Understanding the role of S-nitrosylation/nitrosative stress in inflammation and the role of cellular denitrosylases in inflammation modulation: Implications in health and diseases

eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effects

(2021) Ariel Caviedes et al.   Cell Death & Disease

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

(2020) Jonathan Muri et al.   eLife

Enhanced Inflammation and Nitrosative Stress in the Saliva and Plasma of Patients with Plaque Psoriasis

(2020) Anna Skutnik-Radziszewska et al.   Journal of Clinical Medicine

Oxidative and nitrosative stress involvement in the pathogenesis of obstructive lung diseases of increasing severity

(2020) Antonino Di Stefano et al.   CURRENT MEDICINAL CHEMISTRY

Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation

(2020) Ajanta Chatterji et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase

(2019) Kei Hayashida et al.   CIRCULATION

Inhibitory Effects of Sildenafil and Tadalafil on Inflammation, Oxidative stress and Nitrosative stress in Animal model of Bronchial Asthma

(2019) Vijaya Laxmi et al.   Pharmacological Reports

Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer’s Disease Brain

(2019) Lexiao Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Nitrosative stress in asthma-chronic obstructive pulmonary disease overlap

(2019) Yorihiko Kyogoku et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells

(2019) Paramita Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel and conserved functions of S-nitrosoglutathione reductase (GSNOR) in tomato

(2019) Adil Hussain et al.   JOURNAL OF EXPERIMENTAL BOTANY

Disability in multiple sclerosis is associated with age and inflammatory, metabolic and oxidative/nitrosative stress biomarkers: results of multivariate and machine learning procedures

(2019) Tamires Flauzino et al.   METABOLIC BRAIN DISEASE

S-nitrosylation and its role in breast cancer angiogenesis and metastasis

(2019) Pamela Ehrenfeld et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

S-Nitrosylation of α1-Antitrypsin Triggers Macrophages Toward Inflammatory Phenotype and Enhances Intra-Cellular Bacteria Elimination

(2019) Ziv Kaner et al.   Frontiers in Immunology

Surfactant Protein-D Modulation of Pulmonary Macrophage Phenotype is Controlled by S-Nitrosylation

(2019) Changjiang Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis

(2019) Xiong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative proteomics of synaptosome S ‐nitrosylation in Alzheimer's disease

(2019) Teodora Stella Wijasa et al.   JOURNAL OF NEUROCHEMISTRY

Nitrosative stress in patients with asthma−chronic obstructive pulmonary disease overlap

(2019) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S-Nitrosylation: An Emerging Paradigm of Redox Signaling

(2019) Veani Fernando et al.   Antioxidants

Anti-Allergic and Anti-Inflammatory Effects and Molecular Mechanisms of Thioredoxin on Respiratory System Diseases

(2019) JieDong Zhou et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke

(2019) Mushfiquddin Khan et al.   Journal of Stroke & Cerebrovascular Diseases

A thioredoxin-mimetic peptide exerts potent anti-inflammatory, anti-oxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet

(2018) Fanny Canesi et al.   CARDIOVASCULAR RESEARCH

S-Nitrosylation in regulation of inflammation and cell damage

(2018) Subhajit Dasgupta et al.   CURRENT DRUG TARGETS

S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis

(2018) Nishant Saxena et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence

(2018) Hiroki Hayashi et al.   MOLECULAR CELL

Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis

(2018) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Identification of a Novel Inhibitor of HRV Replication and Inflammation in Airway Epithelial Cells

(2018) Zhonghui Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL’s

(2018) Wei Wu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase

(2018) Colin T. Stomberski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F 508 DEL - CFTR

(2017) Scott H. Donaldson et al.   Journal of Cystic Fibrosis

Reduction of nitric oxide and DNA/RNA oxidation products are associated with active disease in systemic lupus erythematosus patients

(2017) T M V Iriyoda et al.   LUPUS

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model

(2017) Paula Voabil et al.   OPHTHALMIC RESEARCH

Nitrosothiol-Trapping-Based Proteomic Analysis of S-Nitrosylation in Human Lung Carcinoma Cells

(2017) Shani Ben-Lulu et al.   PLoS One

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53

(2017) Harumasa Nakazawa et al.   PLoS One

Aβ-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet

(2016) In-Hyun Ryu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

(2016) Joseph Footitt et al.   CHEST

Thioredoxin-mimetic peptides (TXM) inhibit inflammatory pathways associated with high-glucose and oxidative stress

(2016) Katia Lejnev et al.   FREE RADICAL BIOLOGY AND MEDICINE

S-nitrosylation of fatty acid synthase regulates its activity through dimerization

(2016) Min Sik Choi et al.   JOURNAL OF LIPID RESEARCH

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome

(2016) Gerwyn Morris et al.   MOLECULAR NEUROBIOLOGY

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI)

(2016) Renana Baratz-Goldstein et al.   PLoS One

Thioredoxin-mimetic peptides as catalysts of S-denitrosylation and anti-nitrosative stress agents

(2015) Gali Kronenfeld et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipopolysaccharides PromoteS-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophagesin Vivo

(2015) Zhaoyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Nitrosylation of Bcl-2 Negatively Affects Autophagy in Lung Epithelial Cells

(2015) Clayton Wright et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1

(2015) Mirza Saqib Baig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and Asthma-Like Changes in Lungs

(2015) Vijay Pal Singh et al.   PLoS One

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Implications of glial nitric oxide in neurodegenerative diseases

(2015) Jose Enrique Yuste et al.   Frontiers in Cellular Neuroscience

Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin

(2014) Elina Isakov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition

(2014) Jie Jia et al.   CELL

Associations between Indicators of Nitrosative Stress and Levels of soluble HLA-I, CD95 Molecules in Patients with COPD

(2014) Nailya Kubysheva et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Mitochondrial DNA acquires immunogenicity on exposure to nitrosative stress in patients with vitiligo

(2014) Hani A. Al-Shobaili et al.   HUMAN IMMUNOLOGY

A Novel Suppressive Effect of Alcohol Dehydrogenase 5 in Neuronal Differentiation

(2014) Kaiyuan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of RAGE Contributes to Cigarette Smoke-Induced Nitric Oxide Generation in COPD

(2014) Lei Chen et al.   LUNG

S-Nitrosylation in Alzheimer's disease

(2014) Qing-Fei Zhao et al.   MOLECULAR NEUROBIOLOGY

dbSNO 2.0: a resource for exploring structural environment, functional and disease association and regulatory network of protein S-nitrosylation

(2014) Yi-Ju Chen et al.   NUCLEIC ACIDS RESEARCH

Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

(2014) Joan P Blonder et al.   BMC Pulmonary Medicine

Characterization of reactive nitrogen species in allergic asthma

(2013) Li Zuo et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease

(2013) Jinsu Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity

(2013) Azusa Kodama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Studies on peroxynitrite-modified H1 histone: Implications in systemic lupus erythematosus

(2013) M. Asad Khan et al.   BIOCHIMIE

Original article Evaluation of oxidative and nitrosative stress in relapsing remitting multiple sclerosis: effect of corticosteroid therapy

(2013) Arzu Seven et al.   FOLIA NEUROPATHOLOGICA

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo

(2013) Qiumei Chen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Thioredoxin-mediated Denitrosylation Regulates Cytokine-induced Nuclear Factor κB (NF-κB) Activation

(2013) Zachary T. Kelleher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis

(2013) Dler Faieeq Darweesh Mahmood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Physicochemical and immunological studies on mitochondrial DNA modified by peroxynitrite: implications of neo-epitopes of mitochondrial DNA in the etiopathogenesis of systemic lupus erythematosus

(2013) HA Al-Shobaili et al.   LUPUS

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Photobiomodulation Induced by 670 nm Light Ameliorates MOG35-55 Induced EAE in Female C57BL/6 Mice: A Role for Remediation of Nitrosative Stress

(2013) Kamaldeen A. Muili et al.   PLoS One

Increased S-Nitrosylation and Proteasomal Degradation of Caspase-3 during Infection Contribute to the Persistence of Adherent Invasive Escherichia coli (AIEC) in Immune Cells

(2013) Karl A. Dunne et al.   PLoS One

S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity

(2013) Maria E. Ferrini et al.   PLoS One

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis

(2013) B. Selvakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-nitrosoglutathione reductases are low-copy number, cysteine-rich proteins in plants that control multiple developmental and defense responses in Arabidopsis

(2013) Shengbao Xu et al.   Frontiers in Plant Science

The Role of Nitrosative Stress in the Pathogenesis of Unexplained Chronic Cough with Cough Hypersensitivity

(2012) Yun-Jeong Bae et al.   American Journal of Rhinology & Allergy

Emerging Role of Protein-Protein Transnitrosylation in Cell Signaling Pathways

(2012) Tomohiro Nakamura et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy

(2012) Qiuping Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitrosothiols in the Immune System: Signaling and Protection

(2012) Pablo Hernansanz-Agustín et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-1 Promotes Anti-Inflammatory Macrophages of the M2 Phenotype and Antagonizes Atherosclerosis

(2012) Khadija El Hadri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

dbSNO: a database of cysteine S-nitrosylation

(2012) Tzong-Yi Lee et al.   BIOINFORMATICS

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease

(2012) Puneet Anand et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke

(2012) Mushfiquddin Khan et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition

(2012) Matthew W. Foster et al.   JOURNAL OF PROTEOME RESEARCH

Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation

(2012) M. Malik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function

(2012) F. Beigi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-κB p65

(2011) Zachary T. Kelleher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response

(2011) In-Hyun Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation

(2011) Elena N. Atochina-Vasserman   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity

(2011) Jacqueline M. Heilman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin in Allergic Inflammation

(2011) Wataru Ito et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Regulation byS-Nitrosylation of Protein Post-translational Modification

(2011) Douglas T. Hess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitrative stress in inflammatory lung diseases

(2011) Hisatoshi Sugiura et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Aminoguanidine andN-acetyl-cysteine supress oxidative and nitrosative stress in EAE rat brains

(2011) Srdjan Ljubisavljevic et al.   REDOX REPORT

A nonclinical safety and pharmacokinetic evaluation of N6022: A first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma

(2011) Dorothy B. Colagiovanni et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Airway epithelium mediates the anti-inflammatory effects of exercise on asthma

(2011) Rodolfo Paula Vieira et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Discovery of S-Nitrosoglutathione Reductase Inhibitors: Potential Agents for the Treatment of Asthma and Other Inflammatory Diseases

(2011) Xicheng Sun et al.   ACS Medicinal Chemistry Letters

Simvastatin Improves Epithelial Dysfunction and Airway Hyperresponsiveness

(2010) Tanveer Ahmad et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity

(2010) Yunfei Wu et al.   ATHEROSCLEROSIS

S -Nitrosylation in Cardiovascular Signaling

(2010) Brian Lima et al.   CIRCULATION RESEARCH

SP-D and regulation of the pulmonary innate immune system in allergic airway changes

(2010) L. R. Forbes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Exhaled nitric oxide, susceptibility and new-onset asthma in the Children's Health Study

(2010) T. M. Bastain et al.   EUROPEAN RESPIRATORY JOURNAL

Peroxynitrite-induced modification of H2A histone presents epitopes which are strongly bound by human anti-DNA autoantibodies: Role of peroxynitrite-modified-H2A in SLE induction and progression

(2010) Kiran Dixit et al.   HUMAN IMMUNOLOGY

S-Nitrosylation Regulates Nuclear Translocation of Chloride Intracellular Channel Protein CLIC4

(2010) Mariam Malik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric-oxide Synthase FormsN-NO-pterin andS-NO-Cys

(2010) Robin J. Rosenfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation

(2010) P.-T. Doulias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation from GSNOR Deficiency Impairs DNA Repair and Promotes Hepatocarcinogenesis

(2010) W. Wei et al.   Science Translational Medicine

Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction

(2009) Csaba Szabo   BRITISH JOURNAL OF PHARMACOLOGY

Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation

(2009) Mie Torii et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular Mechanisms of Thioredoxin and Glutaredoxin as Hydrogen Donors for Mammalian S Phase Ribonucleotide Reductase

(2009) Farnaz Zahedi Avval et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Nitrosylation of Cardiac Ion Channels

(2009) Daniel R Gonzalez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Immune Reconstitution during Pneumocystis Lung Infection: Disruption of Surfactant Component Expression and Function by S-Nitrosylation

(2009) E. N. Atochina-Vasserman et al.   JOURNAL OF IMMUNOLOGY

Structural Analysis of Cysteine S-Nitrosylation: A Modified Acid-Based Motif and the Emerging Role of Trans-Nitrosylation

(2009) Stefano M. Marino et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence

(2009) T. Islam et al.   THORAX

Protein S-nitrosylation in health and disease: a current perspective

(2009) Matthew W. Foster et al.   TRENDS IN MOLECULAR MEDICINE

Thioredoxin-1 Ameliorates Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

(2008) A. Sato et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of S-nitrosylation in apoptosis resistance and carcinogenesis

(2008) Anand Krishnan V. Iyer et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

S-Nitrosylation of mannose binding lectin regulates its functional activities and the formation of autoantibody in rheumatoid arthritis

(2008) Bhawna Gupta et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

(2008) M. Benhar et al.   SCIENCE