Article
Pharmacology & Pharmacy
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Summary: In this study, it was found that Methylsulfonylmethane (MSM) can enhance the autophagy flux through the AMPK/mTOR/ULK1 pathway, improving hepatic steatosis and potentially serving as a treatment for obesity-related MAFLD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Juan Xiao, Xiaofang Shen, Ruiming Kou, Ke Wang, Lihong Zhai, Lu Ding, Huabo Chen, Chun Mao
Summary: This study aimed to investigate the protective role of kirenol in inflammation induced by lipopolysaccharide (LPS) in acute lung injury (ALI) cell and mouse models and unravel the underlying mechanisms, with a particular focus on autophagy. The results showed that kirenol could significantly inhibit inflammatory cytokines secretion and enhance autophagy, possibly through activating the AMPK-mTOR-ULK1 pathway. RNA sequencing results suggested the involvement of kirenol in acute inflammatory response and the AMPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Mao-xia Liu, Jia Yang, Yan Qin, Zheng-da Li, Jun Jin, Yan-bing Zhang, Xin-jing Yang
Summary: The aim of this study was to investigate the effect of esmolol (ES) on LPS-induced cardiac injury and the possible mechanism. The results showed that ES could alleviate LPS-induced myocardial damage through activating the AMPK/mTOR/ULK1 signal pathway-regulated autophagy, which was demonstrated by hematoxylin-eosin staining and measurement of cardiac troponin.
Article
Immunology
Xing Zhang, HuaQiang Zhang, YingKui Gao, ZhongHua Hao, JingJing Liu, GuangWei Zhou, Fang Liu, Xiao Li, Chao Tong, XueBing Wang
Summary: This study found that Forsythoside A (FTA) can alleviate inflammation and oxidative stress in bovine mammary epithelial cells (MAC-T) induced by lipopolysaccharides (LPS), improve autophagy function, and inhibit cell apoptosis by activating the AMPK pathway. These results suggest that FTA inhibits LPS-induced autophagy, apoptosis, and inflammatory damage in MAC-T cells by activating the AMPK pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman, Yoonjeong Cho, Ghilsoo Nam, Hyewhon Rhim
Summary: Oxyresveratrol affects the function of astrocytes by promoting autophagy signaling and inhibiting APP production. Co-treatment with chloroquine significantly enhances autophagic flux, and the regulation of autophagy substrates and pathways by Oxyresveratrol depends on the PI3 kinase pathway.
Article
Immunology
Youli Yu, Jialiang Pan, Mengting Liu, Haiqin Jiang, Jingshu Xiong, Lei Tao, Feng Xue, Fang Tang, Hongsheng Wang, Jianjun Dai
Summary: In this study, the role of GBP2b in regulating autophagy during M. bovis infection was investigated. The results showed that GBP2b is associated with autophagy, mTOR signaling, and AMPK signaling. Down-regulation of GBP2b impaired autophagy, promoting intracellular survival of M. bovis.
Article
Chemistry, Medicinal
Di Zhang, Yinghui Zhang, Zhilan Wang, Lei Lei
Summary: This study demonstrates the beneficial effects of thymoquinone (TQ) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) and human hepatocellular carcinoma cells. TQ promotes hepatic autophagy through the AMPK/mTOR/ULK1 signaling pathway, reducing lipid accumulation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Toxicology
Yue Xu, Shangwen Wang, Chi-Kwan Leung, Hao Chen, Chan Wang, Huijie Zhang, Shuwei Zhang, Yi Tan, Haowei Wang, Lin Miao, Yi Li, Yizhen Huang, Xiaoxing Zhang, Genmeng Yang, Ruilin Zhang, Xiaofeng Zeng
Summary: Amanitin poisoning is a dangerous mushroom poisoning characterized by the toxic effects of alpha-Amanitin on the liver. The mechanism by which alpha-Amanitin induces liver injury and the role of autophagy in this process are not fully understood.
TOXICOLOGY LETTERS
(2023)
Article
Immunology
Zhao-Ling Qin, Qiu-Feng Yao, Ping Zhao, Hao Ren, Zhong-Tian Qi
Summary: This study found that ZIKV infection induces lipophagy through activation of the AMPK-ULK1 signaling pathway, leading to a decrease in lipid droplet size and triglyceride content, as well as an increase in lysosomal biosynthesis and LD-lysosome fusion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liuran Li, Qinghua Li, Wenbin Huang, Yibing Han, Huiting Tan, Min An, Qianru Xiang, Rui Zhou, Li Yang, Yanzhen Cheng
Summary: The study showed that dapagliflozin can alleviate hepatocyte steatosis by reducing lipogenic enzyme, inducing fatty acid oxidation enzyme, and autophagy, which may be associated with AMPK activation. The results also indicate that dapagliflozin induces autophagy via the AMPK-mTOR pathway, revealing a novel clinical application and functional mechanism in the treatment of NAFLD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Weiyu Hou, Fanrui Zhao, Li Fang, Xiyan Wang, Dan Wu, Chunlei Liu, Yue Leng, Yawen Gao, Junxi Fu, Ji Wang, Weihong Min
Summary: Walnut-derived peptides can improve insulin resistance, lower blood glucose and dyslipidemia by activating the AMPK/mTOR/ULK1 pathway, thus alleviating the symptoms of type 2 diabetes mellitus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zi-ang Yao, Ling Xu, Li-ming Jin, Tian-sheng Wang, Bai-xiang Wang, Jiang-zhou Li, Ying Bai, Hai-ge Wu
Summary: KOS can protect microglia from over-activated inflammation by inducing autophagy and inhibiting the release of inflammatory cytokines. Additionally, KOS can regulate the autophagy pathway and inhibit the inflammatory response of over-activated microglia by reducing the expression of proteins related to the AMPK/ULK1 pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Zhenwei Huang, Xian Zhou, Xiaoqin Zhang, Lili Huang, Yibin Sun, Zaixing Cheng, Wen Xu, Chun-Guang Li, Yanfang Zheng, Mingqing Huang
Summary: The study demonstrated that the traditional Chinese medicine Pien-Tze-Huang (PTH) can inhibit NLRP3 inflammasome-mediated neuroinflammation through enhancing autophagy and the AMPK/mTOR/ULK1 pathway both in vitro and in vivo, which was validated in experiments with cell cultures and rat models.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Qian Xua, Huanxi Wua, Haibin Zhua, Chengxuan Lu, Jiangjia Tao, Ziqiu Zhou, Jianbin Zhang
Summary: This study explored the molecular biological mechanism of grain-sized moxibustion to regulate hepatic autophagy in hyperlipidemic rats by affecting ULK1 and TFEB through the AMPK/mTOR signaling pathway. The results showed that grain-sized moxibustion improved hyperlipidemia and hepatocyte steatosis, increased the expression of LC3, p-AMPK, p-ULK1, and nuclear TFEB in the liver, but decreased the expression of p62 and p-mTOR.
Article
Biochemistry & Molecular Biology
Teng Ma, Xiangpeng Wang, Wenjing Qu, Lingsen Yang, Cheng Jing, Bingrui Zhu, Yongkui Zhang, Wenpeng Xie
Summary: The study showed that osthole can inhibit the progression of KOA by activating autophagy in rat chondrocytes, potentially involving the AMPK/ULK1 signaling pathway. Osthole may be a novel and effective therapeutic agent for clinical treatment of KOA.
Article
Environmental Sciences
Jianqing Chen, Shuai Zhang, Jianyu Tong, Xiaojie Teng, Zhongyuan Zhang, Shu Li, Xiaohua Teng
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Dechun Chen, Guanghui Hu, Shuai Zhang, Hongfu Zhang, Xiaohua Teng
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Environmental Sciences
Dechun Chen, Fangyong Ning, Jingyang Zhang, You Tang, Xiaohua Teng
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Agriculture, Dairy & Animal Science
Syed Waqas Ali Shah, Shuai Zhang, Muhammad Ishfaq, You Tang, Xiaohua Teng
Summary: Ammonia induced autophagy in chicken BF by reducing ATPase activity and altering autophagy-related factors, leading to disturbance in energy metabolism. MiRNA-99a-3p was found to be the key player in this process.
Article
Environmental Sciences
Wei Zhao, Yutong Cui, Xiping Sun, Hongyan Wang, Xiaohua Teng
Summary: The study showed that corn stover biochar immobilized mercury in soil, reduced the migration of mercury from soil to leaching solution and spinach, and increased the edible safety of spinach.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Marine & Freshwater Biology
Jianqing Chen, Dechun Chen, Jingxin Li, Yuanlong Liu, Xianhong Gu, Xiaohua Teng
Summary: Cadmium-induced damage in carp gills is associated with apoptosis, mainly involving oxidative stress, immunosuppression, and apoptosis-related genes. Cadmium exposure resulted in cadmium accumulation and apoptotic injury caused by mitochondrion, along with oxidative stress and immunosuppression mediated through the JNK-FoxO3a-PUMA pathway.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Zhiying Miao, Kun Zhang, Rongkun Bao, Jingxin Li, You Tang, Xiaohua Teng
Summary: This study investigated the molecular mechanism of inflammatory injury caused by excess manganese in the chicken nervous system. Excess manganese was found to induce inflammatory damage and inflammatory response, leading to Th1/Th2 imbalance and immunosuppression, with the involvement of heat shock proteins (HSPs) in mediating the manganese-induced inflammatory injury via the NF-kappa B pathway in chicken nervous system in vivo and in vitro.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Yuhao Liu, Meijin Yu, Jiawen Cui, Ye Du, Xiaohua Teng, Zuozhong Zhang
Summary: This study aimed to investigate the mechanism of damage caused by excess Mn in chicken livers and found that Mn exposure led to inflammatory injury via NF-kappa B pathway. Additionally, Mn exposure induced oxidative stress and up-regulated HSPs expression, which mediated inflammatory damage. Time- and dose-dependent effects were observed on Mn-induced chicken liver inflammatory injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Zhuo Li, Syed Waqas Ali Shah, Qin Zhou, Xiujie Yin, Xiaohua Teng
Summary: Cadmium-induced oxidative stress led to autophagy in common carp hepatopancreas. The imbalance between peroxide level and antioxidant capacity caused by Cd triggered oxidative stress, leading to autophagy through the AMPK/mTOR/ULK1 signaling pathway.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Zhiying Miao, Zhiruo Miao, Xiaohua Teng, Shiwen Xu
Summary: CPF exposure induces pyroptosis in EPC cells by regulating the miR-124-3p/CAPN1 axis. Pyroptosis leads to mitochondrial dysfunction and upregulation of inflammatory genes.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Marine & Freshwater Biology
Qi Sun, Yuhao Liu, Xiaojie Teng, Peng Luan, Xiaohua Teng, Xiujie Yin
Summary: This study aimed to investigate the toxic effects of 4-octylphenol (4-OP) on fish and the molecular mechanism of gill inflammatory injury caused by 4-OP exposure. The results showed that 4-OP activated complement, induced immunosuppression, and caused inflammatory damage, posing a threat to fish health.
AQUATIC TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dechun Chen, Jiatian Liang, Chunyu Jiang, Di Wu, Bin Huang, Xiaohua Teng, You Tang
Summary: The study found that manganese (Mn) poisoning in chickens suppressed the expression levels of heat shock protein 40 and 60 genes, while increasing the expression levels of heat shock protein 27, 70, and 90 genes. In addition, Mn poisoning also damaged the myoid cells, spermatocytes, and Sertoli cells in chicken testes, and caused abnormal shapes and extensive vacuolation of mitochondria. This study provides new insights into the identification of manganese toxicity in chicken testes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Jingyang Zhang, Jiawen Cui, Yueyang Wang, Xu Lin, Xiaohua Teng, You Tang
Summary: This study established an ammonia poisoning model of chicken PBLs and explored the mechanism of ammonia-induced apoptosis in chicken PBLs. The results showed that miR-27b-3p participated in apoptosis through targeting the TNF-α/TNFR1/Caspase-8 and Bid/Cytc/Caspase-9 pathways in ammonia-treated chicken PBLs. In addition, ammonia exposure led to immunosuppression and activated HSPs.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
He Huang, Jianqing Chen, Qi Sun, Yuhao Liu, You Tang, Xiaohua Teng
Summary: This study investigated the mitigative effect of Selenium (Se) on lead (Pb)-induced renal inflammatory injury in chickens. The results showed that Se can alleviate Pb-induced damage by reducing oxidative stress and inflammation in the kidneys. Overall, Se plays a protective role against Pb toxicity by modulating oxidative stress indicators, cytokines, and inflammation-related genes in chicken kidneys.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)