标题
The detection and characterization of pleiotropy: discovery, progress, and promise
作者
关键词
-
出版物
BRIEFINGS IN BIOINFORMATICS
Volume 17, Issue 1, Pages 13-22
出版商
Oxford University Press (OUP)
发表日期
2016-01-20
DOI
10.1093/bib/bbv050
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?
- (2014) Chi Hua Sarah Lin et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies
- (2014) Catherine A McCarty et al. BMC Medical Genomics
- PhenX RISING: real world implementation and sharing of PhenX measures
- (2014) Catherine A McCarty et al. BMC Medical Genomics
- Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: The Population Architecture using Genomics and Epidemiology Study
- (2014) S. L. Park et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia
- (2014) Veronica Wendy Setiawan et al. CARCINOGENESIS
- Analysis of Metabolic Syndrome Components in >15 000 African Americans Identifies Pleiotropic Variants: Results From the Population Architecture Using Genomics and Epidemiology Study
- (2014) C. L. Carty et al. Circulation-Cardiovascular Genetics
- Data compatibility in the addiction sciences: An examination of measure commonality
- (2014) Kevin P. Conway et al. DRUG AND ALCOHOL DEPENDENCE
- Phenome-wide association studies (PheWASs) for functional variants
- (2014) Zhan Ye et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- A genetic interaction network model of a complex neurological disease
- (2014) A. L. Tyler et al. GENES BRAIN AND BEHAVIOR
- Estimating and Testing Pleiotropy of Single Genetic Variant for Two Quantitative Traits
- (2014) Qunyuan Zhang et al. GENETIC EPIDEMIOLOGY
- The Nature and Extent of Mutational Pleiotropy in Gene Expression of Male Drosophila serrata
- (2014) K. McGuigan et al. GENETICS
- Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia
- (2014) S. Lani Park et al. JNCI-Journal of the National Cancer Institute
- Pleiotropic genes for metabolic syndrome and inflammation
- (2014) Aldi T. Kraja et al. MOLECULAR GENETICS AND METABOLISM
- Pleiotropy of Cancer Susceptibility Variants on the Risk of Non-Hodgkin Lymphoma: The PAGE Consortium
- (2014) Unhee Lim et al. PLoS One
- Canonical Correlation Analysis for Gene-Based Pleiotropy Discovery
- (2014) Jose A. Seoane et al. PLoS Computational Biology
- Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
- (2014) Molly A. Hall et al. PLoS Genetics
- The multiscale backbone of the human phenotype network based on biological pathways
- (2014) Christian Darabos et al. BioData Mining
- Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies
- (2014) Sabrina L Mitchell et al. BioData Mining
- Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss
- (2014) Larry J. Leamy et al. PeerJ
- eMERGEing progress in genomics—the first seven years
- (2014) Dana C. Crawford et al. Frontiers in Genetics
- Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis
- (2014) Bahram Namjou et al. Frontiers in Genetics
- Genome-wide modeling of complex phenotypes in Caenorhabditis elegans and Drosophila melanogaster
- (2013) Supriyo De et al. BMC GENOMICS
- Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes
- (2013) Jacqueline K. White et al. CELL
- Genome- and Phenome-Wide Analyses of Cardiac Conduction Identifies Markers of Arrhythmia Risk
- (2013) Marylyn D. Ritchie et al. CIRCULATION
- Putting Pleiotropy and Selection Into Context Defines a New Paradigm for Interpreting Genetic Data
- (2013) Irene M. Predazzi et al. Circulation-Cardiovascular Genetics
- A PheWAS approach in studying HLA-DRB1*1501
- (2013) S J Hebbring et al. GENES AND IMMUNITY
- Genome-wide association mapping of natural variation in odour-guided behaviour inDrosophila
- (2013) E. B. Brown et al. GENES BRAIN AND BEHAVIOR
- A General Framework for Association Tests With Multivariate Traits in Large-Scale Genomics Studies
- (2013) Qianchuan He et al. GENETIC EPIDEMIOLOGY
- Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia
- (2013) Iona Cheng et al. GUT
- A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
- (2013) Khader Shameer et al. HUMAN GENETICS
- Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities
- (2013) Weili Li et al. HUMAN GENETICS
- Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
- (2013) Joshua C Denny et al. NATURE BIOTECHNOLOGY
- Pleiotropy in complex traits: challenges and strategies
- (2013) Nadia Solovieff et al. NATURE REVIEWS GENETICS
- Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals
- (2013) Monika Reissmann et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Multi-trait and multi-environment QTL analyses of yield and a set of physiological traits in pepper
- (2013) N. A. Alimi et al. THEORETICAL AND APPLIED GENETICS
- CAPE: An R Package for Combined Analysis of Pleiotropy and Epistasis
- (2013) Anna L. Tyler et al. PLoS Computational Biology
- Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
- (2013) Sarah A. Pendergrass et al. PLoS Genetics
- Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls
- (2012) Katherine P. Liao et al. ARTHRITIS AND RHEUMATISM
- Exploring the human diseasome: the human disease network
- (2012) K.-I. Goh et al. Briefings in Functional Genomics
- Abstract 4352: Systemic levels of neuropeptide Y are elevated in Ewing's sarcoma patients
- (2012) Jason U. Tilan et al. CANCER RESEARCH
- Using PhenX measures to identify opportunities for cross-study analysis
- (2012) Huaqin Pan et al. HUMAN MUTATION
- Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk?
- (2012) Omri Gottesman et al. PLoS One
- Use of Pleiotropy to Model Genetic Interactions in a Population
- (2012) Gregory W. Carter et al. PLoS Genetics
- The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study
- (2011) Tara C. Matise et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Variants Near FOXE1 Are Associated with Hypothyroidism and Other Thyroid Conditions: Using Electronic Medical Records for Genome- and Phenome-wide Studies
- (2011) Joshua C. Denny et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test
- (2011) Michael C. Wu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Abundant Pleiotropy in Human Complex Diseases and Traits
- (2011) Shanya Sivakumaran et al. AMERICAN JOURNAL OF HUMAN GENETICS
- PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies
- (2011) Jie Huang et al. BIOINFORMATICS
- The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery
- (2011) S.A. Pendergrass et al. GENETIC EPIDEMIOLOGY
- New IBD genetics: common pathways with other diseases
- (2011) C. W. Lees et al. GUT
- Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
- (2011) Yukinori Okada et al. HUMAN MOLECULAR GENETICS
- The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
- (2011) Günter P. Wagner et al. NATURE REVIEWS GENETICS
- A Knock-In Mouse Model for the R120G Mutation of αB-Crystallin Recapitulates Human Hereditary Myopathy and Cataracts
- (2011) Usha P. Andley et al. PLoS One
- PhenX: a toolkit for interdisciplinary genetics research
- (2010) Patrick J Stover et al. CURRENT OPINION IN LIPIDOLOGY
- One Hundred Years of Pleiotropy: A Retrospective
- (2010) F. W. Stearns GENETICS
- Clinical assessment incorporating a personal genome
- (2010) Euan A Ashley et al. LANCET
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Phenomics: the next challenge
- (2010) David Houle et al. NATURE REVIEWS GENETICS
- Genomic patterns of pleiotropy and the evolution of complexity
- (2010) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Shadows of complexity: what biological networks reveal about epistasis and pleiotropy
- (2009) Anna L. Tyler et al. BIOESSAYS
- Identifying disease associations via genome-wide association studies
- (2009) Wenhui Huang et al. BMC BIOINFORMATICS
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A multivariate test of association
- (2008) Manuel A. R. Ferreira et al. BIOINFORMATICS
- Detecting shared pathogenesis from the shared genetics of immune-related diseases
- (2008) Alexandra Zhernakova et al. NATURE REVIEWS GENETICS
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