, allowing for in-depth exploration of motor activation and control, as well as investigating acute and chronic responses in the motor cortex in sport science. This technique can enhance cortical excitability, facilitate the learning process, and is considered a principal strategy for acquiring motor skills in training settings.
Letter
Clinical Neurology
Daniele Belvisi, Matteo Costanzo, Roberta Pellicciari, Nicola Modugno, Alessandra Nicoletti, Giovanni Fabbrini, Michele Tinazzi, Giovanni Defazio, Alfredo Berardelli
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Christian Geroin, Jorik Nonnekes, Roberto Erro, Serena Camozzi, Bastiaan R. Bloem, Michele Tinazzi
Summary: This study explored the role of the Shoulder-Touch test in revealing a functional etiology of postural instability in patients with functional motor disorders (FMD). The results showed that the S-Touch test has a high specificity but a modest sensitivity in detecting functional etiology of postural instability in FMD patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Benedetta Demartini, Angela Marotta, Anna Castelnovo, Lidia Del Piccolo, Veronica Nistico, Orsola Gambini, Michele Tinazzi
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Mirta Fiorio, Miriam Braga, Angela Marotta, Bernardo Villa-Sanchez, Mark J. Edwards, Michele Tinazzi, Diletta Barbiani
Summary: Functional neurological disorder (FND) refers to neurological symptoms that cannot be explained by structural neurological causes. The Bayesian predictive coding model suggests that perception relies on top-down cortical predictions to infer sensory information. This model may also apply to placebo and nocebo effects. The relationship between FND and placebo and nocebo effects extends beyond diagnosis and treatment, and shared cognitive, personality, and neuroanatomical factors may be involved. This new perspective offers potential insights into the pathogenesis of FND and the identification of therapeutic targets.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Clinical Neurology
Marcello Romano, Sergio Bagnato, Maria Concetta Altavista, Laura Avanzino, Daniele Belvisi, Matteo Bologna, Francesco Bono, Miryam Carecchio, Anna Castagna, Roberto Ceravolo, Antonella Conte, Giuseppe Cosentino, Roberto Eleopra, Tommaso Ercoli, Marcello Esposito, Giovanni Fabbrini, Gina Ferrazzano, Stefania Lalli, Marcello Maria Mascia, Maurizio Osio, Roberta Pellicciari, Simona Petrucci, Enza Maria Valente, Francesca Valentino, Mario Zappia, Maurizio Zibetti, Paolo Girlanda, Michele Tinazzi, Giovanni Defazio, Alfredo Berardell
Summary: This paper outlines diagnostic and therapeutic recommendations for dystonia provided by a panel of Italian experts. It covers clinical methods and instrumental assessment, pharmacological, surgical and rehabilitative options, and a hospital-territory network model.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Carlo Alberto Artusi, Elisa Montanaro, Roberto Erro, Nils Margraf, Christian Geroin, Andrea Pilotto, Luca Magistrelli, Francesca Spagnolo, Alberto Marchet, Lidia Sarro, Sofia Cuoco, Marta Sacchetti, Marianna Riello, Barbara Capellero, Paola Berchialla, Bettina Moeller, Beeke Vullriede, Maurizio Zibetti, Augusto Maria Rini, Paolo Barone, Cristoforo Comi, Alessandro Padovani, Michele Tinazzi, Leonardo Lopiano
Summary: Pisa syndrome and camptocormia in patients with Parkinson's disease are associated with neuropsychological functioning. Pisa syndrome patients showed worse visuospatial performances and subjective visual vertical perception, while camptocormia patients did not exhibit significant differences. Furthermore, more than 60% of patients with these postural abnormalities had reduced awareness of their condition.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Ilaria A. Di Vico, Jon Stone, Laura Mcwhirter, Marianna Riello, Maria Elisabetta Zanolin, Michela Colombari, Mirta Fiorio, Michele Tinazzi
Summary: This study aimed to examine the failure rate of nonlitigant, non-compensation-seeking FMD patients on three different PVTs and compared their performance to healthy controls and healthy simulators. The results showed that FMD patients had low failure rates on two of the tests, similar to the performance of healthy controls, but significantly different from that of healthy simulators.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Engineering, Electrical & Electronic
Ata Jahangir Moshayedi, Maziar Hosseinzadeh, Bhagyashree P. Joshi, Mehran Emadi Andani
Summary: Proper rest is often neglected but has proven health benefits. This paper proposes a systematic framework to find suitable pillows and mattresses for individuals to have proper rest and sleep. The framework includes sensors and software to monitor and identify ergonomic products for users.
IETE JOURNAL OF RESEARCH
(2023)
Article
Clinical Neurology
Mohammad Al-Wardat, Christian Geroin, Tommaso Schirinzi, Mohammad Etoom, Michele Tinazzi, Antonio Pisani, Silvia Natoli
Summary: Axial postural abnormalities and pain are significant factors affecting the quality of life in Parkinson's disease patients. This study aimed to assess the characteristics of pain and other non-motor symptoms in PD patients with Pisa syndrome and camptocormia. The results showed that PD patients with Pisa syndrome or camptocormia experience more musculoskeletal, chronic, and fluctuation pain compared to PD patients without axial postural abnormalities, suggesting different etiologies of pain and potential differences in treatment approaches.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Editorial Material
Clinical Neurology
Alessandro Dinoto, Enrico Marcuzzo, Vanessa Chiodega, Francesco Dall'Ora, Sara Mariotto, Michele Tinazzi
Summary: This study found that serum neurofilament light chain (NfL) levels are similar in patients with functional motor disorders (FMDs) and healthy controls, indicating the lack of neuroaxonal damage. These results have important implications for pathogenesis and clinical practice, suggesting that serum NfL may serve as a promising diagnostic biomarker to differentiate functional and structural neurological disorders.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Francesca Magrinelli, Clarissa Rocca, Roberto Simone, Riccardo Zenezini Chiozzi, Zane Jaunmuktane, Niccolo E. Mencacci, Michele Tinazzi, Sandeep Jayawant, Andrea H. H. Nemeth, German Demidov, Henry Houlden, Kailash P. P. Bhatia
Summary: This study identified a novel exonic AluYa5 insertion causing NKX2-1-related disorder, which is challenging to detect in routine diagnostics. MEI analysis of short-read sequencing data or targeted long-read sequencing could reveal the molecular diagnosis of unresolved movement disorder cases.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marialuisa Gandolfi, Mirta Fiorio, Christian Geroin, Paolo Torneri, Zoe Menaspa, Nicola Smania, Nir Giladi, Michele Tinazzi
Summary: Functional gait disorders (FGDs) are disabling symptoms of Functional Motor Disorders. Our study aimed to investigate the effect of different dual task paradigms on spatio-temporal gait parameters in FGDs. The results showed that FGDs patients had poorer gait performance and less automaticity and steadiness compared to healthy controls. However, dual tasking affected gait performance but not automaticity and steadiness in FGDs.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Gabriele Imbalzano, Serena Camozzi, Stefano Aldegheri, Leonardo Lopiano, Michele Tinazzi, Nicola Bombieri
Summary: The study developed a new software based on Deep Neural Networks to automatically measure axial postural abnormalities in Parkinson's disease (PD), which accurately supports the diagnosis of Pisa syndrome and camptocormia.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Neurosciences
C. Barbi, G. Vernillo, M. Emadi Andani, G. Giuriato, F. G. Laginestra, A. Cavicchia, G. Fiorini Aloisi, C. Martignon, A. Pedrinolla, F. Schena, M. Venturelli
Summary: Researchers evaluated the accuracy of neuronavigated TMS (nTMS) and a standardized function-guided procedure for maintaining TMS coil position during neuromuscular evaluations. The study found that the spatial accuracy of TMS coil position did not affect corticospinal excitability and inhibition in knee extensors. Variability in MEP and SP responses was attributed to spontaneous fluctuations in corticospinal excitability and inhibition, unaffected by the stability of the stimulation point.
NEUROSCIENCE LETTERS
(2023)
Article
Chemistry, Analytical
Ata Jahangir Moshayedi, Nafiz Md Imtiaz Uddin, Amir Sohail Khan, Jianxiong Zhu, Mehran Emadi Andani
Summary: The sleep visual analyzer (VSleep) is a system that analyzes sleep data using non-intrusive methods. It utilizes camera data to evaluate sleep quality and patterns, providing valuable insights for researching sleep-related disorders.