Article
Gastroenterology & Hepatology
Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E. Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M. Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Haeussinger, Jan Pfeiffenberger, Peter R. Galle, Anett Schmiedeknecht, Thomas Berg
Summary: In this multicenter controlled trial, G-CSF did not show significant beneficial effects on ACLF patients compared to standard medical therapy alone. The study was terminated prematurely due to futility after analysis. Therefore, G-CSF should not be recommended as a standard treatment for ACLF.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell & Tissue Engineering
Yahaira Naaldijk, Lauren S. Sherman, Natalia Turrini, Yannick Kenfack, Mariusz Z. Ratajczak, Nizar Souayah, Pranela Rameshwar, Henning Ulrich
Summary: Neurodegenerative diseases continue to be a significant healthcare problem, and their association with neuroinflammation is well recognized. This study investigated the role of mesenchymal stem cells (MSC) in modulating activated microglial cells through exosome release. The findings suggest that MSC-induced exosomes can suppress the inflammatory response of M1 macrophages while promoting a more balanced inflammation in M2 macrophages. This insight into the potential of MSCs for tissue regeneration and neuroinflammation is valuable.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Multidisciplinary Sciences
Chang-Yeon Kim, Namkyun Kim, Jae-Hyung Roh
Summary: This study investigated the relationship between NAFLD and the incidence of venous thromboembolism (VTE) in Korea. The study found that FLI was associated with VTE risk, with higher FLI values correlating with higher incidence of VTE.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Maria Effenberger, Anissa A. Widjaja, Felix Grabherr, Benedikt Schaefer, Christoph Grander, Lisa Mayr, Julian Schwaerzler, Barbara Enrich, Patrizia Moser, Julia Fink, Alisa Pedrini, Nikolai Jaschke, Alexander Kirchmair, Alexandra Pfister, Bela Hausmann, Reto Bale, Daniel Putzer, Heinz Zoller, Sebastian Schafer, Petra Pjevac, Zlatko Trajanoski, Georg Oberhuber, Timon Adolph, Stuart Cook, Herbert Tilg
Summary: This study found that IL-11 plays a crucial role in the pathogenesis of alcoholic liver disease and could serve as an independent prognostic factor for transplant-free survival. Blocking IL-11 signaling might be a therapeutic option in alcoholic liver disease, particularly alcoholic hepatitis.
Review
Gastroenterology & Hepatology
Thierry Gustot, Vanessa Stadlbauer, Wim Laleman, Carlo Alessandria, Mark Thursz
Summary: The transition from compensated to decompensated cirrhosis is a critical point in the probability of patient survival, influenced by a complex interplay of factors. As cirrhosis progresses, patients accumulate multiple disorders, predisposing them to decompensation, which is triggered by precipitating events leading to acute decompensation like ascites, hepatic encephalopathy, variceal bleeding, and jaundice.
JOURNAL OF HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Thit Mynster Kronborg, Henriette Ytting, Lise Hobolth, Soren Moller, Nina Kimer
Summary: Liver cirrhosis is a serious disease with increasing prevalence worldwide. Current treatment is only symptomatic without a cure for the chronic inflammation. Various potential healing drugs have been suggested in the literature, particularly in rodent studies, with a need for human trials to confirm findings.
FRONTIERS IN MEDICINE
(2021)
Article
Cell & Tissue Engineering
Rosanna Di Tinco, Giulia Bertani, Alessandra Pisciotta, Laura Bertoni, Elisa Pignatti, Monia Maccaferri, Jessika Bertacchini, Paola Sena, Antonio Vallarola, Rossella Tupler, Stefania Croci, Martina Bonacini, Carlo Salvarani, Gianluca Carnevale
Summary: The study showed that DPSCs can regulate the inflammatory process by activating the PD-L1 pathway in response to inflammatory stimuli, reducing pro-inflammatory cytokines in pre-activated T lymphocytes. Their immunomodulatory/anti-inflammatory properties are closely related to their stemness status, highlighting the importance of communication with the inflammatory microenvironment.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Danielle Adebayo, Florence Wong
Summary: Hepatorenal syndrome is a complication of liver cirrhosis and ascites caused by various pathogenetic mechanisms. It is characterized by hemodynamic changes, renal dysfunction, and inflammation. The presence of cardiac dysfunction, intra-abdominal pressure, and other factors contribute to the development of renal dysfunction. Future developments in the field include the use of metabolomics for early diagnosis and treatment strategies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Economics
Sumi Cho, Doori Kim, Sang-Ho Lee
Summary: The study finds that free licensing strategies lead to greater privatization and welfare, while the interaction between foreign and public licensors in free licensing depends on passive ownership and technology gap.
ECONOMIC MODELLING
(2022)
Review
Immunology
Leticia Munoz, Esther Caparros, Agustin Albillos, Ruben Frances
Summary: Cirrhosis is the end-stage of chronic liver diseases and is characterized by altered bile acids metabolism, increased blood-brain barrier permeability, and dysbiosis of intestinal microbiota. These changes disrupt gut immunity, leading to liver disease progression. This review focuses on the contribution of liver and brain metabolites in shaping intestinal immune status and discusses therapeutic approaches targeting intestinal homeostasis in cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Candelaria Martin-Gonzalez, Elisa Espelosin-Ortega, Pedro Abreu-Gonzalez, Camino Fernandez-Rodriguez, Victor Eugenio Vera-Delgado, Lourdes Gonzalez-Navarrete, Alen Garcia-Rodriguez, Antonio Martinez Riera, Emilio Gonzalez-Reimers
Summary: This study found that in alcoholic liver disease, the levels of Klotho increase and are related to serum levels of inflammatory markers and mortality.
Article
Hematology
Ellen G. Driever, Marta Magaz, Jelle Adelmeijer, Fanny Turon, Anna Baiges, Pol Olivas, Valeria Perez-Campuzano, Virginia Hernandez-Gea, Annabel Blasi, Juan-Carlos Garcia-Pagan, Ton Lisman
Summary: This study aimed to determine whether the portal vein (PV) has specific proinflammatory/hypercoagulable characteristics by comparing plasma sampled in the PV, hepatic vein (HV), and the systemic circulation. The results showed that although there were slightly higher levels of inflammatory markers in the PV, there was no clear proinflammatory or prothrombotic environment in the PV of cirrhotic patients. Multiple markers were found to be lower in the HV compared to the PV and systemic circulation, indicating that the liver plays a role in the clearance of these markers.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Maria Belen Sanchez-Rodriguez, Erica Tellez, Mireia Casulleras, Francesc E. Borras, Vicente Arroyo, Joan Claria, Maria-Rosa Sarrias
Summary: This study analyzed the macrophage anti-inflammatory protein CD5L in the plasma extracellular vesicles (EVs) of patients with acute-on chronic liver failure (ACLF) and its relationship with lipid mediators. The circulating EV contents in ACLF were significantly altered, leading to a loss of anti-inflammatory and pro-resolving molecules involved in the control of acute inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Takayuki Kondo, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Sadahisa Ogasawara, Yoshihiko Ooka, Shingo Nakamoto, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Satoshi Kuboki, Masayuki Ohtsuka, Naoya Kato
Summary: Organ failure in patients with acute decompensation is a defining characteristic of acute-on-chronic liver failure. The occurrence of acute decompensation is closely related to prognosis, regardless of cirrhosis and HCC stage, with early-onset having a negative impact. Surgical resection may have a positive impact on AD incidence in intermediate-advanced-stage HCC patients, while renal impairment is predictive of AD development after systemic therapy for HCC.
Review
Pharmacology & Pharmacy
Virender Kumar, Xiaofei Xin, Jingyi Ma, Chalet Tan, Natalia Osna, Ram I. Mahato
Summary: Type 2 diabetes mellitus associated non-alcoholic fatty liver disease is the fourth leading cause of death, with complications such as nephropathy and cirrhosis. Etiological factors involve hyperglycemia and insulin resistance, with treatment targets including FFA homeostasis and lipid metabolism. Strategies to enhance drug delivery to specific liver cell types have the potential to improve efficacy and reduce off-target effects.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Eduardo Vilar-Gomez, Raj Vuppalanchi, Andrea Mladenovic, Niharika Samala, Samer Gawrieh, Phil N. Newsome, Naga Chalasani
Summary: The prevalence of high-risk NASH in the US population is estimated to be at least 2 million adults. Among them, the prevalence of high-risk NASH in individuals with metabolic syndrome is 3.4%, while it ranges between 8.7% and 22.5% in individuals with type 2 diabetes mellitus. These findings support the need for coordinated case-finding and management.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Arun J. Sanyal, Julie Foucquier, Zobair M. Younossi, Stephen A. Harrison, Philip N. Newsome, Wah-Kheong Chan, Yusuf Yilmaz, Victor De Ledinghen, Charlotte Costentin, Ming-Hua Zheng, Vincent Wai-Sun Wong, Magdy Elkhashab, Ryan S. Huss, Robert P. Myers, Marine Roux, Aymeric Labourdette, Marie Destro, Celine Fournier-Poizat, Veronique Miette, Laurent Sandrin, Jerome Boursier
Summary: This study aims to develop and validate two new scoring systems (Agile 4 and Agile 3+) to accurately identify cirrhosis or advanced fibrosis among individuals with non-alcoholic fatty liver disease (NAFLD) attending liver clinics. The results showed that these two novel non-invasive scores outperformed existing scoring systems in identifying cirrhosis or advanced fibrosis and reduced the need for liver biopsy.
JOURNAL OF HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Julia Ast, Daniela Nasteska, Nicholas H. F. Fine, Daniel J. Nieves, Zsombor Koszegi, Yann Lanoiselee, Federica Cuozzo, Katrina Viloria, Andrea Bacon, Nguyet T. Luu, Philip N. Newsome, Davide Calebiro, Dylan M. Owen, Johannes Broichhagen, David J. Hodson
Summary: The authors generated mice with an enzyme self-label genome-edited into the endogenous glucagon-like peptide-1 receptor locus, designed fluorescent dyes for specific labeling in complex tissue, and revealed the localization, organization, and dynamics of endogenous GLP1R in cells and tissue. These results not only demonstrate the utility of enzyme self-labels for visualization and interrogation of endogenous proteins, but also provide insights into the biology of class B GPCRs.
NATURE COMMUNICATIONS
(2023)
Correction
Public, Environmental & Occupational Health
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Nuria Fabrellas, Llorenc Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Joern M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernandez, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adria Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Soenke Detlefsen, Pere Toran, Guillem Pera, Celine Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falco, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Gines
Editorial Material
Gastroenterology & Hepatology
Neeraj Bhala, James W. Ferguson, Neil Rajoriya, Philip N. Newsome
Review
Cell & Tissue Engineering
Sheeba Khan, Sara Mahgoub, Nada Fallatah, Patricia F. Lalor, Philip N. Newsome
Summary: The limited availability of liver organs for transplantation has led to the exploration of alternative therapies, such as mesenchymal stromal cells (MSCs), which have anti-inflammatory and immunomodulatory properties. There is encouraging efficacy and safety data from clinical studies, but standardized protocols and further research are needed. The use of MSC-derived extracellular vesicles as an alternative to MSCs is also being investigated.
Article
Gastroenterology & Hepatology
Rohit Loomba, Manal F. Abdelmalek, Matthew J. Armstrong, Maximilian Jara, Mette Skalshoi Kjaer, Niels Krarup, Eric Lawitz, Vlad Ratziu, Arun J. Sanyal, Jorn M. Schattenberg, Philip N. Newsome
Summary: The efficacy and safety of the glucagon-like peptide-1 analogue semaglutide in patients with NASH and compensated cirrhosis were investigated in this study. The results showed that semaglutide did not significantly improve fibrosis or achieve NASH resolution. The importance of this study lies in providing insights into the effects of this medication in NASH and compensated cirrhosis.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ferenc E. Mozes, Jenny A. Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E. Stauber, Adriaan G. Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jerome Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupsor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbold, Thomas Karlas, Johannes Wiegand, Giada Sebastiani, Emmanuel Tsochatzis, Antonio Liguori, Masato Yoneda, Atsushi Nakajima, Hannes Hagstrom, Camilla Akbari, Masashi Hirooka, Wah-Kheong Chan, Sanjiv Mahadeva, Ruveena Rajaram, Ming-Hua Zheng, Jacob George, Mohammed Eslam, Salvatore Petta, Grazia Pennisi, Mauro Vigano, Sofia Ridolfo, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Dae Ho Lee, Mattias Ekstedt, Patrik Nasr, Christophe Cassinotto, Victor de Ledinghen, Annalisa Berzigotti, Yuly P. Mendoza, Mazen Noureddin, Emily Truong, Celine Fournier-Poizat, Andreas Geier, Miljen Martic, Theresa Tuthill, Quentin M. Anstee, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Non-invasive tests show comparable prognostic performance to histologically assessed fibrosis in predicting clinical outcomes in NAFLD patients, suggesting they could be considered as alternatives to liver biopsy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Francesco Cosentino, Subodh Verma, Philip Ambery, Marianne Bach Treppendahl, Martin van Eickels, Stefan D. Anker, Michele Cecchini, Paola Fioretto, Per-Henrik Groop, David Hess, Kamlesh Khunti, Carolyn S. P. Lam, Isabelle Richard-Lordereau, Lars H. Lund, Paul McGreavy, Philip N. Newsome, Naveed Sattar, Scott Solomon, Franz Weidinger, Faiez Zannad, Andreas Zeiher
Summary: Metabolic comorbidities are common in cardiorenal disease and are associated with increased risk of poor outcomes of COVID-19 infection. Recognition and treatment of cardiometabolic diseases, as well as improving lifestyle and developing new biomarkers, are essential for prevention and management.
EUROPEAN HEART JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Quentin M. Anstee, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Amalia Gastaldelli, Hannes Hagstrom, Terry T. K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Norah A. Terrault, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Joern M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: Fatty liver disease is a major public health threat, and focused interventions are urgently needed. A consensus-driven action agenda has been developed, which includes 29 priorities such as early diagnosis, addressing the needs of patients with multiple morbidities, and incorporating fatty liver disease into non-communicable disease strategies and guidance.
Letter
Gastroenterology & Hepatology
Philip Newsome, Mary E. Rinella, Jeffrey V. Lazarus, Norah Terrault
Article
Multidisciplinary Sciences
Jerome Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Celine Fournier-Poizat, Aldo Trylesinski, Clemence M. Canivet, Sophie Michalak, Brigitte Le Bail, Valerie Paradis, Pierre Bedossa, Natalie Sturm, Victor de Ledinghen, Philip. N. Newsome
Summary: The practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD are not well defined. Here, the authors develop and validate two diagnostic tools: a stepwise stratification algorithm including a cirrhosis group, and a risk prediction chart providing a personalized assessment of the individual probability of cirrhosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin Correa, Marco Romano, Silvia Cellone Trevelin, Qi Peng, Elena Crespo, Mauro Corrado, Juan-Jose Lozano, Erika L. Pearce, Elena Perpinan, Anna Zoccarato, Leonard Siew, Joy Edwards-Hicks, Reenam Khan, Nguyet-Thin Luu, Mark R. Thursz, Philip N. Newsome, Marc Martinez-Llordella, Naina Shah, Robert I. Lechler, Ajay M. Shah, Alberto Sanchez-Fueyo, Giovanna Lombardi, Niloufar Safinia
Summary: This study reveals that functional redox homeostasis is crucial for the function, stability, and survival of regulatory T cells (Tregs). Targeting Treg-specific antioxidant pathways may have therapeutic potential to reverse Treg impairment in conditions of oxidative damage such as advanced liver disease.
Editorial Material
Gastroenterology & Hepatology
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Christel McMullan, Ameeta Retzer, Sarah E. Hughes, Olalekan Lee Aiyegbusi, Camilla Bathurst, Alan Boyd, Jamie Coleman, Elin Haf Davies, Alastair K. Denniston, Helen Dunster, Chris Frost, Rosie Harding, Amanda Hunn, Derek Kyte, Rebecca Malpass, Gary McNamara, Sandra Mitchell, Saloni Mittal, Philip N. Newsome, Gary Price, Anna Rowe, Wilma van Reil, Anita Walker, Roger Wilson, Melanie Calvert
Summary: This study developed an electronic platform for patients to report their symptoms and conducted usability testing with patient partners and research nurses. The results showed that most people with inflammatory conditions found it easy to report their symptoms using an app on their own device, and they liked the simplicity and responsiveness of the platform. Additionally, research nurses had positive feedback on the usability of the clinical dashboard.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)