Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

(2020) Enyong Dai et al.   Autophagy

Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload

(2020) Lisa J. Routhe et al.   GLIA

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

(2020) Minyi Xu et al.   Cell Death & Disease

Emerging treatments for inflammatory bowel disease

(2020) Karl Hazel et al.   Therapeutic Advances in Chronic Disease

MELK Accelerates the Progression of Colorectal Cancer via Activating the FAK/Src Pathway

(2020) Guangming Liu et al.   BIOCHEMICAL GENETICS

Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma

(2020) Zhiwei Zhang et al.   Frontiers in Oncology

Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway

(2020) Yeru Chen et al.   IMMUNOLOGY LETTERS

Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4

(2020) Shujun Wang et al.   LIFE SCIENCES

The Application of Ferroptosis in Diseases

(2020) Yangmin Qiu et al.   PHARMACOLOGICAL RESEARCH

Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm

(2019) Fumiaki Shikata et al.   HYPERTENSION

Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)

(2019) Meige Sun et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

(2019) Hengameh Chloé Mirsepasi-Lauridsen et al.   CLINICAL MICROBIOLOGY REVIEWS

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis

(2019) Alasdair J Scott et al.   GUT

Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer

(2019) Dianbo Yao et al.   INFLAMMATORY BOWEL DISEASES

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

(2019) Wenhan Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ulcerative Colitis

(2019) Joseph D. Feuerstein et al.   MAYO CLINIC PROCEEDINGS

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

(2019) Shinya Tsurusaki et al.   Cell Death & Disease

Protective Role of Fecal Microbiota Transplantation on Colitis and Colitis-Associated Colon Cancer in Mice Is Associated With Treg Cells

(2019) Zitao Wang et al.   Frontiers in Microbiology

NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function

(2019) Junjie Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

(2018) Xianling Gong et al.   BMC CANCER

REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer

(2018) Qingwei Wang et al.   CLINICAL CANCER RESEARCH

Intestinal Lactobacillus in health and disease, a driver or just along for the ride?

(2018) Dustin D Heeney et al.   CURRENT OPINION IN BIOTECHNOLOGY

Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity on multiple myeloma bone disease

(2018) Joséphine Muller et al.   HAEMATOLOGICA

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer

(2018) Shreena J. Desai et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

PKB/Akt-dependent regulation of inflammation in cancer

(2018) Fengyuan Tang et al.   SEMINARS IN CANCER BIOLOGY

Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity on multiple myeloma bone disease

(2018) Joséphine Muller et al.   HAEMATOLOGICA

The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease

(2018) Tao Zuo et al.   Frontiers in Microbiology

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway

(2018) Dong Zhao et al.   Biomolecules & Therapeutics

Fenvalerate induces oxidative hepatic lesions through an overload of intracellular calcium triggered by the ERK/IKK/NF-κB pathway

(2018) Liang-Lin Qiu et al.   FASEB JOURNAL

Non-transferrin-bound iron transporters

(2018) Mitchell D. Knutson   FREE RADICAL BIOLOGY AND MEDICINE

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

(2018) Shiyu Duan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels

(2017) Jacob Sterling et al.   EXPERIMENTAL EYE RESEARCH

The Expanding Therapeutic Armamentarium for Inflammatory Bowel Disease: How to Choose the Right Drug[s] for Our Patients?

(2017) Pieter Hindryckx et al.   Journal of Crohns & Colitis

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

(2016) Jean-Philippe Pradère et al.   Science Signaling

Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

(2016) Alexis Mosca et al.   Frontiers in Microbiology

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

(2016) Jean-Philippe Pradère et al.   Science Signaling

Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function

(2015) Gregory J. Guthrie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis

(2015) Natalia Castaño-Rodríguez et al.   GUT

Macrophage development and polarization in chronic inflammation

(2015) Madhur P. Motwani et al.   SEMINARS IN IMMUNOLOGY

Apigenin blocks IKKα activation and suppresses prostate cancer progression

(2015) Sanjeev Shukla et al.   Oncotarget

Mutation of cysteine 46 in IKK-beta increases inflammatory responses

(2015) Ting Li et al.   Oncotarget

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases

(2014) Wei Zhu et al.   IMMUNOLOGICAL INVESTIGATIONS

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

(2014) Puneet Kaur Randhawa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

The gut microbiota and inflammatory bowel disease

(2014) Katsuyoshi Matsuoka et al.   Seminars in Immunopathology

Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis

(2014) Marco Scarpa   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammation Is an Independent Risk Factor for Colonic Neoplasia in Patients With Ulcerative Colitis: A Case–Control Study

(2013) David T. Rubin et al.   Clinical Gastroenterology and Hepatology

The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD

(2013) Erin C. Steinbach et al.   INFLAMMATORY BOWEL DISEASES

Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells

(2011) Rika Saito et al.   CANCER SCIENCE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Then and now: use of 16S rDNA gene sequencing for bacterial identification and discovery of novel bacteria in clinical microbiology laboratories

(2008) P.C.Y. Woo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

(2008) J. B. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA