Review
Oncology
Sha She, Qian Zhang, Jinzhi Shi, Fan Yang, Kai Dai
Summary: This review summarizes the physiological function of ATX and the ATX-LPA axis in liver cancer, analyzes their role in tumorigenesis and metastasis, and discusses therapeutic strategies targeting the ATX-LPA axis, paving the way for new therapeutic developments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Jiaqi Shen, Wei Zhu
Summary: This review discusses the important role of mesenchymal stem cells (MSCs) in gastric cancer (GC) and their impact on tumor progression, treatment response, and immune evasion in the tumor microenvironment. Research on GC-MSCs may contribute to the development of novel therapeutic strategies against gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Liangyu Huang, Wenwei Qian, Yihan Xu, Zhen Guo, Yi Yin, Feilong Guo, Weiming Zhu, Yi Li
Summary: The study found that the ATX-LPA axis in hypertrophic mesenteric adipose tissue is associated with intestinal fibrosis in Crohn's disease patients. Inhibition of ATX was associated with improvement in morphology and function of diseased adipose tissue, as well as ameliorated intestinal inflammation and fibrosis in mice. In vitro studies showed that hypoxia stimulated adipocyte ATX expression and LPA stabilized HIF-1 alpha protein, leading to adipocyte dysfunction.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Cell & Tissue Engineering
Caroline Hochheuser, Laurens J. Windt, Nina Y. Kunze, Dieuwke L. de Vos, Godelieve A. M. Tytgat, Carlijn Voermans, Ilse Timmerman
Summary: Neuroblastoma is the second most common solid cancer in childhood, with bone marrow being a common site of distant metastasis. Therapy resistance of residual tumor cells in BM remains a major obstacle for the cure of NB. The role of mesenchymal stromal cells in NB development and progression is not fully understood, with a focus on BM as a metastatic niche.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Zelei Yang, Xiaoyun Tang, Todd P. W. McMullen, David N. Brindley, Denise G. Hemmings
Summary: The study found that HCMV infection in the tumor microenvironment preferentially targets tumor-associated fibroblasts and breast cancer cells expressing PDGFR alpha, and the infection rates in different cell lines are closely related to the expression level of PDGFRA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Li Liu, Lilong Zhang, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Zhongkai Wu, Wenhong Deng
Summary: This review summarizes recent progress in the identification of hormones associated with intestinal stem cells, which can promote or prevent their development. Several hormones, such as thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone, and progastrin, promote the development of intestinal stem cells, while somatostatin and melatonin prevent their proliferation. This provides potential new therapeutic targets for the diagnosis and treatment of intestinal illnesses.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Melanie A. Dacheux, Sue Chin Lee, Yoojin Shin, Derek D. Norman, Kuan-Hung Lin, E. Shuyu, Junming Yue, Zoltan Benyo, Gabor J. Tigyi
Summary: This study investigates the role of autotaxin (ATX) produced by alveolar type II epithelial (ATII) pneumocytes in the progression of B16-F10 melanoma-derived lung metastases. The results show that ATX derived from ATII cells can affect the progression of lung metastasis by modulating cytokine levels and the infiltration of CD8(+) T cells.
Article
Pharmacology & Pharmacy
Sepideh Mirzaei, Asal Jalal Abadi, Mohammad Hossein Gholami, Farid Hashemi, Amirhossein Zabolian, Kiavash Hushmandi, Ali Zarrabi, Maliheh Entezari, Amir Reza Aref, Haroon Khan, Milad Ashrafizadeh, Saeed Samarghandian
Summary: This article explores the issue of drug resistance in cancer cells, focusing on the role of the epithelial-to-mesenchymal transition (EMT) mechanism in enhancing cancer cell resistance to chemotherapy drug doxorubicin (DOX).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Megumi Watanabe, Masato Furuhashi, Yuri Tsugeno, Yosuke Ida, Fumihito Hikage, Hiroshi Ohguro
Summary: The study evaluated the effects of the ATX-LPA signaling axis on HTM, finding that exposure to LPA and ATX resulted in decreased size and increased stiffness of HTM spheroids, with different impacts on the function and gene expression of 2D and 3D HTM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Sekaran Balaji, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan
Summary: The interactions between cancer and non-cancerous cells in the TME through exosomes play a significant role in influencing tumor progression, therapeutic resistance, and metastasis. Wnt signaling, which is often involved in exosomal transport, represents a potential therapeutic target in inhibiting these processes.
Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Prakrit R. Kumar, Mona Saad, Charlotte Hellmich, Jayna J. Mistry, Jamie A. Moore, Shannon Conway, Christopher J. Morris, Kristian M. Bowles, Marc D. Moncrieff, Stuart A. Rushworth
Summary: Melanoma cells stimulate mitochondrial biogenesis in bone marrow-derived stromal cells, which leads to the transfer of mitochondria to melanoma cells. This study reveals metabolic interactions between melanoma and its microenvironment and provides new therapeutic approaches for melanoma treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Medicine, Research & Experimental
Milad Ashrafizadeh, Sepideh Mirzaei, Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Hossein Saleki, Seyed Omid Sharifzadeh, Leyla Soleymani, Salman Daneshi, Kiavash Hushmandi, Haroon Khan, Alan Prem Kumar, Amir Reza Aref, Saeed Samarghandian
Summary: EMT mechanism is responsible for cancer cell metastasis and migration, as well as drug resistance. Taxene chemotherapeutic agents PTX and DTX induce cancer cell cycle arrest by preventing microtubule depolymerization, while upstream mediators of EMT such as ZEB1/2 and TGF-ll affect cancer cells' response to these drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Boyang Fan, Qian Zhang, Ning Wang, Guiyu Wang
Summary: This review evaluates the role of lncRNAs in regulating CRCSC signaling pathways and their involvement in promoting and suppressing colorectal cancer. The potential clinical applications of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer are also discussed, providing new ideas and protocols for the prevention and treatment of this disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Linglong Peng, Yongfu Xiong, Rong Wang, Ling Xiang, He Zhou, Zhongxue Fu
Summary: PRDX2 is highly expressed in colon cancer stem cells (CCSCs) and its overexpression is closely correlated with stemness maintenance, tumor initiation, and invasion of CCSCs. Inhibition of PRDX2 leads to increased ROS production in CCSCs, sensitizing them to oxidative stress and chemotherapy. These findings suggest that PRDX2 could be a potential therapeutic target in CCSCs.
Article
Cell Biology
Bryan Kuo, Erzsebet Szabo, Sue Chin Lee, Andrea Balogh, Derek Norman, Asuka Inoue, Yuki Ono, Junken Aoki, Gabor Tigyi
CELLULAR SIGNALLING
(2018)
Review
Oncology
Sue Chin Lee, Melanie A. Dacheux, Derek D. Norman, Louisa Balazs, Raul M. Torres, Corinne E. Augelli-Szafran, Gabor J. Tigyi
Article
Cell Biology
Dina Wafa, Nora Koch, Janka Kovacs, Margit Kerek, Richard L. Proia, Gabor J. Tigyi, Zoltan Benyo, Zsuzsanna Miklos
Article
Oncology
Melanie A. Dacheux, Sue Chin Lee, Yoojin Shin, Derek D. Norman, Kuan-Hung Lin, E. Shuyu, Junming Yue, Zoltan Benyo, Gabor J. Tigyi
Summary: This study investigates the role of autotaxin (ATX) produced by alveolar type II epithelial (ATII) pneumocytes in the progression of B16-F10 melanoma-derived lung metastases. The results show that ATX derived from ATII cells can affect the progression of lung metastasis by modulating cytokine levels and the infiltration of CD8(+) T cells.
Review
Biochemistry & Molecular Biology
Souvik Banerjee, Suechin Lee, Derek D. Norman, Gabor J. Tigyi
Summary: The ATX-LPA-LPAR1 signaling pathway has a universal role in various cellular responses and is associated with metabolic and inflammatory diseases. Selective inhibitors have been developed, but their clinical efficacy in cancer and rheumatoid arthritis remains to be evaluated. Dual-targeting therapies show promise, although limited research has been done on dual ATX-LPAR1 inhibitors.
Article
Biochemistry & Molecular Biology
Eva Ruisanchez, Anna Janovicz, Rita Cecilia Panta, Levente Kiss, Adrienn Parkanyi, Zsuzsa Straky, David Korda, Karoly Liliom, Gabor Tigyi, Zoltan Benyo
Summary: Enhanced sphingomyelinase activity in a mouse model of type 2 diabetes mellitus leads to altered vascular effects, showing marked relaxation in diabetic mice. Sphingomyelinase has dual vasoactive effects, including TP-mediated vasoconstriction and NO-mediated vasorelaxation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Anna Janovicz, Aliz Majer, Monika Kosztelnik, Miklos Geiszt, Jerold Chun, Satoshi Ishii, Gabor Jozsef Tigyi, Zoltan Benyo, Eva Ruisanchez
Summary: This study investigates the molecular mechanisms underlying LPC-induced impairment of endothelium-dependent vasorelaxation and identifies the involvement of the ATX-LPA-LPA5 receptor axis in this process.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kuan-Hung Lin, Sue Chin Lee, Melanie A. Dacheux, Derek D. Norman, Andrea Balogh, Mitul Bavaria, Hsinyu Lee, Gabor Tigyi
Summary: Dysregulation of ATX-LPA signaling is involved in cancer development and resistance to therapy. In mice, p53 inhibits ATX expression through E2F7, but this mechanism is not present in human cells.