期刊
EUROPEAN NEUROLOGY
卷 85, 期 2, 页码 132-135出版社
KARGER
DOI: 10.1159/000518899
关键词
Case series; Calcitonin gene-related peptide; Erenumab; Galcanezumab; Monoclonal antibody; Refractory migraine
Some nonresponsive patients may benefit from switching between monoclonal antibodies with different therapeutic targets.
Monoclonal antibodies targeting the calcitonin gene-related peptide have been introduced into the therapeutic arsenal of migraine prophylaxis. Clinical trials report similar efficacy between them, and there is no evidence of switching to another one after failure. We aim to describe our experience in switching from erenumab to galcanezumab after therapeutic failure. We retrospectively reviewed 30 migraine patients who received monoclonal antibodies, with 15 of them switched after failure to achieve reduction in migraine days per month >= 30%. A >= 30% reduction in migraine days per month compared to baseline was observed in 8/15 (4/15 >= 50%) patients after switch. Some nonresponsive patients may benefit from switching between monoclonal antibodies with different therapeutic targets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据