Critical role of VGLL4 in the regulation of chronic normobaric hypoxia‐induced pulmonary hypertension in mice

MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension

(2020) Hui Shen et al.   CIRCULATION

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice

(2020) Qiuyun Tian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

VGLL4 plays a critical role in heart valve development and homeostasis

(2019) Wei Yu et al.   PLoS Genetics

Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy

(2019) Prakash Chelladurai et al.   BRITISH JOURNAL OF PHARMACOLOGY

VGLL4 interacts with STAT3 to function as a tumor suppressor in triple-negative breast cancer

(2019) Hongming Song et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension

(2018) Kurt R Stenmark et al.   CARDIOVASCULAR RESEARCH

Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation

(2018) Giada Zurlo et al.   JOURNAL OF HYPERTENSION

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

SIRT1 Mediates Apelin-13 in Ameliorating Chronic Normobaric Hypoxia-induced Anxiety-like Behavior by Suppressing NF-κB Pathway in Mice Hippocampus

(2018) Junming Fan et al.   NEUROSCIENCE

DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension

(2018) Ying Wang et al.   PHYSIOLOGICAL GENOMICS

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

Loss of VGLL4 suppresses tumor PD‐L1 expression and immune evasion

(2018) Ailing Wu et al.   EMBO JOURNAL

NUAK2 is a critical YAP target in liver cancer

(2018) Wei-Chien Yuan et al.   Nature Communications

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

The cancer theory of pulmonary arterial hypertension

(2017) Olivier Boucherat et al.   Pulmonary Circulation

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

(2016) Sudakshina Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

miR-146b-5p within BCR-ABL1-Positive Microvesicles Promotes Leukemic Transformation of Hematopoietic Cells

(2016) H.-M. Zhang et al.   CANCER RESEARCH

Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth

(2016) Zhiqiang Lin et al.   DEVELOPMENTAL CELL

The emerging role of epigenetics in pulmonary hypertension

(2016) Elisabetta Gamen et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension

(2016) Feng Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-κB

(2016) Junming Fan et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats

(2015) Mingge Ding et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit

(2015) Thomas Bertero et al.   Cell Reports

Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling

(2014) Bernadette Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

(2013) B Mao et al.   ONCOGENE

Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation

(2013) Sun-Zhong Mao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Histone Deacetylation Inhibition in Pulmonary Hypertension

(2012) Lan Zhao et al.   CIRCULATION

Plumbagin reverses proliferation and resistance to apoptosis in experimental PAH

(2012) Audrey Courboulin et al.   EUROPEAN RESPIRATORY JOURNAL

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

(2011) Roxane Paulin et al.   CIRCULATION

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: A potential role for atrogin-1 in smooth muscle

(2011) Michael L. Paffett et al.   VASCULAR PHARMACOLOGY

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) Anna Csiszar et al.   HYPERTENSION

The Cooperative Induction of Hypoxia-Inducible Factor-1  and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

(2009) M. Z. Noman et al.   JOURNAL OF IMMUNOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Diagnosis and Assessment of Pulmonary Arterial Hypertension

(2009) David B. Badesch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Cancer Paradigm of Severe Pulmonary Arterial Hypertension

(2008) Pradeep R. Rai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE