Article
Chemistry, Analytical
Arnab Sarkar, Samaresh Hansda, Tiasha Dutta, Sourav Ghoshal, Sujay Mukhopadhyay, Pranab Sarkar, Sushil Kumar Mandal, Nimai Chandra Saha, Pabitra Chattopadhyay, Koushik Dhara
Summary: This study developed and synthesized two fluorescent probes, ER-NapNO2 and ER-NapAllyl, which can target the endoplasmic reticulum (ER) and selectively detect carbon monoxide (CO) in aqueous buffer medium. These probes showed selective detection behavior towards CO without the presence of any metal ions, and had high selectivity at low concentrations.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Physiology
Patrick Ernst, Seulhee Kim, Zengqiao Yang, Xiaoguang Margaret Liu, Lufang Zhou
Summary: This study characterizes the spectral properties of MitoView 633 in live cells and evaluates its mitochondrial staining, resistance to photobleaching, and dynamics during DYm depolarization. The results demonstrate that MitoView 633 is a superb molecular probe for the assessment of DYm and other indicators in live cell imaging applications.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tugrul Cem Bicak, Maylis Garnier, Michele Sabbah, Nebewia Griffete
Summary: A new strategy for synthesizing fluorescent acrylamide gels using a cost-effective and commercially available hydrogen donor, rhodamine B, in a type II photoinitiation system is developed. The resulting hydrogels are fluorescent and have limited fluorophore leaching over time due to the covalent bond formed between the polymer network and rhodamine dye.
CHEMICAL COMMUNICATIONS
(2022)
Article
Cell Biology
Britta A. M. Bouwman, Nicola Crosetto, Magda Bienko
Summary: This article highlights the role of nuclear RNAs (nucRNAs) in shaping the three-dimensional architecture of the genome within the nucleus. The non-homogeneous distribution of nucRNAs within the nucleus can form gradients that contribute to the formation and coordination of different types of 3D genome structures.
CURRENT OPINION IN CELL BIOLOGY
(2022)
Article
Biology
Diyan Li, Mengnan He, Qianzi Tang, Shilin Tian, Jiaman Zhang, Yan Li, Danyang Wang, Long Jin, Chunyou Ning, Wei Zhu, Silu Hu, Keren Long, Jideng Ma, Jing Liu, Zhihua Zhang, Mingzhou Li
Summary: The three-dimensional architecture of the genome plays a crucial role in gene expression regulation and conservation across species. This study compares the 3D genomes of fish, chickens, and 10 mammalian species, and reveals that genome size and chromosome length influence the higher hierarchical organization of the genome, while local transcriptional availability is selected through vertebrate evolution. Additionally, conservation of topologically associating domains is associated with modularity of expression profiles, and LINE and SINE transposable elements contribute to heterochromatin and euchromatin organization during genome evolution.
Article
Chemistry, Multidisciplinary
Madison R. Herling, Ivan J. Dmochowski
Summary: To monitor the process of RNA delivery, we developed a pH probe based on 2'-OMe RNA that exhibits enhanced pH sensitivity by guanine proximal effect. The probe, in duplex with a DNA complement, showed a significant FAM fluorescence enhancement from pH 4.5 to pH 8.0, indicating endosomal entrapment and release when delivered to HeLa cells. Moreover, the probe, in complex with an antisense RNA complement, acted as an siRNA mimic and successfully achieved protein knockdown in HEK293T cells, demonstrating its potential for studying the localization and pH microenvironment of oligonucleotides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Computer Science, Artificial Intelligence
Antonio LaTorre, Lidia Alonso-Nanclares, Jose Maria Pena, Javier DeFelipe
Summary: The study presents a method to improve 3D reconstruction of neuronal nuclei for accurate identification, excluding non-neuronal cell types. It highlights the differences and inaccuracies in existing automatic tools and emphasizes the importance of automatic segmentation tools for neuroanatomical studies.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Review
Neurosciences
Yuki Fujita, Sarshan R. Pather, Guo-li Ming, Hongjun Song
Summary: This review explores the different aspects of spatial genome organization in the nervous system and its role in regulating gene expression, as well as its dysregulation in brain disorders. It also highlights new technologies used to study and manipulate chromatin architecture, and discusses the potential of investigating spatial genome organization for a better understanding of the nervous system and associated disorders.
Article
Biochemical Research Methods
Petar Markov, Anthony J. Hayes, Hanxing Zhu, Craig Boote, Emma J. Blain
Summary: This study presents a comprehensive image processing pipeline for creating unified three-dimensional reconstructions of cell cytoskeletal networks and nuclei, successfully applied to fibroblast cytoskeletal reorganization in the scleral connective tissue of the eye.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biochemical Research Methods
Zixuan Cang, Yanxiang Zhao, Axel A. A. Almet, Adam Stabell, Raul Ramos, Maksim V. V. Plikus, Scott X. X. Atwood, Qing Nie
Summary: COMMOT is a computational framework for spatially inferring cell-cell communication from transcriptomics data based on a variant of optimal transport (OT). It can handle complex molecular interactions and spatial constraints, and infer spatial signaling directionality and genes regulated by signaling using machine learning models.
Article
Plant Sciences
Keith E. Duncan, Kirk J. Czymmek, Ni Jiang, August C. Thies, Christopher N. Topp
Summary: This study presents technical advances in using lab-based X-ray microscopy for high-resolution 3D imaging of plant samples at multiple scales. Serial imaging and improved sample preparation methods allow for the generation of sub-micron 3D volumes co-registered with lower magnification scans, providing explicit contextual reference. This method bridges the imaging gap between light and electron microscopy and can be applied to various economically and scientifically important plant systems.
Article
Chemistry, Multidisciplinary
Yufan Fan, Fangyuan Wang, Fanbin Hou, Lai Wei, Guanghao Zhu, Dongfang Zhao, Qing Hu, Tao Lei, Ling Yang, Ping Wang, Guangbo Ge
Summary: Human serum albumin (HSA) serves as an important biomarker and prognostic indicator for various human diseases. A novel near-infrared fluorescent probe (7-HTCF) was developed for real-time sensing and in-situ imaging of HSA. The probe exhibited excellent selectivity, good chemical stability, rapid fluorescent response, and ultra-high sensitivity for HSA detection. It can be used for quantitative detection of HSA in diluted plasma samples and for in-situ imaging of reabsorbed HSA in living cells.
CHINESE CHEMICAL LETTERS
(2023)
Article
Computer Science, Artificial Intelligence
Qiang Wu, Xunpen Qin, Kang Dong, Aixian Shi, Zeqi Hu
Summary: This paper presents a two-stage convolutional neural network (CNN) method for crack defect detection and segmentation of metal parts. The first stage detects potential cracks and crops them to a small area, while the second stage learns the context of cracks in the detected patches. A window-based stereo matching method is then used to map crack pixels to 3D world points. Experimental results show that the proposed method achieves high accuracy and efficiency in target detection and pixel-level segmentation.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Agriculture, Multidisciplinary
Bolai Xin, Mark Whitty
Summary: This article proposes a new grape bunch reconstruction pipeline which detects visible berries and predicts their morphological positions using a 2D image, achieving reconstruction. It also fills invisible elements using a Restricted Reconstruction Grammar, resulting in a fully reconstructed bunch model. Compared to existing work, this pipeline shows significant improvement in quantity and length estimation, as well as element coincidence.
COMPUTERS AND ELECTRONICS IN AGRICULTURE
(2022)
Article
Optics
Huanyu Sun, Shiling Wang, Jinxi Bai, Jianpu Zhang, Jin Huang, Xiaoyan Zhou, Dong Liu, Chong Liu
Summary: The paper introduces a method for detecting subsurface damage (SSD) in large polished optics that is difficult to observe, using confocal laser scanning and three-dimensional reconstruction techniques. This method can quickly and accurately display the morphology of SSDs and provide quantitative evaluations of SSDs.
OPTICS AND LASERS IN ENGINEERING
(2021)
Article
Chemistry, Physical
Gianluca Del Frate, Marina Macchiagodena, Muhammad Jan Akhunzada, Francesca D'Autilia, Andrea Catte, Nicholus Bhattacharjee, Vincenzo Barone, Francesco Cardarelli, Giuseppe Brancato
Summary: An integrated theoretical and experimental strategy was used to investigate the effect of environmental factors on the spectroscopic parameters of DPAP. The results showed that DPAP is sensitive to different environments, confirming its applicability as a probe for detecting different structures and levels of plasma membrane organization.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Cardarelli, Basset El Essawy, Anna Solini, Ivan C. Gerling, Cristina Bianchi, Gabriella Becchi, Serena Mazzucchelli, Domenico Corradi, Gian Paolo Fadini, Diego Foschi, James F. Markmann, Emanuela Orsi, Jan Skrha, Maria Gabriella Camboni, Reza Abdi, A. M. James Shapiro, Franco Folli, Johnny Ludvigsson, Stefano Del Prato, Gianvincenzo Zuccotti, Paolo Fiorina
Summary: In this study, the Authors demonstrated that the IGFBP3/TMEM219 pathway plays a crucial role in regulating pancreatic beta cell homeostasis and its dysregulation is associated with diabetes. Targeting the IGFBP3/TMEM219 pathway may be a potential therapeutic option for treating diabetes.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Filippo Begarani, Francesca D'Autilia, Gianmarco Ferri, Luca Pesce, Fabio Azzarello, Valentina De Lorenzi, William Durso, Ambra Del Grosso, Marco Cecchini, Francesco Cardarelli
Summary: This study demonstrates the use of fast fluorescence fluctuation spectroscopy to extract information on the dynamics of molecules within subcellular nanostructures. The technique, known as Raster Image Correlation Spectroscopy (RICS), allows for the measurement of molecular diffusion and the extraction of information on the average properties of subcellular nanostructures. Results from this study provide insights into the behavior of molecules in moving, nanoscopic reference systems and advance our knowledge on cell function at the subcellular scale.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lishan Cui, Serena Renzi, Erica Quagliarini, Luca Digiacomo, Heinz Amenitsch, Laura Masuelli, Roberto Bei, Gianmarco Ferri, Francesco Cardarelli, Junbiao Wang, Augusto Amici, Daniela Pozzi, Cristina Marchini, Giulio Caracciolo
Summary: The study focused on the use of DNA-loaded lipid nanoparticles (LNPs) for tumor treatment, evaluating their transfection efficiency and toxicity in vitro. LNPs were found to effectively deliver DNA vaccine targeting the HER2 antigen, demonstrating massive expression on the cell membrane of HEK-293 cells.
Article
Oncology
Mariangela Morelli, Francesca Lessi, Serena Barachini, Romano Liotti, Nicola Montemurro, Paolo Perrini, Orazio Santo Santonocito, Carlo Gambacciani, Matija Snuderl, Francesco Pieri, Filippo Aquila, Azzurra Farnesi, Antonio Giuseppe Naccarato, Paolo Viacava, Francesco Cardarelli, Gianmarco Ferri, Paul Mulholland, Diego Ottaviani, Fabiola Paiar, Gaetano Liberti, Francesco Pasqualetti, Michele Menicagli, Paolo Aretini, Giovanni Signore, Sara Franceschi, Chiara Maria Mazzanti
Summary: This study developed a novel functional precision medicine approach to test the response to anticancer treatments in organoids derived from the resected tumors of glioblastoma patients. FLIM-based metabolic imaging was used to stratify tumors and identify new target genes associated with TMZ treatment and survival. This approach has the potential to improve the clinical management of GB patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Erica Quagliarini, Junbiao Wang, Serena Renzi, Lishan Cui, Luca Digiacomo, Gianmarco Ferri, Luca Pesce, Valentina De Lorenzi, Giulia Matteoli, Heinz Amenitsch, Laura Masuelli, Roberto Bei, Daniela Pozzi, Augusto Amici, Francesco Cardarelli, Cristina Marchini, Giulio Caracciolo
Summary: Lipid nanoparticles (LNPs) have shown promise as effective gene delivery vehicles, with a specific formulation (LNP15) demonstrating successful transfection and potential application in cancer vaccines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Lara Russo, Chiara Giacomelli, Mariagrazia Fortino, Tiziano Marzo, Gianmarco Ferri, Mariantonietta Calvello, Alessandro Viegi, Antonio Magri, Alessandro Pratesi, Adriana Pietropaolo, Francesco Cardarelli, Claudia Martini, Enrico Rizzarelli, Laura Marchetti, Diego La Mendola, Maria Letizia Trincavelli
Summary: A novel BDNF mimetic peptide was synthesized and shown to act as an agonist by promoting phosphorylation of TrkB and activation of downstream signaling pathways, demonstrating its neurotrophic activity and ability to promote neurite outgrowth.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biology
Fabio Azzarello, Luca Pesce, Valentina De Lorenzi, Gianmarco Ferri, Marta Tesi, Silvia Del Guerra, Piero Marchetti, Francesco Cardarelli
Summary: By combining live imaging with immunofluorescence, this research reveals the relationship between metabolic shifts in islet cells and cell types, and discovers an inverse correlation between tissue metabolic responses and insulin secretion power.
COMMUNICATIONS BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Mario Bernardi, Giovanni Signore, Aldo Moscardini, Licia Anna Pugliese, Luca Pesce, Fabio Beltram, Francesco Cardarelli
Summary: This study investigated the physical state and transformation process of Onivyde drug using fluorescence imaging techniques. The analysis revealed the coexistence of two physical states within Onivyde liposomes, with the gelated/precipitated phase dissolving rapidly upon dilution. The study also demonstrated the appearance of the SN-38 metabolite during intracellular processing. These findings provide fresh insights into the synthetic identity of Onivyde and highlight the importance of advanced imaging techniques in understanding drug formulations and improving delivery applications.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mario Bernardi, Michael Vernizzi, Laura Baraldi, Sandor Balog, Irene Bassanetti, Elisa Sgarbi, Luca Fornasari, Chiara Arrigoni, Francesco Cardarelli
Summary: Fluorescence lifetime imaging microscopy (FLIM) is used to study the supramolecular organization of liposomal all-trans retinoic acid (ATRA), exploiting its intrinsic fluorescence as signal and phasor transformation as a fit-free analytical tool. The results are validated by independent small-angle X-ray scattering (SAXS) and nano-differential scanning calorimetry (NanoDSC) measurements, probing ATRA's position on the membrane and its effect on membrane organization. This study not only provides insights on the specific case-study, but also confirms the effectiveness of Phasor-FLIM analysis in elucidating the nanoscale supramolecular organization of fluorescent drugs in pharmaceutical formulations.
Article
Chemistry, Multidisciplinary
Francesca Giulimondi, Luca Digiacomo, Elisabetta Vulpis, Luisa Loconte, Gianmarco Ferri, Francesco Cardarelli, Daniela Pozzi, Alessandra Zingoni, Giulio Caracciolo
Summary: The study demonstrates that nanoparticles with a protein corona can be captured by immune cells and modulate immune responses by regulating the production of inflammatory factors. This finding provides new approaches for disease treatment and prevention.
Article
Chemistry, Multidisciplinary
Paolo Tentori, Giovanni Signore, Andrea Camposeo, Annalisa Carretta, Gianmarco Ferri, Pasqualantonio Pingue, Stefano Luin, Daniela Pozzi, Enrico Gratton, Fabio Beltram, Giulio Caracciolo, Francesco Cardarelli
Summary: The supramolecular organization of Doxorubicin within the standard liposomal formulation was investigated using phasor approach to fluorescence lifetime imaging. The study revealed the existence and molar fractions of three fluorescent species: crystallized, free, and membrane-bound Doxorubicin within the formulation. This research is important for understanding the distribution of drugs in vivo.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)