Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Applications of Bioorthogonal Chemistry in Tumor-Targeted Drug Discovery

(2019) Gang Liu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

(2019) Gang Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nitro-Group-Containing Drugs

(2018) Kunal Nepali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Quinoline–Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity

(2018) Wenlong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

(2017) Satoshi Mikami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Palladium-Catalyzed Formal [4 + 1] Annulation via Metal Carbene Migratory Insertion and C(sp2)–H Bond Functionalization

(2017) Shuai Xu et al.   ACS Catalysis

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Direct Activation of Bax Protein for Cancer Therapy

(2015) Zhiqing Liu et al.   MEDICINAL RESEARCH REVIEWS

Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

(2015) Núbia Boechat et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Practical olefin hydroamination with nitroarenes

(2015) J. Gui et al.   SCIENCE

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Small-molecule Bax agonists for cancer therapy

(2014) Meiguo Xin et al.   Nature Communications

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells

(2013) S. Bandarra et al.   MUTAGENESIS

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells

(2011) J. G. Valero et al.   JOURNAL OF CELL SCIENCE

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

(2011) Loren D. Walensky et al.   TRENDS IN BIOCHEMICAL SCIENCES