RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

(2020) Sarah Theresa Boyle et al.   NATURE CELL BIOLOGY

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

(2019) Mirella Georgouli et al.   CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma

(2019) Daniela Pankova et al.   EMBO JOURNAL

The long non-coding RNA ANRASSF1 in the regulation of alternative protein-coding transcripts RASSF1A and RASSF1C in human breast cancer cells: implications to epigenetic therapy

(2019) Naiade Calanca et al.   Epigenetics

RASSF 1A is required for the maintenance of nuclear actin levels

(2019) Maria Chatzifrangkeskou et al.   EMBO JOURNAL

Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial

(2018) Jorge E. Cortes et al.   JOURNAL OF CLINICAL ONCOLOGY

Bone marrow-derived mesenchymal stem cells promote invasiveness and transendothelial migration of osteosarcoma cells via a mesenchymal to amoeboid transition

(2018) Laura Pietrovito et al.   Molecular Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

(2018) Angelos Papaspyropoulos et al.   Nature Communications

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Epigenetic Biomarkers of Promoter DNA Methylation in the New Era of Cancer Treatment

(2018) Keishi Yamashita et al.   CANCER SCIENCE

Co-expression of Cancer Stem Cell Markers OCT4 and NANOG Predicts Poor Prognosis in Renal Cell Carcinomas

(2018) Arezoo Rasti et al.   Scientific Reports

A window-of-opportunity clinical trial of dasatinib in women with newly diagnosed endometrial cancer

(2018) Linda R. Duska et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dual Src and EGFR inhibition in combination with gemcitabine in advanced pancreatic cancer: phase I results

(2017) Dana B. Cardin et al.   INVESTIGATIONAL NEW DRUGS

Syntenin mediates SRC function in exosomal cell-to-cell communication

(2017) Naga Sailaja Imjeti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis

(2016) Min-Goo Lee et al.   CANCER RESEARCH

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

(2016) Dafni-Eleftheria Pefani et al.   MOLECULAR CELL

Modes of invasion during tumour dissemination

(2016) Pahini Pandya et al.   Molecular Oncology

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

(2016) David Cano-Rodriguez et al.   Nature Communications

RASSF1A Site-Specific Methylation Hotspots in Cancer and Correlation with RASSF1C and MOAP-1

(2016) Natalia Volodko et al.   Cancers

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Three-Dimensional Balance of Cortical Tension and Axial Contractility Enables Fast Amoeboid Migration

(2015) Begoña Álvarez-González et al.   BIOPHYSICAL JOURNAL

Clinical utility of RASSF1A methylation in human malignancies

(2015) A M Grawenda et al.   BRITISH JOURNAL OF CANCER

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

(2015) Nikola Vlahov et al.   CURRENT BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement

(2015) Dinari A. Harris et al.   PLoS One

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

(2014) Maria Taddei et al.   Cell Communication and Signaling

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

The role and regulation of blebs in cell migration

(2013) Ewa K Paluch et al.   CURRENT OPINION IN CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Reactivation of the Tumour Suppressor RASSF1A in Breast Cancer by Simultaneous Targeting of DNA and E2F1 Methylation

(2012) María F. Montenegro et al.   PLoS One

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

(2011) Marco Mineo et al.   ANGIOGENESIS

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

(2011) Giorgio Malpeli et al.   BMC CANCER

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Cancer Cells Cyclically Lose and Regain Drug-Resistant Highly Tumorigenic Features Characteristic of a Cancer Stem-like Phenotype

(2011) K. He et al.   MOLECULAR CANCER THERAPEUTICS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

(2010) Edneia AS Ramos et al.   BMC CANCER

Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

(2010) Mark E Reeves et al.   BMC CANCER

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

(2010) M. Canel et al.   CANCER RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY