STK25 is a critical determinant in nonalcoholic steatohepatitis

Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model

(2015) Manoj Amrutkar et al.   DIABETES

Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans

(2015) Manoj Amrutkar et al.   DIABETOLOGIA

Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH

(2015) Manoj Amrutkar et al.   FASEB JOURNAL

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

(2014) Zoon Tariq et al.   LIVER INTERNATIONAL

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

(2014) Ligong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

(2013) Peter H. Sugden et al.   BIOCHEMICAL JOURNAL

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet

(2013) Emmelie Cansby et al.   FASEB JOURNAL

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Hepatic-specific activation of peroxisome proliferator-activated receptor γ coactivator-1β protects against steatohepatitis

(2013) Elena Bellafante et al.   HEPATOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models

(2013) Stephanie Coulon et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease

(2013) James L. McManaman et al.   JOURNAL OF LIPID RESEARCH

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration

(2013) Tohru Matsuki et al.   Neural Development

PNPLA3 I148M polymorphism and progressive liver disease

(2013) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

The innate immune response to products of phospholipid peroxidation

(2012) David Weismann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Translocator protein (18kDa), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease

(2012) Lin Xie et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

(2011) Felix Heymann et al.   HEPATOLOGY

NASH animal models: Are we there yet?

(2011) Rohit Kohli et al.   JOURNAL OF HEPATOLOGY

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

(2010) Nitika Arora Gupta et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Liver-Specific β-Catenin Knockout Mice Exhibit Defective Bile Acid and Cholesterol Homeostasis and Increased Susceptibility to Diet-Induced Steatohepatitis

(2009) Jaideep Behari et al.   AMERICAN JOURNAL OF PATHOLOGY

Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis

(2009) Stephen H. Caldwell et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY