Mammalian tolloid proteinases: role in growth factor signalling

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

(2016) Helen Troilo et al.   MATRIX BIOLOGY

Diversity between mammalian tolloid proteinases: Oligomerisation and non-catalytic domains influence activity and specificity

(2016) Christopher P. Bayley et al.   Scientific Reports

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity

(2015) H. Troilo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

(2015) Jennifer Winstanley et al.   eLife

LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation

(2015) Clementine Menz et al.   PLoS One

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

(2014) Frédéric Delolme et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils

(2014) Tadashi Inoue et al.   HUMAN MOLECULAR GENETICS

The NTR domain of procollagen C-proteinase enhancer-1 (PCPE-1) mediates PCPE-1 binding to syndecans-1, -2 and -4 as well as fibronectin

(2014) Tali Weiss et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Function of Latent TGFβ Binding Protein 4 and Fibulin 5 in Elastogenesis and Lung Development

(2014) Branka Dabovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

(2014) H. Troilo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis

(2013) Mohamed A. Sideek et al.   MATRIX BIOLOGY

Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation

(2013) J.-M. Bourhis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo

(2013) J.-L. Plouhinec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuated BMP1 Function Compromises Osteogenesis, Leading to Bone Fragility in Humans and Zebrafish

(2012) P.V. Asharani et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Matrix control of transforming growth factor-  function

(2012) M. Horiguchi et al.   JOURNAL OF BIOCHEMISTRY

B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats

(2012) Xinhua Lin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Multistep molecular mechanism for Bone morphogenetic protein extracellular transport in the Drosophila embryo

(2012) A. Sawala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta

(2011) Víctor Martínez-Glez et al.   HUMAN MUTATION

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Defining the Earliest Transcriptional Steps of Chondrogenic Progenitor Specification during the Formation of the Digits in the Embryonic Limb

(2011) Carlos I. Lorda-Diez et al.   PLoS One

Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus

(2010) Takayuki Onai et al.   DEVELOPMENTAL BIOLOGY

Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development

(2010) Vesna Todorovic et al.   DEVELOPMENTAL DYNAMICS

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity

(2010) Mourad Bekhouche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF  family signaling: novel insights in development and disease

(2009) K. Wharton et al.   DEVELOPMENT

Structural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase

(2009) Richard Berry et al.   FEBS LETTERS

Enhanced Osteoclastogenesis Causes Osteopenia in Twisted Gastrulation-Deficient Mice Through Increased BMP Signaling

(2009) Julio E Sotillo Rodriguez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of dimerization and substrate exclusion in the regulation of bone morphogenetic protein-1 and mammalian tolloid

(2009) R. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Stability of the Embryonic Axial Pattern Requires a Secreted Scaffold for Chordin Degradation

(2008) Hidehiko Inomata et al.   CELL

MT1-MMP releases latent TGF-β1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1

(2008) O TATTI et al.   EXPERIMENTAL CELL RESEARCH

Regional and cellular localisation of BMPs and their inhibitors’ expression in human fractures

(2008) Francois N. K. Kwong et al.   INTERNATIONAL ORTHOPAEDICS

Structural Basis for the Substrate Specificity of Bone Morphogenetic Protein 1/Tolloid-like Metalloproteases

(2008) A. Mac Sweeney et al.   JOURNAL OF MOLECULAR BIOLOGY

Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice

(2008) Makoto Ikeya et al.   MECHANISMS OF DEVELOPMENT

Scaling of the BMP activation gradient in Xenopus embryos

(2008) Danny Ben-Zvi et al.   NATURE

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY