Article
Chemistry, Analytical
Kaicha Chen, Hongli Zhao, Zhenxing Wang, Fangfang Zhou, Minbo Lan
Summary: A sandwich-type electrochemical aptasensor was constructed for the simultaneous detection of cardiac troponin I (cTnI) and myoglobin (Myo). The aptasensor demonstrated excellent performance in clinical diagnosis of acute myocardial infarction. The results showed wide linear ranges and low detection limits, indicating the potential application of the aptasensor.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Junfeng Zhang, Kai Sun, Jiangtao Ren, Han Wang, Jing Cheng
Summary: A metallic nanowire aptasensor with high sensitivity and short detection time was developed for the early diagnosis and prognostic monitoring of heart failure by detecting cardiac troponin I (cTnI). The sensor exhibited excellent detection performance, including high sensitivity, short detection time, high specificity, and good reproducibility, making it a potential application in portable devices for continuous monitoring of cardiomyocyte injury.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Zhiping Song, Juan Song, Feng Gao, Xiaoping Chen, Qinghua Wang, Yanan Zhao, Xuguang Huang, Chaoyong Yang, Qingxiang Wang
Summary: In this study, an electrochemical aptasensor for the detection of cardiac troponin I was developed by utilizing the physical and electrochemical properties of ferrocene-based covalent organic framework nanosheets. The sensor exhibited ultra-low detection limit and a wide linear range, demonstrating excellent performance in practical applications, such as serum assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Zhiping Song, Juan Song, Feng Gao, Xiaoping Chen, Qinghua Wang, Yanan Zhao, Xuguang Huang, Chaoyong Yang, Qingxiang Wang
Summary: In this study, a novel electrochemical aptasensor was developed for the rapid and accurate determination of cardiac troponin I. The sensor exhibited ultra-low detection limit and a wide linear range.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Kaicha Chen, Hongli Zhao, Zhenxing Wang, Fangfang Zhou, Zehui Shi, Shida Cao, Minbo Lan
Summary: In this study, a sensitive sandwich-type cTnI electrochemical aptasensor was developed, showing excellent performance such as a wide linear range, ultra-low detection limit, good selectivity, stability, and recovery rate.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Kaicha Chen, Hongli Zhao, Zhenxing Wang, Fangfang Zhou, Zehui Shi, Shida Cao, Minbo Lan
Summary: A sensitive sandwich-type cTnI electrochemical aptasensor was developed using Au/Zr-C as electrode-modified material and snowflake-like PtCuNi catalyst as label material. The synthesized aptasensor exhibited excellent electrochemical performance, including a wide linear range, low detection limit, good reproducibility, stability, and recovery.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biophysics
Ana M. Ulloa-Gomez, Alejandra Agredo, Alec Lucas, Sandeep B. Somvanshi, Lia Stanciu
Summary: We developed an aptasensing platform for the detection of cTnT in the immediate and early phases of AMI. The platform uses a microfluidic paper-based analytical device modified with gold-decorated polystyrene microparticles functionalized with a highly specific cTnT aptamer. The platform showed high selectivity and stability, and provides a label-free, smartphone-based detection method with shorter processing time compared to traditional methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Nanoscience & Nanotechnology
Fatemeh Momeni, Seyyed Mehdi Khoshfetrat, Kobra Zarei
Summary: An electrochemical aptasensor with excellent sensitivity and accuracy was developed for the detection of cardiac troponin I (cTnI). The optimized sensor showed a broad dynamic range and exceptional selectivity, and was effectively used for cTnI detection in plasma samples from AMI patients.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Analytical
Ruiting Wen, Chunhong Zhou, Jiuying Tian, Jusheng Lu
Summary: In this study, a three-dimensional nanozyme-catalytic nanoreactor was constructed by confining MOF-818 nanozyme in the pore of macroporous tungsten trioxide (p-WO3). The catalytic activity of the nanozyme could be regulated by changing the pore size of p-WO3, and it exhibited excellent performance for 3,5-DTBC oxidation. Moreover, the nanozyme-catalytic nanoreactor was successfully used for the construction of a colorimetric aptasensor for selective determination of cardiac troponin I.
Article
Chemistry, Analytical
Yongjiao Sun, Zhenting Zhao, Rui Zhou, Pengwei Li, Wendong Zhang, Koichi Suematsu, Jie Hu
Summary: The study successfully prepared different sizes of cubic indium oxide nanocube clusters and their composites with Au nanoparticles using a solvothermal method, demonstrating that the Au@In2O3 system exhibits the best sensing properties. The Au nanoparticles enhance the receptor function of the semiconductor gas sensor, leading to increased sensing response.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Environmental
Lizhu Zeng, Chenjia Lin, Peiqing Liu, Duanping Sun, Jing Lu
Summary: A novel colorimetric biosensor was developed for sensitive and rapid detection of cardiac troponin I (cTnI), a principal biomarker of acute myocardial infarction. The biosensor utilized multifunctional hybrid nanoprobes coupled with triple-aptamer-modified tetrahedral DNA nanostructures (TAPT-TDNs) for cTnI detection. The biosensor displayed excellent analytical performance with a detection limit of 27 pg·mL-1.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Goeun Park, Hoseok Lee, Moonbong Jang, Jeong Ah Park, Hanbin Park, Chulhwan Park, Tae-Hyung Kim, Min-Ho Lee, Taek Lee
Summary: In this study, a rapid electrical biosensor based on a carbon nanotube network and DNA aptamer was developed to detect cardiac troponin I (cTnI) in human serum samples for the early diagnosis of acute myocardial infarction (AMI). An alternating current electrothermal flow (ACEF) method was employed to enhance the affinity between the DNA aptamer and the target molecule, enabling the detection of cTnI within 10 mins. The biosensor exhibited high selectivity, detecting cTnI in a wide linear range (1 pM to 100 nM) with a detection limit of 6.59 fM.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Medical Laboratory Technology
Nils A. Soerensen, Alina Gossling, Johannes T. Neumann, Tau S. Hartikainen, Paul M. Haller, Lea Scharlemann, Jonas Lehmacher, Andreas Ziegler, Stefan Blankenberg, Tanja Zeller, Gerhard Nordholt, Thomas Renne, Dirk Westermann
Summary: This study assessed the diagnostic accuracy of a high-sensitivity cardiac troponin I assay in patients with suspected acute MI, developing and validating a 0/1 hour diagnostic algorithm. The algorithm showed high negative predictive value and sensitivity, making it suitable for rapid diagnostic stratification of patients with suspected MI.
CLINICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Yujie Han, Xujie Su, Lifang Fan, Zhiguang Liu, Yujing Guo
Summary: In this study, an electrochemical aptasensor was developed for the detection of cTnI using CuNWs/MoS2/rGO structure, showing excellent detection performance with a wide linear range and low detection limit. The sensor demonstrated good selectivity, stability, and reproducibility, making it applicable for cTnI analysis in human blood samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yizhou Zhu, Wanglong Hong, Xiangmei Liu, Lei Tan, Jun Wu, Congyang Mao, Yiming Xiang, Shuilin Wu, Kenneth M. C. Cheung, Kelvin W. K. Yeung
Summary: Sonodynamic therapy (SDT) driven by ultrasound (US) can address deep tissue bacterial infections. A new type of antibacterial sonosensitizer, Au@Cu2O hybrid nanocubes, with an interfacial Schottky junction was designed, which can efficiently produce reactive oxygen species (ROS) to kill bacteria under US stimulation. The study shows promising results in enhancing antibacterial efficacy against Staphylococcus aureus.
Article
Chemistry, Analytical
Nisha Zhuang, Jieyu Ma, Lu Yang, Rui Xue, Xiujuan Qian, Minjiao Chen, Sijian Zhang, Zhenyu Chu, Weiliang Dong, Jie Zhou, Min Jiang
Summary: An amperometric biosensor utilizing PB nanocubes microchip was developed for rapid and accurate determination of sucrose and glucose contents in fermentation broth and juice samples. The biosensor showed high performance and strong anti-interference, with fast response time, wide linear range, and good recovery rate, indicating its potential for applications in fermentation industry and beverage products.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jingyu Feng, Yu Liu, Yuansheng Shan, Ying Xie, Zhenyu Chu, Wanqin Jin
Summary: A core-shell nanowires constructed electrochemical sensor was proposed for highly sensitive and selective recognition of Ascorbic acid (AA), with long-term reusability. The sensor exhibited excellent sensitivity and an ultrawide linear range, accurately detecting AA concentration within a short period of time.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Ying Xie, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: The emergence of nanomaterials has greatly accelerated the development of enzymatic biosensors in various fields. The superior surface area and conductivity of regular nanostructures enable effective promotion of enzymatic reactions and electron transfer, making nanostructure control of biosensing materials a research hotspot. The recent progress of electrochemical enzymatic biosensors based on regular nanostructured materials, including preparation methods and advances, as well as the advantages and disadvantages in enzymatic detection of various analytes in different fields, have been carefully discussed.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Yiqing Wang, Tao Liu, Min Yang, Chuanjian Wu, Wei Zhang, Zhenyu Chu, Wanqin Jin
Summary: The handheld device designed in this study based on dual-gate ISFET showed high sensitivity, wide linear range, and low detection limit for cTnI detection in serum, providing reliable results and potential applications for early screening and diagnosis of AMI.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Biomedical
Huajie Zou, Fuhai Cai, Jianghua Zhang, Zhenyu Chu
Summary: With the development of environmental energy harvesting technology, the research focus has shifted towards the energy harvesting system of coupled environmental vibration sources, particularly on the piezoelectric energy harvesting technology based on the piezoelectric effect. The study reviewed and summarized the different types of piezoelectric energy harvesting, highlighting the benefits of rotational types, the limitations of vortex-induced vibration and flutter types, and the effectiveness of resonant types in improving energy and power output. The future main development tendencies involve multiple frequency excitation and multi-piezoelectric array for enhanced power generation capacity and broader range of airflow velocity.
JOURNAL OF VIBROENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Wei Zhang, Tao Liu, Yuansheng Shan, Bailing Hou, Zhenyu Chu, Xiaoping Gu, Zhengliang Ma, Wanqin Jin
Summary: An ultrafast and ultrasensitive aptasensor was designed for quantitatively detecting the highly specific and sensitive biomarker cTnI for AMI. With high accuracy and excellent selectivity, the aptasensor can accurately report cTnI concentration within 4 minutes, meeting clinical demands.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biophysics
Tao Liu, Bowen Lin, Xueli Yuan, Zhenyu Chu, Wanqin Jin
Summary: In this study, a novel electrochemical aptasensor was developed for ultrasensitive and quantitative detection of trace Hg2+. The aptasensor utilized an urchin-like architecture of Cu@carbon nanoneedles as the electroactive probe and employed an exonuclease III-assisted cycling amplification strategy to enhance the signal strength of trace Hg2+. The developed aptasensor exhibited a low detection limit and wide linear range, and it shows promising potential for early warning and efficient pollution monitoring of heavy metal ions.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Food Science & Technology
Ke Zhang, Hui Zeng, Jingyu Feng, Zhengkun Liu, Zhenyu Chu, Wanqin Jin
Summary: Allura red (AR) is commonly used as a food and soft drink additive, but due to the special harm of the azo structure to the human body, dosage control is necessary. To address the issues of time-consuming, expensive, and complicated detection methods, a core-shell nanocube sensor has been developed for ultrawide detection range and selective recognition of AR. This sensor exhibits excellent selectivity with an ultra-wide linear range and remarkable anti-interference and reusability over 30 days.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ke Zhang, Meiqi Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: In this study, we developed an ultrasensitive biosensor microchip that can rapidly and accurately detect sucrose concentration by constructing a special microarchitecture. This research is of great importance for industrial fermentation and synthetic biology research.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Engineering, Chemical
Xiaoyue Yao, Yu Liu, Zhenyu Chu, Wanqin Jin
Summary: Since the global outbreak of COVID-19, membrane technology has received significant attention for its crucial role in clinical treatments. Membranes are essential in various fields of life science and possess additional functions to meet specific clinical requirements. This review introduces and discusses advanced membranes and their functions in four typical areas of life science. A comparison of the advantages and disadvantages of these membranes is provided, along with guidance for selecting and fabricating the appropriate membrane material.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Environmental Sciences
Jing Zhang, Jing Lei, Zhengkun Liu, Zhenyu Chu, Wanqin Jin
Summary: With the rapid development of industrial society, phenolic pollutants in water pose serious threats to human health. Traditional detection techniques are not cost-effective and lack on-site detection abilities. Electrochemical enzymatic biosensors have gained increasing attention as an effective strategy for the recognition of phenolic compounds. However, challenges such as enzyme deactivation, poor stability, and low sensitivity need to be addressed. Effective immobilization methods of enzymes and nanomaterials with excellent properties are being extensively researched to achieve high-sensitivity and high-stability biosensing platforms. Simultaneous detection of multiple phenols is also an area of focus for future research.
ENVIRONMENTAL RESEARCH
(2022)
Review
Engineering, Biomedical
Xueli Yuan, Bowen Lin, Tao Liu, Wei Zhang, Zhenyu Chu, Xiaoping Gu, Zhengliang Ma, Wanqin Jin
Summary: Cancer is a malignant disease with a high fatality rate, and early screening with rapid and accurate detection is crucial for improving the survival rate. Electrochemical biosensors that detect cancer biomarkers in blood offer advantages such as low invasiveness, fast diagnosis, and low cost. However, there is a trade-off between sensitivity and selectivity, which limits the detection of trace amounts of biomarkers. Recently, nanomaterials with improved sensitivity and selectivity have been developed to address this issue. This review introduces different categories of state-of-the-art electrochemical biosensors, discusses their operating principles and advantages/disadvantages, and evaluates the existing detection strategies and performance of nanomaterial-based cancer biosensors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Shilin Yang, Cuimei Bo, Jun Li, Qiang Tan, Yiqing Wang, Hao Wu, Zhenyu Chu, Wanqin Jin
Summary: A homemade enzymatic biosensor chip and a specific signal conversion system were proposed for online glucose analysis. The system exhibited high sensitivity and a wide linear range, enabling accurate detection of glucose concentration during fermentation.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
