Article
Cell Biology
M. Constanza Baroni Pietto, Paola R. Lev, Ana C. Glembotsky, Cecilia P. Marin Oyarzun, Graciela Gomez, Victoria Collado, Cecilia Pisoni, Ramiro A. Gomez, Matias Grodzielski, Jacqueline Gonzalez, Karina Marino, Paula G. Heller, Nora P. Goette, Rosana F. Marta
Summary: The study found that systemic lupus erythematosus (SLE) patients with thrombocytopenia have abnormalities in platelet clearance and production, mainly due to apoptosis and desialylation leading to low platelet count. These abnormalities are more frequently observed in patients with thrombocytopenia and active disease.
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Yixiao Dong, Kunkun Zhao, Xuemei Qin, Guanhua Du, Li Gao
Summary: The perineuronal net (PNN) is an important extracellular matrix in the central nervous system that is regulated by various factors and undergoes abnormal changes in aging and neurological diseases. Limited research has been conducted on the relationship between PNN and aging or age-related neurological diseases.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Xiaohua Xu, Chou-Wei Chang, Min Li, Chao Liu, Yilun Liu
Summary: The RECQ4 gene encodes an ATP-dependent DNA helicase in human cells, mutations of which are linked to various clinical diseases and high cancer risks. Understanding the molecular dysfunctions of different RECQ4 disease mutations is crucial for improving our knowledge of RECQ4 clinical phenotypes and its roles in cancer development.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Gerasimos Siasos, Costas Tsioufis, Dimitris Tousoulis
Summary: Maintenance of endothelial cell integrity is crucial for human health, as dysfunction can lead to various diseases. Activated and injured endothelial cells release inflammatory mediators and enter a pro-thrombotic state, ultimately promoting atherosclerosis progression. Various pathways and mechanisms contribute to endothelial dysfunction, highlighting the complexity of this process.
Article
Urology & Nephrology
Tariq E. Farrah, Vanessa Melville, Alicja Czopek, Henry Fok, Lorraine Bruce, Nicholas L. Mills, Matthew A. Bailey, David J. Webb, James W. Dear, Neeraj Dhaun
Summary: This study investigates the mechanisms of cardiovascular disease in patients with anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and strategies for risk reduction. The study finds that patients with AAV in long-term remission have an increased cardiovascular risk, and endothelin-1 plays a crucial role in this. Additionally, the study suggests that endothelin receptor blockers can reduce cardiovascular risk by decreasing arterial stiffness and increasing circulating tissue plasminogen activator (tPA) activity.
KIDNEY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Xin Liu, Shao-Jun Tang
Summary: This review aims to summarize the pathology and associated factors of chronic pain among individuals with HIV infection. Research suggests that viral proteins and antiretroviral drugs play a critical role in the interactions between neurons, glial cells, and non-neural cells.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Jibao Chen, Ren Zhou, Ye Feng, Lin Cheng
Summary: Physical activity is considered an essential element for promoting human health. Recent advances in molecular biotechnology have revealed the physiological responses triggered by exercise, uncovering the mechanisms of exercise regulation on the human body. Exercise has been identified as a potential approach for alleviating various diseases and promoting tissue regeneration. The capacity of exercise to promote tissue regeneration has attracted attention, and there is a growing interest in developing exercise mimetics as pharmaceutical alternatives. This comprehensive review focuses on the benefits of exercise on tissue regeneration in different organs, the molecular mechanisms involved, and the challenges and opportunities associated with therapeutic exercise mimetics.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Karolina Luczkowska, Dorota Roginska, Piotr Kulig, Anna Bielikowicz, Bartlomiej Baumert, Boguslaw Machalinski
Summary: This study examined the effect of low-dose bortezomib (BTZ) on nerve cells, showing a significant decrease in global histone H3 acetylation and histone H3 lysine 9 acetylation. Genetic microarray and miRNA microarray analyses revealed changes in epigenetic processes and signaling pathways that may play a pivotal role in peripheral neuropathy (PN) development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aisling Forder, Rebecca Zhuang, Vanessa G. P. Souza, Liam J. Brockley, Michelle E. Pewarchuk, Nikita Telkar, Greg L. Stewart, Katya Benard, Erin A. Marshall, Patricia P. Reis, Wan L. Lam
Summary: Lung cancer risk is higher in individuals with chronic obstructive pulmonary disease (COPD), and this is influenced by genetic, immune, and microenvironment dysregulation. Factors such as genetic and epigenetic changes, oxidative stress from smoking, sex differences in tobacco metabolism, and dysregulation of the lung microenvironment contribute to the increased risk. It is important to better identify individuals with COPD who are at high risk for lung cancer and develop personalized screening strategies using biomarkers and exhaled breath analysis. Additionally, the use of corticosteroids and statins as chemopreventive agents should be considered. Optimization of current detection and management methods for lung cancer and COPD is crucial for improving health outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hui Zhang, Aya Laux, Kurt R. Stenmark, Cheng-Jun Hu
Summary: The study reveals reduced levels of mature miRNAs in pulmonary artery fibroblasts from IPAH patients, which can be restored by HDACi. It was found that decreased miR-124 levels in PH-Fibs are mainly due to reduced gene transcription, and HDACi can relax chromatin structure to increase miR-124-1 gene transcription. The data suggest epigenetic events play a crucial role in controlling miRNA levels in chronic pulmonary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Hirotaka Iijima, Gabrielle Gilmer, Kai Wang, Sruthi Sivakumar, Christopher Evans, Yusuke Matsui, Fabrisia Ambrosio
Summary: This study used a combined approach of meta-analysis and multi-omics data analysis to uncover the pathogenic mechanisms of age-related knee osteoarthritis (KOA) in mice. Inflammation, autophagy, and cellular senescence were identified as primary hallmarks of age-related KOA. The Advanced Glycation End-Product (AGE)/Receptor for AGE pathway was found to be the most statistically robust pathway associated with age-related KOA. The molecular profiles of cartilage aging were distinct from those observed in surgically induced post-traumatic OA models, suggesting different mechanisms at play.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Megan K. Freiler, Troy Smith
Summary: This article discusses the interrelationship between sociality and communication, highlighting the need for communication systems to evolve with social systems. The "social complexity hypothesis" is introduced, which suggests that social complexity necessitates communicative complexity and is supported in studies of vocalizing mammals. However, this hypothesis has not been widely tested outside the acoustic modality, and comparisons across studies are complicated by varying definitions of complexity. The article also argues the importance of exploring the neuroendocrine mechanisms underlying the coevolution of sociality and communication, specifically focusing on steroid hormones, monoamines, and nonapeptides. Weakly electric fishes are proposed as an ideal system for studying these mechanisms in a novel modality.
FRONTIERS IN NEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
James S. Novak, Davi A. G. Mazala, Marie Nearing, Ravi Hindupur, Prech Uapinyoying, Nayab F. Habib, Tessa Dickson, Olga B. Ioffe, Brent T. Harris, Marie N. Fidelia-Lambert, Christopher T. Rossi, D. Ashely Hill, Kathryn R. Wagner, Eric P. Hoffman, Terence A. Partridge
Summary: The age-related loss of muscle mass and strength is likely not caused by intrinsic loss of myogenicity in satellite cells, but rather by progressive and detrimental changes in the muscle microenvironment that affect the myogenic function of these cells.
Article
Microbiology
Dandan Fu, Qianqian Zheng, Xiaoyan Wu, Jianmei Wu, Ying Shao, Zhenyu Wang, Jian Tu, Xiangjun Song, Kezong Qi
Summary: Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis in poultry. In this study, it was found that regulator EtrA positively regulates the expression of OmpW, and both EtrA and OmpW contribute to the motility, biofilm formation, serum resistance, and pathogenicity of APEC.
VETERINARY MICROBIOLOGY
(2023)
Article
Ophthalmology
Rinky Agarwal, Seema Sen, Seema Kashyap, Tanuj Dada, Tapas Chandra Nag, Viney Gupta, Ramanjit Sihota
Summary: The purpose of this study is to correlate histopathological changes of trabecular meshwork (TM) with clinical features in primary congenital glaucoma (PCG). The findings suggest that fused trabecular beams are associated with higher baseline intraocular pressure (IOP), while thicker TM and lower trabecular endothelial cell (TEC) count are associated with lower IOP at final follow-up. Larger studies are required to validate these results.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cell Biology
Subhash Bhukya, S. Singh, S. Sarwar, J. A. Quadri, A. Ahmed, Neerja Rani, K. Dheeraj, A. Dubey, Tapas Chandra Nag, A. Shariff
Summary: The neural crest cell-derived enteric nervous system is the intrinsic innervation of the gastrointestinal tract, consisting of neurons and enteric glia cells with various functions on the GIT. Understanding the development morphology of innervations at different segments of the gut during fetal growth may aid in comprehending the pathophysiology of congenital diseases affecting the ENS.
JOURNAL OF HISTOTECHNOLOGY
(2021)
Article
Anatomy & Morphology
T. C. Nag, S. Chakraborti, D. Das
Summary: We report the ocular features of the tongue sole, Cynoglossus bilineatus (Lacepede, 1802), a marine, bottom-dwelling flatfish. The findings reveal the adaptations of its eyes to the dim-light environment and the structural changes during larval metamorphosis.
Article
Cell Biology
Tapas C. Nag
Summary: This study demonstrates neuronal alterations in PMD, including thinning of the inner retinal layers, patchy or inconspicuous OPL, and elongation of cone photoreceptor cells, among others.
Article
Medicine, Research & Experimental
Shikha Upreti, Seema Sen, Tapas Chandra Nag, Madhumita P. Ghosh
Summary: This study aims to investigate the combined effect of L-Dopa and IGF-1 on diabetic retinopathy, and found that it has a protective effect on the retina and attenuates angiogenesis by modulating VEGF and IGF-1 receptor levels. This is the first report on the synergistic effect of L-Dopa+IGF-1 in a rat model of diabetic retinopathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Materials Science, Multidisciplinary
Shikha Chaudhary, Preeti Rai, Arti Joshi, Pooja Yadav, Kishore Sesham, Shailendra Kumar, Asit Ranjan Mridha, Upendra Baitha, Tapas Chandra Nag, Kapil Dev Soni, Anjan Trikha, Subhash Chandra Yadav
Summary: In this study, the cellular infectivity and ultrastructural changes caused by SARS-CoV-2 infection were examined in bronchoalveolar fluid (BALF) cells from different age groups and patients with comorbidities. The study found that younger patients had higher infection rates and better preservation of subcellular structures compared to older patients. Patients without comorbidities had higher viral load in BALF cells compared to those with comorbidities. Diabetic patients showed the most severe ultrastructural damage in BALF cells within the comorbid group.
MICROSCOPY AND MICROANALYSIS
(2022)
Article
Neurosciences
Avishek Roy, Sakshi Sharma, Tapas Chandra Nag, Jatinder Katyal, Yogendra Kumar Gupta, Suman Jain
Summary: Research suggests that ICV-STZ injection can lead to cognitive and neuropsychiatric abnormalities due to structural loss at the neuronal and synaptic levels, which is closely associated with changes in neuronal metabolism.
NEUROTOXICITY RESEARCH
(2022)
Article
Clinical Neurology
Binney Sharma, Avishek Roy, Trina Sengupta, Lal Chandra Vishwakarma, Anuraag Singh, Ritesh Netam, Tapas Chandra Nag, Nasreen Akhtar, Hruda Nanda Mallick
Summary: Sleep has an impact on both brain function and neuromuscular junction morphology and neurochemistry.
Article
Dentistry, Oral Surgery & Medicine
Bikash Chaurasia, Nitesh Tewari, Vijay Prakash Mathur, Tapas Chandra Nag, Subhash Chandra Yadav, Morankar Rahul, Deepika Mishra, Kalpana Bansal
Summary: This proof-of-concept study aimed to investigate the microscopic changes in resin penetration characteristics of tooth fragments after different rehydration protocols. The results showed that rehydration with distilled water resulted in the greatest depth and width of resin tags, followed by rehydration in a humidification chamber. Additionally, there were more resin tags in the samples rehydrated with distilled water and humidification compared to the samples with no rehydration.
DENTAL TRAUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Reshal Suri, Tapas C. Nag, Nikita Mehra, Yub Raj Neupane, Sadat Shafi, Devyani Sharma, Kalicharan Sharma, Yasmin Sultana, Kanchan Kohli
Summary: This study found that chitosan functionalized PLGA nanoparticles can effectively and sustainedly deliver sirolimus to the retina for the treatment of AMD. Compared to plain sirolimus, these nanoparticles provide better protection against retinal degeneration and have no toxic side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Indrani Mukherjee, Subhrajit Biswas, Sunil Singh, Joyeeta Talukdar, Mohammed S. S. Alqahtani, Mohamed Abbas, Tapas Chandra Nag, Asit Ranjan Mridha, Surabhi Gupta, Jai Bhagwan Sharma, Supriya Kumari, Ruby Dhar, Subhradip Karmakar
Summary: The overproduction of ROS has been linked to various human diseases. Monosodium glutamate (MSG), a food additive commonly used in Asian cuisine, has been associated with ROS generation. This study found that MSG exposure influenced trophoblast invasion and differentiation, two critical functions during placenta formation, through increased ROS production. The findings suggest that long-term exposure to MSG may have adverse health effects, compromising important trophoblast functions.
Article
Ophthalmology
Tapas C. Nag
Summary: This study investigated age-related changes in Muller glial cells in donor human retina and found that these cells undergo osmotic changes, gliosis, and lipid peroxidation with advanced aging. Photoreceptor cells also experience oxidative-nitrosative stress with aging. Muller glial cells respond to oxidative stress through different mechanisms, but their phagocytic potential decreases with aging.
EXPERIMENTAL EYE RESEARCH
(2023)
Meeting Abstract
Peripheral Vascular Disease
Khushboo Bisht, Dharam Vir Singh Arya, Vipin Kumar Verma, Zia Abdullah, Ruma Ray, Rajiv Narang, Tapas Chandra Nag, Jagriti Bhatia
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Clinical Neurology
S. C. Sarangi, D. Sharma, S. S. Pattnaik, A. Nambirajan, T. C. Nag, M. Tripathi
Meeting Abstract
Clinical Neurology
B. Sharma, A. Roy, L. C. Vishwakarma, R. Neetam, T. C. Nag, N. Akhtar, H. N. Mallick