Article
Oncology
Yi-Jie Lu, Yi-Ting Deng, Hui-Hsin Ko, Hsin-Hui Peng, Hsiang-Chieh Lee, Mark Yen-Ping Kuo, Shih-Jung Cheng
Summary: LOXL2 expression is significantly associated with clinical stage, lymph node metastasis, and overall survival time in oral squamous cell carcinoma (OSCC). Overexpression of LOXL2 enhances migration, invasion, epithelial-mesenchymal transition (EMT), and cancer stem cell (CSC) phenotypes, independent of its enzymatic activity. LOXL2 also increases the levels of IFIT1 and IFIT3, which are key downstream components of LOXL2 action in migration, invasion, EMT, and CSC phenotypes.
Article
Biochemistry & Molecular Biology
Kuo-Chu Lai, Prabha Regmi, Chung-Ji Liu, Jeng-Fan Lo, Te-Chang Lee
Summary: The study demonstrates that IFIT2 depletion promotes the CSC-like phenotypes in oral cancer cells. Clinically, there is a positive correlation between IFIT2 and CD24 in oral cancer patients, and the expression pattern of IFIT2(high)/CD24(high)/CD44(low) predicts a better prognosis. Furthermore, TNF-alpha blockade can abolish the sphere formation induced by IFIT2 depletion, suggesting its involvement in CSC-like phenotypes in oral cancer.
Article
Oceanography
Wang Lei, Ma Teng, Xu Wenteng, Chen Zhangfan, Zhou Qian, Zheng Guiliang, Chen Songlin
Summary: ELIFIT1 gene plays an important antiviral role in Epinephelus lanceolatus, with high expression in blood and immunity-related tissues. Upon viral infection, its expression is significantly upregulated and reaches peak levels within a specific timeframe.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2021)
Article
Oncology
Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li, Hong-Tao Cao, Xiao-Ying Yang, Xing-Tong Zhou, Wei-Bin Wang
Summary: The study identified widespread expression of IFIT1 in pancreatic cancer, and found that it promotes proliferation, migration, and invasion of pancreatic cancer cells by activating the Wnt/β-catenin pathway and regulating epithelial-mesenchymal transition (EMT). IFIT1 may serve as a potential therapeutic target for pancreatic cancer.
Article
Medicine, Research & Experimental
Bing-fen Yang, Fei Zhai, Shan Yu, Hong-juan An, Zhi-hong Cao, Yan-hua Liu, Ruo Wang, Xiao-xing Cheng
Summary: This study identified potential biomarkers for discriminating active tuberculosis (TB) from latent TB infection by transcriptome sequencing. IFIT3 and ORM1 showed high diagnostic value in distinguishing patients with active TB from individuals with latent TB infection, providing a new method for TB diagnosis.
CURRENT MEDICAL SCIENCE
(2022)
Review
Oncology
Shuna Liu, Ming Wu, Fang Wang
Summary: Ovarian cancer presents a serious threat to women's health due to its low early diagnosis rate and tendency for metastasis and recurrence. Conventional treatment involving platinum and paclitaxel chemotherapy based on surgery may not effectively address the recurrence and progression of the disease. By understanding the molecular pathways involved in ovarian cancer recurrence and progression, biomarker-guided treatment options have the potential to significantly improve patient prognosis and lead to personalized treatment strategies.
Article
Veterinary Sciences
Jianhua Sun, Qi Zhang, Xiaokun Liu, Xiaoming Shang
Summary: IFIT3 plays a crucial role in myocardial infarction (MI), and its knockdown can alleviate myocardial injury and inflammatory response, improve cardiac function, reduce infarct size and myocardial fibrosis. The study demonstrates that IFIT3 is involved in regulating the inflammatory response and myocardial fibrosis in MI through inhibition of the MAPK pathway.
EXPERIMENTAL ANIMALS
(2021)
Article
Genetics & Heredity
Yifan Zhao, Yi Zhang, Wenyi Lu, Rui Sun, Ruiting Guo, Xinping Cao, Xingzhong Liu, Cuicui Lyu, Mingfeng Zhao
Summary: The IFIT family genes, IFIT1/2/3/5, are upregulated and have high diagnostic ability in AML patients. Higher levels of IFIT2/3/5 expression predict poor prognosis in AML patients. Additionally, IFIT2/3/5 expression is significantly positively associated with immune cell infiltration and immune checkpoint expression. IFIT family genes may serve as biomarkers for diagnosis, prognosis, and drug sensitivity in AML patients.
BMC MEDICAL GENOMICS
(2023)
Article
Infectious Diseases
Wenbin Qiao, Jiahui Fan, Xiaoqian Shang, Liang Wang, Bahetibieke Tuohetaerbaike, Ying Li, Li Zhang, YiShan Huo, Jing Wang, Xiumin Ma
Summary: Through bioinformatics analysis, we identified IFIT1 as an important substance involved in central nervous system tuberculosis, with significantly higher expression in the lesion tissue.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Chihwan David Cha, Seung Han Son, Chul Geun Kim, Hosub Park, Min Sung Chung
Summary: YY1 overexpression is a favorable prognostic biomarker in patients with breast cancer, and it has a negative correlation with CP2c at the protein level. The study shows that YY1 overexpression is associated with early stage and hormone receptor-positive subtype of breast cancer, and functions as an independent prognostic factor. These findings provide new insights into the prognostic significance of YY1 and its association with CP2c in breast cancer.
Review
Biochemistry & Molecular Biology
Woong Kim, Seok-Jun Kim
Summary: HSF1, a highly expressed gene in various cancers, is correlated with the prognosis of gastric cancer patients, serving as a potential biomarker.
Article
Genetics & Heredity
Kaitlyn Hohrman, Davi Goncalves, Kevin A. Morano, Jill L. Johnson
Summary: Research discovered that certain Hsp90 mutants disrupt the activity of various client proteins, while others affecting client protein activity lead to client-specific effects. These mutants offer new insights into how Hsp90 and co-chaperones identify and interact with different clients.
Article
Genetics & Heredity
Takahiro Seimiya, Motoyuki Otsuka, Takuma Iwata, Eri Tanaka, Kazuma Sekiba, Chikako Shibata, Masaru Moriyama, Ryo Nakagawa, Reo Maruyama, Kazuhiko Koike
Summary: A large-scale circRNA profiling analysis was conducted in PDAC tissues using circular RNA-specific RNA sequencing, identifying over 40,000 previously unknown circRNAs, some of which were upregulated in PDAC tissues. A novel circRNA, named circPDAC RNA, was found to be upregulated in PDAC but not expressed in normal human cells, serving as a potential biomarker for cancers including PDAC.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Khadija El Hindi, Sebastian Brachtendorf, Jennifer C. Hartel, Christoph Renne, Kerstin Birod, Karin Schilling, Sandra Labocha, Dominique Thomas, Nerea Ferreiros, Lisa Hahnefeld, Erika Dorochow, Domenico Del Turco, Thomas Deller, Klaus Scholich, Dominik C. Fuhrmann, Andreas Weigert, Bernhard Bruene, Gerd Geisslinger, Ilka Wittig, Karl-Heinrich Link, Sabine Groesch
Summary: This study identifies CerS4 and CerS5 as prognostic markers for advanced colon cancer patients and provides a comprehensive overview of the associated cellular metabolic changes. Downregulation of CerS4 or CerS5 in advanced CRC cells enhances tumor formation and cell proliferation, while depletion of CerS4 or CerS5 reduces tumor growth in Caco-2 cells. Lipidomic and proteomic analysis reveals significant changes in tumor-promoting cellular pathways and cellular transporters.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemical Research Methods
Ozan Yazici, Mutlu Dogan, Guze Ozal, Sedef Hande Aktas, Ahmet Demirkazik, Gungor Utkan, Filiz Cay Senler, Fikri Icli, Hakan Akbulut
Summary: The study indicates that higher serum OPN levels are associated with shorter survival time in patients with advanced gastric cancer. Patients who respond to DCF treatment have lower plasma OPN levels, with performance status and plasma OPN levels being significant factors in overall survival.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
