期刊
DYES AND PIGMENTS
卷 190, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109325
关键词
Photochemistry; Phthalocyanines; Singlet oxygen; Sonochemistry; Sono-photochemistry
资金
- TUBITAK [115R030]
- Research Fund of the Istanbul Technical University [TDK-2019-42066]
This study utilized a sono-photochemical method to investigate the properties of lutetium phthalocyanines, synthesizing a series of new compounds. The results demonstrated that sono-photochemical properties enhance therapeutic effects more effectively than photochemical properties.
This study performs a sono-photochemical method to get more effective therapeutic outcomes for cancer treatment. Additionally, sonochemical and sono-photochemical properties of lutetium phthalocyanines have been presented in this study for the first time. Although it aims to synthesize a series of new peripherally/nonperipherally mono lutetium (III) phthalocyanines (1-3Lu), the related double-decker lutetium (III) phthalocyanines (1?-3?Lu) were simultaneously synthesized. Characterization of the resulting macromolecules was carried out using diverse spectroscopic approaches including NMR (1H and 13C NMR; for 1-3Lu), UV?Vis, FT-IR, and Mass spectroscopy. The double-decker lutetium (III) phthalocyanines (1?-3?Lu) were also characterized by performing electron spin resonance (ESR) measurements. The solubility of all the new macromolecules was studied using different polar and non-polar organic solvents. The photophysicochemical properties of the resulting mono lutetium (III) complexes were analyzed and photochemical, sonochemical, and sono-photochemical properties were investigated to determine the efficiencies of singlet oxygen. When the data were compared, the highest singlet oxygen quantum yields (?? = 0.86 for 1-Lu, 0.96 for 2-Lu, 0.83 for 3-Lu) were obtained for the sonophotochemical studies. The results prove that sono-photochemical properties improve the therapeutic effects compared to photochemical ones.
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