Article
Environmental Sciences
Yvonne Rericha, Lisa Truong, Connor Leong, Dunping Cao, Jennifer A. Field, Robyn L. Tanguay
Summary: Ubiquitous anthropogenic contaminants of concern, per- and polyfluoroalkyl substances (PFAS) are frequently detected in the environment and human populations around the world. Diet is a predominate route of human exposure, and PFAS are frequently measured in food. However, the current amount of data to support safety assessments of these alternatives is not yet sufficient. The present study investigated the effects of a 42-day dietary exposure to 1, 10, or 100 ng/g PFHxA in juvenile zebrafish. In conclusion, PFHxA exposure induced abnormal adult anxiety behaviors that persisted transgenerationally, and abnormal behavior was also observed in the F1 generation. This study highlights the need for further investigation of this and other alternative short-chain PFAS.
Article
Physiology
Melissa Faria, Marina Bellot, Oscar Soto, Eva Prats, Nicola Montemurro, Diana Manjarres, Cristian Gomez-Canela, Demetrio Raldua
Summary: The number of people with mental health problems is increasing, with anxiety and depression being the most commonly diagnosed conditions. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to treat these conditions and are commonly found in aquatic ecosystems. This study examined the effects of the SSRI Sertraline (SER) on zebrafish, and found that even environmentally relevant concentrations of SER can affect behavior and serotonin levels in the fish.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Jiawen Ji, Jinze Huang, Niannian Cao, Xianghong Hao, Yanhua Wu, Yongqiang Ma, Dong An, Sen Pang, Xuefeng Li
Summary: This study investigated the toxic effects of 6PPD and its metabolites on adult zebrafish using machine vision. Abnormal behaviors induced by 6PPD and its metabolites were observed and analyzed using meandering, body angle, top time, and 3D trajectory. Changes in neurotransmitters were also measured to explore the causes of abnormal behavior. The study provides important insights into the biological toxicity of 6PPD and its metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Bala Murali Krishna Vasamsetti, Kyongmi Chon, Chang-Young Yoon, Juyeong Kim, Ji-Yeong Choi, Sojeong Hwang, Kyeong-Hun Park
Summary: In this study, a zebrafish model was used to investigate the molecular pathways associated with the developmental toxicity of Etridiazole. The analysis of the transcriptome revealed differentially expressed genes related to sensory perception, visual perception, organ development, and visual system development, as well as involvement in various signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michael G. Morash, Kelly H. Soanes, John C. Achenbach, Lee D. Ellis
Summary: Catechol, a commonly used chemical in fragrance, pharmaceutical, and flavorant manufacturing, has limited toxicity information despite its widespread use. This study utilized a larval zebrafish toxicity assay to uncover previously unknown toxic effects of catechol, including decreased activity and damaged melanocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xixi Li, Guodong Ge, Guili Song, Qing Li, Zongbin Cui
Summary: Human obesity is a global epidemic associated with various metabolic diseases. The molecular mechanisms underlying obesity development are not yet fully understood, but this study on zebrafish models treated with high-fat diet or overfeeding diet has identified common genes and signaling pathways potentially related to obesity. These findings provide insights for understanding obesity mechanisms and developing strategies for preventing nutritionally induced obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Bala Murali Krishna Vasamsetti, Kyongmi Chon, Ji-Yeong Choi, Juyeong Kim, Chang-Young Yoon
Summary: This study examined the developmental and transcriptomic effects of thiram exposure on zebrafish embryos. The thiram-exposed embryos exhibited developmental abnormalities and differential gene expression related to reproduction. These findings provide insights into the molecular mechanisms underlying thiram toxicity in zebrafish.
Article
Environmental Sciences
Ekrem Sulukan, Alper Baran, Meryem Kankaynar, Tugba Kiziltan, Ismail Bolat, Serkan Yildirim, Hacer Akguel Ceyhun, Saltuk Bugrahan Ceyhun
Summary: The increase in temperature due to global warming affects the toxicity of pesticides in the aquatic ecosystem, particularly in terms of the sustainability of ecosystems. This study investigated the effects of parental exposure to glyphosate and temperature increase on the next generation using a zebrafish model. The results showed that the offspring exhibited lower survival rate, delayed hatching, increased body malformations, and lower blood flow and heart rate.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Developmental Biology
Allison R. Harman, Zully E. Contreras-Correa, Riley D. Messman, Rebecca M. Swanson, Caleb O. Lemley
Summary: Recent research focuses on the placental fetal brain axis, with limited information available for large animals. Melatonin supplementation is being explored as a potential therapeutic approach for fetal growth restriction. This study investigates the impact of maternal nutrient restriction and melatonin supplementation on neurotransmitter pathways in fetal blood, cotyledonary and hypothalamus tissue.
Article
Environmental Sciences
Zhongkun Du, Kaixuan Hou, Tongtong Zhou, Baihui Shi, Cheng Zhang, Lusheng Zhu, Bing Li, Jinhua Wang, Jun Wang
Summary: This study found that PHCZs cause cardiac developmental toxicity and behavioral changes in fish, while disrupting multiple pathways linked to organ development, immunization, metabolism, and protein synthesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Marine & Freshwater Biology
Zongzhe He, Liangliang Zhou, Yuting Tan, Zhen Wang, Haiyan Shi, Minghua Wang
Summary: This study investigated the toxicity, bioaccumulation, elimination, and metabolic transformation of the fungicide CPZ in zebrafish. The results showed stereoselective toxicity and rapid elimination of CPZ in zebrafish. CPZ also induced oxidative stress responses in zebrafish. Multiple metabolic pathways of CPZ in zebrafish were proposed for the first time.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Noraini Abu Bakar, Wan Norhamidah Wan Ibrahim, Che Azurahanim Che Abdullah, Nurul Farhana Ramlan, Khozirah Shaari, Shamarina Shohaimi, Ahmed Mediani, Nurrul Shaqinah Nasruddin, Cheol-Hee Kim, Siti Munirah Mohd Faudzi
Summary: This study provides new insight into the potential mechanism of arsenic toxicity leading to long-term learning impairment in zebrafish. The researchers found that exposure to arsenic trioxide (As2O3) resulted in increased mortality and various behavioral deficits in zebrafish, including motor behavior deficits and impaired color preference. The study also identified changes in gene regulation and metabolic pathways associated with the toxic effects of As2O3. These findings may be useful for future risk assessments of environmental toxins.
Article
Environmental Sciences
Xinyu Ni, Yudie Lu, Meiyu Li, Yue Liu, Miao Zhang, Fuqiang Sun, Sijun Dong, Lining Zhao
Summary: This study found that the trace element selenium (Se) can alleviate the hepatotoxicity of cadmium tellurium quantum dots (CdTe QDs) by enhancing the function of the intracellular antioxidant defense system and upregulating the expression of antioxidant selenoproteins. In addition, Se-Met can regulate apoptosis-inducing factors to reduce cell apoptosis. This study is of great importance for reducing the toxicity of CdTe QDs and expanding their applications.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Kun Zhang, Jiahui Liang, Nadja R. Brun, Yanbin Zhao, Andreas A. Werdich
Summary: A rapid zebrafish behavioral profiling assay was developed to quantify the neurodevelopmental effects of environmental substances and provide additional information. The assay successfully captured the impacts of different neuroactive substances on spontaneous movement. Additionally, the web-based tool EMAnalysis was provided to accelerate the discovery of neurotoxic environmental contaminants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Feng Yao, Miaomiao Zhao, Yaowen Du, Guoli Chang, Chuanpeng Li, Ruiyu Zhu, Chenggang Cai, Suqing Shao
Summary: This study provides transcriptome analysis and toxicological investigation of DON in the zebrafish liver and intestine, offering insights into gene expression patterns and potential detoxification pathways.
Article
Engineering, Environmental
Shuiqing He, Dan Li, Feipeng Wang, Chaoyue Zhang, Chen Yue, Yaling Huang, Lingtian Xie, Yu Ting Zhang, Jingli Mu
Summary: The study reveals that the exposure of marine organisms to a mixture of antibiotics and nanoplastics can affect the growth and gut microbiota of their offspring, with different exposure conditions leading to varying degrees of weight loss and alterations in microbial composition.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Dan Li, Weijun Sun, Hongxing Chen, Haojun Lei, Xiao Li, Hongsong Liu, Guo-yong Huang, Wen-jun Shi, Guang-Guo Ying, Yongju Luo, Lingtian Xie
Summary: The study investigated the toxicity of cyclophosphamide on zebrafish embryos, revealing the effects on malformation, mortality, swimming capacity, retina and liver tissues, and key gene expressions. Low concentrations of cyclophosphamide pose ecological risks to aquatic organisms, highlighting the need for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Jiefeng Tan, Hongxing Chen, Shanduo Chen, Junjie Hu, Xiaolan Wang, Yifan Wang, Shuling Liao, Peixian Chen, Chuyan Liang, Menglin Dai, Qianping Du, Liping Hou
Summary: Progestins and estrogens have interactive effects on the transcriptional level of the HPT axis in zebrafish embryos, with their mixtures showing higher toxicity than individual chemicals. The developmental and neurotoxic effects of Gestodene and 17 alpha-ethinylestradiol on zebrafish indicate potential risks on both the gene expression and whole organismal level.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Dimitri Van de Perre, Dan Li, Kai-Sheng Yao, Hao-Jun Lei, Paul J. Van den Brink, Guang-Guo Ying
Summary: The study evaluated the impact of Cyclophosphamide (CP) on a sub-tropical freshwater ecosystem, showing treatment-related effects on different organisms at varying concentrations of CP, indicating a potential environmental risk at relevant concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Ecology
Xinrong Wei, Xiao Li, Hongsong Liu, Haojun Lei, Weijun Sun, Dan Li, Wu Dong, Hongxing Chen, Lingtian Xie
Summary: Cadmium exposure in Daphnia magna led to increased body burden of Cd, decreased body length and weight, reduced heart rate and thoracic limb activity, disrupted oxidative stress and antioxidant system, impaired reproductive capacity, and altered gene expression related to molting and reproduction.
Article
Environmental Sciences
Yongzhuang Wang, Xiangying Peng, Liuying Lai, Hao Li, Xinying Zhang, Hongxing Chen, Lingtian Xie
Summary: Understanding the effects of different phosphorus fertilizers on cadmium uptake, root morphology, and cadmium extractability in rhizospheric soils is important for evaluating the remediation effect of cadmium-contaminated soils. This five-year field experiment found that calcium magnesium phosphate can be used as a potential amendment agent for acidic cadmium-contaminated soils cultivated with maize.
Article
Environmental Sciences
Jichen Yang, Xin Yan, Hongsong Liu, Hongxing Chen, Wei Zhang, Wu Dong, Dan Li, Lingtian Xie
Summary: This study investigates the dynamic changes of selenium speciation and concentrations in sediments, as well as the accumulation and depuration of Se(IV) and Se-Met in the oligochaete L. variegatus. The findings provide essential data for understanding the ecological risk of selenium to freshwater benthic communities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Xiuli Zhang, Jianjie Chen, Guodong Wang, Hongxing Chen, Jinling Cao, Lingtian Xie, Yongju Luo
Summary: This study found that seleno-L-methionine can alleviate liver and intestinal injury induced by fluoride in fish when co-occur at specific concentrations, and the gut-liver axis pathway may be involved in these alleviative effects.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Xinrong Wei, Xiao Li, Ping Liu, Lixia Li, Hongxing Chen, Dan Li, Juan Liu, Lingtian Xie
Summary: This study investigated the developmental toxicity of Thallium (Tl) in zebrafish embryos. The results showed that Tl exposure led to decreased hatching rate, increased malformation rate, and reduced swimming velocity in the larvae. Histopathological analysis revealed liver damage and transcriptomic analysis identified differentially expressed genes and enriched pathways related to Tl toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Xiao-Pei Li, Shu-Qing Qiu, Dong-Qiao Lei, Chen-Si Wang, Lingtian Xie, Guang-Guo Ying, Guo-Yong Huang
Summary: In this study, the ecotoxicological effects of Bisphenol 4-[1-(4-hydroxyphenyl)-3,3,5-trimethylcyclohexyl] phenol (BPTMC) on marine medaka embryos were examined. Low concentrations of BPTMC stimulated certain developmental and behavioral effects, while higher concentrations led to inflammatory response and altered heart rate and swimming velocity. BPTMC also affected the concentrations of estrogen receptors, vitellogenin, and endogenous 17 beta-estradiol, as well as transcriptional levels of estrogen responsive genes in the embryos or/and larvae.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Weijun Sun, Tianming Liu, Haojun Lei, Xinrong Wei, Lixia Li, Hongxing Chen, Lingtian Xie, Dan Li
Summary: This study elucidated the mechanisms of cyclophosphamide (CP) toxicity on Daphnia magna, identifying changes in amino acid, energy, and lipid metabolism pathways. CP not only altered behavior and reproduction in D. magna, but also affected the expression of genes associated with the nervous system and metabolism pathways.