Review
Endocrinology & Metabolism
Ines Bucci, Cesidio Giuliani, Giulia Di Dalmazi, Gloria Formoso, Giorgio Napolitano
Summary: The regulation of the female reproductive system by thyroid hormones is crucial for normal menstrual function, fertility, and successful pregnancy. Thyroid autoimmunity (TAI) is prevalent among women and is associated with infertility and negative reproductive outcomes. The role of TAI, especially in the absence of thyroid dysfunction, in assisted reproductive technology (ART) is still controversial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Genetics & Heredity
Mira H. Kheil, Fady Sharara, Jean Marc Ayoubi, Sara Rahman, Gaby Moawad
Summary: The current evidence is inconclusive on whether endometriomas should be surgically removed prior to ART. Further large randomized controlled trials are needed for a definite answer, and until then, management should be individualized.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Mary M. Quien, Anais Hausvater, Susan M. Maxwell, Catherine R. Weinberg
Summary: This study aims to evaluate the cardiac, reproductive, and obstetric outcomes of assisted reproductive technology (ART) in women with heart disease (HD). The study found that the risks posed by ART in this small, low-risk cohort of women with HD were similar to those in healthy controls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mustapha Benkhalifa, Fabien Joao, Cynthia Duval, Debbie Montjean, Molka Bouricha, Rosalie Cabry, Marie-Claire Belanger, Hatem Bahri, Pierre Miron, Moncef Benkhalifa
Summary: After more than four decades of assisted reproductive technology (ART) practice, the failure of in vitro fertilization (IVF) treatments and recurrent implantation failures (RIFs) and repeated pregnancy loss (RPL) remain significant issues. This article reviews different therapeutic options and suggests that immunomodulation and predictive biomarkers may be promising solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kimberly W. Keefe, Andrea Lanes, Kayla Stratton, Daniel M. Green, Eric J. Chow, Kevin C. Oeffinger, Sara Barton, Lisa Diller, Yutaka Yasui, Wendy M. Leisenring, Gregory T. Armstrong, Elizabeth S. Ginsburg
Summary: Linking the Childhood Cancer Survivor Study database to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System revealed that childhood cancer survivors are as likely to undergo treatment with assisted reproductive technology as their siblings. The success of assisted reproductive technology was not reduced after alkylator exposure.
Review
Medicine, General & Internal
Jessica Marinaro, Marc Goldstein
Summary: Male factor is significant in a couple's reproductive success, and advances in reproductive technology have overcome traditional barriers to male fertility. Collaborative work between reproductive endocrinologists and reproductive urologists is essential for optimizing fertility outcomes, improving men's health, and providing cost-effective care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Brigita Vaigauskaite-Mazeikiene, Raminta Bausyte, Elvina Valatkaite, Ruta Mazelyte, Edita Kazenaite, Diana Ramasauskaite, Ruta Navakauskiene
Summary: In this study, the outcomes of ART in 223 couples with unexplained infertility were analyzed, and the gene expression associated with DNA modification, cell death, immune response, and senescence in infertile women's endometrium and follicular fluid were investigated. The results showed significant differences in women who successfully got pregnant compared to those unable to conceive, depending on age, duration of infertility, number of retrieved oocytes, zygotes, and transferred embryos. Furthermore, gene expression analysis revealed upregulation of genes associated with cell death and immune response in the endometrium of women who successfully got pregnant.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Obstetrics & Gynecology
Tawaqualit Abimbola Ottun, Adeniyi Abiodun Adewunmi, Faosat Olayiwola Jinadu, Ayokunle Moses Olumodeji, Fatimat Motunrayo Akinlusi, Kabiru Afolarin Rabiu, Oluwarotimi Ireti Akinola, Adetokunbo Olusegun Fabamwo
Summary: This study presents a 10-year review of assisted reproductive technology in a public tertiary center in Lagos, Nigeria. Despite the increasing use and success of assisted reproductive technology, there is still room for improvement in clinical pregnancy rates and live birth rates. Complication rates are low.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Psychology, Multidisciplinary
Marcella Paterlini, Federica Andrei, Erica Neri, Elena Trombini, Sara Santi, Maria Teresa Villani, Lorenzo Aguzzoli, Francesca Agostini
Summary: The study found that parents who conceived through ART had more positive representations of their child compared to naturally conceiving parents, while naturally conceiving parents showed improved scores in the partner dimension from T1 to T2. Different ART histories may impact parents' self-as-woman/man dimension, and different causes of infertility can affect parents' representations of their own parents.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biology
Rajani Dube, Subhranshu Sekhar Kar
Summary: The balance between different bacterial species is crucial for vaginal health, and the genital microbiota may play a role in predicting outcomes of assisted reproductive treatment (ART), although clear evidence is currently lacking.
Article
Endocrinology & Metabolism
Xinru Xia, Lingling Chen, Jing Wang, Xiang Yu, Li Gao, Yuan Zhang, Feiyang Diao, Yugui Cui, Jiayin Liu, Yan Meng
Summary: This study investigated the differences in bone mineral density (BMD) between ART-conceived children and naturally conceived children, and found that paternal childbearing age and the use of ART independently affected the BMD Z score of the offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Ahmed Elhakeem, Amy E. Taylor, Hazel M. Inskip, Jonathan Huang, Muriel Tafflet, Johan L. Vinther, Federica Asta, Jan S. Erkamp, Luigi Gagliardi, Kathrin Guerlich, Jane Halliday, Margreet W. Harskamp-van Ginkel, Jian-Rong He, Vincent W. V. Jaddoe, Sharon Lewis, Gillian M. Maher, Yannis Manios, Toby Mansell, Fergus P. McCarthy, Sheila W. McDonald, Emanuela Medda, Lorenza Nistico, Angela Pinot de Moira, Maja Popovic, Irwin K. M. Reiss, Carina Rodrigues, Theodosia Salika, Ash Smith, Maria A. Stazi, Caroline Walker, Muci Wu, Bjorn O. Asvold, Henrique Barros, Sonia Brescianini, David Burgner, Jerry K. Y. Chan, Marie-Aline Charles, Johan G. Eriksson, Romy Gaillard, Veit Grote, Siri E. Haberg, Barbara Heude, Berthold Koletzko, Susan Morton, George Moschonis, Deirdre Murray, Desmond O'Mahony, Daniela Porta, Xiu Qiu, Lorenzo Richiardi, Franca Rusconi, Richard Saffery, Suzanne C. Tough, Tanja G. M. Vrijkotte, Scott M. Nelson, Anne-Marie Nybo Andersen, Maria C. Magnus, Deborah A. Lawlor
Summary: This study found that offspring conceived via assisted reproductive technology (ART) were shorter, lighter, and thinner than those conceived naturally during infancy to early adolescence. However, these differences diminished with older child age and were no longer evident in late adolescence. Hence, individuals conceived or conceiving through ART can be reassured that early growth and adiposity differences are small and temporary.
Review
Multidisciplinary Sciences
Janaina Ferreira Aderaldo, Beatriz Helena Dantas Rodrigues de Albuquerque, Maryana Thalyta Ferreira Camara de Oliveira, Mychelle de Medeiros Garcia Torres, Daniel Carlos Ferreira Lanza
Summary: This study conducted a scoping review of the global assisted reproductive technologies (ART) market, identifying the main terms and categorizing them into different topics. The findings highlight the complexity of the market, with strong associations with economic, social, and geographic aspects. The study also emphasizes the need for further analysis of market elements related to technical improvements to enhance the success rate of in vitro fertilization (IVF).
Review
Gastroenterology & Hepatology
Robyn Laube, Yvonne Tran, Sudarshan Paramsothy, Rupert W. Leong
Summary: Infertility in women with Crohn's disease and ulcerative colitis may be addressed through assisted reproductive technology (ART), with pregnancy and live birth rates similar to the general population. However, efficacy of ART may be reduced in patients with CD-related surgery and IPAA failure.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Obstetrics & Gynecology
Wen Zhang, Ningning Pan, Bing Han, Xiaoxue Li, Rong Li, Caihong Ma, Jie Qiao
Summary: This retrospective cohort study explored the relationship between uterine volume and in vitro fertilization (IVF) reproductive outcomes in infertile patients with adenomyosis. The study included 1155 patients who underwent IVF from 2009 to 2019. The results showed that clinical pregnancy rate was not significantly correlated with uterine volume, while miscarriage rate increased with uterine volume and live birth rate decreased with uterine volume. Patients with a uterine volume larger than 8 weeks of gestation had higher miscarriage rate and lower live birth rate in all ET cycles. The study highlights the negative impact of uterine volume on IVF reproductive outcomes in infertile patients with adenomyosis.
REPRODUCTIVE SCIENCES
(2023)
Article
Nutrition & Dietetics
Mariel Arvizu, Lidia Minguez-Alarcon, Siwen Wang, Makiko Mitsunami, Jennifer J. Stuart, Janet W. Rich-Edwards, Bernard Rosner, Jorge E. Chavarro
Summary: This study found that pre-pregnancy intake of trans fatty acids was associated with a higher risk of hypertensive disorders of pregnancy (HDP), while intake of monounsaturated fatty acids, saturated fats, and total fats were unrelated to HDP. High intake of long-chain omega-3 fatty acids was associated with a lower risk of HDP.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Albert Salas-Huetos, Mariel Arvizu, Lidia Minguez-Alarcon, Makiko Mitsunami, Jordi Ribas-Maynou, Marc Yeste, Jennifer B. Ford, Irene Souter, Jorge E. Chavarro
Summary: This study found that women's consumption of omega-3 fatty acids and omega-3-rich foods may improve the probability of conception by decreasing the risk of pregnancy loss. Additionally, men's intake of omega-3 fatty acids may influence semen quality.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Jenny L. Carwile, Shravanthi M. Seshasayee, Katherine A. Ahrens, Russ Hauser, Jorge E. Chavarro, Abby F. Fleisch
Summary: The study found that children with diets characterized by higher consumption of certain starchy vegetables, quick breads, and citrus juices prepared at a restaurant had higher urinary phthalate metabolites. More detailed information on the specific methods of food processing and details on packaging materials is needed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Oncology
Andres V. Ardisson Korat, Yu-Han Chiu, Kimberly A. Bertrand, Shumin Zhang, Mara M. Epstein, Bernard A. Rosner, Stephanie Chiuve, Hannia Campos, Edward L. Giovannucci, Jorge E. Chavarro, Brenda M. Birmann
Summary: Published studies on the association between polyunsaturated fatty acid (PUFA) intake and non-Hodgkin lymphoma (NHL) risk have yielded inconsistent results. This nested case-control study, involving participants from the Nurses' Health Study and Health Professionals Follow-Up Study, found no overall association between red blood cell (RBC) membrane PUFA levels and NHL risk. However, certain PUFA were associated with specific types of lymphoma, and the reasons for these unexpected associations remain unclear.
LEUKEMIA & LYMPHOMA
(2022)
Article
Medicine, General & Internal
Keyi Si, Yang Hu, Molin Wang, Caroline M. Apovian, Jorge E. Chavarro, Qi Sun
Summary: This study suggests that individuals with obesity who attempted to lose weight, regardless of the weight loss strategies used, tended to gain less body weight and have a lower risk of diabetes. In contrast, lean individuals who intentionally lost weight tended to gain more weight and have a higher risk of diabetes.
Article
Nutrition & Dietetics
Jiaxi Yang, Deirdre K. Tobias, Shanshan Li, Shilpa N. Bhupathiraju, Sylvia H. Ley, Stefanie N. Hinkle, Frank Qian, Zhangling Chen, Yeyi Zhu, Wei Bao, Jorge E. Chavarro, Frank B. Hu, Cuilin Zhang
Summary: The study found that among females with a history of GDM, greater consumption of caffeinated coffee was associated with a lower risk of T2D.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Makiko Mitsunami, Lidia Minguez-Alarcon, Andrea A. Florio, Siwen Wang, Jill A. Attaman, Irene Souter, Russ Hauser, Jorge E. Chavarro
Summary: This study aimed to investigate the association between intake of soy food and isoflavone with ovarian reserve. Previous studies on the relationship between soy intake and human fertility are inconsistent. However, no studies have evaluated the relationship between soy or isoflavone intake with markers of ovarian reserve other than follicle-stimulating hormone (FSH).
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Lidia Minguez-Alarcon, Paige L. Williams, Irene Souter, Jennifer B. Ford, Ramy Abou Ghayda, Russ Hauser, Jorge E. Chavarro
Summary: Men working non-daytime/rotating shifts and those with physically demanding jobs have higher sperm concentration and total sperm count as well as higher estradiol and total testosterone concentrations.
HUMAN REPRODUCTION
(2023)
Article
Nursing
Melissa Perez Capotosto, Christopher S. Lee, Corrine Y. Jurgens, Siwen Wang, Makiko Mitsunami, Brittany M. Charlton, Jorge E. Chavarro
Summary: This study aimed to identify predictors of fertility-awareness-based method use among women trying to conceive or contemplating pregnancy. The results showed that the duration of ongoing pregnancy attempt and gravidity were the only significant predictors for the number of fertility-awareness-based methods used among women actively trying to conceive, while partnership was the only significant predictor of the number of fertility-awareness-based methods among women contemplating pregnancy.
Article
Cardiac & Cardiovascular Systems
Leslie V. Farland, Yi-Xin Wang, Audrey J. Gaskins, Janet W. Rich-Edwards, Siwen Wang, Maria Christine Magnus, Jorge E. Chavarro, Kathryn M. Rexrode, Stacey A. Missmer
Summary: Infertility is associated with an increased risk of coronary heart disease, but not stroke. The risk differs depending on the age at first infertility diagnosis and the specific cause of infertility.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Siwen Wang, Audrey J. Gaskins, Leslie V. Farland, Dan Zhang, Brenda M. Birmann, Janet W. Rich-Edwards, Yi-Xin Wang, Rulla M. Tamimi, Stacey A. Missmer, Jorge E. Chavarro
Summary: This prospective cohort study examined the association between infertility and the incidence of invasive cancer in women. It found that women who reported infertility had a higher risk of developing cancer, especially obesity-related reproductive cancers. The risk was also higher for women who first reported infertility at a younger age.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
N. Jimenez-Cardozo, M. Mitsunami, L. Minguez-Alarcon, E. Ortiz-Panozo, S. Wang, I Souter, R. Hauser, J. E. Chavarro
Summary: This study found that supplemental iron intake above 45 mg/day is associated with lower ovarian reserve among women seeking fertility care.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Robert B. Hood, Donghai Liang, Youran Tan, Jennifer B. Ford, Irene Souter, Jorge E. Chavarro, Dean P. Jones, Russ Hauser, Audrey J. Gaskins
Summary: This study identified the metabolic pathways and metabolites in the serum and follicular fluid that are associated with peak estradiol levels and the number of mature oocytes. The serum metabolome mainly involves fatty acid and amino acid pathways, while the follicular fluid metabolome mainly involves lipid, vitamin, and hormone pathways. These findings provide insights into the biological mechanisms underlying follicular and oocyte development.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Sheryl L. Rifas-Shiman, Izzuddin M. Aris, Karen M. Switkowski, Jessica Young, Abby F. Fleisch, Tamarra James-Todd, Ami R. Zota, Wei Perng, Marie-France Hivert, Janet W. Rich-Edwards, Melissa Perez Capotosto, Jorge E. Chavarro, Emily Oken
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Diana C. C. Soria-Contreras, Izzuddin M. M. Aris, Sheryl L. L. Rifas-Shiman, Wei Perng, Marie-France Hivert, Jorge E. E. Chavarro, Emily Oken
Summary: This study aimed to evaluate the associations of age at first birth and parity with weight, waist circumference (WC), and body fat across midlife. A secondary data analysis was conducted with 735 participants from Project Viva. The results showed that women who had their first birth before age 23 years or after age 40 years, as well as those with four or more births, had a higher trajectory of weight, WC, and body fat after their final birth.