期刊
FARADAY DISCUSSIONS
卷 187, 期 -, 页码 521-537出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5fd00184f
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资金
- Defence and Science Technology Laboratory (Dstl, UK)
- Direction Generale de l'Armement (DGA, France)
- Societe d'Acceleration du Transfert de Technologie (SATT) NORD
- EPSRC
- Dstl
- Rosemere Cancer Foundation
- Brain Tumour North West
- Sydney Driscoll Neuroscience Foundation
Several proof-of-concept studies on the vibrational spectroscopy of biofluids have demonstrated that the methodology has promising potential as a clinical diagnostic tool. However, these studies also show that there is a lack of a standardised protocol in sample handling and preparation prior to spectroscopic analysis. One of the most important sources of analytical errors is the pre-analytical phase. For the technique to be translated into clinics, it is clear that a very strict protocol needs to be established for such biological samples. This study focuses on some of the aspects of the pre-analytical phase in the development of the high-throughput Fourier Transform Infrared (FTIR) spectroscopy of some of the most common biofluids such as serum, plasma and bile. Pre-analytical considerations that can impact either the samples (solvents, anti-coagulants, freeze-thaw cycles ... ) and/or spectroscopic analysis (sample preparation such as drying, deposit methods, volumes, substrates, operators dependence ... ) and consequently the quality and the reproducibility of spectral data will be discussed in this report.
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