Review
Cell Biology
Ling Chen, Mingxia Bi, Zhen Zhang, Xixun Du, Xi Chen, Qian Jiao, Hong Jiang
Summary: IRE1 alpha is a protein that resides in the endoplasmic reticulum and acts as a sensor for ER stress. It plays important roles in maintaining protein homeostasis and regulating various cellular processes. In addition, IRE1 alpha is crucial in neurodegenerative diseases, making it a potential target for treatment.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Roberta Gonnella, Maria Saveria Gilardini Montani, Luisa Guttieri, Maria Anele Romeo, Roberta Santarelli, Mara Cirone
Summary: This study demonstrates the crucial role of the IRE1α/XBP1 axis in the survival of PEL cells, with minor influence from PERK and ATF6, and the ability of the IRE1α/XBP1 axis to induce the release of IL-6, IL-10, and VEGF. Additionally, IRE1α/XBP1 inhibition reduces STAT3 phosphorylation and induces pro-survival autophagy in PEL cells, suggesting that targeting this axis may be a promising strategy against PEL cells.
Article
Cell Biology
Zhe Li, Tong Xu, Lin Peng, Xinyu Tang, Qianru Chi, Ming Li, Shu Li
Summary: Nanoplastics pollution poses a huge threat to the ecosystem, and this study found that polystyrene nanoplastics can aggravate lipopolysaccharide-induced renal cell apoptosis through oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Virology
Anna Shishova, Ilya Dyugay, Ksenia Fominykh, Victoria Baryshnikova, Alena Dereventsova, Yuriy Turchenko, Anna A. Slavokhotova, Yury Ivin, Sergey E. Dmitriev, Anatoly Gmyl
Summary: The study demonstrates that enteroviruses actively modulate the host defensive pathway by inducing phosphorylation and proteolytic cleavage of the ER stress sensor Ire1, as well as down-regulating its splicing activity. Inactivation of Ire1 could be a novel mode of the UPR manipulation employed by viruses to modify the ER stress response in infected cells.
Article
Food Science & Technology
Su Been Park, Gun Hee Cho, Young Eun Park, Hyang Sook Chun
Summary: Emodin induces endoplasmic reticulum stress and apoptosis in HepG2 cells, suggesting its potential hepatotoxicity.
Article
Multidisciplinary Sciences
Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cecile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi
Summary: IRE1, an enzyme essential for the unfolded-protein response (UPR), plays a crucial role in mitigating endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved endomotif sequence via regulated IRE1-dependent decay (RIDD). The authors also identify a more promiscuous IRE1 activity called RIDD lacking endomotif (RIDDLE) in human cells, shedding light on the mechanisms of UPR.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Anirban Roy, Meiricris Tomaz da Silva, Raksha Bhat, Kyle R. Bohnert, Takao Iwawaki, Ashok Kumar
Summary: IRE1 alpha, along with its downstream target XBP1, play a crucial role in regulating skeletal muscle regeneration by promoting proliferation of satellite cells. The ablation of IRE1 alpha diminishes Notch signaling and canonical NF-kappa B pathway, leading to reduced satellite cell abundance and impaired muscle regeneration in both normal and Duchenne muscular dystrophy models.
Article
Multidisciplinary Sciences
Aparajita Madhavan, Bernard P. Kok, Bibiana Rius, Julia M. D. Grandjean, Adekunle Alabi, Verena Albert, Ara Sukiasyan, Evan T. Powers, Andrea Galmozzi, Enrique Saez, R. Luke Wiseman
Summary: Signaling through the IRE1 arm of the unfolded protein response has both protective and harmful effects in obesity. A selective pharmacological activator of IRE1/XBP1s signaling can stimulate adaptive remodeling in the liver and pancreas, and mitigate obesity-linked metabolic dysfunction. The activator improves systemic glucose metabolism, liver insulin action, and enhances pancreatic function.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Silvia Gomez-Puerta, Roberto Ferrero, Tobias Hochstoeger, Ivan Zubiri, Jeffrey Chao, Tomas Aragon, Franka Voigt
Summary: This study reveals the role of IRE1α oligomers in the splicing of XBP1 mRNA and uncovers the mechanism underlying the association of XBP1 mRNA with the ER membrane. The findings provide valuable insights into the regulation of the unfolded protein response pathway.
Article
Oncology
Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Daisuke Kubota, Keisuke Akaike, Taketo Okubo, Takuo Hayashi, Tatsuya Takagi, Takashi Yao, Muneaki Ishijima, Yoshiyuki Suehara
Summary: Based on the investigation of ER stress activities in osteosarcoma (OS) cells, inhibition of the IRE1 alpha-XBP1 pathway is expected to be a promising new target for OS treatment, with potential significance in improving therapeutic outcomes.
Article
Multidisciplinary Sciences
Jia Li, Jingzhen Zhu, Xinliang Yang, Bishao Sun, Xin Luo, Ji Zheng, Zhenqiang Fang
Summary: This study focuses on the therapeutic effect of endoplasmic reticulum stress and autophagy on protamine/lipopolysaccharide-induced interstitial cystitis. The results show that the endoplasmic reticulum stress inhibitor 4-PBA can alleviate the inflammatory response, inhibit apoptosis, and improve bladder micturition function.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Sylwia Bartoszewska, Jakub Slawski, James F. Collawn, Rafal Bartoszewski
Summary: The unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions, and cancer cells exploit this pathway to avoid cell death. One specific pathway activated during UPR is the inositol-requiring enzyme 1a (IRE1) pathway, which is associated with cell fate decisions and has potential as a cancer therapeutic target. This article discusses different UPR signaling pathways and focuses on IRE1 inhibitors as a potential effective cancer treatment.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Neurosciences
Helike Lohelaid, Jenni E. Anttila, Hock-Kean Liew, Kuan-Yin Tseng, Jaakko Teppo, Vassilis Stratoulias, Mikko Airavaara
Summary: Stroke is a devastating medical condition with no current treatment to hasten recovery. Boosting endogenous pro-survival pathways through the unfolded protein response (UPR) may provide a potential strategy to improve stroke outcomes, with mesencephalic astrocyte-derived neurotrophic factor (MANF) being identified as a promising UPR responsive gene with neuroprotective effects.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Microbiology
Jessica M. Oda, Andreas B. den Hartigh, Shoen M. Jackson, Ana R. Tronco, Susan L. Fink
Summary: The cellular processes and host factors that are important for human coronavirus replication and severe disease are not fully understood. This study demonstrates that IRE1a and XBP1 play crucial roles in the replication of human coronaviruses and that ER stress promotes viral replication. Moreover, elevated levels of XBP1 are found in COVID-19 patients.
Article
Biochemistry & Molecular Biology
Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang
Summary: This study reveals that excessive ER Ca2+ can directly activate the IRE1a-XBP1 pathway, and inhibition of over-activated IRE1a-XBP1 signaling in TMCO1-deficient cells can lead to significant cell death.
CELL AND BIOSCIENCE
(2023)
Article
Immunology
Teresa C. Calegari-Silva, Aislan C. Vivarini, Renata de M. S. Pereira, Karina L. Dias-Teixeira, Carolina T. Rath, Amanda S. S. Pacheco, Gabrielle B. L. Silva, Charlene A. S. Pinto, Jose V. dos Santos, Alessandra M. Saliba, Carlos E. P. Corbett, Claudia M. de Castro Gomes, Nicolas Fasel, Ulisses G. Lopes
EUROPEAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Bruna T. Dias, Karina Luisa Dias-Teixeira, Joseane P. Godinho, Marilia S. Faria, Teresa Calegari-Silva, Maowia M. Mukhtar, Ulisses Lopes, Jeremy C. Mottram, Ana Paula C. A. Lima
Article
Infectious Diseases
Carolina Torturella Rath, Laila Castro Schnellrath, Clarissa R. Damaso, Luciana Barros de Arruda, Pedro Fernando da Costa Vasconcelos, Claudia Gomes, Marcia Dalastra Laurenti, Teresa Cristina Calegari Silva, Aislan de Carvalho Vivarini, Nicolas Fasel, Renata Meirelles Santos Pereira, Ulisses Gazos Lopes
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Chemistry, Medicinal
Qingwen Zhang, Ronghui Du, Guilherme Rodrigo Reis Monteiro dos Santos, Revital Yefidoff-Freedman, Andrew Bohm, Jose Halperin, Michael Chorev, Bertal H. Aktas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Editorial Material
Pathology
Karina Dias-Teixeira
AMERICAN JOURNAL OF PATHOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Guilherme dos Santos, Ana Leite, Noelia Lander, Miguel Chiurillo, Roberto Docampo, Anibal Vercesi
Article
Biochemistry & Molecular Biology
Georgi A. Georgiev, Mohammad Sharifian Gh, Jeff Romano, Karina L. Dias Teixeira, Craig Struble, Denise S. Ryan, Rose K. Sia, Jay P. Kitt, Joel M. Harris, Ku-Lung Hsu, Adam Libby, Marc G. Odrich, Tatiana Suarez, Robert L. McKown, Gordon W. Laurie
Summary: Complex lipids enriched with proteins at air/liquid interfaces reduce surface tension, maintaining the stability of the tear film on the eyes. Dry eye disease, affecting 7 to 10% of individuals globally, may be caused by alterations in specific proteome and lipidome, leading to incomplete processing of the protein lacritin's C-terminus and subsequent loss of tear stability. The turnover of lacritin proteoforms in tears can restore stability and prevent collapse of the tear film, demonstrating a natural slow release mechanism for maintaining epithelial homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tiago R. Figueira, Annelise Francisco, Juliana A. Ronchi, Guilherme R. R. M. dos Santos, William dos Santos, Jason R. Treberg, Roger F. Castilho
Summary: The study demonstrates that NNT plays a crucial role in supporting the removal of H2O2 in skeletal muscle mitochondria. The absence of NNT can be compensated by other NADP(+)-reducing enzymes, maintaining the elimination of H2O2.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Guilherme Rodrigo R. M. Dos Santos, Ana Catarina Rezende Leite, Noelia Lander, Miguel Angel Chiurillo, Anibal Eugenio Vercesi, Roberto Docampo
Summary: Letm1 is crucial for mitochondrial Ca2+ uptake and release in Trypanosoma cruzi, affecting growth, metabolism, and cell viability.
Article
Immunology
Nubia Carolina Manchola Varon, Guilherme Rodrigo R. M. dos Santos, Walter Colli, Maria Julia M. Alves
Summary: The interaction between Trypanosoma cruzi and mammalian cells involves adhesion to the extracellular matrix (ECM) and an early phase of calcium signaling. The increase in intracellular calcium concentration during this interaction depends on Ca2+ uptake from the medium and is crucial for host cell invasion. The mitochondrion plays a significant role in Ca2+ homeostasis in Trypomastigotes during their interaction with ECM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Karina Dias Teixeira, Mazhar Adli, John Doench, Gordon W. Laurie
Meeting Abstract
Ophthalmology
Karina Luiza Dias Teixeira, Jeff Romano, Gordon W. Laurie
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Karina Luiza Dias Teixeira, John Doench, Gordon W. Laurie
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Ophthalmology
Gordon W. Laurie, Jeff Romano, Leran Mao, Karina Luiza Dias Teixeira, Robert L. McKown, Denise Ryan, Bruce Rivers
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Karina Luiza Dias Teixeira, Leran Mao, John Doench, Gordon W. Laurie