A central role for phosphatidic acid as a lipid mediator of regulated exocytosis in apicomplexa

Review: Progresses in understanding N-ethylmaleimide sensitive factor (NSF) mediated disassembly of SNARE complexes

(2016) Je-Kyung Ryu et al.   BIOPOLYMERS

Phosphatidic Acid-Mediated Signaling Regulates Microneme Secretion in Toxoplasma

(2016) Hayley E. Bullen et al.   Cell Host & Microbe

Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion inToxoplasma gondii

(2016) Kevin M. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant phospholipases D and C and their diverse functions in stress responses

(2016) Yueyun Hong et al.   PROGRESS IN LIPID RESEARCH

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

(2016) Hana L. Goldschmidt et al.   Cell Reports

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

(2015) Brittany L. Howard et al.   ACS Chemical Biology

Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket

(2015) Ramya Ganesan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The calcium signaling toolkit of the Apicomplexan parasites Toxoplasma gondii and Plasmodium spp

(2015) Sebastian Lourido et al.   CELL CALCIUM

ADP Ribosylation Factor 6 (ARF6) Promotes Acrosomal Exocytosis by Modulating Lipid Turnover and Rab3A Activation

(2015) Leonardo E. Pelletán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gliding motility in apicomplexan parasites

(2015) Matthew B. Heintzelman   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

(2015) Pedro Torres-Ayuso et al.   Oncotarget

Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca2+ influxes

(2014) Megumi Sakuma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress ofPlasmodium falciparumgametocytes

(2014) Christine C. Wirth et al.   CELLULAR MICROBIOLOGY

Plasmodium falciparum double C2 domain protein, PfDOC2, binds to calcium when associated with membranes

(2014) Sophonie Jean et al.   EXPERIMENTAL PARASITOLOGY

Live-cell imaging of phosphatidic acid dynamics in pollen tubes visualized by Spo20p-derived biosensor

(2014) Martin Potocký et al.   NEW PHYTOLOGIST

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity

(2014) Marijo S. Roiko et al.   PLoS Pathogens

A perforin-like protein mediates disruption of the erythrocyte membrane during egress ofPlasmodium bergheimale gametocytes

(2013) Elena Deligianni et al.   CELLULAR MICROBIOLOGY

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

(2013) F. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method

(2013) Mayu Sato et al.   PHARMACOLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites

(2013) Swati Garg et al.   Nature Communications

Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase

(2013) Steven A. Arisz et al.   Frontiers in Plant Science

Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function

(2013) Sruti Krishna et al.   Frontiers in Immunology

Lipid metabolism in Drosophila: development and disease

(2012) Z. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate

(2012) Cecilia I. Lopez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Distinct signalling pathways controlToxoplasmaegress and host-cell invasion

(2012) Sebastian Lourido et al.   EMBO JOURNAL

Generation of second messengers in Plasmodium

(2012) Alexandre Budu et al.   MICROBES AND INFECTION

A DOC2 Protein Identified by Mutational Profiling Is Essential for Apicomplexan Parasite Exocytosis

(2012) A. Farrell et al.   SCIENCE

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma

(2012) Erin Garrison et al.   PLoS Pathogens

TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells

(2012) James M. McCoy et al.   PLoS Pathogens

The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses

(2011) K. Schwarz et al.   JOURNAL OF NEUROSCIENCE

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(2011) Neil Holden et al.   MOLECULAR MEDICINE

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

Plant PA signaling via diacylglycerol kinase

(2009) Steven A. Arisz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

(2009) Jana A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity

(2009) Robert Lavieri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

(2009) Wenjuan Su et al.   Future Oncology

ARF6 Regulates the Synthesis of Fusogenic Lipids for Calcium-regulated Exocytosis in Neuroendocrine Cells

(2009) Aurélie Béglé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function

(2008) Jaclyn S. Long et al.   BIOCHEMICAL JOURNAL

5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis

(2008) W. Su et al.   MOLECULAR PHARMACOLOGY

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

(2008) B. F. C. Kafsack et al.   SCIENCE